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Protein

Transmembrane protein 115

Gene

Tmem115

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 115Curated
Alternative name(s):
Protein PL6 homologCurated
Gene namesi
Name:Tmem115Imported
Synonyms:Pl6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1930765 Tmem115

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicCuratedAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 97LumenalCuratedAdd BLAST57
Transmembranei98 – 118Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini119 – 126CytoplasmicCurated8
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 165LumenalCuratedAdd BLAST18
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 350CytoplasmicCuratedAdd BLAST164

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584521 – 350Transmembrane protein 115Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei329PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9WUH1
MaxQBiQ9WUH1
PaxDbiQ9WUH1
PRIDEiQ9WUH1

PTM databases

iPTMnetiQ9WUH1
PhosphoSitePlusiQ9WUH1
SwissPalmiQ9WUH1

Expressioni

Gene expression databases

BgeeiENSMUSG00000010045 Expressed in 277 organ(s), highest expression level in ear vesicle
CleanExiMM_TMEM115
ExpressionAtlasiQ9WUH1 baseline and differential
GenevisibleiQ9WUH1 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with COPB1. May interact with LMAN1. Interacts with the COG complex; probably through COG3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207950, 3 interactors
STRINGi10090.ENSMUSP00000010189

Structurei

3D structure databases

ProteinModelPortaliQ9WUH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 205Mediates homooligomerizationBy similarityAdd BLAST205
Regioni206 – 229Mediates localization to the GolgiBy similarityAdd BLAST24

Sequence similaritiesi

Belongs to the TMEM115 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2890 Eukaryota
ENOG410XQM0 LUCA
GeneTreeiENSGT00390000002470
HOGENOMiHOG000007827
HOVERGENiHBG027575
InParanoidiQ9WUH1
OMAiGKVCFRT
OrthoDBiEOG091G0B9B
PhylomeDBiQ9WUH1
TreeFamiTF315100

Family and domain databases

InterProiView protein in InterPro
IPR013861 DUF1751_Mem_euk
PANTHERiPTHR13377 PTHR13377, 1 hit
PfamiView protein in Pfam
PF08551 DUF1751, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WUH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRALPGARQ HLGAILASAS VVVKALCAVV LFLYLLSFAV DTGCLAVTPG
60 70 80 90 100
YLFPPNFWIW TLATHGLMEQ HVWDVAISLA TVVVAGRLLE PLWGALELLI
110 120 130 140 150
FFSVVNVSVG LLGALAYLLT YMASFNLVYL FTIRIHGALG FLGGVLVALK
160 170 180 190 200
QTMGDCVVLR VPQVRVSVVP MLLLALLLLL RLATLLQSPA LASYGFGLLS
210 220 230 240 250
SWVYLRFYQR HSRGRGDMAD HFAFATFFPE ILQPVVGLLA NLVHGLLVKV
260 270 280 290 300
KICQKTVKRY DVGAPSSITI SLPGTDPQDA ERRRQLALKA LNERLKRVED
310 320 330 340 350
QSAWPSMDDD EEEAGAKTDS PLPLEEASTP PGKVTVPESS LITLETAPLL
Length:350
Mass (Da):38,099
Last modified:November 1, 1999 - v1
Checksum:i9D8B9B164CA2842D
GO

Sequence cautioni

The sequence AAH09099 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134238 mRNA Translation: AAD24193.1
BC009099 mRNA Translation: AAH09099.1 Different initiation.
BC019473 mRNA Translation: AAH19473.1
CCDSiCCDS23490.1
RefSeqiNP_062678.1, NM_019704.2
UniGeneiMm.260153

Genome annotation databases

EnsembliENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045
GeneIDi56395
KEGGimmu:56395
UCSCiuc009rlk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134238 mRNA Translation: AAD24193.1
BC009099 mRNA Translation: AAH09099.1 Different initiation.
BC019473 mRNA Translation: AAH19473.1
CCDSiCCDS23490.1
RefSeqiNP_062678.1, NM_019704.2
UniGeneiMm.260153

3D structure databases

ProteinModelPortaliQ9WUH1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207950, 3 interactors
STRINGi10090.ENSMUSP00000010189

PTM databases

iPTMnetiQ9WUH1
PhosphoSitePlusiQ9WUH1
SwissPalmiQ9WUH1

Proteomic databases

EPDiQ9WUH1
MaxQBiQ9WUH1
PaxDbiQ9WUH1
PRIDEiQ9WUH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010189; ENSMUSP00000010189; ENSMUSG00000010045
GeneIDi56395
KEGGimmu:56395
UCSCiuc009rlk.1 mouse

Organism-specific databases

CTDi11070
MGIiMGI:1930765 Tmem115

Phylogenomic databases

eggNOGiKOG2890 Eukaryota
ENOG410XQM0 LUCA
GeneTreeiENSGT00390000002470
HOGENOMiHOG000007827
HOVERGENiHBG027575
InParanoidiQ9WUH1
OMAiGKVCFRT
OrthoDBiEOG091G0B9B
PhylomeDBiQ9WUH1
TreeFamiTF315100

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport

Miscellaneous databases

PROiPR:Q9WUH1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010045 Expressed in 277 organ(s), highest expression level in ear vesicle
CleanExiMM_TMEM115
ExpressionAtlasiQ9WUH1 baseline and differential
GenevisibleiQ9WUH1 MM

Family and domain databases

InterProiView protein in InterPro
IPR013861 DUF1751_Mem_euk
PANTHERiPTHR13377 PTHR13377, 1 hit
PfamiView protein in Pfam
PF08551 DUF1751, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM115_MOUSE
AccessioniPrimary (citable) accession number: Q9WUH1
Secondary accession number(s): Q91VT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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