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Protein

Glucose-6-phosphate exchanger SLC37A2

Gene

Slc37a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.By similarity

Activity regulationi

Inhibited by vanadate but not by chlorogenic acid.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-70263 Gluconeogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate exchanger SLC37A2Curated
Alternative name(s):
Solute carrier family 37 member 2Imported
cAMP-inducible protein 21 Publication
Gene namesi
Name:Slc37a2Imported
Synonyms:Ci21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1929693 Slc37a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei118 – 140HelicalSequence analysisAdd BLAST23
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083231 – 501Glucose-6-phosphate exchanger SLC37A2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9WU81
PeptideAtlasiQ9WU81
PRIDEiQ9WU81

PTM databases

iPTMnetiQ9WU81
PhosphoSitePlusiQ9WU81
SwissPalmiQ9WU81

Expressioni

Tissue specificityi

Highly expressed in bone marrow derived macrophages, and weakly in spleen.1 Publication

Inductioni

Up-regulated by cAMP in macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000032122 Expressed in 113 organ(s), highest expression level in parotid gland
GenevisibleiQ9WU81 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124569

Structurei

3D structure databases

ProteinModelPortaliQ9WU81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP3Z Eukaryota
COG2271 LUCA
GeneTreeiENSGT00530000062949
HOGENOMiHOG000230522
HOVERGENiHBG005851
InParanoidiQ9WU81
KOiK13783
OMAiQWGLSFV
OrthoDBiEOG091G06AK
PhylomeDBiQ9WU81
TreeFamiTF314991

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9WU81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSSLAPGVW FLRAFSRDSW FRGFILLLTF LIYACYHMSR KPISIVKSRL
60 70 80 90 100
HQNCSEMVRP VNDTHDLNDT TWCSWSPFDK DDYKELLGAV DNAFLVAYAI
110 120 130 140 150
GMFISGIFGE RLPLRYYLSA GMVLSGLFTS LFGLGYFWNI HMLWYFVLIQ
160 170 180 190 200
ICNGLVQTTG WPSVVTCVGN WFGKGKRGFI MGIWNSHTSV GNILGSLIAG
210 220 230 240 250
VWVNQHWGLS FIVPGIITAI MGVITFLFLI EYPEDVDCTP PRHHDDPEKE
260 270 280 290 300
QDNPEDPVNS PYSSRESNVD IAASSSKEQG PEPEAISFLG ALRIPGVIEF
310 320 330 340 350
SLCLLFAKLV SYTFLYWLPL YIFNVAHFSA KEAGDLSTLF DVGGIIGGIM
360 370 380 390 400
AGLISDYTNS RATTCCIMLI LAAPMMFLYN YIGQNGITSS IVMLIICGVL
410 420 430 440 450
VNGPYALITT AVSADLGTHE SLKGNAKALS TVTAIIDGTG SIGAALGPLL
460 470 480 490 500
AGLISPTGWN NVFYMLISAD VLACLLLCRL VYKEILAWKT ACGRSSGYKQ

I
Length:501
Mass (Da):55,073
Last modified:November 1, 1999 - v1
Checksum:i3E053502DF907FBC
GO
Isoform 2 (identifier: Q9WU81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-501: YKQI → SSLALTHPR

Show »
Length:506
Mass (Da):55,504
Checksum:iA77332B9C93394D3
GO

Sequence cautioni

The sequence BAD90337 differs from that shown. Reason: Frameshift at position 109.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339L → V in BAC37639 (PubMed:16141072).Curated1
Sequence conflicti423K → E in AAH63326 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028964498 – 501YKQI → SSLALTHPR in isoform 2. 3 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121081 mRNA Translation: AAD24571.1
AK028984 mRNA Translation: BAC26224.1
AK031045 mRNA Translation: BAC27227.1
AK079414 mRNA Translation: BAC37639.1
AK079823 mRNA Translation: BAC37758.1
BC022752 mRNA Translation: AAH22752.1
BC063326 mRNA Translation: AAH63326.1
AK220151 mRNA Translation: BAD90337.1 Frameshift.
CCDSiCCDS40582.1 [Q9WU81-1]
CCDS52769.1 [Q9WU81-2]
RefSeqiNP_001139432.1, NM_001145960.1 [Q9WU81-2]
NP_064654.3, NM_020258.4 [Q9WU81-1]
UniGeneiMm.440037

Genome annotation databases

EnsembliENSMUST00000115068; ENSMUSP00000110720; ENSMUSG00000032122 [Q9WU81-1]
ENSMUST00000161114; ENSMUSP00000124569; ENSMUSG00000032122 [Q9WU81-2]
GeneIDi56857
KEGGimmu:56857
UCSCiuc009ouk.2 mouse [Q9WU81-1]
uc009oul.2 mouse [Q9WU81-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121081 mRNA Translation: AAD24571.1
AK028984 mRNA Translation: BAC26224.1
AK031045 mRNA Translation: BAC27227.1
AK079414 mRNA Translation: BAC37639.1
AK079823 mRNA Translation: BAC37758.1
BC022752 mRNA Translation: AAH22752.1
BC063326 mRNA Translation: AAH63326.1
AK220151 mRNA Translation: BAD90337.1 Frameshift.
CCDSiCCDS40582.1 [Q9WU81-1]
CCDS52769.1 [Q9WU81-2]
RefSeqiNP_001139432.1, NM_001145960.1 [Q9WU81-2]
NP_064654.3, NM_020258.4 [Q9WU81-1]
UniGeneiMm.440037

3D structure databases

ProteinModelPortaliQ9WU81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124569

PTM databases

iPTMnetiQ9WU81
PhosphoSitePlusiQ9WU81
SwissPalmiQ9WU81

Proteomic databases

PaxDbiQ9WU81
PeptideAtlasiQ9WU81
PRIDEiQ9WU81

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115068; ENSMUSP00000110720; ENSMUSG00000032122 [Q9WU81-1]
ENSMUST00000161114; ENSMUSP00000124569; ENSMUSG00000032122 [Q9WU81-2]
GeneIDi56857
KEGGimmu:56857
UCSCiuc009ouk.2 mouse [Q9WU81-1]
uc009oul.2 mouse [Q9WU81-2]

Organism-specific databases

CTDi219855
MGIiMGI:1929693 Slc37a2

Phylogenomic databases

eggNOGiENOG410IP3Z Eukaryota
COG2271 LUCA
GeneTreeiENSGT00530000062949
HOGENOMiHOG000230522
HOVERGENiHBG005851
InParanoidiQ9WU81
KOiK13783
OMAiQWGLSFV
OrthoDBiEOG091G06AK
PhylomeDBiQ9WU81
TreeFamiTF314991

Enzyme and pathway databases

ReactomeiR-MMU-70263 Gluconeogenesis

Miscellaneous databases

PROiPR:Q9WU81
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032122 Expressed in 113 organ(s), highest expression level in parotid gland
GenevisibleiQ9WU81 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000849 Sugar_P_transporter
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG6PT3_MOUSE
AccessioniPrimary (citable) accession number: Q9WU81
Secondary accession number(s): Q571N8
, Q6P4P0, Q8BV90, Q8C144, Q8R1Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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