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Entry version 134 (17 Jun 2020)
Sequence version 2 (10 Jul 2007)
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Protein

Inner nuclear membrane protein Man1

Gene

Lemd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi717 – 736By similarityAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2980766 Nuclear Envelope Breakdown
R-MMU-2995383 Initiation of Nuclear Envelope Reformation
R-MMU-4419969 Depolymerisation of the Nuclear Lamina

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner nuclear membrane protein Man1
Alternative name(s):
LEM domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lemd3
Synonyms:Man1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3580376 Lemd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002061501 – 921Inner nuclear membrane protein Man1Add BLAST921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei140PhosphoserineCombined sources1
Modified residuei261PhosphoserineBy similarity1
Modified residuei263PhosphoserineCombined sources1
Modified residuei287PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei787PhosphoserineBy similarity1
Modified residuei893PhosphothreonineBy similarity1
Modified residuei921PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9WU40

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9WU40

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WU40

PRoteomics IDEntifications database

More...
PRIDEi
Q9WU40

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WU40

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WU40

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD1, SMAD2, SMAD3 and SMAD5. Binds to both phosphorylated and unphosphorylated R-SMADS (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
237587, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9WU40, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9WU40

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000113103

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9WU40 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WU40

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 51LEMPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni709 – 921Interaction with SMAD1, SMAD2, SMAD3 and SMAD5By similarityAdd BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi52 – 62Poly-GlnAdd BLAST11
Compositional biasi74 – 79Poly-Asn6
Compositional biasi151 – 157Poly-Gly7
Compositional biasi264 – 272Poly-Glu9
Compositional biasi329 – 332Poly-Ala4
Compositional biasi349 – 357Poly-Gly9
Compositional biasi424 – 429Poly-Ala6
Compositional biasi645 – 650Poly-Leu6
Compositional biasi669 – 672Poly-Glu4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0147 Eukaryota
ENOG410XP20 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WU40

KEGG Orthology (KO)

More...
KOi
K19410

Database of Orthologous Groups

More...
OrthoDBi
873705at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12286 RRM_Man1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1180, 1 hit
1.10.720.40, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011015 LEM/LEM-like_dom_sf
IPR003887 LEM_dom
IPR034997 Man1
IPR034394 Man1_RRM
IPR041885 MAN1_winged_helix_dom
IPR018996 MSC
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13428:SF10 PTHR13428:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03020 LEM, 1 hit
PF09402 MSC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00540 LEM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit
SSF63451 SSF63451, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50954 LEM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9WU40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATAAAAP QQLSDEELFS QLRRYGLSPG PVTESTRPVY LKKLKKLREE
60 70 80 90 100
EQQQQQQQQQ QQHRAGGRGN KTRNSNNNNT ATAMGGRPGS GDLAYLRSPA
110 120 130 140 150
GLGRLSASAA ESPVAGGSGG AAAVPAAGSK VLLGFSSDES DVEASPREQA
160 170 180 190 200
GGGGGGGARR DRAALQYRGL RAPPAPPAAG EVTGGHPGER RKPHSWWGAR
210 220 230 240 250
RPAGPEPQPP AAGSDGAAED ADEELADGED RDPEAEEPLW ASRAVNGSRL
260 270 280 290 300
LPYSSCREHY SDSEEEEEEG EEDGDVAPAR QVLKDDSLAR HRPRRSHSKP
310 320 330 340 350
FSALTAKSGG SRQETSVQGG GALAMNDRAA AAGSLDRSRN LEEAAAEPGG
360 370 380 390 400
GGGGGCGCDP VDSIPRYRAG AKKLAPLLSP PSPDGDSTLE SPTGPLLKTN
410 420 430 440 450
NHIGGGAFGV DSPGLYANSL PPGATAAAAP GTLRINHANH TGSNHTYLKT
460 470 480 490 500
AYGKPKLCEP EEELLQQFKR EEVSPTGSFS AHYLSMFLLT AACLFFLILG
510 520 530 540 550
LTYLGMRGTG VPEDGGLIKN PFDETFGKIQ ESEKNLLMST LYKLHDRLAQ
560 570 580 590 600
IAGDHECGSS SQRMLSVQEA AAYLKNLGPE YEDVFNTSLL WIFKNGKDVG
610 620 630 640 650
IRCVGYGPEE DLTNITDVQF LQSTRPQMPF WCRFRRAFIT VTHRLLLLCL
660 670 680 690 700
GVVLVCVALR YMRYRWTKEE EETRQMYDMV VKIIDVLRSH NEACQETKDL
710 720 730 740 750
QPYMPLPHVR DSLIQPQDRK KMKKVWDRAV DFLAANESRV RTETRRVGGA
760 770 780 790 800
DFLVWRWIQP SASCDKTLVI PSKVWQGQAF HLDRRNSPPN SLTPCLKIRN
810 820 830 840 850
MFDPVMEIGD HWHLAIQEAI LEKCSDNDGI VHIAVDRNSR EGCVYVKCLS
860 870 880 890 900
PEYAGKAFKA LHGSWFDGKL VTVKYLRLDR YHHRFPQALT CNTPLKPANK
910 920
HMNSLSHLRL RTGLANSQGS S
Length:921
Mass (Da):100,307
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBFA12FE19D79F3D
GO
Isoform 2 (identifier: Q9WU40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     575-575: K → KVHLVFKITAENLCFKTLSDASN

Show »
Length:943
Mass (Da):102,739
Checksum:iC1A46ECEB922CD4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QP59E9QP59_MOUSE
Inner nuclear membrane protein Man1
Lemd3
918Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YU56D3YU56_MOUSE
Inner nuclear membrane protein Man1
Lemd3
940Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC082610 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti804P → Q in BAE24418 (PubMed:16141072).Curated1
Sequence conflicti861L → F in BAE24418 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026782575K → KVHLVFKITAENLCFKTLSD ASN in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC140381 Genomic DNA No translation available.
AF112300 mRNA Translation: AAD31594.1
BC082610 mRNA No translation available.
AK140538 mRNA Translation: BAE24418.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074662.2, NM_001081193.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
380664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:380664

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140381 Genomic DNA No translation available.
AF112300 mRNA Translation: AAD31594.1
BC082610 mRNA No translation available.
AK140538 mRNA Translation: BAE24418.1
RefSeqiNP_001074662.2, NM_001081193.2

3D structure databases

SMRiQ9WU40
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi237587, 2 interactors
IntActiQ9WU40, 1 interactor
MINTiQ9WU40
STRINGi10090.ENSMUSP00000113103

PTM databases

iPTMnetiQ9WU40
PhosphoSitePlusiQ9WU40

Proteomic databases

EPDiQ9WU40
jPOSTiQ9WU40
PaxDbiQ9WU40
PRIDEiQ9WU40

Genome annotation databases

GeneIDi380664
KEGGimmu:380664

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23592
MGIiMGI:3580376 Lemd3

Phylogenomic databases

eggNOGiKOG0147 Eukaryota
ENOG410XP20 LUCA
InParanoidiQ9WU40
KOiK19410
OrthoDBi873705at2759

Enzyme and pathway databases

ReactomeiR-MMU-2980766 Nuclear Envelope Breakdown
R-MMU-2995383 Initiation of Nuclear Envelope Reformation
R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
380664 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lemd3 mouse

Protein Ontology

More...
PROi
PR:Q9WU40
RNActiQ9WU40 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd12286 RRM_Man1, 1 hit
Gene3Di1.10.10.1180, 1 hit
1.10.720.40, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR011015 LEM/LEM-like_dom_sf
IPR003887 LEM_dom
IPR034997 Man1
IPR034394 Man1_RRM
IPR041885 MAN1_winged_helix_dom
IPR018996 MSC
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
PANTHERiPTHR13428:SF10 PTHR13428:SF10, 1 hit
PfamiView protein in Pfam
PF03020 LEM, 1 hit
PF09402 MSC, 1 hit
SMARTiView protein in SMART
SM00540 LEM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF63451 SSF63451, 1 hit
PROSITEiView protein in PROSITE
PS50954 LEM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAN1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WU40
Secondary accession number(s): Q0VGU6, Q3USB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 10, 2007
Last modified: June 17, 2020
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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