Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 13B

Gene

Tnfsf13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.1 Publication
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • B cell costimulation Source: MGI
  • B cell homeostasis Source: MGI
  • immune response Source: InterPro
  • immunoglobulin secretion Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of germinal center formation Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • regulation of immune response Source: MGI
  • T cell costimulation Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5669034 TNFs bind their physiological receptors
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 13B
Alternative name(s):
B-cell-activating factor
BAFF
CD_antigen: CD257
Cleaved into the following 2 chains:
Gene namesi
Name:Tnfsf13b
Synonyms:Baff
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1344376 Tnfsf13b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini69 – 309ExtracellularSequence analysisAdd BLAST241

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000345301 – 309Tumor necrosis factor ligand superfamily member 13b, membrane formAdd BLAST309
ChainiPRO_0000034531127 – 309Tumor necrosis factor ligand superfamily member 13b, soluble formAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 269By similarity
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126 – 127CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WU72
PRIDEiQ9WU72

PTM databases

iPTMnetiQ9WU72
PhosphoSitePlusiQ9WU72

Expressioni

Tissue specificityi

Isoform 2 is expressed in many myeloid cell lines.1 Publication

Gene expression databases

BgeeiENSMUSG00000031497 Expressed in 135 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ9WU72 baseline and differential
GenevisibleiQ9WU72 MM

Interactioni

Subunit structurei

Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204896, 1 interactor
STRINGi10090.ENSMUSP00000033892

Structurei

3D structure databases

ProteinModelPortaliQ9WU72
SMRiQ9WU72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHQ4 Eukaryota
ENOG4111XFQ LUCA
GeneTreeiENSGT00530000063837
HOGENOMiHOG000036810
HOVERGENiHBG061472
InParanoidiQ9WU72
KOiK05476
OMAiCVSILPQ
OrthoDBiEOG091G0GBQ
PhylomeDBiQ9WU72
TreeFamiTF332331

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9WU72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDESAKTLPP PCLCFCSEKG EDMKVGYDPI TPQKEEGAWF GICRDGRLLA
60 70 80 90 100
ATLLLALLSS SFTAMSLYQL AALQADLMNL RMELQSYRGS ATPAAAGAPE
110 120 130 140 150
LTAGVKLLTP AAPRPHNSSR GHRNRRAFQG PEETEQDVDL SAPPAPCLPG
160 170 180 190 200
CRHSQHDDNG MNLRNIIQDC LQLIADSDTP TIRKGTYTFV PWLLSFKRGN
210 220 230 240 250
ALEEKENKIV VRQTGYFFIY SQVLYTDPIF AMGHVIQRKK VHVFGDELSL
260 270 280 290 300
VTLFRCIQNM PKTLPNNSCY SAGIARLEEG DEIQLAIPRE NAQISRNGDD

TFFGALKLL
Length:309
Mass (Da):34,192
Last modified:November 1, 1999 - v1
Checksum:iF3DE6056E66034B4
GO
Isoform 2 (identifier: Q9WU72-2) [UniParc]FASTAAdd to basket
Also known as: DeltaBAFF

The sequence of this isoform differs from the canonical sequence as follows:
     166-185: IIQDCLQLIADSDTPTIRKG → R

Show »
Length:290
Mass (Da):32,166
Checksum:iBC289F9FF8187C9C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BVA3Q8BVA3_MOUSE
Tumor necrosis factor ligand superf...
Tnfsf13b
194Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti79N → S in strain: NZB. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041184166 – 185IIQDC…TIRKG → R in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119383 mRNA Translation: AAD22475.1
AF352245 mRNA Translation: AAL83939.1
AY290823 mRNA Translation: AAP82036.1
CH466566 Genomic DNA Translation: EDL22044.1
BC106840 mRNA Translation: AAI06841.1
CCDSiCCDS22094.1 [Q9WU72-1]
CCDS85498.1 [Q9WU72-2]
RefSeqiNP_001334238.1, NM_001347309.1 [Q9WU72-2]
NP_296371.1, NM_033622.1 [Q9WU72-1]
UniGeneiMm.28835

Genome annotation databases

EnsembliENSMUST00000033892; ENSMUSP00000033892; ENSMUSG00000031497 [Q9WU72-2]
ENSMUST00000207792; ENSMUSP00000146694; ENSMUSG00000031497 [Q9WU72-1]
GeneIDi24099
KEGGimmu:24099
UCSCiuc009kup.1 mouse [Q9WU72-1]
uc009kuq.1 mouse [Q9WU72-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119383 mRNA Translation: AAD22475.1
AF352245 mRNA Translation: AAL83939.1
AY290823 mRNA Translation: AAP82036.1
CH466566 Genomic DNA Translation: EDL22044.1
BC106840 mRNA Translation: AAI06841.1
CCDSiCCDS22094.1 [Q9WU72-1]
CCDS85498.1 [Q9WU72-2]
RefSeqiNP_001334238.1, NM_001347309.1 [Q9WU72-2]
NP_296371.1, NM_033622.1 [Q9WU72-1]
UniGeneiMm.28835

3D structure databases

ProteinModelPortaliQ9WU72
SMRiQ9WU72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204896, 1 interactor
STRINGi10090.ENSMUSP00000033892

PTM databases

iPTMnetiQ9WU72
PhosphoSitePlusiQ9WU72

Proteomic databases

PaxDbiQ9WU72
PRIDEiQ9WU72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033892; ENSMUSP00000033892; ENSMUSG00000031497 [Q9WU72-2]
ENSMUST00000207792; ENSMUSP00000146694; ENSMUSG00000031497 [Q9WU72-1]
GeneIDi24099
KEGGimmu:24099
UCSCiuc009kup.1 mouse [Q9WU72-1]
uc009kuq.1 mouse [Q9WU72-2]

Organism-specific databases

CTDi10673
MGIiMGI:1344376 Tnfsf13b

Phylogenomic databases

eggNOGiENOG410IHQ4 Eukaryota
ENOG4111XFQ LUCA
GeneTreeiENSGT00530000063837
HOGENOMiHOG000036810
HOVERGENiHBG061472
InParanoidiQ9WU72
KOiK05476
OMAiCVSILPQ
OrthoDBiEOG091G0GBQ
PhylomeDBiQ9WU72
TreeFamiTF332331

Enzyme and pathway databases

ReactomeiR-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5669034 TNFs bind their physiological receptors
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Miscellaneous databases

PROiPR:Q9WU72
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031497 Expressed in 135 organ(s), highest expression level in cleaving embryo
ExpressionAtlasiQ9WU72 baseline and differential
GenevisibleiQ9WU72 MM

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTN13B_MOUSE
AccessioniPrimary (citable) accession number: Q9WU72
Secondary accession number(s): Q7TQ58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again