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Protein

Tyrosine-protein phosphatase non-receptor type 4

Gene

Ptpn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act at junctions between the membrane and the cytoskeleton.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei820SubstrateBy similarity1
Active sitei852Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei896SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 4 (EC:3.1.3.48)
Alternative name(s):
Testis-enriched protein tyrosine phosphatase
Gene namesi
Name:Ptpn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1099792 Ptpn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200751 – 926Tyrosine-protein phosphatase non-receptor type 4Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei474PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9WU22
PaxDbiQ9WU22
PeptideAtlasiQ9WU22
PRIDEiQ9WU22

PTM databases

iPTMnetiQ9WU22
PhosphoSitePlusiQ9WU22

Expressioni

Tissue specificityi

Highly expressed in testis. Specifically expressed in spermatocytes and spermatids within seminiferous tubules (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026384
CleanExiMM_PTPN4
ExpressionAtlasiQ9WU22 baseline and differential
GenevisibleiQ9WU22 MM

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WU22, 3 interactors
MINTiQ9WU22
STRINGi10090.ENSMUSP00000067614

Structurei

3D structure databases

ProteinModelPortaliQ9WU22
SMRiQ9WU22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMPROSITE-ProRule annotationAdd BLAST284
Domaini517 – 589PDZPROSITE-ProRule annotationAdd BLAST73
Domaini655 – 911Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni852 – 858Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000007048
HOVERGENiHBG008322
InParanoidiQ9WU22
KOiK18037
OMAiHTCTDFW
OrthoDBiEOG091G016K
TreeFamiTF315900

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WU22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFRVNKHDQ
60 70 80 90 100
GQVLLDIVFK HLDLTERDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP
110 120 130 140 150
YNLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLS CPCNTAALLA
160 170 180 190 200
SFAVQSELGD YNQSENLAGY LSDYSFIPNQ PQDFEKEIAK LHQQHVGLSP
210 220 230 240 250
AEAEFNYLNA ARTLELYGVE FHYARDQSNN EILIGVMSGG ILIYKNRVRM
260 270 280 290 300
NTFLWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKTLWKA
310 320 330 340 350
CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN
360 370 380 390 400
KDRVFARSPS KPLARKLMDW EVVSRNSLSD DRLETQSLPS RSPPGTPNHR
410 420 430 440 450
NSSFTQEATR VRPSSVGHLV DHVVHMSPSE DFVSQRSPSS TQANSIVLES
460 470 480 490 500
SPSQETPEDG QPPALPPKQS KKNSWNQIHF SNSQQDLVTH TNESFDVPSS
510 520 530 540 550
PEKSTPNGGI PHDNLVLIKM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG
560 570 580 590 600
TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC EKHSGELVLL
610 620 630 640 650
VRPNAVYDVV EEKLESEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL
660 670 680 690 700
ITGTVLAQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVLLKG
710 720 730 740 750
NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCKDFWQM TWEQGSSMVV
760 770 780 790 800
MLTTQVERGR VKCHQYWPEP SESSSYGCYQ VTCHSEEGNP AYIFRKMTLF
810 820 830 840 850
NQEKNESRQL TQIQYTAWPD HGVPDDSSDF LDFVCHVRDQ RAGKEEPIIV
860 870 880 890 900
HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ
910 920
YRFVCEAILK VYEEGFVKPL TTSSNK
Length:926
Mass (Da):105,832
Last modified:September 18, 2013 - v2
Checksum:i73E465D804C9C5FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311D → G in AAD22773 (PubMed:11054567).Curated1
Sequence conflicti359P → S in AAD22773 (PubMed:11054567).Curated1
Sequence conflicti741T → I in AAD22773 (PubMed:11054567).Curated1
Sequence conflicti781V → A in AAD22773 (PubMed:11054567).Curated1
Sequence conflicti800F → I in AAD22773 (PubMed:11054567).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106702 mRNA Translation: AAD22773.1
AC123955 Genomic DNA No translation available.
AC124760 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39812.1
CCDSiCCDS15227.1
RefSeqiNP_064317.2, NM_019933.2
UniGeneiMm.458796

Genome annotation databases

EnsembliENSMUST00000064091; ENSMUSP00000067614; ENSMUSG00000026384
GeneIDi19258
KEGGimmu:19258
UCSCiuc007ciz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTN4_MOUSE
AccessioniPrimary (citable) accession number: Q9WU22
Secondary accession number(s): G5E8E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 18, 2013
Last modified: July 18, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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