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Protein

Protein Wnt-8b

Gene

Wnt8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: MGI
  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-8b
Gene namesi
Name:Wnt8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109485 Wnt8b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004145122 – 350Protein Wnt-8bAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 64By similarity
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 111By similarity
Disulfide bondi113 ↔ 131By similarity
Disulfide bondi179 ↔ 193By similarity
Disulfide bondi181 ↔ 188By similarity
Lipidationi185O-palmitoleoyl serineBy similarity1
Disulfide bondi255 ↔ 293By similarity
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi271 ↔ 286By similarity
Disulfide bondi290 ↔ 332By similarity
Disulfide bondi308 ↔ 323By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi315 ↔ 316By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).By similarity
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ9WUD6
PRIDEiQ9WUD6

Expressioni

Gene expression databases

CleanExiMM_WNT8B

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042867

Structurei

3D structure databases

ProteinModelPortaliQ9WUD6
SMRiQ9WUD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
HOVERGENiHBG001595
InParanoidiQ9WUD6
PhylomeDBiQ9WUD6

Family and domain databases

InterProiView protein in InterPro
IPR034311 Protein_Wnt-8B
IPR005817 Wnt
IPR013301 Wnt8
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF94 PTHR12027:SF94, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01892 WNT8PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WUD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLMKPVCVL LVTCVLHRSH AWSVNNFLMT GPKAYLVYSS SVAAGAQSGI
60 70 80 90 100
EECKYQFAWD RWNCPERALQ LSSHGGLRSA NRETAFVHAI SSAGVMYTLT
110 120 130 140 150
RNCSLGDFDN CGCDDSRNGQ LGGQGWLWGG CSDNVGFGEA ISKQFVDALE
160 170 180 190 200
TGQDARAAMN LHNNEAGRKA VKGTMKRTCK CHGVSGSCTT QTCWLQLPEF
210 220 230 240 250
REVGAHLKEK YHAALKVDLL QGAGNSAAGR GAIADTFRSI STRELVHLED
260 270 280 290 300
SPDYCLENKT LGLLGTEGRE CLRRGRALGR WERRSCRRLC GDCGLAVEER
310 320 330 340 350
RAETVSSCNC KFHWCCAVRC EQCRRRVTKY FCSRAERPPR GAAHKPGKNS
Length:350
Mass (Da):38,576
Last modified:November 1, 1999 - v1
Checksum:i69CEE7790461597A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BQD1Q8BQD1_MOUSE
Protein Wnt
Wnt8b
368Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130349 mRNA Translation: AAD31816.1
UniGeneiMm.88365

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130349 mRNA Translation: AAD31816.1
UniGeneiMm.88365

3D structure databases

ProteinModelPortaliQ9WUD6
SMRiQ9WUD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042867

Proteomic databases

PaxDbiQ9WUD6
PRIDEiQ9WUD6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109485 Wnt8b

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
HOVERGENiHBG001595
InParanoidiQ9WUD6
PhylomeDBiQ9WUD6

Miscellaneous databases

PROiPR:Q9WUD6
SOURCEiSearch...

Gene expression databases

CleanExiMM_WNT8B

Family and domain databases

InterProiView protein in InterPro
IPR034311 Protein_Wnt-8B
IPR005817 Wnt
IPR013301 Wnt8
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF94 PTHR12027:SF94, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01892 WNT8PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWNT8B_MOUSE
AccessioniPrimary (citable) accession number: Q9WUD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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