UniProtKB - Q9WUF2 (EGR4_MOUSE)
Protein
Early growth response protein 4
Gene
Egr4
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 372 – 396 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 402 – 424 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 430 – 452 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Early growth response protein 4Short name: EGR-4 |
Gene namesi | Name:Egr4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99252, Egr4 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047129 | 1 – 478 | Early growth response protein 4Add BLAST | 478 |
Proteomic databases
PaxDbi | Q9WUF2 |
PRIDEi | Q9WUF2 |
PTM databases
iPTMneti | Q9WUF2 |
PhosphoSitePlusi | Q9WUF2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000071341, Expressed in head and 51 other tissues |
ExpressionAtlasi | Q9WUF2, baseline and differential |
Genevisiblei | Q9WUF2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000093433 |
Miscellaneous databases
RNActi | Q9WUF2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the EGR C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 372 – 396 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 402 – 424 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 430 – 452 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162199 |
HOGENOMi | CLU_044356_0_0_1 |
InParanoidi | Q9WUF2 |
OMAi | PEHPHDP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9WUF2 |
TreeFami | TF318980 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q9WUF2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW
60 70 80 90 100
ALSSCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF
110 120 130 140 150
NLMSGILGLA PFPGPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP
160 170 180 190 200
EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP
210 220 230 240 250
YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG
260 270 280 290 300
PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
310 320 330 340 350
APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR
360 370 380 390 400
KGRRGGKCSA RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK
410 420 430 440 450
PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK
460 470
VHLKQKARAE ERLKGLGFYS LGLSFAAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132613 Genomic DNA Translation: AAD28267.1 |
CCDSi | CCDS20297.1 |
RefSeqi | NP_065621.1, NM_020596.2 |
Genome annotation databases
Ensembli | ENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341 |
GeneIDi | 13656 |
KEGGi | mmu:13656 |
UCSCi | uc009cpy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132613 Genomic DNA Translation: AAD28267.1 |
CCDSi | CCDS20297.1 |
RefSeqi | NP_065621.1, NM_020596.2 |
3D structure databases
SMRi | Q9WUF2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000093433 |
PTM databases
iPTMneti | Q9WUF2 |
PhosphoSitePlusi | Q9WUF2 |
Proteomic databases
PaxDbi | Q9WUF2 |
PRIDEi | Q9WUF2 |
Protocols and materials databases
Antibodypediai | 16536, 112 antibodies |
DNASUi | 13656 |
Genome annotation databases
Ensembli | ENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341 |
GeneIDi | 13656 |
KEGGi | mmu:13656 |
UCSCi | uc009cpy.1, mouse |
Organism-specific databases
CTDi | 1961 |
MGIi | MGI:99252, Egr4 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162199 |
HOGENOMi | CLU_044356_0_0_1 |
InParanoidi | Q9WUF2 |
OMAi | PEHPHDP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9WUF2 |
TreeFami | TF318980 |
Miscellaneous databases
BioGRID-ORCSi | 13656, 0 hits in 17 CRISPR screens |
PROi | PR:Q9WUF2 |
RNActi | Q9WUF2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071341, Expressed in head and 51 other tissues |
ExpressionAtlasi | Q9WUF2, baseline and differential |
Genevisiblei | Q9WUF2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EGR4_MOUSE | |
Accessioni | Q9WUF2Primary (citable) accession number: Q9WUF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families