UniProtKB - Q9WUI9 (NCOA2_RAT)
Nuclear receptor coactivator 2
Ncoa2
Functioni
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer.
By similarityGO - Molecular functioni
- aryl hydrocarbon receptor binding Source: RGD
- chromatin binding Source: RGD
- DNA polymerase binding Source: RGD
- estrogen receptor binding Source: RGD
- glucocorticoid receptor binding Source: RGD
- nuclear receptor binding Source: RGD
- nuclear receptor coactivator activity Source: RGD
- PDZ domain binding Source: RGD
- progesterone receptor binding Source: RGD
- protein-containing complex binding Source: RGD
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: RGD
- retinoic acid receptor binding Source: RGD
- retinoid X receptor binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- signaling receptor binding Source: RGD
- thyroid hormone receptor binding Source: RGD
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- cellular response to hormone stimulus Source: GO_Central
- cellular response to Thyroglobulin triiodothyronine Source: RGD
- cerebellum development Source: RGD
- circadian regulation of gene expression Source: UniProtKB
- circadian rhythm Source: RGD
- locomotor rhythm Source: RGD
- male gonad development Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of female receptivity Source: RGD
- positive regulation of glucocorticoid receptor signaling pathway Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of gene expression Source: RGD
- regulation of glucose metabolic process Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- response to progesterone Source: RGD
Keywordsi
Molecular function | Activator |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-RNO-159418, Recycling of bile acids and salts R-RNO-192105, Synthesis of bile acids and bile salts R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-RNO-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-RNO-211976, Endogenous sterols R-RNO-3214847, HATs acetylate histones R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-RNO-9707564, Cytoprotection by HMOX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor coactivator 2Short name: NCoA-2 Alternative name(s): Transcriptional intermediary factor 2 |
Gene namesi | Name:Ncoa2 Synonyms:Tif2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620108, Ncoa2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- microtubule Source: RGD
Endoplasmic reticulum
- rough endoplasmic reticulum Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Nucleus
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- dendrite Source: RGD
- dendritic spine Source: RGD
- neuronal cell body Source: RGD
- postsynaptic density Source: RGD
- presynaptic active zone Source: RGD
- protein-containing complex Source: RGD
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000094404 | 2 – 1465 | Nuclear receptor coactivator 2Add BLAST | 1464 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 29 | PhosphoserineBy similarity | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 338 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 396 | PhosphoserineCombined sources | 1 | |
Modified residuei | 487 | PhosphoserineBy similarity | 1 | |
Modified residuei | 493 | PhosphoserineCombined sources | 1 | |
Modified residuei | 499 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineBy similarity | 1 | |
Modified residuei | 565 | PhosphoserineBy similarity | 1 | |
Modified residuei | 636 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 640 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 648 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 682 | PhosphoserineBy similarity | 1 | |
Modified residuei | 699 | PhosphoserineCombined sources | 1 | |
Cross-linki | 705 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 731 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 736 | PhosphoserineBy similarity | 1 | |
Modified residuei | 771 | PhosphoserineBy similarity | 1 | |
Modified residuei | 780 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 785 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 785 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 864 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 874 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1173 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1177 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1190 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1196 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1203 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1221 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1240 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1261 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1266 | Asymmetric dimethylarginineBy similarity | 1 | |
Cross-linki | 1455 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9WUI9 |
PRIDEi | Q9WUI9 |
PTM databases
iPTMneti | Q9WUI9 |
PhosphoSitePlusi | Q9WUI9 |
Interactioni
Subunit structurei
Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP.
Interacts (via C-terminus) with CREBBP.
Interacts with ESR1, HIF1A, NCOA1, APEX1, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300.
Interacts with CASP8AP2 and TTLL5/STAMP.
Interacts with PSMB9 and DDX5.
Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif).
Interacts with RWDD3.
Interacts with CLOCK and ARNTL/BMAL1.
Interacts with NR4A3; potentiates the activity of the NR4A3 (By similarity).
Interacts with NR1H3 (By similarity).
By similarityGO - Molecular functioni
- aryl hydrocarbon receptor binding Source: RGD
- DNA polymerase binding Source: RGD
- estrogen receptor binding Source: RGD
- glucocorticoid receptor binding Source: RGD
- nuclear receptor binding Source: RGD
- PDZ domain binding Source: RGD
- progesterone receptor binding Source: RGD
- protein dimerization activity Source: InterPro
- protein domain specific binding Source: RGD
- retinoic acid receptor binding Source: RGD
- retinoid X receptor binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- signaling receptor binding Source: RGD
- thyroid hormone receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011026 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9WUI9 |
SMRi | Q9WUI9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9WUI9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 83 | bHLHPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 119 – 183 | PASPROSITE-ProRule annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 449 – 528 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 547 – 741 | DisorderedSequence analysisAdd BLAST | 195 | |
Regioni | 691 – 743 | CASP8AP2-bindingBy similarityAdd BLAST | 53 | |
Regioni | 730 – 1121 | Interaction with ARNTLBy similarityAdd BLAST | 392 | |
Regioni | 1052 – 1075 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1311 – 1330 | DisorderedSequence analysisAdd BLAST | 20 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 641 – 645 | LXXLL motif 1 | 5 | |
Motifi | 690 – 694 | LXXLL motif 2 | 5 | |
Motifi | 745 – 749 | LXXLL motif 3 | 5 | |
Motifi | 878 – 882 | LXXLL motif 4 | 5 | |
Motifi | 1079 – 1087 | LLXXLXXXL motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 11 – 40 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 449 – 488 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 505 – 528 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 556 – 572 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 637 – 678 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 712 – 729 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
InParanoidi | Q9WUI9 |
PhylomeDBi | Q9WUI9 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.20, 1 hit |
IDEALi | IID50249 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032565, DUF4927 IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028822, NCOA2 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF2, PTHR10684:SF2, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 1 hit PF16279, DUF4927, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 1 hit SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA
60 70 80 90 100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS
110 120 130 140 150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN
160 170 180 190 200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWTGEP PRRNSHTFNC
210 220 230 240 250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDKQSCLI
260 270 280 290 300
CVARRVPMKE RPALPSSESF TTRQDLQGKI TFLDTSTMRD AMKPGWEDLV
310 320 330 340 350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ
360 370 380 390 400
TKSKLIRSQT TNEPQLVISI HMLHREQNVC VMNPDLTGQA MGKPLSPMSS
410 420 430 440 450
SSPARQAMCS GNPGQDVALG SNMNFPMNGP REQMSMPMGR FGGSGGMNHV
460 470 480 490 500
SGMQATTPQG SNYALKMNSP SQSSPGLNPG QPSSVLSPRH RMSPGVAGSP
510 520 530 540 550
RVPPSQFSPA GSLHSPAGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGP
560 570 580 590 600
SLASPDLKMG NSQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA
610 620 630 640 650
QASCHPEEQK RPNDSSMPQA ASEDRAEGHS RLHESKGQTK LLQLLTTKSD
660 670 680 690 700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP
710 720 730 740 750
VDLAKLTAEA TGKELNQESS GTAPGSEVTV KQEPASPKKK ENALLRYLLD
760 770 780 790 800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG
810 820 830 840 850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS
860 870 880 890 900
SPVTPVGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG
910 920 930 940 950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRSSMP
960 970 980 990 1000
SGEWAPQSPA VRVTCAATTG AMNRPIQGGM IRNPTASIPM RANSQPGQRQ
1010 1020 1030 1040 1050
MLQPQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFGS
1060 1070 1080 1090 1100
QNRHPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL
1110 1120 1130 1140 1150
GIPELVSQSQ AVDPEQFSSQ ESSMMLEQKP PVFPQQYASQ TQMAQGSYNP
1160 1170 1180 1190 1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ
1210 1220 1230 1240 1250
QNRQPLMNQI SGVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR
1260 1270 1280 1290 1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPT GLPAAMSNPR IPQANAQQFP
1310 1320 1330 1340 1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQPA
1360 1370 1380 1390 1400
SDINGWAQGS MGGNSMFSQQ SPPHFGQQAN TSMYNNNMNI NVSMATNTAG
1410 1420 1430 1440 1450
LSNMNQMTGQ MSMTSVTSVP TSGLSSMGPE QVNDPALRGS SLFTTNQLPG
1460
MDMIKQEGDG SRKYC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1MA61 | F1MA61_RAT | Nuclear receptor coactivator | Ncoa2 | 1,465 | Annotation score: | ||
A0A8I6AJ68 | A0A8I6AJ68_RAT | Nuclear receptor coactivator 2 | Ncoa2 | 1,396 | Annotation score: | ||
A0A8I6AVI1 | A0A8I6AVI1_RAT | Nuclear receptor coactivator 2 | Ncoa2 | 265 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF136943 mRNA Translation: AAD24587.1 |
RefSeqi | NP_114010.1, NM_031822.1 |
Genome annotation databases
GeneIDi | 83724 |
KEGGi | rno:83724 |
UCSCi | RGD:620108, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF136943 mRNA Translation: AAD24587.1 |
RefSeqi | NP_114010.1, NM_031822.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XLS | X-ray | 2.96 | I/J/K/L/M/N/O/P | 740-756 | [»] | |
3HLV | X-ray | 3.00 | C/D | 686-698 | [»] | |
3HM1 | X-ray | 2.33 | C/D | 686-698 | [»] | |
3L03 | X-ray | 1.90 | C/D | 686-698 | [»] | |
AlphaFoldDBi | Q9WUI9 | |||||
SMRi | Q9WUI9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000011026 |
PTM databases
iPTMneti | Q9WUI9 |
PhosphoSitePlusi | Q9WUI9 |
Proteomic databases
PaxDbi | Q9WUI9 |
PRIDEi | Q9WUI9 |
Genome annotation databases
GeneIDi | 83724 |
KEGGi | rno:83724 |
UCSCi | RGD:620108, rat |
Organism-specific databases
CTDi | 10499 |
RGDi | 620108, Ncoa2 |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
InParanoidi | Q9WUI9 |
PhylomeDBi | Q9WUI9 |
Enzyme and pathway databases
Reactomei | R-RNO-159418, Recycling of bile acids and salts R-RNO-192105, Synthesis of bile acids and bile salts R-RNO-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-RNO-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-RNO-211976, Endogenous sterols R-RNO-3214847, HATs acetylate histones R-RNO-400206, Regulation of lipid metabolism by PPARalpha R-RNO-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-RNO-9707564, Cytoprotection by HMOX1 |
Miscellaneous databases
EvolutionaryTracei | Q9WUI9 |
PROi | PR:Q9WUI9 |
Family and domain databases
CDDi | cd00130, PAS, 1 hit |
Gene3Di | 4.10.280.10, 1 hit 6.10.140.20, 1 hit |
IDEALi | IID50249 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032565, DUF4927 IPR036638, HLH_DNA-bd_sf IPR010011, NCO_DUF1518 IPR028822, NCOA2 IPR009110, Nuc_rcpt_coact IPR014920, Nuc_rcpt_coact_Ncoa-typ IPR037077, Nuc_rcpt_coact_Ncoa_int_sf IPR017426, Nuclear_rcpt_coactivator IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR014935, SRC/p160_LXXLL |
PANTHERi | PTHR10684, PTHR10684, 1 hit PTHR10684:SF2, PTHR10684:SF2, 1 hit |
Pfami | View protein in Pfam PF07469, DUF1518, 1 hit PF16279, DUF4927, 1 hit PF08815, Nuc_rec_co-act, 1 hit PF00989, PAS, 1 hit PF08832, SRC-1, 1 hit |
PIRSFi | PIRSF038181, Nuclear_receptor_coactivator, 1 hit |
SMARTi | View protein in SMART SM01151, DUF1518, 1 hit SM00353, HLH, 1 hit SM00091, PAS, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits SSF69125, SSF69125, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NCOA2_RAT | |
Accessioni | Q9WUI9Primary (citable) accession number: Q9WUI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families