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Protein

Four and a half LIM domains protein 1

Gene

Fhl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 1
Short name:
FHL-1
Gene namesi
Name:Fhl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2615 Fhl1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002349332 – 280Four and a half LIM domains protein 1Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei4N6-acetyllysineBy similarity1
Cross-linki86Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9WUH4
PRIDEiQ9WUH4

PTM databases

iPTMnetiQ9WUH4
PhosphoSitePlusiQ9WUH4

Expressioni

Gene expression databases

BgeeiENSRNOG00000000875
ExpressionAtlasiQ9WUH4 baseline and differential
GenevisibleiQ9WUH4 RN

Interactioni

Protein-protein interaction databases

BioGridi247233, 1 interactor
STRINGi10116.ENSRNOP00000049677

Structurei

3D structure databases

ProteinModelPortaliQ9WUH4
SMRiQ9WUH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 92LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini101 – 153LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST53
Domaini162 – 212LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST51
Domaini221 – 276LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410INGE Eukaryota
ENOG410XSPV LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ9WUH4
KOiK14365
PhylomeDBiQ9WUH4

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WUH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKFDCHYC RDPLQGKKYV QKDGRHCCLK CFDKFCANTC VECRKPISAD
60 70 80 90 100
AKEVHYKNRY WHDTCFRCAK CLHPLASETF VSKDGKILCN KCATREDSPR
110 120 130 140 150
CKGCFKAIVA GDQNVEYKGT IWHKDCFTCS NCKQVIGTGS FFPKGEDFYC
160 170 180 190 200
VTCHETKFAK HCVKCNKAIT SGGITYQDQP WHAECFVCVT CSKKLAGQRF
210 220 230 240 250
TAVEDQYYCV DCYKNFVAKK CAGCKNPITG FGKGSSVVAY EGQSWHDYCF
260 270 280
HCKKCSVNLA NKRFVFHNEQ VYCPDCAKKL
Length:280
Mass (Da):31,904
Last modified:November 1, 1999 - v1
Checksum:iD9738C08B4707027
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134773 mRNA Translation: AAD32624.1
RefSeqiNP_001258128.1, NM_001271199.1
NP_001258129.1, NM_001271200.1
UniGeneiRn.54261

Genome annotation databases

EnsembliENSRNOT00000084594; ENSRNOP00000074052; ENSRNOG00000000875
ENSRNOT00000087274; ENSRNOP00000074817; ENSRNOG00000000875
GeneIDi25177
KEGGirno:25177

Similar proteinsi

Entry informationi

Entry nameiFHL1_RAT
AccessioniPrimary (citable) accession number: Q9WUH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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