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Entry version 102 (02 Jun 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Chloride channel CLIC-like protein 1

Gene

Clcc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to act as a chloride ion channel (PubMed:11279057).

Plays a role in retina development (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride channel CLIC-like protein 1
Alternative name(s):
Mid-1-related chloride channel protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Clcc1
Synonyms:Mclc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
708359, Clcc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029768419 – 541Chloride channel CLIC-like protein 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei434PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei482PhosphothreonineBy similarity1
Modified residuei504PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9WU61

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WU61

PeptideAtlas

More...
PeptideAtlasi
Q9WU61

PRoteomics IDEntifications database

More...
PRIDEi
Q9WU61

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WU61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WU61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis (spermatocytes), liver and lung (at protein level). Expressed in spleen, liver, testis, kidney, heart, brain and lung.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with mitochondrial protein PIGBOS1 (via C-terminus); the interaction occurs at the mitochondria-associated endoplasmic reticulum (ER) membrane, a zone of contact between the ER and mitochondrial membranes, but does not appear to play a role in ER-mitochondria tethering and is not affected by ER stress (By similarity).

Interacts with CALR (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000042185

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni362 – 381DisorderedSequence analysisAdd BLAST20
Regioni511 – 541DisorderedSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chloride channel MCLC family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSP7, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WU61

Database of Orthologous Groups

More...
OrthoDBi
1001950at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9WU61

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009231, Chloride_chnl_CLIC-like

The PANTHER Classification System

More...
PANTHERi
PTHR34093, PTHR34093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05934, MCLC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9WU61-1) [UniParc]FASTAAdd to basket
Also known as: rMCLC-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCSLLLCGC LLLITGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGTSE
60 70 80 90 100
KKEVNPGLSD AQELSDCLQR LDSLTHKVDD CEKKKMKDYE SQSNPVFRRY
110 120 130 140 150
LNKILIEAGK LGLPDEDRVD VRYDAEILLT RQTLLEIQKF LSGEEWKPGA
160 170 180 190 200
LDDALSDILT NFKSHDAEAW KWQFEDYFGV DPYNVFMVLL CLLCIVALVA
210 220 230 240 250
TELWTYVRWH TQLKRVCIIS FLVSLGWNWI YLYKVAFAQH QANVAKMAPL
260 270 280 290 300
NDVCAKKMDW TENLWEWFRI SWTYKDDPCQ KYYELLIVNP IWLVPPTKAL
310 320 330 340 350
AVTFTNFVTE PLKYIGKGTG EFIKALMKEI PVLLQIPVLV ILALAVLGFC
360 370 380 390 400
YGAGQSVPML RHFRGPEREP PRALEPDDRR RQKELDYRFH GGAGDADFSY
410 420 430 440 450
RGPAGSIEQG PYDKMHVCER DVLRQRQVNM RFPSGNKSPE VLRAFDLPDT
460 470 480 490 500
EAQEHPEVVP SHKPSIVNTS LKETSELPRE STLAECSQCA KDGSGQVPST
510 520 530 540
AESSPIVEKA QLKTDSECRP HSTEAAAAAA RGTDPVSSPC G
Length:541
Mass (Da):61,174
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07954FC608C8FF40
GO
Isoform 2 (identifier: Q9WU61-2) [UniParc]FASTAAdd to basket
Also known as: rMCLC-2

The sequence of this isoform differs from the canonical sequence as follows:
     44-77: Missing.

Show »
Length:507
Mass (Da):57,430
Checksum:i9D0ED4926970BBF5
GO
Isoform 3 (identifier: Q9WU61-3) [UniParc]FASTAAdd to basket
Also known as: rMCLC-3

The sequence of this isoform differs from the canonical sequence as follows:
     394-394: G → A
     395-541: Missing.

Show »
Length:394
Mass (Da):45,398
Checksum:i05900C221B89611E
GO
Isoform 4 (identifier: Q9WU61-4) [UniParc]FASTAAdd to basket
Also known as: rMCLC-4

The sequence of this isoform differs from the canonical sequence as follows:
     44-77: Missing.
     394-394: G → A
     395-541: Missing.

Show »
Length:360
Mass (Da):41,653
Checksum:i59DAD3D160226EEB
GO
Isoform 5 (identifier: Q9WU61-5) [UniParc]FASTAAdd to basket
Also known as: rMCLC-5

The sequence of this isoform differs from the canonical sequence as follows:
     394-395: GD → EP
     396-541: Missing.

Show »
Length:395
Mass (Da):45,553
Checksum:i6423500C221B8961
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140TAF5A0A140TAF5_RAT
Chloride channel CLIC-like protein ...
Clcc1 rCG_29098
541Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZKI2D3ZKI2_RAT
Chloride channel CLIC-like protein ...
Clcc1 rCG_29098
360Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57G → D in AAH81736 (PubMed:15489334).Curated1
Sequence conflicti167A → S in AAH81736 (PubMed:15489334).Curated1
Sequence conflicti417V → A in AAH81736 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02735044 – 77Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_027351394 – 395GD → EP in isoform 5. 1 Publication2
Alternative sequenceiVSP_027352394G → A in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_027353395 – 541Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_027354396 – 541Missing in isoform 5. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB052919 mRNA Translation: BAB79264.1
AB052920 mRNA Translation: BAB79265.1
AB052921 mRNA Translation: BAB79266.1
AB052922 mRNA Translation: BAB59019.1
AB052923 mRNA Translation: BAB79267.1
AF117330 mRNA Translation: AAD26207.1
BC081736 mRNA Translation: AAH81736.1

NCBI Reference Sequences

More...
RefSeqi
NP_596905.1, NM_133414.1 [Q9WU61-1]
XP_006233189.1, XM_006233127.2
XP_006233190.1, XM_006233128.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170927

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:170927

UCSC genome browser

More...
UCSCi
RGD:708359, rat [Q9WU61-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052919 mRNA Translation: BAB79264.1
AB052920 mRNA Translation: BAB79265.1
AB052921 mRNA Translation: BAB79266.1
AB052922 mRNA Translation: BAB59019.1
AB052923 mRNA Translation: BAB79267.1
AF117330 mRNA Translation: AAD26207.1
BC081736 mRNA Translation: AAH81736.1
RefSeqiNP_596905.1, NM_133414.1 [Q9WU61-1]
XP_006233189.1, XM_006233127.2
XP_006233190.1, XM_006233128.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042185

PTM databases

iPTMnetiQ9WU61
PhosphoSitePlusiQ9WU61

Proteomic databases

jPOSTiQ9WU61
PaxDbiQ9WU61
PeptideAtlasiQ9WU61
PRIDEiQ9WU61

Genome annotation databases

GeneIDi170927
KEGGirno:170927
UCSCiRGD:708359, rat [Q9WU61-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23155
RGDi708359, Clcc1

Phylogenomic databases

eggNOGiENOG502QSP7, Eukaryota
InParanoidiQ9WU61
OrthoDBi1001950at2759
PhylomeDBiQ9WU61

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9WU61

Family and domain databases

InterProiView protein in InterPro
IPR009231, Chloride_chnl_CLIC-like
PANTHERiPTHR34093, PTHR34093, 1 hit
PfamiView protein in Pfam
PF05934, MCLC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLCC1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WU61
Secondary accession number(s): Q66HQ5
, Q8VIE8, Q8VIE9, Q8VIF0, Q8VIF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: November 1, 1999
Last modified: June 2, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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