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Protein

Origin recognition complex subunit 6

Gene

Orc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).By similarity

GO - Molecular functioni

  • DNA replication origin binding Source: GO_Central

GO - Biological processi

  • DNA-dependent DNA replication Source: MGI
  • DNA replication initiation Source: GO_Central
  • negative regulation of cell division Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 6
Gene namesi
Name:Orc6
Synonyms:Orc6l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1929285 Orc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270981 – 262Origin recognition complex subunit 6Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei239PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9WUJ8
MaxQBiQ9WUJ8
PaxDbiQ9WUJ8
PRIDEiQ9WUJ8

PTM databases

iPTMnetiQ9WUJ8
PhosphoSitePlusiQ9WUJ8

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4.By similarity1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-1915 Nuclear origin of replication recognition complex
CORUMiQ9WUJ8
STRINGi10090.ENSMUSP00000034132

Structurei

3D structure databases

ProteinModelPortaliQ9WUJ8
SMRiQ9WUJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC6 family.Curated

Phylogenomic databases

eggNOGiKOG4557 Eukaryota
ENOG4111GUY LUCA
HOGENOMiHOG000065679
HOVERGENiHBG007876
InParanoidiQ9WUJ8
PhylomeDBiQ9WUJ8

Family and domain databases

InterProiView protein in InterPro
IPR008721 ORC6
IPR020529 ORC6_met/pln
PANTHERiPTHR13394 PTHR13394, 1 hit
PfamiView protein in Pfam
PF05460 ORC6, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD315657 Origin_recog_cplx_su6-like, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9WUJ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESELVRRLA PRLGLAEPSV LRKAEEFLRL SKVKCVSLSA RSSETSNAVI
60 70 80 90 100
CLDLAASCRK CPLDRAYLIR LSGLNKMMYQ SCLKSFECLL GLNSNVGIRD
110 120 130 140 150
LAVQFSCTEA VNLAAEILQS YKSGLPETQR ADLDLSRPLF TTAALLSACK
160 170 180 190 200
ILKIKVDKTK MITTSGVKKA ILDRLCKQLE KIGQQINRDS ADLARPALKR
210 220 230 240 250
KKPEFSPTLK KKEPGLEPPA KEIEVIETLH KLPKDEDLTQ DYEEWKRKIL
260
ENAAKAQTAT AE
Length:262
Mass (Da):29,188
Last modified:November 1, 1999 - v1
Checksum:iF8D27EF9C87DE16C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q66JV6Q66JV6_MOUSE
Origin recognition complex subunit ...
Orc6 Orc6l
262Annotation score:
Q3TQX1Q3TQX1_MOUSE
Origin recognition complex subunit ...
Orc6 Orc6l
186Annotation score:
A0A1B0GR56A0A1B0GR56_MOUSE
Origin recognition complex subunit ...
Orc6
156Annotation score:
A0A1B0GSE2A0A1B0GSE2_MOUSE
Origin recognition complex subunit ...
Orc6
160Annotation score:
A0A1B0GRE5A0A1B0GRE5_MOUSE
Origin recognition complex subunit ...
Orc6
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139659 mRNA Translation: AAD32667.1
CCDSiCCDS22497.1
UniGeneiMm.29709

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139659 mRNA Translation: AAD32667.1
CCDSiCCDS22497.1
UniGeneiMm.29709

3D structure databases

ProteinModelPortaliQ9WUJ8
SMRiQ9WUJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1915 Nuclear origin of replication recognition complex
CORUMiQ9WUJ8
STRINGi10090.ENSMUSP00000034132

PTM databases

iPTMnetiQ9WUJ8
PhosphoSitePlusiQ9WUJ8

Proteomic databases

EPDiQ9WUJ8
MaxQBiQ9WUJ8
PaxDbiQ9WUJ8
PRIDEiQ9WUJ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1929285 Orc6

Phylogenomic databases

eggNOGiKOG4557 Eukaryota
ENOG4111GUY LUCA
HOGENOMiHOG000065679
HOVERGENiHBG007876
InParanoidiQ9WUJ8
PhylomeDBiQ9WUJ8

Miscellaneous databases

ChiTaRSiOrc6 mouse
PROiPR:Q9WUJ8
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR008721 ORC6
IPR020529 ORC6_met/pln
PANTHERiPTHR13394 PTHR13394, 1 hit
PfamiView protein in Pfam
PF05460 ORC6, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD315657 Origin_recog_cplx_su6-like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORC6_MOUSE
AccessioniPrimary (citable) accession number: Q9WUJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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