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UniProtKB - Q9WUI9 (NCOA2_RAT)

Entry version 156 (25 May 2022)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
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Protein

Nuclear receptor coactivator 2

Gene

Ncoa2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-159418, Recycling of bile acids and salts
R-RNO-192105, Synthesis of bile acids and bile salts
R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-RNO-211976, Endogenous sterols
R-RNO-3214847, HATs acetylate histones
R-RNO-400206, Regulation of lipid metabolism by PPARalpha
R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-RNO-9707564, Cytoprotection by HMOX1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 2
Short name:
NCoA-2
Alternative name(s):
Transcriptional intermediary factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncoa2
Synonyms:Tif2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		620108, Ncoa2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944042 – 1465Nuclear receptor coactivator 2Add BLAST1464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei29PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei338Asymmetric dimethylarginineBy similarity1
Modified residuei396PhosphoserineCombined sources1
Modified residuei487PhosphoserineBy similarity1
Modified residuei493PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei554PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei636N6-acetyllysineBy similarity1
Modified residuei640N6-acetyllysineBy similarity1
Cross-linki648Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei682PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki731Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei736PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Modified residuei780N6-acetyllysineBy similarity1
Modified residuei785N6-acetyllysineBy similarity1
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei864Asymmetric dimethylarginineBy similarity1
Modified residuei874Asymmetric dimethylarginineBy similarity1
Modified residuei1173Asymmetric dimethylarginineBy similarity1
Modified residuei1177Asymmetric dimethylarginineBy similarity1
Modified residuei1190Asymmetric dimethylarginineBy similarity1
Modified residuei1196Asymmetric dimethylarginineBy similarity1
Modified residuei1203Asymmetric dimethylarginineBy similarity1
Modified residuei1221Asymmetric dimethylarginineBy similarity1
Modified residuei1240Asymmetric dimethylarginineBy similarity1
Modified residuei1261Omega-N-methylarginineBy similarity1
Modified residuei1266Asymmetric dimethylarginineBy similarity1
Cross-linki1455Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9WUI9

PRoteomics IDEntifications database

More...PRIDEi		Q9WUI9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9WUI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9WUI9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP.

Interacts (via C-terminus) with CREBBP.

Interacts with ESR1, HIF1A, NCOA1, APEX1, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300.

Interacts with CASP8AP2 and TTLL5/STAMP.

Interacts with PSMB9 and DDX5.

Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif).

Interacts with RWDD3.

Interacts with CLOCK and ARNTL/BMAL1.

Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity).

Interacts with NR1H3 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000011026

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9WUI9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9WUI9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9WUI9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 83bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini119 – 183PASPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni449 – 528DisorderedSequence analysisAdd BLAST80
Regioni547 – 741DisorderedSequence analysisAdd BLAST195
Regioni691 – 743CASP8AP2-bindingBy similarityAdd BLAST53
Regioni730 – 1121Interaction with ARNTLBy similarityAdd BLAST392
Regioni1052 – 1075DisorderedSequence analysisAdd BLAST24
Regioni1311 – 1330DisorderedSequence analysisAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi641 – 645LXXLL motif 15
Motifi690 – 694LXXLL motif 25
Motifi745 – 749LXXLL motif 35
Motifi878 – 882LXXLL motif 45
Motifi1079 – 1087LLXXLXXXL motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 40Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi449 – 488Polar residuesSequence analysisAdd BLAST40
Compositional biasi505 – 528Polar residuesSequence analysisAdd BLAST24
Compositional biasi556 – 572Polar residuesSequence analysisAdd BLAST17
Compositional biasi637 – 678Polar residuesSequence analysisAdd BLAST42
Compositional biasi712 – 729Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.By similarity
The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.By similarity
Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3561, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9WUI9

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9WUI9

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit
6.10.140.20, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50249

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR032565, DUF4927
IPR036638, HLH_DNA-bd_sf
IPR010011, NCO_DUF1518
IPR028822, NCOA2
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL

The PANTHER Classification System

More...PANTHERi		PTHR10684, PTHR10684, 1 hit
PTHR10684:SF2, PTHR10684:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07469, DUF1518, 1 hit
PF16279, DUF4927, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038181, Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01151, DUF1518, 1 hit
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9WUI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA 
        60         70         80         90        100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 
       110        120        130        140        150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN 
       160        170        180        190        200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWTGEP PRRNSHTFNC 
       210        220        230        240        250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDKQSCLI 
       260        270        280        290        300
CVARRVPMKE RPALPSSESF TTRQDLQGKI TFLDTSTMRD AMKPGWEDLV 
       310        320        330        340        350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 
       360        370        380        390        400
TKSKLIRSQT TNEPQLVISI HMLHREQNVC VMNPDLTGQA MGKPLSPMSS 
       410        420        430        440        450
SSPARQAMCS GNPGQDVALG SNMNFPMNGP REQMSMPMGR FGGSGGMNHV 
       460        470        480        490        500
SGMQATTPQG SNYALKMNSP SQSSPGLNPG QPSSVLSPRH RMSPGVAGSP 
       510        520        530        540        550
RVPPSQFSPA GSLHSPAGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGP 
       560        570        580        590        600
SLASPDLKMG NSQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 
       610        620        630        640        650
QASCHPEEQK RPNDSSMPQA ASEDRAEGHS RLHESKGQTK LLQLLTTKSD 
       660        670        680        690        700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP 
       710        720        730        740        750
VDLAKLTAEA TGKELNQESS GTAPGSEVTV KQEPASPKKK ENALLRYLLD 
       760        770        780        790        800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG 
       810        820        830        840        850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS 
       860        870        880        890        900
SPVTPVGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 
       910        920        930        940        950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRSSMP 
       960        970        980        990       1000
SGEWAPQSPA VRVTCAATTG AMNRPIQGGM IRNPTASIPM RANSQPGQRQ 
      1010       1020       1030       1040       1050
MLQPQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFGS 
      1060       1070       1080       1090       1100
QNRHPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL 
      1110       1120       1130       1140       1150
GIPELVSQSQ AVDPEQFSSQ ESSMMLEQKP PVFPQQYASQ TQMAQGSYNP 
      1160       1170       1180       1190       1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 
      1210       1220       1230       1240       1250
QNRQPLMNQI SGVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR 
      1260       1270       1280       1290       1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPT GLPAAMSNPR IPQANAQQFP 
      1310       1320       1330       1340       1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQPA 
      1360       1370       1380       1390       1400
SDINGWAQGS MGGNSMFSQQ SPPHFGQQAN TSMYNNNMNI NVSMATNTAG 
      1410       1420       1430       1440       1450
LSNMNQMTGQ MSMTSVTSVP TSGLSSMGPE QVNDPALRGS SLFTTNQLPG 
      1460 
MDMIKQEGDG SRKYC
Length:1,465
Mass (Da):159,436
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36625B573EB0B39C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1MA61F1MA61_RAT
Nuclear receptor coactivator
Ncoa2
1,465Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I6AJ68A0A8I6AJ68_RAT
Nuclear receptor coactivator 2
Ncoa2
1,396Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I6AVI1A0A8I6AVI1_RAT
Nuclear receptor coactivator 2
Ncoa2
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF136943 mRNA Translation: AAD24587.1

NCBI Reference Sequences

More...RefSeqi		NP_114010.1, NM_031822.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:83724

UCSC genome browser

More...UCSCi		RGD:620108, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136943 mRNA Translation: AAD24587.1
RefSeqiNP_114010.1, NM_031822.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XLSX-ray2.96I/J/K/L/M/N/O/P740-756[»]
3HLVX-ray3.00C/D686-698[»]
3HM1X-ray2.33C/D686-698[»]
3L03X-ray1.90C/D686-698[»]
AlphaFoldDBiQ9WUI9
SMRiQ9WUI9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011026

PTM databases

iPTMnetiQ9WUI9
PhosphoSitePlusiQ9WUI9

Proteomic databases

PaxDbiQ9WUI9
PRIDEiQ9WUI9

Genome annotation databases

GeneIDi83724
KEGGirno:83724
UCSCiRGD:620108, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10499
RGDi620108, Ncoa2

Phylogenomic databases

eggNOGiKOG3561, Eukaryota
InParanoidiQ9WUI9
PhylomeDBiQ9WUI9

Enzyme and pathway databases

ReactomeiR-RNO-159418, Recycling of bile acids and salts
R-RNO-192105, Synthesis of bile acids and bile salts
R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-RNO-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-RNO-211976, Endogenous sterols
R-RNO-3214847, HATs acetylate histones
R-RNO-400206, Regulation of lipid metabolism by PPARalpha
R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-RNO-9707564, Cytoprotection by HMOX1

Miscellaneous databases

EvolutionaryTraceiQ9WUI9

Protein Ontology

More...PROi		PR:Q9WUI9

Family and domain databases

CDDicd00130, PAS, 1 hit
Gene3Di4.10.280.10, 1 hit
6.10.140.20, 1 hit
IDEALiIID50249
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR032565, DUF4927
IPR036638, HLH_DNA-bd_sf
IPR010011, NCO_DUF1518
IPR028822, NCOA2
IPR009110, Nuc_rcpt_coact
IPR014920, Nuc_rcpt_coact_Ncoa-typ
IPR037077, Nuc_rcpt_coact_Ncoa_int_sf
IPR017426, Nuclear_rcpt_coactivator
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR014935, SRC/p160_LXXLL
PANTHERiPTHR10684, PTHR10684, 1 hit
PTHR10684:SF2, PTHR10684:SF2, 1 hit
PfamiView protein in Pfam
PF07469, DUF1518, 1 hit
PF16279, DUF4927, 1 hit
PF08815, Nuc_rec_co-act, 1 hit
PF00989, PAS, 1 hit
PF08832, SRC-1, 1 hit
PIRSFiPIRSF038181, Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151, DUF1518, 1 hit
SM00353, HLH, 1 hit
SM00091, PAS, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
SSF69125, SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WUI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: May 25, 2022
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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