UniProtKB - Q9WUD6 (WNT8B_MOUSE)
Protein
Protein Wnt-8b
Gene
Wnt8b
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- receptor ligand activity Source: MGI
- signaling receptor binding Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: MGI
- canonical Wnt signaling pathway Source: MGI
- cell-cell signaling Source: MGI
- cell fate commitment Source: GO_Central
- negative regulation of gene expression Source: MGI
- neuron differentiation Source: GO_Central
- positive regulation of gene expression Source: MGI
- signal transduction Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-3238698, WNT ligand biogenesis and trafficking R-MMU-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-8b |
Gene namesi | Name:Wnt8b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109485, Wnt8b |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000041451 | 22 – 350 | Protein Wnt-8bAdd BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 64 | By similarity | ||
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 103 ↔ 111 | By similarity | ||
Disulfide bondi | 113 ↔ 131 | By similarity | ||
Disulfide bondi | 179 ↔ 193 | By similarity | ||
Disulfide bondi | 181 ↔ 188 | By similarity | ||
Lipidationi | 185 | O-palmitoleoyl serineBy similarity | 1 | |
Disulfide bondi | 255 ↔ 293 | By similarity | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 271 ↔ 286 | By similarity | ||
Disulfide bondi | 290 ↔ 332 | By similarity | ||
Disulfide bondi | 308 ↔ 323 | By similarity | ||
Disulfide bondi | 310 ↔ 320 | By similarity | ||
Disulfide bondi | 315 ↔ 316 | By similarity |
Post-translational modificationi
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
PaxDbi | Q9WUD6 |
PRIDEi | Q9WUD6 |
PTM databases
GlyGeni | Q9WUD6, 2 sites |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- frizzled binding Source: GO_Central
- receptor ligand activity Source: MGI
- signaling receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000042867 |
Miscellaneous databases
RNActi | Q9WUD6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Wnt family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
InParanoidi | Q9WUD6 |
PhylomeDBi | Q9WUD6 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR034311, Protein_Wnt-8B IPR005817, Wnt IPR013301, Wnt8 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF94, PTHR12027:SF94, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01892, WNT8PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WUD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI
60 70 80 90 100
EECKYQFAWD RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT
110 120 130 140 150
RNCSLGDFDN CGCDDSRNGQ LGGQGWLWGG CSDNVGFGEA ISKQFVDALE
160 170 180 190 200
TGQDARAAMN LHNNEAGRKA VKGTMKRTCK CHGVSGSCTT QTCWLQLPEF
210 220 230 240 250
REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI STRELVHLED
260 270 280 290 300
SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER
310 320 330 340 350
RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8BQD1 | Q8BQD1_MOUSE | Protein Wnt | Wnt8b | 368 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130349 mRNA Translation: AAD31816.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130349 mRNA Translation: AAD31816.1 |
3D structure databases
SMRi | Q9WUD6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000042867 |
PTM databases
GlyGeni | Q9WUD6, 2 sites |
Proteomic databases
PaxDbi | Q9WUD6 |
PRIDEi | Q9WUD6 |
Organism-specific databases
MGIi | MGI:109485, Wnt8b |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
InParanoidi | Q9WUD6 |
PhylomeDBi | Q9WUD6 |
Enzyme and pathway databases
Reactomei | R-MMU-3238698, WNT ligand biogenesis and trafficking R-MMU-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane |
Miscellaneous databases
PROi | PR:Q9WUD6 |
RNActi | Q9WUD6, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR034311, Protein_Wnt-8B IPR005817, Wnt IPR013301, Wnt8 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit PTHR12027:SF94, PTHR12027:SF94, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01892, WNT8PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT8B_MOUSE | |
Accessioni | Q9WUD6Primary (citable) accession number: Q9WUD6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | August 12, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families