UniProtKB - Q9WUB4 (DCTN6_MOUSE)
Protein
Dynactin subunit 6
Gene
Dctn6
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- catalytic activity Source: UniProtKB
- dynein complex binding Source: UniProtKB
GO - Biological processi
- lipid biosynthetic process Source: UniProtKB
- mitochondrion organization Source: UniProtKB
- mitotic spindle organization Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Dynactin subunit 6Alternative name(s): Dynactin subunit p27 Protein WS-3 |
Gene namesi | Name:Dctn6 Synonyms:Ws3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1343154, Dctn6 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- kinetochore By similarity
Cytoskeleton
- centrosome Source: MGI
- dynactin complex Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, KinetochorePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079831 | 1 – 190 | Dynactin subunit 6Add BLAST | 190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | Phosphothreonine; by CDK1By similarity | 1 |
Post-translational modificationi
Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9WUB4 |
MaxQBi | Q9WUB4 |
PaxDbi | Q9WUB4 |
PRIDEi | Q9WUB4 |
PTM databases
iPTMneti | Q9WUB4 |
PhosphoSitePlusi | Q9WUB4 |
Expressioni
Inductioni
Up-regulated in Ant1-deficient mice.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031516, Expressed in female gonad and 304 other tissues |
ExpressionAtlasi | Q9WUB4, baseline and differential |
Genevisiblei | Q9WUB4, MM |
Interactioni
Subunit structurei
Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.
Interacts with PLK1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 204585, 6 interactors |
IntActi | Q9WUB4, 2 interactors |
MINTi | Q9WUB4 |
STRINGi | 10090.ENSMUSP00000033913 |
Miscellaneous databases
RNActi | Q9WUB4, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4042, Eukaryota |
GeneTreei | ENSGT00390000017890 |
InParanoidi | Q9WUB4 |
OrthoDBi | 1278795at2759 |
PhylomeDBi | Q9WUB4 |
TreeFami | TF352888 |
Family and domain databases
InterProi | View protein in InterPro IPR027777, DCTN6 IPR001451, Hexapep IPR011004, Trimer_LpxA-like_sf |
PANTHERi | PTHR13072, PTHR13072, 1 hit |
Pfami | View protein in Pfam PF00132, Hexapep, 1 hit |
SUPFAMi | SSF51161, SSF51161, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9WUB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIII
60 70 80 90 100
GEGNLIEEQA LIINAHPDNI IPDTEDTEPK PMIIGTNNVF EVGCHSQAMK
110 120 130 140 150
MGDNNVIESK AYVGRNVILT SGCIIGACCS LNTFEAIPEN TVIYGADCLR
160 170 180 190
RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT MKGSSTPVKN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z4E5 | D3Z4E5_MOUSE | Dynactin subunit 6 | Dctn6 | 195 | Annotation score: | ||
D3Z6H3 | D3Z6H3_MOUSE | Dynactin subunit 6 | Dctn6 | 185 | Annotation score: | ||
D3Z6A1 | D3Z6A1_MOUSE | Dynactin subunit 6 | Dctn6 | 103 | Annotation score: | ||
F6XWI6 | F6XWI6_MOUSE | Dynactin subunit 6 | Dctn6 | 163 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 100 | K → T in AAF05616 (PubMed:10525537).Curated | 1 | |
Sequence conflicti | 168 | M → I in BAC40276 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124788 mRNA Translation: AAD30477.1 AF190796 mRNA Translation: AAF05616.1 AK003618 mRNA Translation: BAB22892.1 AK088312 mRNA Translation: BAC40276.1 BC029249 mRNA Translation: AAH29249.1 |
CCDSi | CCDS22238.1 |
RefSeqi | NP_001280686.1, NM_001293757.1 NP_001280687.1, NM_001293758.1 NP_001280688.1, NM_001293759.1 NP_035852.1, NM_011722.4 |
Genome annotation databases
Ensembli | ENSMUST00000033913; ENSMUSP00000033913; ENSMUSG00000031516 |
GeneIDi | 22428 |
KEGGi | mmu:22428 |
UCSCi | uc009lko.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124788 mRNA Translation: AAD30477.1 AF190796 mRNA Translation: AAF05616.1 AK003618 mRNA Translation: BAB22892.1 AK088312 mRNA Translation: BAC40276.1 BC029249 mRNA Translation: AAH29249.1 |
CCDSi | CCDS22238.1 |
RefSeqi | NP_001280686.1, NM_001293757.1 NP_001280687.1, NM_001293758.1 NP_001280688.1, NM_001293759.1 NP_035852.1, NM_011722.4 |
3D structure databases
SMRi | Q9WUB4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204585, 6 interactors |
IntActi | Q9WUB4, 2 interactors |
MINTi | Q9WUB4 |
STRINGi | 10090.ENSMUSP00000033913 |
PTM databases
iPTMneti | Q9WUB4 |
PhosphoSitePlusi | Q9WUB4 |
Proteomic databases
EPDi | Q9WUB4 |
MaxQBi | Q9WUB4 |
PaxDbi | Q9WUB4 |
PRIDEi | Q9WUB4 |
Protocols and materials databases
Antibodypediai | 10535, 158 antibodies |
DNASUi | 22428 |
Genome annotation databases
Ensembli | ENSMUST00000033913; ENSMUSP00000033913; ENSMUSG00000031516 |
GeneIDi | 22428 |
KEGGi | mmu:22428 |
UCSCi | uc009lko.3, mouse |
Organism-specific databases
CTDi | 10671 |
MGIi | MGI:1343154, Dctn6 |
Phylogenomic databases
eggNOGi | KOG4042, Eukaryota |
GeneTreei | ENSGT00390000017890 |
InParanoidi | Q9WUB4 |
OrthoDBi | 1278795at2759 |
PhylomeDBi | Q9WUB4 |
TreeFami | TF352888 |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-MMU-6807878, COPI-mediated anterograde transport R-MMU-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 22428, 10 hits in 18 CRISPR screens |
ChiTaRSi | Dctn6, mouse |
PROi | PR:Q9WUB4 |
RNActi | Q9WUB4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031516, Expressed in female gonad and 304 other tissues |
ExpressionAtlasi | Q9WUB4, baseline and differential |
Genevisiblei | Q9WUB4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027777, DCTN6 IPR001451, Hexapep IPR011004, Trimer_LpxA-like_sf |
PANTHERi | PTHR13072, PTHR13072, 1 hit |
Pfami | View protein in Pfam PF00132, Hexapep, 1 hit |
SUPFAMi | SSF51161, SSF51161, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCTN6_MOUSE | |
Accessioni | Q9WUB4Primary (citable) accession number: Q9WUB4 Secondary accession number(s): Q8C2M9, Q9QZB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families