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Protein

Semaphorin-4G

Gene

Sema4g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXNB2. May play a role in axon guidance.1 Publication

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4G
Gene namesi
Name:Sema4g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1347047 Sema4g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 673ExtracellularSequence analysisAdd BLAST656
Transmembranei674 – 694HelicalSequence analysisAdd BLAST21
Topological domaini695 – 837CytoplasmicSequence analysisAdd BLAST143

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000003233418 – 837Semaphorin-4GAdd BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 115By similarity
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 142By similarity
Disulfide bondi268 ↔ 375By similarity
Disulfide bondi292 ↔ 335By similarity
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi506 ↔ 523By similarity
Disulfide bondi515 ↔ 532By similarity
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi582 ↔ 630By similarity
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei794PhosphoserineBy similarity1
Modified residuei836PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9WUH7
PaxDbiQ9WUH7
PeptideAtlasiQ9WUH7
PRIDEiQ9WUH7

PTM databases

iPTMnetiQ9WUH7
PhosphoSitePlusiQ9WUH7

Expressioni

Tissue specificityi

Brain, spinal cord, and several sensory organs as well as specific populations of projection neurons.

Developmental stagei

Expressed early in development.

Gene expression databases

BgeeiENSMUSG00000025207 Expressed in 236 organ(s), highest expression level in liver
GenevisibleiQ9WUH7 MM

Interactioni

Subunit structurei

Interacts with PLXNB2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiQ9WUH7
STRINGi10090.ENSMUSP00000026225

Structurei

3D structure databases

ProteinModelPortaliQ9WUH7
SMRiQ9WUH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 503SemaPROSITE-ProRule annotationAdd BLAST469
Domaini505 – 556PSIAdd BLAST52
Domaini565 – 647Ig-like C2-typeAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi563 – 566Poly-Pro4
Compositional biasi762 – 773Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ9WUH7
KOiK06521
OMAiLTTQWKT
OrthoDBiEOG091G01W0
PhylomeDBiQ9WUH7
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGRLWPLLF SFLTVTAVPG PSLRRPSREL DATPRLTISY EELSQIRHFK
60 70 80 90 100
GQTQNYSTLL LEEASERLLV GARGALFSLS ARDIRDRTHK EIHWEASPEM
110 120 130 140 150
QSKCHQKGKN NQTECFNHVR FLQRLNATHF YACGTHAFQP LCAAIDAETF
160 170 180 190 200
ILPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP
210 220 230 240 250
HSLRTEEAPM HWLNDAEFVF SVLVRESKTS AVGDDDKIYF FFMEREEGSS
260 270 280 290 300
SFTQSRSSHR VARVARVCKG DLGGKKILQK KWTSFLKARL ICHIPQYETL
310 320 330 340 350
RGVCSLNADT SSHTHFYAVF TLTTQWKTLE ASAICRYDLA EIQAVFTGPF
360 370 380 390 400
MEYQDGARRW GRYEGGVPEP RPGSCITDSL RSRGYNSSQD LPSLVLDFVK
410 420 430 440 450
LHPLMARPVV PTRGRPLLLK RNVRYTHLTG THVSTPAGPT YDLLFLGTAD
460 470 480 490 500
GWIHKAVVLG SGMHIIEEIQ VFREPQSVDN LVISPMQHSL YVGAASGVLQ
510 520 530 540 550
FPLSSCSRYQ SCYDCILARD PYCGWDSSIH ACMVATTVAN RTELIQDIER
560 570 580 590 600
GNRGCEGSRD AGPPPPLKTR SVLRGDDVLL PCDQPSNLAR ALWLLNGSKS
610 620 630 640 650
LSDGQDGYRV GVDGLLVTDT QLEHSGNYGC YAEENGLRML LASYSLTVRP
660 670 680 690 700
ATPAPAPQAP ATPGAQLAHD MRMFYVVAIA ILGGLCLILA SSLLYVACLK
710 720 730 740 750
GGRRGRRRKY SLGRAGRAGG SAVQLQTVSG QCPGEEDEGD DGEGTGGLES
760 770 780 790 800
GCLQIIPGEG APAPPPPPPP PPPAELTNGL VALPSRLRRM NGNSYVLLRQ
810 820 830
SNNGVPAGPC SFAEELSRIL EKRKHTQLVE QLDESSV
Length:837
Mass (Da):92,378
Last modified:November 1, 1999 - v1
Checksum:i5C6E9C9C8A545EB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134918 mRNA Translation: AAD30541.1
BC049183 mRNA Translation: AAH49183.1
CCDSiCCDS29853.1
RefSeqiNP_036106.1, NM_011976.1
UniGeneiMm.34404

Genome annotation databases

EnsembliENSMUST00000026225; ENSMUSP00000026225; ENSMUSG00000025207
ENSMUST00000130549; ENSMUSP00000138321; ENSMUSG00000025207
ENSMUST00000179305; ENSMUSP00000137395; ENSMUSG00000025207
GeneIDi26456
KEGGimmu:26456
UCSCiuc008hqf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134918 mRNA Translation: AAD30541.1
BC049183 mRNA Translation: AAH49183.1
CCDSiCCDS29853.1
RefSeqiNP_036106.1, NM_011976.1
UniGeneiMm.34404

3D structure databases

ProteinModelPortaliQ9WUH7
SMRiQ9WUH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ9WUH7
STRINGi10090.ENSMUSP00000026225

PTM databases

iPTMnetiQ9WUH7
PhosphoSitePlusiQ9WUH7

Proteomic databases

MaxQBiQ9WUH7
PaxDbiQ9WUH7
PeptideAtlasiQ9WUH7
PRIDEiQ9WUH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026225; ENSMUSP00000026225; ENSMUSG00000025207
ENSMUST00000130549; ENSMUSP00000138321; ENSMUSG00000025207
ENSMUST00000179305; ENSMUSP00000137395; ENSMUSG00000025207
GeneIDi26456
KEGGimmu:26456
UCSCiuc008hqf.1 mouse

Organism-specific databases

CTDi57715
MGIiMGI:1347047 Sema4g

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ9WUH7
KOiK06521
OMAiLTTQWKT
OrthoDBiEOG091G01W0
PhylomeDBiQ9WUH7
TreeFamiTF316102

Miscellaneous databases

ChiTaRSiSema4g mouse
PROiPR:Q9WUH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025207 Expressed in 236 organ(s), highest expression level in liver
GenevisibleiQ9WUH7 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4G_MOUSE
AccessioniPrimary (citable) accession number: Q9WUH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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