UniProtKB - Q9WUI9 (NCOA2_RAT)

BLAST

>sp|Q9WUI9|NCOA2_RAT Nuclear receptor coactivator 2 OS=Rattus norvegicus OX=10116 GN=Ncoa2 PE=1 SV=1
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDI
DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSM
VNGGSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
EGEDKQSCLICVARRVPMKERPALPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLV
RRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
TNEPQLVISIHMLHREQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALG
SNMNFPMNGPREQMSMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPG
QPSSVLSPRHRMSPGVAGSPRVPPSQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQAL
SEGHGVSLGPSLASPDLKMGNSQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA
QASCHPEEQKRPNDSSMPQAASEDRAEGHSRLHESKGQTKLLQLLTTKSDQMEPSPLPSS
LSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESS
GTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK
LIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAII
NDLMQLTADSSPVTPVGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG
PFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRSSMPSGEWAPQSPA
VRVTCAATTGAMNRPIQGGMIRNPTASIPMRANSQPGQRQMLQPQVMNIGPSELEMNMGG
PQYNQQQAPPNQTAPWPESILPIDQASFGSQNRHPFGSSPDDLLCPHPAAESPSDEGALL
DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQESSMMLEQKPPVFPQQYASQ
TQMAQGSYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQ
QNRQPLMNQISGVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ
RTLMMRGQGLNMTPSMVAPTGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT
PQSPLMSPRMAHTQSPMMQQSQANPAYQPASDINGWAQGSMGGNSMFSQQSPPHFGQQAN
TSMYNNNMNINVSMATNTAGLSNMNQMTGQMSMTSVTSVPTSGLSSMGPEQVNDPALRGS
SLFTTNQLPGMDMIKQEGDGSRKYC

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History
Entry version 143 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
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Protein

Nuclear receptor coactivator 2

Gene

Ncoa2

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer.By similarity

GO - Molecular functionⁱ

DNA polymerase binding
Source: RGD
Inferred from physical interactionⁱ
- 11734998
estrogen receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 20678994
glucocorticoid receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 9742117
nuclear hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 20678994
- 9742117
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
PDZ domain binding
Source: RGD
Inferred from physical interactionⁱ
- 17084383
progesterone receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 20678994
protein-containing complex binding
Source: RGD
Inferred from physical interactionⁱ
- 15234273
protein dimerization activity Source: InterPro
retinoic acid receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 15234273
retinoid X receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 15234273
thyroid hormone receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 9742117
transcription coactivator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hormone stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cerebellum development
Source: RGD
Inferred from expression patternⁱ
- 10803578
circadian regulation of gene expression Source: UniProtKB
male gonad development
Source: RGD
Inferred from expression patternⁱ
- 16189181
positive regulation of female receptivity
Source: RGD
Inferred from mutant phenotypeⁱ
- 12089347
positive regulation of glucocorticoid receptor signaling pathway
Source: RGD
Inferred from mutant phenotypeⁱ
- 17481888
positive regulation of transcription by RNA polymerase II
Source: RGD
Inferred from mutant phenotypeⁱ
- 17481888

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Biological rhythms, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor coactivator 2 Short name: NCoA-2 Alternative name(s): Transcriptional intermediary factor 2
Gene namesⁱ	Name:Ncoa2 Synonyms:Tif2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	620108 Ncoa2

RGDⁱ

620108 Ncoa2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000094404	2 – 1465	Nuclear receptor coactivator 2Add BLAST		1464

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	29	PhosphoserineBy similarity	1
Cross-linkⁱ	239	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	338	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	396	PhosphoserineCombined sources	1
Modified residueⁱ	487	PhosphoserineBy similarity	1
Modified residueⁱ	493	PhosphoserineCombined sources	1
Modified residueⁱ	499	PhosphoserineCombined sources	1
Modified residueⁱ	554	PhosphoserineBy similarity	1
Modified residueⁱ	565	PhosphoserineBy similarity	1
Modified residueⁱ	636	N6-acetyllysineBy similarity	1
Modified residueⁱ	640	N6-acetyllysineBy similarity	1
Cross-linkⁱ	648	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	682	PhosphoserineBy similarity	1
Modified residueⁱ	699	PhosphoserineCombined sources	1
Cross-linkⁱ	705	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	731	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	736	PhosphoserineBy similarity	1
Modified residueⁱ	771	PhosphoserineBy similarity	1
Modified residueⁱ	780	N6-acetyllysineBy similarity	1
Modified residueⁱ	785	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	785	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	864	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	874	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1173	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1177	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1190	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1196	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1203	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1221	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1240	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	1261	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	1266	Asymmetric dimethylarginineBy similarity	1
Cross-linkⁱ	1455	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9WUI9
PRIDEⁱ	Q9WUI9

PTM databases

iPTMnetⁱ	Q9WUI9
PhosphoSitePlusⁱ	Q9WUI9

Interactionⁱ

Subunit structureⁱ

Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. Interacts with CLOCK and ARNTL/BMAL1. Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity). Interacts with NR1H3 (By similarity).By similarity

GO - Molecular functionⁱ

DNA polymerase binding
Source: RGD
Inferred from physical interactionⁱ
- 11734998
estrogen receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 20678994
glucocorticoid receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 9742117
nuclear hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 20678994
- 9742117
PDZ domain binding
Source: RGD
Inferred from physical interactionⁱ
- 17084383
progesterone receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 20678994
protein dimerization activity Source: InterPro
retinoic acid receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 15234273
retinoid X receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 15234273
thyroid hormone receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 9742117

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011026

STRINGⁱ

10116.ENSRNOP00000011026

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	689 – 695	Combined sources		7
Helixⁱ	744 – 748	Combined sources		5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9WUI9
SMRⁱ	Q9WUI9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9WUI9

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 83	bHLHPROSITE-ProRule annotationAdd BLAST		58
Domainⁱ	119 – 183	PASPROSITE-ProRule annotationAdd BLAST		65

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	691 – 743	CASP8AP2-bindingAdd BLAST		53
Regionⁱ	730 – 1121	Interaction with ARNTLBy similarityAdd BLAST		392

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	641 – 645	LXXLL motif 1	5
Motifⁱ	690 – 694	LXXLL motif 2	5
Motifⁱ	745 – 749	LXXLL motif 3	5
Motifⁱ	878 – 882	LXXLL motif 4	5
Motifⁱ	1079 – 1087	LLXXLXXXL motif	9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1254 – 1260	Poly-Gln		7

Domainⁱ

Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (By similarity).By similarity

The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.By similarity

Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.By similarity

Sequence similaritiesⁱ

Belongs to the SRC/p160 nuclear receptor coactivator family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5S Eukaryota ENOG410XPF9 LUCA
HOGENOMⁱ	HOG000230947
HOVERGENⁱ	HBG052583
InParanoidⁱ	Q9WUI9
KEGG Orthology (KO) More...KOⁱ	K11255
PhylomeDBⁱ	Q9WUI9

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 1 hit
Gene3Dⁱ	1.10.287.1070, 1 hit 4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR010011 DUF1518 IPR032565 DUF4927 IPR036638 HLH_DNA-bd_sf IPR028822 NCOA2 IPR009110 Nuc_rcpt_coact IPR014920 Nuc_rcpt_coact_Ncoa-typ IPR037077 Nuc_rcpt_coact_Ncoa_int_sf IPR017426 Nuclear_rcpt_coactivator IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR014935 SRC/p160_LXXLL
PANTHERⁱ	PTHR10684 PTHR10684, 1 hit PTHR10684:SF2 PTHR10684:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07469 DUF1518, 1 hit PF16279 DUF4927, 1 hit PF08815 Nuc_rec_co-act, 1 hit PF00989 PAS, 1 hit PF08832 SRC-1, 1 hit
PIRSFⁱ	PIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTⁱ	View protein in SMART SM01151 DUF1518, 1 hit SM00353 HLH, 1 hit SM00091 PAS, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits SSF69125 SSF69125, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9WUI9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA 
        60         70         80         90        100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 
       110        120        130        140        150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN 
       160        170        180        190        200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWTGEP PRRNSHTFNC 
       210        220        230        240        250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDKQSCLI 
       260        270        280        290        300
CVARRVPMKE RPALPSSESF TTRQDLQGKI TFLDTSTMRD AMKPGWEDLV 
       310        320        330        340        350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 
       360        370        380        390        400
TKSKLIRSQT TNEPQLVISI HMLHREQNVC VMNPDLTGQA MGKPLSPMSS 
       410        420        430        440        450
SSPARQAMCS GNPGQDVALG SNMNFPMNGP REQMSMPMGR FGGSGGMNHV 
       460        470        480        490        500
SGMQATTPQG SNYALKMNSP SQSSPGLNPG QPSSVLSPRH RMSPGVAGSP 
       510        520        530        540        550
RVPPSQFSPA GSLHSPAGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGP 
       560        570        580        590        600
SLASPDLKMG NSQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 
       610        620        630        640        650
QASCHPEEQK RPNDSSMPQA ASEDRAEGHS RLHESKGQTK LLQLLTTKSD 
       660        670        680        690        700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP 
       710        720        730        740        750
VDLAKLTAEA TGKELNQESS GTAPGSEVTV KQEPASPKKK ENALLRYLLD 
       760        770        780        790        800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG 
       810        820        830        840        850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS 
       860        870        880        890        900
SPVTPVGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 
       910        920        930        940        950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRSSMP 
       960        970        980        990       1000
SGEWAPQSPA VRVTCAATTG AMNRPIQGGM IRNPTASIPM RANSQPGQRQ 
      1010       1020       1030       1040       1050
MLQPQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFGS 
      1060       1070       1080       1090       1100
QNRHPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL 
      1110       1120       1130       1140       1150
GIPELVSQSQ AVDPEQFSSQ ESSMMLEQKP PVFPQQYASQ TQMAQGSYNP 
      1160       1170       1180       1190       1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 
      1210       1220       1230       1240       1250
QNRQPLMNQI SGVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR 
      1260       1270       1280       1290       1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPT GLPAAMSNPR IPQANAQQFP 
      1310       1320       1330       1340       1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQPA 
      1360       1370       1380       1390       1400
SDINGWAQGS MGGNSMFSQQ SPPHFGQQAN TSMYNNNMNI NVSMATNTAG 
      1410       1420       1430       1440       1450
LSNMNQMTGQ MSMTSVTSVP TSGLSSMGPE QVNDPALRGS SLFTTNQLPG 
      1460 
MDMIKQEGDG SRKYC

Length:1,465

Mass (Da):159,436

Last modified:November 1, 1999 - v1

Checksum:ⁱ36625B573EB0B39C

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F1MA61	F1MA61_RAT		Nuclear receptor coactivator Nuclear receptor coactivator	Ncoa2	1,465	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136943 mRNA Translation: AAD24587.1
NCBI Reference Sequences More...RefSeqⁱ	NP_114010.1, NM_031822.1
UniGeneⁱ	Rn.49136

Genome annotation databases

GeneIDⁱ	83724
KEGGⁱ	rno:83724
UCSC genome browser More...UCSCⁱ	RGD:620108 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WUI9	Nuclear receptor coactivator 2	)	MOUSE		1462	UniRef90_Q61026
Nuclear receptor coactivator 2	)	HUMAN		1464
Nuclear receptor coactivator		RHIRO		1475
Nuclear receptor coactivator		RHIBE		1475
Nuclear receptor coactivator		MACMU		1468
+184

Protein	Similar proteins		Species	Score	Length	Source
Q9WUI9	Nuclear receptor coactivator 2	)	MOUSE		1462	UniRef50_Q61026
Nuclear receptor coactivator 2	)	HUMAN		1464
Nuclear receptor coactivator		RHIRO		1475
Nuclear receptor coactivator		RHIBE		1475
Nuclear receptor coactivator		PAPAN		1468
+193

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136943 mRNA Translation: AAD24587.1
RefSeqⁱ	NP_114010.1, NM_031822.1
UniGeneⁱ	Rn.49136

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XLS	X-ray	2.96	I/J/K/L/M/N/O/P	740-756	[»]
	3HLV	X-ray	3.00	C/D	686-698	[»]
	3HM1	X-ray	2.33	C/D	686-698	[»]
	3L03	X-ray	1.90	C/D	686-698	[»]
ProteinModelPortalⁱ	Q9WUI9
SMRⁱ	Q9WUI9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000011026

STRINGⁱ

10116.ENSRNOP00000011026

PTM databases

iPTMnetⁱ	Q9WUI9
PhosphoSitePlusⁱ	Q9WUI9

Proteomic databases

PaxDbⁱ	Q9WUI9
PRIDEⁱ	Q9WUI9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	83724
KEGGⁱ	rno:83724
UCSCⁱ	RGD:620108 rat

Organism-specific databases

CTDⁱ	10499
RGDⁱ	620108 Ncoa2

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5S Eukaryota ENOG410XPF9 LUCA
HOGENOMⁱ	HOG000230947
HOVERGENⁱ	HBG052583
InParanoidⁱ	Q9WUI9
KOⁱ	K11255
PhylomeDBⁱ	Q9WUI9

Miscellaneous databases

EvolutionaryTraceⁱ	Q9WUI9
Protein Ontology More...PROⁱ	PR:Q9WUI9

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 1 hit
Gene3Dⁱ	1.10.287.1070, 1 hit 4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR010011 DUF1518 IPR032565 DUF4927 IPR036638 HLH_DNA-bd_sf IPR028822 NCOA2 IPR009110 Nuc_rcpt_coact IPR014920 Nuc_rcpt_coact_Ncoa-typ IPR037077 Nuc_rcpt_coact_Ncoa_int_sf IPR017426 Nuclear_rcpt_coactivator IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold IPR014935 SRC/p160_LXXLL
PANTHERⁱ	PTHR10684 PTHR10684, 1 hit PTHR10684:SF2 PTHR10684:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF07469 DUF1518, 1 hit PF16279 DUF4927, 1 hit PF08815 Nuc_rec_co-act, 1 hit PF00989 PAS, 1 hit PF08832 SRC-1, 1 hit
PIRSFⁱ	PIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTⁱ	View protein in SMART SM01151 DUF1518, 1 hit SM00353 HLH, 1 hit SM00091 PAS, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits SSF69125 SSF69125, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NCOA2_RAT
Accessionⁱ	Q9WUI9Primary (citable) accession number: Q9WUI9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - Q9WUI9 (NCOA2_RAT)

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Nuclear receptor coactivator 2

Ncoa2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Endoplasmic reticulum

Golgi apparatus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ