Nuclear receptor coactivator 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• aryl hydrocarbon receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions."
    Watt K., Jess T.J., Kelly S.M., Price N.C., McEwan I.J.
    Biochemistry 44:734-743(2005) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGDInferred from sequence orthologyⁱ
  • "Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation."
    Winnay J.N., Hammer G.D.
    Mol. Endocrinol. 20:147-166(2006) [PubMed] [Europe PMC] [Abstract]
• DNA polymerase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Interaction of DNA polymerase beta with GRIP1 during meiosis."
    Jonason A.S., Baker S.M., Sweasy J.B.
    Chromosoma 110:402-410(2001) [PubMed] [Europe PMC] [Abstract]
• estrogen receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors."
    Yore M.A., Im D., Webb L.K., Zhao Y., Chadwick J.G. Jr., Molenda-Figueira H.A., Haidacher S.J., Denner L., Tetel M.J.
    Neuroscience 169:1017-1028(2010) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid receptor binding Source: RGDInferred from physical interactionⁱ
  • Ref.1

    "Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2."
    Leers J., Treuter E., Gustafsson J.-A.
    Mol. Cell. Biol. 18:6001-6013(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• nuclear hormone receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Coactivators for the orphan nuclear receptor RORalpha."
    Atkins G.B., Hu X., Guenther M.G., Rachez C., Freedman L.P., Lazar M.A.
    Mol. Endocrinol. 13:1550-1557(1999) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors."
    Yore M.A., Im D., Webb L.K., Zhao Y., Chadwick J.G. Jr., Molenda-Figueira H.A., Haidacher S.J., Denner L., Tetel M.J.
    Neuroscience 169:1017-1028(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2."
    Leers J., Treuter E., Gustafsson J.-A.
    Mol. Cell. Biol. 18:6001-6013(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• nuclear receptor transcription coactivator activity Source: RGDInferred from sequence orthologyⁱ
  • "The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2."
    Huang S.M., Huang C.J., Wang W.M., Kang J.C., Hsu W.C.
    J. Mol. Endocrinol. 32:481-496(2004) [PubMed] [Europe PMC] [Abstract]
  • "The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor."
    Flajollet S., Lefebvre B., Cudejko C., Staels B., Lefebvre P.
    Mol. Cell. Endocrinol. 270:23-32(2007) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from physical interactionⁱ
  • "CASK associates with glutamate receptor interacting protein and signaling molecules."
    Hong C.J., Hsueh Y.P.
    Biochem. Biophys. Res. Commun. 351:771-776(2006) [PubMed] [Europe PMC] [Abstract]
• progesterone receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors."
    Yore M.A., Im D., Webb L.K., Zhao Y., Chadwick J.G. Jr., Molenda-Figueira H.A., Haidacher S.J., Denner L., Tetel M.J.
    Neuroscience 169:1017-1028(2010) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch. Biochem. Biophys. 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• protein domain specific binding Source: RGDInferred from sequence orthologyⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
• retinoic acid receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch. Biochem. Biophys. 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch. Biochem. Biophys. 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors."
    Vella K.R., Ramadoss P., Costa-E-Sousa R.H., Astapova I., Ye F.D., Holtz K.A., Harris J.C., Hollenberg A.N.
    Mol. Cell. Biol. 34:1564-1575(2014) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors."
    Vella K.R., Ramadoss P., Costa-E-Sousa R.H., Astapova I., Ye F.D., Holtz K.A., Harris J.C., Hollenberg A.N.
    Mol. Cell. Biol. 34:1564-1575(2014) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors."
    Hong H., Kohli K., Trivedi A., Johnson D.L., Stallcup M.R.
    Proc. Natl. Acad. Sci. U.S.A. 93:4948-4952(1996) [PubMed] [Europe PMC] [Abstract]
• thyroid hormone receptor binding Source: RGDInferred from physical interactionⁱ
  • Ref.1

    "Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2."
    Leers J., Treuter E., Gustafsson J.-A.
    Mol. Cell. Biol. 18:6001-6013(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• thyroid hormone receptor coactivator activity Source: RGDInferred from sequence orthologyⁱ
  • "The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2."
    Huang S.M., Huang C.J., Wang W.M., Kang J.C., Hsu W.C.
    J. Mol. Endocrinol. 32:481-496(2004) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: UniProtKB
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
    Xie H., Sadim M.S., Sun Z.
    J. Immunol. 175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to hormone stimulus Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to Thyroglobulin triiodothyronine Source: RGDInferred from sequence orthologyⁱ
  • "Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors."
    Vella K.R., Ramadoss P., Costa-E-Sousa R.H., Astapova I., Ye F.D., Holtz K.A., Harris J.C., Hollenberg A.N.
    Mol. Cell. Biol. 34:1564-1575(2014) [PubMed] [Europe PMC] [Abstract]
• cerebellum development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status."
    Martinez de Arrieta C., Koibuchi N., Chin W.W.
    Endocrinology 141:1693-1698(2000) [PubMed] [Europe PMC] [Abstract]
• circadian regulation of gene expression Source: UniProtKB
• circadian rhythm Source: RGDInferred from sequence orthologyⁱ
  • "SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm."
    Stashi E., Lanz R.B., Mao J., Michailidis G., Zhu B., Kettner N.M., Putluri N., Reineke E.L., Reineke L.C., Dasgupta S., Dean A., Stevenson C.R., Sivasubramanian N., Sreekumar A., Demayo F., York B., Fu L., O'Malley B.W.
    Cell Rep. 6:633-645(2014) [PubMed] [Europe PMC] [Abstract]
• locomotor rhythm Source: RGDInferred from sequence orthologyⁱ
  • "SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm."
    Stashi E., Lanz R.B., Mao J., Michailidis G., Zhu B., Kettner N.M., Putluri N., Reineke E.L., Reineke L.C., Dasgupta S., Dean A., Stevenson C.R., Sivasubramanian N., Sreekumar A., Demayo F., York B., Fu L., O'Malley B.W.
    Cell Rep. 6:633-645(2014) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: RGDInferred from expression patternⁱ
  • "Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis."
    Igarashi-Migitaka J., Takeshita A., Koibuchi N., Yamada S., Ohtani-Kaneko R., Hirata K.
    Eur. J. Endocrinol. 153:595-604(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors."
    Hong H., Kohli K., Trivedi A., Johnson D.L., Stallcup M.R.
    Proc. Natl. Acad. Sci. U.S.A. 93:4948-4952(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors."
    Hong H., Kohli K., Trivedi A., Johnson D.L., Stallcup M.R.
    Proc. Natl. Acad. Sci. U.S.A. 93:4948-4952(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of female receptivity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice."
    Apostolakis E.M., Ramamurphy M., Zhou D., Onate S., O'Malley B.W.
    Mol. Endocrinol. 16:1511-1523(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glucocorticoid receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions."
    Trousson A., Grenier J., Fonte C., Massaad-Massade L., Schumacher M., Massaad C.
    J. Steroid Biochem. Mol. Biol. 104:305-311(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions."
    Trousson A., Grenier J., Fonte C., Massaad-Massade L., Schumacher M., Massaad C.
    J. Steroid Biochem. Mol. Biol. 104:305-311(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells."
    Kommagani R., Szwarc M.M., Kovanci E., Creighton C.J., O'Malley B.W., Demayo F.J., Lydon J.P.
    Biol. Reprod. 90:75-75(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of glucose metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease."
    Chopra A.R., Louet J.F., Saha P., An J., Demayo F., Xu J., York B., Karpen S., Finegold M., Moore D., Chan L., Newgard C.B., O'Malley B.W.
    Science 322:1395-1399(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins."
    Yu G., Zerucha T., Ekker M., Rubenstein J.L.
    Brain Res. Dev. Brain Res. 130:217-230(2001) [PubMed] [Europe PMC] [Abstract]
  • "Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation."
    Lazaro J.B., Bailey P.J., Lassar A.B.
    Genes Dev. 16:1792-1805(2002) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from sequence orthologyⁱ
  • "A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells."
    Kommagani R., Szwarc M.M., Kovanci E., Creighton C.J., O'Malley B.W., Demayo F.J., Lydon J.P.
    Biol. Reprod. 90:75-75(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• aryl hydrocarbon receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions."
    Watt K., Jess T.J., Kelly S.M., Price N.C., McEwan I.J.
    Biochemistry 44:734-743(2005) [PubMed] [Europe PMC] [Abstract]
• DNA polymerase binding Source: RGDInferred from physical interactionⁱ
  • "Interaction of DNA polymerase beta with GRIP1 during meiosis."
    Jonason A.S., Baker S.M., Sweasy J.B.
    Chromosoma 110:402-410(2001) [PubMed] [Europe PMC] [Abstract]
• estrogen receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors."
    Yore M.A., Im D., Webb L.K., Zhao Y., Chadwick J.G. Jr., Molenda-Figueira H.A., Haidacher S.J., Denner L., Tetel M.J.
    Neuroscience 169:1017-1028(2010) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid receptor binding Source: RGDInferred from physical interactionⁱ
  • Ref.1

    "Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2."
    Leers J., Treuter E., Gustafsson J.-A.
    Mol. Cell. Biol. 18:6001-6013(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• nuclear hormone receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Coactivators for the orphan nuclear receptor RORalpha."
    Atkins G.B., Hu X., Guenther M.G., Rachez C., Freedman L.P., Lazar M.A.
    Mol. Endocrinol. 13:1550-1557(1999) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors."
    Yore M.A., Im D., Webb L.K., Zhao Y., Chadwick J.G. Jr., Molenda-Figueira H.A., Haidacher S.J., Denner L., Tetel M.J.
    Neuroscience 169:1017-1028(2010) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2."
    Leers J., Treuter E., Gustafsson J.-A.
    Mol. Cell. Biol. 18:6001-6013(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• PDZ domain binding Source: RGDInferred from physical interactionⁱ
  • "CASK associates with glutamate receptor interacting protein and signaling molecules."
    Hong C.J., Hsueh Y.P.
    Biochem. Biophys. Res. Commun. 351:771-776(2006) [PubMed] [Europe PMC] [Abstract]
• progesterone receptor binding Source: RGDInferred from physical interactionⁱ
  • "Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors."
    Yore M.A., Im D., Webb L.K., Zhao Y., Chadwick J.G. Jr., Molenda-Figueira H.A., Haidacher S.J., Denner L., Tetel M.J.
    Neuroscience 169:1017-1028(2010) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• protein domain specific binding Source: RGDInferred from sequence orthologyⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
• retinoic acid receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch. Biochem. Biophys. 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch. Biochem. Biophys. 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors."
    Hong H., Kohli K., Trivedi A., Johnson D.L., Stallcup M.R.
    Proc. Natl. Acad. Sci. U.S.A. 93:4948-4952(1996) [PubMed] [Europe PMC] [Abstract]
• thyroid hormone receptor binding Source: RGDInferred from physical interactionⁱ
  • Ref.1

    "Mechanistic principles in NR box-dependent interaction between nuclear hormone receptors and the coactivator TIF2."
    Leers J., Treuter E., Gustafsson J.-A.
    Mol. Cell. Biol. 18:6001-6013(1998) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• transcription factor binding Source: RGDInferred from sequence orthologyⁱ
  • "RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
    Xie H., Sadim M.S., Sun Z.
    J. Immunol. 175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRSTEKRNRE QENKYIEELA 
        60         70         80         90        100
ELIFANFNDI DNFNFKPDKC AILKETVKQI RQIKEQEKAA AANIDEVQKS 
       110        120        130        140        150
DVSSTGQGVI DKDALGPMML EALDGFFFVV NLEGNVVFVS ENVTQYLRYN 
       160        170        180        190        200
QEELMNKSVY SILHVGDHTE FVKNLLPKSM VNGGSWTGEP PRRNSHTFNC 
       210        220        230        240        250
RMLVKPLPDS EEEGHDNQEA HQKYETMQCF AVSQPKSIKE EGEDKQSCLI 
       260        270        280        290        300
CVARRVPMKE RPALPSSESF TTRQDLQGKI TFLDTSTMRD AMKPGWEDLV 
       310        320        330        340        350
RRCIQKFHTQ HEGESLSYAK RHHHEVLRQG LAFSQIYRFS LSDGTLVAAQ 
       360        370        380        390        400
TKSKLIRSQT TNEPQLVISI HMLHREQNVC VMNPDLTGQA MGKPLSPMSS 
       410        420        430        440        450
SSPARQAMCS GNPGQDVALG SNMNFPMNGP REQMSMPMGR FGGSGGMNHV 
       460        470        480        490        500
SGMQATTPQG SNYALKMNSP SQSSPGLNPG QPSSVLSPRH RMSPGVAGSP 
       510        520        530        540        550
RVPPSQFSPA GSLHSPAGVC SSTGNSHSYT NSSLNALQAL SEGHGVSLGP 
       560        570        580        590        600
SLASPDLKMG NSQNSPVNMN PPPLSKMGSL DSKDCFGLYG EPSEGTTGQA 
       610        620        630        640        650
QASCHPEEQK RPNDSSMPQA ASEDRAEGHS RLHESKGQTK LLQLLTTKSD 
       660        670        680        690        700
QMEPSPLPSS LSDTNKDSTG SLPGPGSTHG TSLKEKHKIL HRLLQDSSSP 
       710        720        730        740        750
VDLAKLTAEA TGKELNQESS GTAPGSEVTV KQEPASPKKK ENALLRYLLD 
       760        770        780        790        800
KDDTKDIGLP EITPKLERLD SKTDPASNTK LIAMKTVKEE VSFEPSDQPG 
       810        820        830        840        850
SELDNLEEIL DDLQNSQLPQ LFPDTRPGAP TGSVDKQAII NDLMQLTADS 
       860        870        880        890        900
SPVTPVGAQK AALRMSQSTF NNPRPGQLGR LLPNQNLPLD ITLQSPTGAG 
       910        920        930        940        950
PFPPIRNSSP YSVIPQPGMM GNQGMLGSQG NLGNNSTGMI GSSTSRSSMP 
       960        970        980        990       1000
SGEWAPQSPA VRVTCAATTG AMNRPIQGGM IRNPTASIPM RANSQPGQRQ 
      1010       1020       1030       1040       1050
MLQPQVMNIG PSELEMNMGG PQYNQQQAPP NQTAPWPESI LPIDQASFGS 
      1060       1070       1080       1090       1100
QNRHPFGSSP DDLLCPHPAA ESPSDEGALL DQLYLALRNF DGLEEIDRAL 
      1110       1120       1130       1140       1150
GIPELVSQSQ AVDPEQFSSQ ESSMMLEQKP PVFPQQYASQ TQMAQGSYNP 
      1160       1170       1180       1190       1200
MQDPNFHTMG QRPNYTTLRM QPRPGLRPTG IVQNQPNQLR LQLQHRLQAQ 
      1210       1220       1230       1240       1250
QNRQPLMNQI SGVSNVNLTL RPGVPTQAPI NAQMLAQRQR EILNQHLRQR 
      1260       1270       1280       1290       1300
QMHQQQQVQQ RTLMMRGQGL NMTPSMVAPT GLPAAMSNPR IPQANAQQFP 
      1310       1320       1330       1340       1350
FPPNYGISQQ PDPGFTGATT PQSPLMSPRM AHTQSPMMQQ SQANPAYQPA 
      1360       1370       1380       1390       1400
SDINGWAQGS MGGNSMFSQQ SPPHFGQQAN TSMYNNNMNI NVSMATNTAG 
      1410       1420       1430       1440       1450
LSNMNQMTGQ MSMTSVTSVP TSGLSSMGPE QVNDPALRGS SLFTTNQLPG 
      1460 
MDMIKQEGDG SRKYC                                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references