Egr4

Functionⁱ

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	372 – 396	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	402 – 424	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	430 – 452	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II Source: MGI
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Early growth response protein 4 Short name: EGR-4
Gene namesⁱ	Name:Egr4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:99252 Egr4

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047129	1 – 478	Early growth response protein 4Add BLAST		478

Proteomic databases

PaxDbⁱ	Q9WUF2
PRIDEⁱ	Q9WUF2

PTM databases

iPTMnetⁱ	Q9WUF2
PhosphoSitePlusⁱ	Q9WUF2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000071341 Expressed in 34 organ(s), highest expression level in head
CleanExⁱ	MM_EGR4
ExpressionAtlasⁱ	Q9WUF2 baseline and differential
Genevisibleⁱ	Q9WUF2 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000093433

STRINGⁱ

10090.ENSMUSP00000093433

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WUF2
SMRⁱ	Q9WUF2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the EGR C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	372 – 396	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	402 – 424	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	430 – 452	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000112347
HOVERGENⁱ	HBG005574
InParanoidⁱ	Q9WUF2
KEGG Orthology (KO) More...KOⁱ	K12498
OMAⁱ	CFCPRPH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VX
PhylomeDBⁱ	Q9WUF2
TreeFamⁱ	TF318980

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9WUF2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW 
        60         70         80         90        100
ALSSCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF 
       110        120        130        140        150
NLMSGILGLA PFPGPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP 
       160        170        180        190        200
EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP 
       210        220        230        240        250
YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG 
       260        270        280        290        300
PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA 
       310        320        330        340        350
APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR 
       360        370        380        390        400
KGRRGGKCSA RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK 
       410        420        430        440        450
PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK 
       460        470 
VHLKQKARAE ERLKGLGFYS LGLSFAAL

Length:478

Mass (Da):49,554

Last modified:November 1, 1999 - v1

Checksum:ⁱ495926882CE4E371

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132613 Genomic DNA Translation: AAD28267.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20297.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065621.1, NM_020596.2
UniGeneⁱ	Mm.44137

Genome annotation databases

Ensemblⁱ	ENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341
GeneIDⁱ	13656
KEGGⁱ	mmu:13656
UCSC genome browser More...UCSCⁱ	uc009cpy.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WUF2	Uncharacterized protein		MOUSE		478	UniRef100_Q9WUF2

Protein	Similar proteins		Species	Score	Length	Source
Q9WUF2	Early growth response protein 4		RAT		478	UniRef90_Q00911
Uncharacterized protein		MOUSE		478
UPI000B4F7C9B		MERUN		568
UPI000A31643C		MUSCR		478
Early growth response 4		RAT		478

Protein	Similar proteins		Species	Score	Length	Source
Q9WUF2	Early growth response protein 4		HUMAN		589	UniRef50_Q05215
Early growth response protein 4		BOVIN		482
Early growth response protein 4		RAT		478
Uncharacterized protein		MANLE		589
Uncharacterized protein		RHIRO		589
+154

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132613 Genomic DNA Translation: AAD28267.1
CCDSⁱ	CCDS20297.1
RefSeqⁱ	NP_065621.1, NM_020596.2
UniGeneⁱ	Mm.44137

3D structure databases

ProteinModelPortalⁱ	Q9WUF2
SMRⁱ	Q9WUF2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000093433

STRINGⁱ

10090.ENSMUSP00000093433

PTM databases

iPTMnetⁱ	Q9WUF2
PhosphoSitePlusⁱ	Q9WUF2

Proteomic databases

PaxDbⁱ	Q9WUF2
PRIDEⁱ	Q9WUF2

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	13656
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341
GeneIDⁱ	13656
KEGGⁱ	mmu:13656
UCSCⁱ	uc009cpy.1 mouse

Organism-specific databases

CTDⁱ	1961
MGIⁱ	MGI:99252 Egr4

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000112347
HOVERGENⁱ	HBG005574
InParanoidⁱ	Q9WUF2
KOⁱ	K12498
OMAⁱ	CFCPRPH
OrthoDBⁱ	EOG091G06VX
PhylomeDBⁱ	Q9WUF2
TreeFamⁱ	TF318980

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9WUF2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000071341 Expressed in 34 organ(s), highest expression level in head
CleanExⁱ	MM_EGR4
ExpressionAtlasⁱ	Q9WUF2 baseline and differential
Genevisibleⁱ	Q9WUF2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EGR4_MOUSE
Accessionⁱ	Q9WUF2Primary (citable) accession number: Q9WUF2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
	Last sequence update:	November 1, 1999
	Last modified:	October 10, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WUF2 (EGR4_MOUSE)

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Early growth response protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ