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Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:Avpr1b
Synonyms:V1br
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1347010 Avpr1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 59Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 93Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini94 – 108ExtracellularSequence analysisAdd BLAST15
Transmembranei109 – 130Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini131 – 151CytoplasmicSequence analysisAdd BLAST21
Transmembranei152 – 173Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini174 – 202ExtracellularSequence analysisAdd BLAST29
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 280CytoplasmicSequence analysisAdd BLAST57
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini301 – 318ExtracellularSequence analysisAdd BLAST18
Transmembranei319 – 338Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini339 – 421CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702041 – 421Vasopressin V1b receptorAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WU02
PRIDEiQ9WU02

PTM databases

PhosphoSitePlusiQ9WU02

Expressioni

Gene expression databases

BgeeiENSMUSG00000026432 Expressed in 20 organ(s), highest expression level in Ammon's horn
CleanExiMM_AVPR1B
ExpressionAtlasiQ9WU02 baseline and differential
GenevisibleiQ9WU02 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027690

Structurei

3D structure databases

ProteinModelPortaliQ9WU02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiQ9WU02
KOiK04227
OMAiKVKTQAW
OrthoDBiEOG091G0DB6
PhylomeDBiQ9WU02
TreeFamiTF106499

Family and domain databases

CDDicd15386 7tmA_V1bR, 1 hit
InterProiView protein in InterPro
IPR015076 DUF1856
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000628 Vprs_rcpt_V1B
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF08983 DUF1856, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00897 VASOPRSNV1BR
SMARTiView protein in SMART
SM01164 DUF1856, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WU02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSEPSWTAT PSPGGTLFVP NTTTPWLGRD EELAKVEIGI LATVLVLATG
60 70 80 90 100
GNLAVLLILG LQGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF
110 120 130 140 150
QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSQST
160 170 180 190 200
YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI
210 220 230 240 250
TWTTMAIFVL PVVVLTACYG LICHEIYKNL KVKTQAGREE RRGWPKSSSS
260 270 280 290 300
AAAAATRGLP SRVSSISTIS RAKIRTVKMT FVIVLAYIAC WAPFFSVQMW
310 320 330 340 350
SVWDENAPNE DSTNVAFTIS MLLGNLSSCC NPWIYMGFNS HLLPRSLSHR
360 370 380 390 400
ACCRGSKPRV HRQLSNSSLA SRRTTLLTHT CGPSTLRLSL NLSLHAKPKP
410 420
AGSLKDLEQV DGEATMETSI S
Length:421
Mass (Da):46,539
Last modified:November 1, 1999 - v1
Checksum:iE867DC0C700F596F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WR95A0A087WR95_MOUSE
Vasopressin V1b receptor
Avpr1b
123Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098867, AF098866 Genomic DNA Translation: AAD27957.1
AB030449 Genomic DNA Translation: BAA89205.1
CCDSiCCDS35703.1
RefSeqiNP_036054.1, NM_011924.2
UniGeneiMm.89986

Genome annotation databases

EnsembliENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432
GeneIDi26361
KEGGimmu:26361
UCSCiuc007cnl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098867, AF098866 Genomic DNA Translation: AAD27957.1
AB030449 Genomic DNA Translation: BAA89205.1
CCDSiCCDS35703.1
RefSeqiNP_036054.1, NM_011924.2
UniGeneiMm.89986

3D structure databases

ProteinModelPortaliQ9WU02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027690

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9WU02

Proteomic databases

PaxDbiQ9WU02
PRIDEiQ9WU02

Protocols and materials databases

DNASUi26361
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027690; ENSMUSP00000027690; ENSMUSG00000026432
GeneIDi26361
KEGGimmu:26361
UCSCiuc007cnl.1 mouse

Organism-specific databases

CTDi553
MGIiMGI:1347010 Avpr1b

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiQ9WU02
KOiK04227
OMAiKVKTQAW
OrthoDBiEOG091G0DB6
PhylomeDBiQ9WU02
TreeFamiTF106499

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:Q9WU02
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026432 Expressed in 20 organ(s), highest expression level in Ammon's horn
CleanExiMM_AVPR1B
ExpressionAtlasiQ9WU02 baseline and differential
GenevisibleiQ9WU02 MM

Family and domain databases

CDDicd15386 7tmA_V1bR, 1 hit
InterProiView protein in InterPro
IPR015076 DUF1856
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000628 Vprs_rcpt_V1B
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF08983 DUF1856, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00897 VASOPRSNV1BR
SMARTiView protein in SMART
SM01164 DUF1856, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV1BR_MOUSE
AccessioniPrimary (citable) accession number: Q9WU02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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