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Protein

Nuclear receptor corepressor 2

Gene

Ncor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-MMU-3214815 HDACs deacetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor corepressor 2
Short name:
N-CoR2
Alternative name(s):
Silencing mediator of retinoic acid and thyroid hormone receptor
Short name:
SMRT
Short name:
SMRTe
T3 receptor-associating factor
Short name:
TRAC
Thyroid-, retinoic-acid-receptor-associated corepressor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncor2
Synonyms:Smrt
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1337080 Ncor2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000556231 – 2472Nuclear receptor corepressor 2Add BLAST2472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Asymmetric dimethylarginineCombined sources1
Modified residuei54PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Modified residuei149PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei215PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei549PhosphothreonineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1
Modified residuei878N6-acetyllysineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei945PhosphothreonineBy similarity1
Modified residuei955PhosphoserineBy similarity1
Modified residuei958N6-acetyllysineBy similarity1
Modified residuei1181N6-acetyllysineBy similarity1
Modified residuei1209N6-acetyllysineBy similarity1
Modified residuei1220PhosphoserineBy similarity1
Modified residuei1350PhosphothreonineCombined sources1
Modified residuei1449PhosphoserineBy similarity1
Modified residuei1509PhosphoserineBy similarity1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1624Asymmetric dimethylarginineBy similarity1
Modified residuei1746PhosphoserineBy similarity1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1819PhosphoserineBy similarity1
Modified residuei1854Omega-N-methylarginineCombined sources1
Modified residuei1920N6-acetyllysineBy similarity1
Modified residuei1963PhosphoserineBy similarity1
Modified residuei1983N6-acetyllysineCombined sources1
Modified residuei2004PhosphoserineCombined sources1
Modified residuei2012PhosphoserineCombined sources1
Modified residuei2015PhosphoserineCombined sources1
Modified residuei2016PhosphoserineCombined sources1
Modified residuei2018PhosphoserineCombined sources1
Modified residuei2020PhosphothreonineCombined sources1
Modified residuei2035PhosphoserineBy similarity1
Modified residuei2161PhosphoserineBy similarity1
Modified residuei2181PhosphoserineCombined sources1
Modified residuei2215PhosphoserineCombined sources1
Modified residuei2371PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9WU42

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9WU42

PeptideAtlas

More...
PeptideAtlasi
Q9WU42

PRoteomics IDEntifications database

More...
PRIDEi
Q9WU42

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WU42

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WU42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Also widely expressed in early embryos.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029478 Expressed in 291 organ(s), highest expression level in olfactory bulb

CleanEx database of gene expression profiles

More...
CleanExi
MM_NCOR2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9WU42 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9WU42 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2. Interacts with ZBTB7A (By similarity). Interacts with AR (By similarity).By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MECP2P516084EBI-6673326,EBI-1189067From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
203350, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9WU42

Database of interacting proteins

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DIPi
DIP-42595N

Protein interaction database and analysis system

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IntActi
Q9WU42, 7 interactors

Molecular INTeraction database

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MINTi
Q9WU42

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000083250

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9WU42

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9WU42

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini606 – 657SANT 2PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni254 – 312Interaction with SIN3A/BBy similarityAdd BLAST59
Regioni2086 – 2090Required for interaction with RARA in the absence of its ligandBy similarity5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili165 – 207Sequence analysisAdd BLAST43
Coiled coili492 – 560Sequence analysisAdd BLAST69
Coiled coili658 – 682Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2094 – 2098CORNR box of ID15
Motifi2296 – 2300CORNR box of ID25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi494 – 507Poly-GlnAdd BLAST14
Compositional biasi775 – 804Pro-richAdd BLAST30
Compositional biasi989 – 999Pro-richAdd BLAST11
Compositional biasi1351 – 1357Pro-rich7
Compositional biasi1615 – 1619Poly-Ala5
Compositional biasi2434 – 2437Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1878 Eukaryota
ENOG410YDXP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113746

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052587

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9WU42

KEGG Orthology (KO)

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KOi
K06065

Identification of Orthologs from Complete Genome Data

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OMAi
TPGVKGH

Family and domain databases

Conserved Domains Database

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CDDi
cd00167 SANT, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00717 SANT, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293 SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha (identifier: Q9WU42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARSHTDVGLL EYQHHPRDYT
60 70 80 90 100
SHLSPGSIIQ PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI
110 120 130 140 150
EFTESKRPRL ELLPDTLLRP SPLLATGQPS GSEDLTKDRS LAGKLEPVSP
160 170 180 190 200
PSPPHADPEL ELAPSRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL
210 220 230 240 250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP
260 270 280 290 300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ
310 320 330 340 350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM
360 370 380 390 400
QSRVGQRGSG LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY
410 420 430 440 450
DADQQRIKFI NMNGLMDDPM KVYKDRQVTN MWSEQERDTF REKFMQHPKN
460 470 480 490 500
FGLIASFLER KTVAECVLYY YLTKKNENYK SLVRRSYRRR GKSQQQQQQQ
510 520 530 540 550
QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE LSKEKTDDTS
560 570 580 590 600
GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL
610 620 630 640 650
ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF
660 670 680 690 700
NYKKRQNLDE ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE
710 720 730 740 750
MEASGASANE EELAEEAEAS QASGNEVPRV GECSGPAAVN NSSDTESVPS
760 770 780 790 800
PRSEATKDTG PKPTGTEALP AATQPPVPPP EEPAVAPAEP SPVPDASGPP
810 820 830 840 850
SPEPSPSPAA PPATVDKDEQ EAPAAPAPQT EDAKEQKSEA EEIDVGKPEE
860 870 880 890 900
PEASEEPPES VKSDHKEETE EEPEDKAKGT EAIETVSEAP LKVEEAGSKA
910 920 930 940 950
AVTKGSSSGA TQDSDSSATC SADEVDEPEG GDKGRLLSPR PSLLTPAGDP
960 970 980 990 1000
RASTSPQKPL DLKQLKQRAA AIPPIVTKVH EPPREDTVPP KPVPPVPPPT
1010 1020 1030 1040 1050
QHLQPEGDVS QQSGGSPRGK SRSPVPPAEK EAEKPAFFPA FPTEGPKLPT
1060 1070 1080 1090 1100
EPPRWSSGLP FPIPPREVIK TSPHAADPSA FSYTPPGHPL PLGLHDSARP
1110 1120 1130 1140 1150
VLPRPPISNP PPLISSAKHP GVLERQLGAI SQQGMSVQLR VPHSEHAKAP
1160 1170 1180 1190 1200
MGPLTMGLPL AVDPKKLGTA LGSATSGSIT KGLPSTRAAD GPSYRGSITH
1210 1220 1230 1240 1250
GTPADVLYKG TISRIVGEDS PSRLDRARED TLPKGHVIYE GKKGHVLSYE
1260 1270 1280 1290 1300
GGMSVSQCSK EDGRSSSGPP HETAAPKRTY DMMEGRVGRT VTSASIEGLM
1310 1320 1330 1340 1350
GRAIPEQHSP HLKEQHHIRG SITQGIPRSY VEAQEDYLRR EAKLLKREGT
1360 1370 1380 1390 1400
PPPPPPPRDL TETYKPRPLD PLGPLKLKPT HEGVVATVKE AGRSIHEIPR
1410 1420 1430 1440 1450
EELRRTPELP LAPRPLKEGS ITQGTPLKYD SGAPSTGTKK HDVRSIIGSP
1460 1470 1480 1490 1500
GRPFPALHPL DIMADARALE RACYEESLKS RSGTSSGAGG SITRGAPVVV
1510 1520 1530 1540 1550
PELGKPRQSP LTYEDHGAPF TSHLPRGSPV TTREPTPRLQ EGSLLSSKAS
1560 1570 1580 1590 1600
QDRKLTSTPR EIAKSPHSTV PEHHPHPISP YEHLLRGVTG VDLYRGHIPL
1610 1620 1630 1640 1650
AFDPTSIPRG IPLEAAAAAY YLPRHLAPSP TYPHLYPPYL IRGYPDTAAL
1660 1670 1680 1690 1700
ENRQTIINDY ITSQQMHHNA ASAMAQRADM LRGLSPRESS LALNYAAGPR
1710 1720 1730 1740 1750
GIIDLSQVPH LPVLVPPTPG TPATAIDRLA YLPTAPPPFS SRHSSSPLSP
1760 1770 1780 1790 1800
GGPTHLAKPT ATSSSERERE RERERDKSIL TSTTTVEHAP IWRPGTEQSS
1810 1820 1830 1840 1850
GAGGSSRPAS HTHQHSPISP RTQDALQQRP SVLHNTSMKG VVTSVEPGTP
1860 1870 1880 1890 1900
TVLRWARSTS TSSPVRPAAT FPPATHCPLG GTLEGVYPTL MEPVLLPKET
1910 1920 1930 1940 1950
SRVARPERPR VDAGHAFLTK PPAREPASSP SKSSEPRSLA PPSSSHTAIA
1960 1970 1980 1990 2000
RTPAKNLAPH HASPDPPAPT SASDLHREKT QSKPFSIQEL ELRSLGYHSG
2010 2020 2030 2040 2050
AGYSPDGVEP ISPVSSPSLT HDKGLSKPLE ELEKSHLEGE LRHKQPGPMK
2060 2070 2080 2090 2100
LSAEAAHLPH LRPLPESQPS SSPLLQTAPG IKGHQRVVTL AQHISEVITQ
2110 2120 2130 2140 2150
DYTRHHPQQL SGPLPAPLYS FPGASCPVLD LRRPPSDLYL PPPDHGTPAR
2160 2170 2180 2190 2200
GSPHSEGGKR SPEPSKTSVL GSSEDAIEPV SPPEGMTEPG HARSTAYPLL
2210 2220 2230 2240 2250
YRDGEQGEPR MGSKSPGNTS QPPAFFSKLT ESNSAMVKSK KQEINKKLNT
2260 2270 2280 2290 2300
HNRNEPEYNI GQPGTEIFNM PAITGAGLMT CRSQAVQEHA STNMGLEAII
2310 2320 2330 2340 2350
RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT ADGRSDHALT
2360 2370 2380 2390 2400
SPGGGGKAKV SGRPSSRKAK SPAPGLASGD RPPSVSSVHS EGDCNRRTPL
2410 2420 2430 2440 2450
TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH
2460 2470
HAWDEEPKPL LCSQYETLSD SE
Length:2,472
Mass (Da):269,807
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8068020DF0AAB9B7
GO
Isoform Beta (identifier: Q9WU42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-254: Missing.

Show »
Length:2,253
Mass (Da):245,029
Checksum:i7FA45277FC6300A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PY55E9PY55_MOUSE
Nuclear receptor corepressor 2
Ncor2
2,468Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9V3E9Q9V3_MOUSE
Nuclear receptor corepressor 2
Ncor2
2,332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQL9F8VQL9_MOUSE
Nuclear receptor corepressor 2
Ncor2
2,507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q701E9Q701_MOUSE
Nuclear receptor corepressor 2
Ncor2
2,473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2J5D3Z2J5_MOUSE
Nuclear receptor corepressor 2
Ncor2
1,025Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEQ5A0A0G2JEQ5_MOUSE
Nuclear receptor corepressor 2
Ncor2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Z4B2F6Z4B2_MOUSE
Nuclear receptor corepressor 2
Ncor2
1,552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YAU7F6YAU7_MOUSE
Nuclear receptor corepressor 2
Ncor2
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SK53F6SK53_MOUSE
Nuclear receptor corepressor 2
Ncor2
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JED1A0A0G2JED1_MOUSE
Nuclear receptor corepressor 2
Ncor2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176M → RL in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti396 – 402PPMLYDA → RHVVRR in AAD22972 (PubMed:10097068).Curated7
Sequence conflicti555D → H in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti756T → M in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti785V → A in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti806 – 846PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20944 (PubMed:10077563).CuratedAdd BLAST41
Sequence conflicti806 – 846PSPAA…EIDVG → HHLPHPRLLWTRMNKKPRLL QLPRQRMPRSRSLRPRRSMW E in AAD20945 (PubMed:10077563).CuratedAdd BLAST41
Sequence conflicti856E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti859E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti867E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti895E → K in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti916S → F in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti975I → IQ in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti1046 – 1063PKLPT…LPFPI → QSYRLSPHAGHRLPSH in AAD22972 (PubMed:10097068).CuratedAdd BLAST18
Sequence conflicti1073 – 1080PHAADPSA → TRADPL in AAD22972 (PubMed:10097068).Curated8
Sequence conflicti1133Missing in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1149Missing in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1157G → E in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1172 – 1201GSATS…SITHG → APPPVEASPRASQYPGCRRP QLQRLYHPR in AAD22972 (PubMed:10097068).CuratedAdd BLAST30
Sequence conflicti1696A → S in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1855 – 1857Missing in AAD22972 (PubMed:10097068).Curated3
Sequence conflicti1909P → A in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti1909P → A in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti1913A → G in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1923A → G in AAD20944 (PubMed:10077563).Curated1
Sequence conflicti1923A → G in AAD20945 (PubMed:10077563).Curated1
Sequence conflicti1956N → S in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti1968A → G in AAD22972 (PubMed:10097068).Curated1
Sequence conflicti2195 – 2196TA → AV in AAD22972 (PubMed:10097068).Curated2
Sequence conflicti2213 – 2214SK → LE in AAD20944 (PubMed:10077563).Curated2
Sequence conflicti2224A → T in AAD20944 (PubMed:10077563).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00341436 – 254Missing in isoform Beta. 1 PublicationAdd BLAST219

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF113001 mRNA Translation: AAD20944.1
AF113002 mRNA Translation: AAD20945.1
AF125671 mRNA Translation: AAD22972.1
AC132118 Genomic DNA No translation available.
AC139377 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57382.1 [Q9WU42-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001240833.1, NM_001253904.1
NP_001240834.1, NM_001253905.1 [Q9WU42-2]
XP_011239133.1, XM_011240831.2 [Q9WU42-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.278646

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111394; ENSMUSP00000107025; ENSMUSG00000029478 [Q9WU42-2]
ENSMUST00000111398; ENSMUSP00000107029; ENSMUSG00000029478 [Q9WU42-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20602

UCSC genome browser

More...
UCSCi
uc008zra.2 mouse [Q9WU42-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113001 mRNA Translation: AAD20944.1
AF113002 mRNA Translation: AAD20945.1
AF125671 mRNA Translation: AAD22972.1
AC132118 Genomic DNA No translation available.
AC139377 Genomic DNA No translation available.
CCDSiCCDS57382.1 [Q9WU42-2]
RefSeqiNP_001240833.1, NM_001253904.1
NP_001240834.1, NM_001253905.1 [Q9WU42-2]
XP_011239133.1, XM_011240831.2 [Q9WU42-1]
UniGeneiMm.278646

3D structure databases

ProteinModelPortaliQ9WU42
SMRiQ9WU42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203350, 12 interactors
CORUMiQ9WU42
DIPiDIP-42595N
IntActiQ9WU42, 7 interactors
MINTiQ9WU42
STRINGi10090.ENSMUSP00000083250

PTM databases

iPTMnetiQ9WU42
PhosphoSitePlusiQ9WU42

Proteomic databases

EPDiQ9WU42
PaxDbiQ9WU42
PeptideAtlasiQ9WU42
PRIDEiQ9WU42

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111394; ENSMUSP00000107025; ENSMUSG00000029478 [Q9WU42-2]
ENSMUST00000111398; ENSMUSP00000107029; ENSMUSG00000029478 [Q9WU42-1]
GeneIDi20602
KEGGimmu:20602
UCSCiuc008zra.2 mouse [Q9WU42-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9612
MGIiMGI:1337080 Ncor2

Phylogenomic databases

eggNOGiKOG1878 Eukaryota
ENOG410YDXP LUCA
GeneTreeiENSGT00940000159022
HOGENOMiHOG000113746
HOVERGENiHBG052587
InParanoidiQ9WU42
KOiK06065
OMAiTPGVKGH

Enzyme and pathway databases

ReactomeiR-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-MMU-3214815 HDACs deacetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ncor2 mouse

Protein Ontology

More...
PROi
PR:Q9WU42

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029478 Expressed in 291 organ(s), highest expression level in olfactory bulb
CleanExiMM_NCOR2
ExpressionAtlasiQ9WU42 baseline and differential
GenevisibleiQ9WU42 MM

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR031557 N-CoR_GPS2_interact
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF15784 GPS2_interact, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOR2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WU42
Secondary accession number(s): E9Q9V0, Q9WU43, Q9WUC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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