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Protein

GATOR complex protein NPRL2

Gene

Nprl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.By similarity
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
GATOR complex protein NPRL2Curated
Alternative name(s):
Gene 21 proteinImported
Short name:
G21 proteinImported
Nitrogen permease regulator 2-like proteinImported
Short name:
NPR2-like proteinImported
Gene namesi
Name:Nprl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914482 Nprl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133201 – 380GATOR complex protein NPRL2Add BLAST380

Proteomic databases

MaxQBiQ9WUE4
PaxDbiQ9WUE4
PRIDEiQ9WUE4

PTM databases

iPTMnetiQ9WUE4
PhosphoSitePlusiQ9WUE4

Expressioni

Gene expression databases

BgeeiENSMUSG00000010057 Expressed in 258 organ(s), highest expression level in heart left ventricle
CleanExiMM_TUSC4
ExpressionAtlasiQ9WUE4 baseline and differential
GenevisibleiQ9WUE4 MM

Interactioni

Subunit structurei

Forms a heterodimer with NPRL3. Interacts with PDPK1 (By similarity). Within the GATOR complex, component of the GATOR1 subcomplex, made of DEPDC5, NPRL2 and NPRL3. GATOR1 mediates the strong interaction of the GATOR complex with RRAGA/RRAGC and RRAGB/RRAGC heterodimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010201

Structurei

3D structure databases

ProteinModelPortaliQ9WUE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 133Interaction with PDPK1By similarityAdd BLAST133

Sequence similaritiesi

Belongs to the NPR2 family.Curated

Phylogenomic databases

eggNOGiKOG3789 Eukaryota
ENOG410XP7B LUCA
GeneTreeiENSGT00390000001414
HOGENOMiHOG000007022
HOVERGENiHBG055255
InParanoidiQ9WUE4
KOiK20405
OMAiYASMTHG
OrthoDBiEOG091G0759
PhylomeDBiQ9WUE4
TreeFamiTF106159

Family and domain databases

InterProiView protein in InterPro
IPR009348 NPR2
PANTHERiPTHR12991 PTHR12991, 2 hits
PfamiView protein in Pfam
PF06218 NPR2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WUE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL
60 70 80 90 100
QNKLITVTAM EKKLIGCPVC IEHKKYSRNA LLFNLGFVCD AQAKTCALEP
110 120 130 140 150
IVKKLAGYLT TLELESSFVS NEESKQKLVP IMTILLEELN ASGRCTLPID
160 170 180 190 200
ESNTIHLKVI EQRPDPPVAQ EYDVPVFTKD KEDFFSSQWD LTTQQILPYI
210 220 230 240 250
DGFRHVQKIS AEADVELNLV RIAIQNLLYY GVVTLVSILQ YSNVYCPTPK
260 270 280 290 300
VQDLVDDKSL QEACLSYVTK QGHKRASLRD VFQLYCSLSP GTTVRDLIGR
310 320 330 340 350
HPQQLQHVDE RKLIQFGLMK NLIRRLQKYP VRVSREERSH PARLYTGCHS
360 370 380
YDEICCKTGM SYHELDERLE NDPNIIICWK
Length:380
Mass (Da):43,644
Last modified:November 1, 1999 - v1
Checksum:i72AE3A46AB50B21D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWX8A0A0A6YWX8_MOUSE
GATOR complex protein NPRL2
Nprl2
163Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131207 mRNA Translation: AAD33474.1
AK013299 mRNA Translation: BAB28777.1
AK010331 mRNA Translation: BAB26858.1
BC026548 mRNA Translation: AAH26548.1
CCDSiCCDS23492.1
RefSeqiNP_061367.1, NM_018879.2
UniGeneiMm.11337

Genome annotation databases

EnsembliENSMUST00000010201; ENSMUSP00000010201; ENSMUSG00000010057
GeneIDi56032
KEGGimmu:56032
UCSCiuc009rln.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131207 mRNA Translation: AAD33474.1
AK013299 mRNA Translation: BAB28777.1
AK010331 mRNA Translation: BAB26858.1
BC026548 mRNA Translation: AAH26548.1
CCDSiCCDS23492.1
RefSeqiNP_061367.1, NM_018879.2
UniGeneiMm.11337

3D structure databases

ProteinModelPortaliQ9WUE4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000010201

PTM databases

iPTMnetiQ9WUE4
PhosphoSitePlusiQ9WUE4

Proteomic databases

MaxQBiQ9WUE4
PaxDbiQ9WUE4
PRIDEiQ9WUE4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010201; ENSMUSP00000010201; ENSMUSG00000010057
GeneIDi56032
KEGGimmu:56032
UCSCiuc009rln.2 mouse

Organism-specific databases

CTDi10641
MGIiMGI:1914482 Nprl2

Phylogenomic databases

eggNOGiKOG3789 Eukaryota
ENOG410XP7B LUCA
GeneTreeiENSGT00390000001414
HOGENOMiHOG000007022
HOVERGENiHBG055255
InParanoidiQ9WUE4
KOiK20405
OMAiYASMTHG
OrthoDBiEOG091G0759
PhylomeDBiQ9WUE4
TreeFamiTF106159

Miscellaneous databases

ChiTaRSiNprl2 mouse
PROiPR:Q9WUE4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010057 Expressed in 258 organ(s), highest expression level in heart left ventricle
CleanExiMM_TUSC4
ExpressionAtlasiQ9WUE4 baseline and differential
GenevisibleiQ9WUE4 MM

Family and domain databases

InterProiView protein in InterPro
IPR009348 NPR2
PANTHERiPTHR12991 PTHR12991, 2 hits
PfamiView protein in Pfam
PF06218 NPR2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNPRL2_MOUSE
AccessioniPrimary (citable) accession number: Q9WUE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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