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Protein

Aquaporin-5

Gene

Aqp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-432047 Passive transport by Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-5
Short name:
AQP-5
Gene namesi
Name:Aqp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:106215 Aqp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 36ExtracellularSequence analysis3
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 87CytoplasmicSequence analysisAdd BLAST30
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 126ExtracellularSequence analysisAdd BLAST18
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 161CytoplasmicSequence analysisAdd BLAST14
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 205ExtracellularSequence analysisAdd BLAST23
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 265CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced Ca2+ entry and loss of regulatory volume decrease in response to hypotonicity in acinar cells. HTS-stimulated Ca2+ entry is significantly decreased in submandibular gland acini and almost completely abolished in parotid acini.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639521 – 265Aquaporin-5Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9WTY4
PaxDbiQ9WTY4
PRIDEiQ9WTY4

PTM databases

iPTMnetiQ9WTY4
PhosphoSitePlusiQ9WTY4

Expressioni

Tissue specificityi

Expressed in salivary glands (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000044217 Expressed in 91 organ(s), highest expression level in cornea
CleanExiMM_AQP5
GenevisibleiQ9WTY4 MM

Interactioni

Subunit structurei

Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085530

Structurei

3D structure databases

ProteinModelPortaliQ9WTY4
SMRiQ9WTY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 71NPA 13
Motifi185 – 187NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG000312
InParanoidiQ9WTY4
KOiK09867
OMAiWEDHREE
OrthoDBiEOG091G166T
PhylomeDBiQ9WTY4
TreeFamiTF312940

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023276 Aquaporin_5
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PTHR19139:SF38 PTHR19139:SF38, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02017 AQUAPORIN5
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WTY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKEVCSVAF FKAVFAEFLA TLIFVFFGLG SALKWPSALP TILQISIAFG
60 70 80 90 100
LAIGTLAQAL GPVSGGHINP AITLALLIGN QISLLRAIFY VAAQLVGAIA
110 120 130 140 150
GAGILYWLAP GNARGNLAVN ALSNNTTPGK AVVVELILTF QLALCIFSST
160 170 180 190 200
DSRRTSPVGS PALSIGLSVT LGHLVGIYFT GCSMNPARSF GPAVVMNRFS
210 220 230 240 250
PSHWVFWVGP IVGAVLAAIL YFYLLFPSSL SLHDRVAVVK GTYEPEEDWE
260
DHREERKKTI ELTAH
Length:265
Mass (Da):28,274
Last modified:November 1, 1999 - v1
Checksum:i917DF4A0C0A4C620
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHL2A0A2R8VHL2_MOUSE
Aquaporin-5
Aqp5
148Annotation score:
A0A2R8VI16A0A2R8VI16_MOUSE
Aquaporin-5
Aqp5
241Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087654 mRNA Translation: AAD32491.1
AK009302 mRNA Translation: BAB26203.1
CCDSiCCDS27823.1
RefSeqiNP_033831.1, NM_009701.4
UniGeneiMm.45580

Genome annotation databases

EnsembliENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217
ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217
GeneIDi11830
KEGGimmu:11830
UCSCiuc007xpt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087654 mRNA Translation: AAD32491.1
AK009302 mRNA Translation: BAB26203.1
CCDSiCCDS27823.1
RefSeqiNP_033831.1, NM_009701.4
UniGeneiMm.45580

3D structure databases

ProteinModelPortaliQ9WTY4
SMRiQ9WTY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085530

PTM databases

iPTMnetiQ9WTY4
PhosphoSitePlusiQ9WTY4

Proteomic databases

MaxQBiQ9WTY4
PaxDbiQ9WTY4
PRIDEiQ9WTY4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088200; ENSMUSP00000085530; ENSMUSG00000044217
ENSMUST00000169082; ENSMUSP00000127611; ENSMUSG00000044217
GeneIDi11830
KEGGimmu:11830
UCSCiuc007xpt.1 mouse

Organism-specific databases

CTDi362
MGIiMGI:106215 Aqp5

Phylogenomic databases

eggNOGiKOG0223 Eukaryota
COG0580 LUCA
GeneTreeiENSGT00760000119223
HOGENOMiHOG000288286
HOVERGENiHBG000312
InParanoidiQ9WTY4
KOiK09867
OMAiWEDHREE
OrthoDBiEOG091G166T
PhylomeDBiQ9WTY4
TreeFamiTF312940

Enzyme and pathway databases

ReactomeiR-MMU-432047 Passive transport by Aquaporins

Miscellaneous databases

PROiPR:Q9WTY4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044217 Expressed in 91 organ(s), highest expression level in cornea
CleanExiMM_AQP5
GenevisibleiQ9WTY4 MM

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023276 Aquaporin_5
IPR034294 Aquaporin_transptr
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PTHR19139:SF38 PTHR19139:SF38, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR02017 AQUAPORIN5
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQP5_MOUSE
AccessioniPrimary (citable) accession number: Q9WTY4
Secondary accession number(s): Q545H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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