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Protein

Insulin-like peptide INSL5

Gene

Insl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity).By similarity

GO - Molecular functioni

  • G protein-coupled receptor binding Source: GO_Central
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of feeding behavior Source: MGI

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-444821 Relaxin receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like peptide INSL5
Short name:
Insulin-like peptide 5
Alternative name(s):
Relaxin/insulin-like factor 2
Relaxin/insulin-like protein
Cleaved into the following 2 chains:
Gene namesi
Name:Insl5
Synonyms:Rif, Rif2, Zins3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346085 Insl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001616623 – 46Insulin-like peptide INSL5 B chainAdd BLAST24
PropeptideiPRO_000001616749 – 114Connecting peptideSequence analysisAdd BLAST66
PeptideiPRO_0000016168115 – 135Insulin-like peptide INSL5 A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 122Interchain (between B and A chains)By similarity
Disulfide bondi41 ↔ 135Interchain (between B and A chains)By similarity
Disulfide bondi121 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9WUG6
PRIDEiQ9WUG6

Expressioni

Tissue specificityi

Highest expression in colon with lower levels in thymus. Minimal levels in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000066090 Expressed in 47 organ(s), highest expression level in left colon
CleanExiMM_INSL5
ExpressionAtlasiQ9WUG6 baseline and differential
GenevisibleiQ9WUG6 MM

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081416

Structurei

3D structure databases

ProteinModelPortaliQ9WUG6
SMRiQ9WUG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4WA Eukaryota
ENOG410YMTH LUCA
GeneTreeiENSGT00510000049372
HOGENOMiHOG000111888
HOVERGENiHBG052135
InParanoidiQ9WUG6
KOiK22001
OMAiCTEGCSM
TreeFamiTF333404

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WUG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGPTLALFL LLVLLAVVEV RSRQTVKLCG LDYVRTVIYI CASSRWRRHL
60 70 80 90 100
EGHFHSQQAE TRNYLQLLDR HEPSKKTLEH SLPKTDLSGQ ELVRDPQAPK
110 120 130
EGLWELKKHS VVSRRDLQAL CCREGCSMKE LSTLC
Length:135
Mass (Da):15,524
Last modified:November 1, 1999 - v1
Checksum:i05FF9A0F613DBF92
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AIY3A2AIY3_MOUSE
Insulin-like 5, isoform CRA_b
Insl5 mCG_16072
145Annotation score:

Sequence cautioni

The sequence AAF09093 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133817 mRNA Translation: AAD29687.1
AF076971 mRNA Translation: AAD48089.1
AF054842 mRNA Translation: AAF09093.1 Different initiation.
AF054843 mRNA Translation: AAF09094.1
BC010968 mRNA Translation: AAH10968.1
CCDSiCCDS18406.1
RefSeqiNP_001277577.1, NM_001290648.1
NP_035961.1, NM_011831.2
UniGeneiMm.100163

Genome annotation databases

EnsembliENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090
GeneIDi23919
KEGGimmu:23919
UCSCiuc008txa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133817 mRNA Translation: AAD29687.1
AF076971 mRNA Translation: AAD48089.1
AF054842 mRNA Translation: AAF09093.1 Different initiation.
AF054843 mRNA Translation: AAF09094.1
BC010968 mRNA Translation: AAH10968.1
CCDSiCCDS18406.1
RefSeqiNP_001277577.1, NM_001290648.1
NP_035961.1, NM_011831.2
UniGeneiMm.100163

3D structure databases

ProteinModelPortaliQ9WUG6
SMRiQ9WUG6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081416

Proteomic databases

PaxDbiQ9WUG6
PRIDEiQ9WUG6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084382; ENSMUSP00000081416; ENSMUSG00000066090
GeneIDi23919
KEGGimmu:23919
UCSCiuc008txa.1 mouse

Organism-specific databases

CTDi10022
MGIiMGI:1346085 Insl5

Phylogenomic databases

eggNOGiENOG410J4WA Eukaryota
ENOG410YMTH LUCA
GeneTreeiENSGT00510000049372
HOGENOMiHOG000111888
HOVERGENiHBG052135
InParanoidiQ9WUG6
KOiK22001
OMAiCTEGCSM
TreeFamiTF333404

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-444821 Relaxin receptors

Miscellaneous databases

PROiPR:Q9WUG6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066090 Expressed in 47 organ(s), highest expression level in left colon
CleanExiMM_INSL5
ExpressionAtlasiQ9WUG6 baseline and differential
GenevisibleiQ9WUG6 MM

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINSL5_MOUSE
AccessioniPrimary (citable) accession number: Q9WUG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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