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Entry version 153 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Syntaxin-binding protein 5

Gene

Stxbp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity).

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntaxin-binding protein 5
Alternative name(s):
Lethal(2) giant larvae protein homolog 3
Tomosyn-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stxbp5
Synonyms:Llgl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
708517, Stxbp5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi724S → A: Strongly reduces phosphorylation. 1 Publication1
Mutagenesisi724S → D: Reduces interaction with STX1A. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512461 – 1152Syntaxin-binding protein 5Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei693PhosphoserineBy similarity1
Modified residuei724Phosphoserine; by PKA1 Publication1
Modified residuei760PhosphoserineCombined sources1
Modified residuei763PhosphothreonineBy similarity1
Modified residuei783PhosphoserineCombined sources1
Modified residuei785PhosphothreonineBy similarity1
Modified residuei786PhosphoserineBy similarity1
Modified residuei901PhosphoserineBy similarity1
Modified residuei903PhosphoserineBy similarity1
Modified residuei1040PhosphothreonineBy similarity1
Modified residuei1059PhosphoserineBy similarity1
Modified residuei1132PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by PKA reduces interaction with STX1A and enhances synaptic neurotransmitter release.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WU70

PRoteomics IDEntifications database

More...
PRIDEi
Q9WU70

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WU70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WU70

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9WU70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is detected in heart, brain, lung, liver, skeletal muscle, kidney and testis. Isoform 2 is detected in brain and in testis. Isoform 3 is detected in testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000013351, Expressed in frontal cortex and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9WU70, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex that contains STXBP5, STX4A and SNAP23 (By similarity).

Interacts with STX1A and STX4A via its v-SNARE homology domain.

Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1.

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
249498, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9WU70

Protein interaction database and analysis system

More...
IntActi
Q9WU70, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000049322

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WU70

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9WU70

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 95WD 1Add BLAST34
Repeati102 – 141WD 2Add BLAST40
Repeati146 – 182WD 3Add BLAST37
Repeati201 – 235WD 4Add BLAST35
Repeati241 – 273WD 5Add BLAST33
Repeati295 – 337WD 6Add BLAST43
Repeati345 – 379WD 7Add BLAST35
Repeati401 – 478WD 8Add BLAST78
Repeati506 – 620WD 9Add BLAST115
Repeati634 – 696WD 10Add BLAST63
Repeati795 – 852WD 11Add BLAST58
Repeati861 – 935WD 12Add BLAST75
Repeati940 – 984WD 13Add BLAST45
Repeati998 – 1021WD 14Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1087 – 1147v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 35DisorderedSequence analysisAdd BLAST22
Regioni557 – 596DisorderedSequence analysisAdd BLAST40
Regioni675 – 731DisorderedSequence analysisAdd BLAST57
Regioni879 – 907DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi566 – 595Polar residuesSequence analysisAdd BLAST30
Compositional biasi711 – 727Polar residuesSequence analysisAdd BLAST17
Compositional biasi881 – 899Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1983, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182906

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002808_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WU70

Identification of Orthologs from Complete Genome Data

More...
OMAi
SIMRMAF

Database of Orthologous Groups

More...
OrthoDBi
84844at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9WU70

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000664, Lethal2_giant
IPR013905, Lgl_C_dom
IPR013577, LLGL2
IPR042855, V_SNARE_CC
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08596, Lgl_C, 1 hit
PF08366, LLGL, 1 hit
PF00400, WD40, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00962, LETHAL2GIANT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50892, V_SNARE, 1 hit
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9WU70-1) [UniParc]FASTAAdd to basket
Also known as: B-tomosyn

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKFNIRKVL DGLTAGSSSA SQQQQQQQHP PGNREPEIQE TLQSEHFQLC
60 70 80 90 100
KTVRHGFPYQ PSALAFDPVQ KILAVGTQTG ALRLFGRPGV ECYCQHDSGA
110 120 130 140 150
AVIQLQFLIN EGALVSALAD DTLHLWNLRQ KRPAVLHSLK FCRERVTFCH
160 170 180 190 200
LPFQSKWLYV GTERGNIHIV NVESFTLSGY VIMWNKAIEL SSKSHPGPVV
210 220 230 240 250
HISDNPMDEG KLLIGFESGT VVLWDLKSKK ADYRYTYDEA IHSVAWHHEG
260 270 280 290 300
KQFICSHSDG TLTIWNVRSP TKPVQTITPH GKQLKDGKKP EPCKPILKVE
310 320 330 340 350
FKTTRSGEPF IILSGGLSYD TVGRRPCLTV MHGKSTAVLE MDYSIVDFLT
360 370 380 390 400
LCETPYPNDF QEPYAVVVLL EKDLVLIDLA QNGYPIFENP YPLSIHESPV
410 420 430 440 450
TCCEYFADCP VDLIPALYSV GARQKRQGYS KKEWPINGGN WGLGAQSYPE
460 470 480 490 500
IIITGHADGS IKFWDASAIT LQVLYKLKTS KVFEKSRNKD DRQNTDIVDE
510 520 530 540 550
DPYAIQIISW CPESRMLCIA GVSAHVIIYR FSKQEVVTEV IPMLEVRLLY
560 570 580 590 600
EINDVETPEG EQPPPLSTPV GSSTSQPIPP QSHPSTSSSS SDGLRDNVPC
610 620 630 640 650
LKVKNSPLKQ SPGYQTELVI QLVWVGGEPP QQITSLALNS SYGLVVFGNS
660 670 680 690 700
NGIAMVDYLQ KAVLLNLSTI ELYGSNDPYR REPRSPRKSR QPSGAGLCDI
710 720 730 740 750
TEGTVVPEDR CKSPTSGSSS PHNSDDEQKV NNFIEKVKTQ SRKFSKMVAS
760 770 780 790 800
DLAKMSRKLS LPTDLKPDLD VKDNSFSRSR SSSVTSIDKE SREAISALHF
810 820 830 840 850
CETFTRKADS SPSPCLWVGT TVGTAFVITL NLPLGPEQRL LQPVIVSPSG
860 870 880 890 900
TILRLKGAIL RMAFLDAAGC LMPPAYEPWT EHNVPEEKDE KEKLKKRRPV
910 920 930 940 950
SVSPSSSQEI SENQYAVICS EKQAKVISLP TQNCAYKQNI TETSFVLRGD
960 970 980 990 1000
IVALSNSVCL ACFCANGHIM TFSLPSLRPL LDVYYLPLTN MRIARTFCFA
1010 1020 1030 1040 1050
NSGQALYLVS PTEIQRLTYS QETCENLQEM LGELFTPVET PEAPNRGFFK
1060 1070 1080 1090 1100
GLFGGGAQSL DREELFGESS SGKASRSLAQ HIPGPGGIEG VKGAASGVVG
1110 1120 1130 1140 1150
ELARARLALD ERGQKLSDLE ERTAAMMSSA DSFSKHAHEM MLKYKDKKWY

QF
Length:1,152
Mass (Da):127,659
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C07CABD8421CBD5
GO
Isoform 2 (identifier: Q9WU70-2) [UniParc]FASTAAdd to basket
Also known as: M-tomosyn

The sequence of this isoform differs from the canonical sequence as follows:
     717-752: Missing.

Show »
Length:1,116
Mass (Da):123,638
Checksum:i034B99A939A987EA
GO
Isoform 3 (identifier: Q9WU70-3) [UniParc]FASTAAdd to basket
Also known as: S-tomosyn

The sequence of this isoform differs from the canonical sequence as follows:
     717-769: Missing.

Show »
Length:1,099
Mass (Da):121,743
Checksum:iB199B25F2FE117CE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016476717 – 769Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_016477717 – 752Missing in isoform 2. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U92072 mRNA Translation: AAD04756.1
AF118889 mRNA Translation: AAD27818.1
AF118890 mRNA Translation: AAD27819.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T42213

NCBI Reference Sequences

More...
RefSeqi
NP_110470.1, NM_030843.2 [Q9WU70-2]
NP_848035.1, NM_178345.1 [Q9WU70-1]
NP_848036.1, NM_178346.1 [Q9WU70-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000040559; ENSRNOP00000044738; ENSRNOG00000013351 [Q9WU70-2]
ENSRNOT00000044778; ENSRNOP00000039502; ENSRNOG00000013351 [Q9WU70-3]
ENSRNOT00000049699; ENSRNOP00000049322; ENSRNOG00000013351 [Q9WU70-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:81022

UCSC genome browser

More...
UCSCi
RGD:708517, rat [Q9WU70-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92072 mRNA Translation: AAD04756.1
AF118889 mRNA Translation: AAD27818.1
AF118890 mRNA Translation: AAD27819.1
PIRiT42213
RefSeqiNP_110470.1, NM_030843.2 [Q9WU70-2]
NP_848035.1, NM_178345.1 [Q9WU70-1]
NP_848036.1, NM_178346.1 [Q9WU70-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1URQX-ray2.00A1086-1145[»]
SMRiQ9WU70
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi249498, 2 interactors
CORUMiQ9WU70
IntActiQ9WU70, 1 interactor
STRINGi10116.ENSRNOP00000049322

PTM databases

iPTMnetiQ9WU70
PhosphoSitePlusiQ9WU70
SwissPalmiQ9WU70

Proteomic databases

PaxDbiQ9WU70
PRIDEiQ9WU70

Genome annotation databases

EnsembliENSRNOT00000040559; ENSRNOP00000044738; ENSRNOG00000013351 [Q9WU70-2]
ENSRNOT00000044778; ENSRNOP00000039502; ENSRNOG00000013351 [Q9WU70-3]
ENSRNOT00000049699; ENSRNOP00000049322; ENSRNOG00000013351 [Q9WU70-1]
GeneIDi81022
KEGGirno:81022
UCSCiRGD:708517, rat [Q9WU70-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
134957
RGDi708517, Stxbp5

Phylogenomic databases

eggNOGiKOG1983, Eukaryota
GeneTreeiENSGT00950000182906
HOGENOMiCLU_002808_0_0_1
InParanoidiQ9WU70
OMAiSIMRMAF
OrthoDBi84844at2759
PhylomeDBiQ9WU70

Miscellaneous databases

EvolutionaryTraceiQ9WU70

Protein Ontology

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PROi
PR:Q9WU70

Gene expression databases

BgeeiENSRNOG00000013351, Expressed in frontal cortex and 20 other tissues
GenevisibleiQ9WU70, RN

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000664, Lethal2_giant
IPR013905, Lgl_C_dom
IPR013577, LLGL2
IPR042855, V_SNARE_CC
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596, Lgl_C, 1 hit
PF08366, LLGL, 1 hit
PF00400, WD40, 1 hit
PRINTSiPR00962, LETHAL2GIANT
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50892, V_SNARE, 1 hit
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 1 hit
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTXB5_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WU70
Secondary accession number(s): Q9WU71, Q9Z152
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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