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Protein

Transient receptor potential cation channel subfamily V member 2

Gene

Trpv2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).By similarity2 Publications

GO - Molecular functioni

  • calcium channel activity Source: GO_Central
  • identical protein binding Source: IntAct

GO - Biological processi

  • negative regulation of cell proliferation Source: RGD
  • response to heat Source: RGD

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 2
Short name:
TrpV2
Alternative name(s):
Osm-9-like TRP channel 2
Short name:
OTRPC2
Stretch-activated channel 2B
Vanilloid receptor-like protein 1
Short name:
VRL-1
Gene namesi
Name:Trpv2
Synonyms:Sac2b, Vrl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3965 Trpv2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 392CytoplasmicSequence analysisAdd BLAST392
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Topological domaini414 – 433ExtracellularSequence analysisAdd BLAST20
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 460CytoplasmicSequence analysis6
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 495ExtracellularSequence analysisAdd BLAST14
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 537CytoplasmicSequence analysisAdd BLAST21
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Intramembranei573 – 609Pore-formingSequence analysisAdd BLAST37
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 761CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2863
GuidetoPHARMACOLOGYi508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153441 – 761Transient receptor potential cation channel subfamily V member 2Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei15PhosphoserineBy similarity1
Modified residuei82PhosphoserineCombined sources1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei748PhosphoserineBy similarity1
Modified residuei760PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated by PKA.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9WUD2
PRIDEiQ9WUD2

PTM databases

iPTMnetiQ9WUD2
PhosphoSitePlusiQ9WUD2
SwissPalmiQ9WUD2

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level).2 Publications

Interactioni

Subunit structurei

Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.Curated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-11689641,EBI-11689641

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-60657N
IntActiQ9WUD2, 1 interactor
STRINGi10116.ENSRNOP00000004248

Chemistry databases

BindingDBiQ9WUD2

Structurei

Secondary structure

1761
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi77 – 86Combined sources10
Helixi89 – 92Combined sources4
Helixi95 – 102Combined sources8
Helixi109 – 111Combined sources3
Turni114 – 116Combined sources3
Helixi120 – 126Combined sources7
Helixi136 – 145Combined sources10
Helixi152 – 154Combined sources3
Turni160 – 164Combined sources5
Helixi167 – 173Combined sources7
Helixi177 – 185Combined sources9
Helixi197 – 199Combined sources3
Beta strandi203 – 205Combined sources3
Helixi213 – 219Combined sources7
Helixi223 – 231Combined sources9
Beta strandi233 – 235Combined sources3
Helixi249 – 256Combined sources8
Helixi261 – 281Combined sources21
Helixi287 – 289Combined sources3
Helixi298 – 304Combined sources7
Helixi308 – 321Combined sources14

3D structure databases

ProteinModelPortaliQ9WUD2
SMRiQ9WUD2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9WUD2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 115ANK 1PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati116 – 162ANK 2PROSITE-ProRule annotation1 PublicationAdd BLAST47
Repeati163 – 208ANK 3PROSITE-ProRule annotation1 PublicationAdd BLAST46
Repeati209 – 244ANK 4PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati245 – 293ANK 5PROSITE-ProRule annotation1 PublicationAdd BLAST49
Repeati294 – 320ANK 6PROSITE-ProRule annotation1 PublicationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 390Required for interaction with SLC50A11 PublicationAdd BLAST390

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
HOGENOMiHOG000234630
HOVERGENiHBG054085
InParanoidiQ9WUD2
KOiK04971
PhylomeDBiQ9WUD2
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024865 TRPV2_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF5 PTHR10582:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WUD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSASSPPAF RLETSDGDEE GNAEVNKGKQ EPPPMESPFQ REDRNSSPQI
60 70 80 90 100
KVNLNFIKRP PKNTSAPSQQ EPDRFDRDRL FSVVSRGVPE ELTGLLEYLR
110 120 130 140 150
WNSKYLTDSA YTEGSTGKTC LMKAVLNLQD GVNACIMPLL QIDKDSGNPK
160 170 180 190 200
LLVNAQCTDE FYQGHSALHI AIEKRSLQCV KLLVENGADV HLRACGRFFQ
210 220 230 240 250
KHQGTCFYFG ELPLSLAACT KQWDVVTYLL ENPHQPASLE ATDSLGNTVL
260 270 280 290 300
HALVMIADNS PENSALVIHM YDGLLQMGAR LCPTVQLEEI SNHQGLTPLK
310 320 330 340 350
LAAKEGKIEI FRHILQREFS GPYQPLSRKF TEWCYGPVRV SLYDLSSVDS
360 370 380 390 400
WEKNSVLEII AFHCKSPNRH RMVVLEPLNK LLQEKWDRLV SRFFFNFACY
410 420 430 440 450
LVYMFIFTVV AYHQPSLDQP AIPSSKATFG ESMLLLGHIL ILLGGIYLLL
460 470 480 490 500
GQLWYFWRRR LFIWISFMDS YFEILFLLQA LLTVLSQVLR FMETEWYLPL
510 520 530 540 550
LVLSLVLGWL NLLYYTRGFQ HTGIYSVMIQ KVILRDLLRF LLVYLVFLFG
560 570 580 590 600
FAVALVSLSR EARSPKAPED NNSTVTEQPT VGQEEEPAPY RSILDASLEL
610 620 630 640 650
FKFTIGMGEL AFQEQLRFRG VVLLLLLAYV LLTYVLLLNM LIALMSETVN
660 670 680 690 700
HVADNSWSIW KLQKAISVLE MENGYWWCRR KKHREGRLLK VGTRGDGTPD
710 720 730 740 750
ERWCFRVEEV NWAAWEKTLP TLSEDPSGPG ITGNKKNPTS KPGKNSASEE
760
DHLPLQVLQS P
Length:761
Mass (Da):86,706
Last modified:April 26, 2005 - v2
Checksum:i8977CDE1D5351EC8
GO

Sequence cautioni

The sequence BAA93435 differs from that shown. Reason: Frameshift at position 758.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151L → P (PubMed:10201375).Curated1
Sequence conflicti151L → P (PubMed:15489334).Curated1
Sequence conflicti158T → I in AAH89215 (PubMed:15489334).Curated1
Sequence conflicti713A → V in AAH89215 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129113 mRNA Translation: AAD26364.1
AB029330 mRNA Translation: BAA88637.1
AB022332 mRNA Translation: BAA93435.1 Frameshift.
BC089215 mRNA Translation: AAH89215.1
RefSeqiNP_001257726.1, NM_001270797.1
NP_001257727.1, NM_001270798.1
NP_058903.2, NM_017207.3
UniGeneiRn.206528

Genome annotation databases

GeneIDi29465
KEGGirno:29465
UCSCiRGD:3965 rat

Similar proteinsi

Entry informationi

Entry nameiTRPV2_RAT
AccessioniPrimary (citable) accession number: Q9WUD2
Secondary accession number(s): Q5FWT3, Q9JMI8, Q9QYH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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