Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Early growth response protein 4

Gene

Egr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Gene namesi
Name:Egr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:99252 Egr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471291 – 478Early growth response protein 4Add BLAST478

Proteomic databases

PaxDbiQ9WUF2
PRIDEiQ9WUF2

PTM databases

iPTMnetiQ9WUF2
PhosphoSitePlusiQ9WUF2

Expressioni

Gene expression databases

BgeeiENSMUSG00000071341 Expressed in 34 organ(s), highest expression level in head
CleanExiMM_EGR4
ExpressionAtlasiQ9WUF2 baseline and differential
GenevisibleiQ9WUF2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093433

Structurei

3D structure databases

ProteinModelPortaliQ9WUF2
SMRiQ9WUF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000112347
HOVERGENiHBG005574
InParanoidiQ9WUF2
KOiK12498
OMAiCFCPRPH
OrthoDBiEOG091G06VX
PhylomeDBiQ9WUF2
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9WUF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHLSDFSGS DALLSKPTEG CAHASPELPR LPARDAPSAA AYPGGDFLSW
60 70 80 90 100
ALSSCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF
110 120 130 140 150
NLMSGILGLA PFPGPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP
160 170 180 190 200
EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP
210 220 230 240 250
YAPWELLSAG VPGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG
260 270 280 290 300
PAARLYQAGA YDTFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
310 320 330 340 350
APPAQLSPLG LRGAATADFS KPLVADLPGG SGVAAPSSPA ASFPAAKARR
360 370 380 390 400
KGRRGGKCSA RCFCPRPHVK AFACPVESCV RSFARSDELN RHLRIHTGHK
410 420 430 440 450
PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK
460 470
VHLKQKARAE ERLKGLGFYS LGLSFAAL
Length:478
Mass (Da):49,554
Last modified:November 1, 1999 - v1
Checksum:i495926882CE4E371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132613 Genomic DNA Translation: AAD28267.1
CCDSiCCDS20297.1
RefSeqiNP_065621.1, NM_020596.2
UniGeneiMm.44137

Genome annotation databases

EnsembliENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341
GeneIDi13656
KEGGimmu:13656
UCSCiuc009cpy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132613 Genomic DNA Translation: AAD28267.1
CCDSiCCDS20297.1
RefSeqiNP_065621.1, NM_020596.2
UniGeneiMm.44137

3D structure databases

ProteinModelPortaliQ9WUF2
SMRiQ9WUF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093433

PTM databases

iPTMnetiQ9WUF2
PhosphoSitePlusiQ9WUF2

Proteomic databases

PaxDbiQ9WUF2
PRIDEiQ9WUF2

Protocols and materials databases

DNASUi13656
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095759; ENSMUSP00000093433; ENSMUSG00000071341
GeneIDi13656
KEGGimmu:13656
UCSCiuc009cpy.1 mouse

Organism-specific databases

CTDi1961
MGIiMGI:99252 Egr4

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000112347
HOVERGENiHBG005574
InParanoidiQ9WUF2
KOiK12498
OMAiCFCPRPH
OrthoDBiEOG091G06VX
PhylomeDBiQ9WUF2
TreeFamiTF318980

Miscellaneous databases

PROiPR:Q9WUF2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071341 Expressed in 34 organ(s), highest expression level in head
CleanExiMM_EGR4
ExpressionAtlasiQ9WUF2 baseline and differential
GenevisibleiQ9WUF2 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR4_MOUSE
AccessioniPrimary (citable) accession number: Q9WUF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again