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Protein

Prefoldin subunit 5

Gene

Pfdn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
EIG-1
Myc modulator 1
c-Myc-binding protein Mm-1
Gene namesi
Name:Pfdn5
Synonyms:Eig1, Mm1, Pfd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1928753 Pfdn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001536622 – 154Prefoldin subunit 5Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei42N6-acetyllysineBy similarity1
Modified residuei56PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9WU28
MaxQBiQ9WU28
PaxDbiQ9WU28
PeptideAtlasiQ9WU28
PRIDEiQ9WU28

2D gel databases

UCD-2DPAGEiQ9WU28

PTM databases

iPTMnetiQ9WU28
PhosphoSitePlusiQ9WU28

Expressioni

Gene expression databases

BgeeiENSMUSG00000001289 Expressed in 267 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_PFDN5
ExpressionAtlasiQ9WU28 baseline and differential
GenevisibleiQ9WU28 MM

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WU28, 1 interactor
MINTiQ9WU28
STRINGi10090.ENSMUSP00000129178

Structurei

3D structure databases

ProteinModelPortaliQ9WU28
SMRiQ9WU28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3048 Eukaryota
COG1730 LUCA
GeneTreeiENSGT00390000008783
HOVERGENiHBG004539
InParanoidiQ9WU28
KOiK04797
OMAiFQPDWEN
OrthoDBiEOG091G0TVG
TreeFamiTF106509

Family and domain databases

Gene3Di1.10.287.370, 1 hit
HAMAPiMF_00308 PfdA, 1 hit
InterProiView protein in InterPro
IPR011599 PFD_alpha_archaea
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
TIGRFAMsiTIGR00293 TIGR00293, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9WU28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL
60 70 80 90 100
NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK
110 120 130 140 150
DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA

TVKA
Length:154
Mass (Da):17,356
Last modified:November 1, 1999 - v1
Checksum:i0DA1EC744548CB14
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q093E9Q093_MOUSE
Prefoldin subunit 5
Pfdn5
72Annotation score:
E9Q5Q8E9Q5Q8_MOUSE
Prefoldin subunit 5
Pfdn5
60Annotation score:
E9PZ62E9PZ62_MOUSE
Prefoldin subunit 5
Pfdn5
109Annotation score:
E9PVG3E9PVG3_MOUSE
Prefoldin subunit 5
Pfdn5
85Annotation score:
H7BWX1H7BWX1_MOUSE
Prefoldin subunit 5
Pfdn5
73Annotation score:

Sequence cautioni

The sequence BAA92269 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108357 mRNA Translation: AAD28373.1
AB011473 mRNA Translation: BAA92269.1 Different initiation.
AK028206 mRNA Translation: BAC25814.1
AK145883 mRNA Translation: BAE26723.1
BC026920 mRNA Translation: AAH26920.1
CCDSiCCDS37227.1
RefSeqiNP_081320.2, NM_027044.3
UniGeneiMm.158264

Genome annotation databases

EnsembliENSMUST00000166658; ENSMUSP00000129178; ENSMUSG00000001289
GeneIDi56612
KEGGimmu:56612
UCSCiuc007xvh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108357 mRNA Translation: AAD28373.1
AB011473 mRNA Translation: BAA92269.1 Different initiation.
AK028206 mRNA Translation: BAC25814.1
AK145883 mRNA Translation: BAE26723.1
BC026920 mRNA Translation: AAH26920.1
CCDSiCCDS37227.1
RefSeqiNP_081320.2, NM_027044.3
UniGeneiMm.158264

3D structure databases

ProteinModelPortaliQ9WU28
SMRiQ9WU28
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WU28, 1 interactor
MINTiQ9WU28
STRINGi10090.ENSMUSP00000129178

PTM databases

iPTMnetiQ9WU28
PhosphoSitePlusiQ9WU28

2D gel databases

UCD-2DPAGEiQ9WU28

Proteomic databases

EPDiQ9WU28
MaxQBiQ9WU28
PaxDbiQ9WU28
PeptideAtlasiQ9WU28
PRIDEiQ9WU28

Protocols and materials databases

DNASUi56612
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166658; ENSMUSP00000129178; ENSMUSG00000001289
GeneIDi56612
KEGGimmu:56612
UCSCiuc007xvh.1 mouse

Organism-specific databases

CTDi5204
MGIiMGI:1928753 Pfdn5

Phylogenomic databases

eggNOGiKOG3048 Eukaryota
COG1730 LUCA
GeneTreeiENSGT00390000008783
HOVERGENiHBG004539
InParanoidiQ9WU28
KOiK04797
OMAiFQPDWEN
OrthoDBiEOG091G0TVG
TreeFamiTF106509

Miscellaneous databases

PROiPR:Q9WU28
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001289 Expressed in 267 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_PFDN5
ExpressionAtlasiQ9WU28 baseline and differential
GenevisibleiQ9WU28 MM

Family and domain databases

Gene3Di1.10.287.370, 1 hit
HAMAPiMF_00308 PfdA, 1 hit
InterProiView protein in InterPro
IPR011599 PFD_alpha_archaea
IPR009053 Prefoldin
IPR004127 Prefoldin_subunit_alpha
PfamiView protein in Pfam
PF02996 Prefoldin, 1 hit
TIGRFAMsiTIGR00293 TIGR00293, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD5_MOUSE
AccessioniPrimary (citable) accession number: Q9WU28
Secondary accession number(s): Q3UKS8, Q9JMJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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