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Protein

Programmed cell death protein 7

Gene

Pdcd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes apoptosis when overexpressed.1 Publication

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 7
Alternative name(s):
ES18
Gene namesi
Name:Pdcd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1859170 Pdcd7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582701 – 482Programmed cell death protein 7Add BLAST482

Proteomic databases

EPDiQ9WTY1
MaxQBiQ9WTY1
PRIDEiQ9WTY1

PTM databases

iPTMnetiQ9WTY1
PhosphoSitePlusiQ9WTY1

Expressioni

Tissue specificityi

Highly expressed in testis, thymus and lymph nodes. Detected at low levels in embryonic stem cells.

Inductioni

Upon induction of apoptosis in embryonic stem cells by treatment with dexamethasone, staurosporine or C2-ceramide.

Gene expression databases

CleanExiMM_PDCD7

Interactioni

Subunit structurei

Interacts with RBM40. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9WTY1
SMRiQ9WTY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili233 – 408Sequence analysisAdd BLAST176

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 129Pro-richAdd BLAST126
Compositional biasi139 – 275Arg-richAdd BLAST137

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG053537
InParanoidiQ9WTY1
PhylomeDBiQ9WTY1

Family and domain databases

InterProiView protein in InterPro
IPR031974 PDCD7
PfamiView protein in Pfam
PF16021 PDCD7, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9WTY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPPFFAQS RQGPPPPQPP PSAPFGCPPP PLPSPAFPPP LPQRPGPFPG
60 70 80 90 100
ASAPFLQPPL ALQPRAPAEA SRGGGGGGAF FPVPPPPLPP PPPQCRPFPG
110 120 130 140 150
PDAVERPRPP PPGPGPPWSP RWAEAPPPPD VLGDAALQRL RDRQWLEAVF
160 170 180 190 200
GNPRRPGGLR TPRTPAGPSL GEVRARLRSA LRLVRRLRSL GQSLREAEAD
210 220 230 240 250
GAAWASLHAQ AAPLRAELAE RLQPLRQAAY VGEARRRLER VRRRVRVRER
260 270 280 290 300
ARDRRLSGRR GAQRTEREQE IDRWRVKCVQ EVEEKKRDEE LKAAADGVLA
310 320 330 340 350
EVRKKQSDTK RMVDILRALE KLRKLRKEAA ARKGVCPPAS ADETFEHHLQ
360 370 380 390 400
RLRKLIKKRS ELYEAEERAL RVMLEGEQEE ERRRELEKKQ RKEKEKLLLQ
410 420 430 440 450
KREIESKLFG DPDEFPLAHL LQPFRQYYLQ AEHSLPALIQ IRHDWDQYLV
460 470 480
PSDHPKGNSV PQGWVLPPLP SNDIWATAIQ LH
Length:482
Mass (Da):54,357
Last modified:November 1, 1999 - v1
Checksum:i622E986F177C00A1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U2X6Q3U2X6_MOUSE
Programmed cell death protein 7
Pdcd7
484Annotation score:
A0A1L1SVC2A0A1L1SVC2_MOUSE
Programmed cell death protein 7
Pdcd7
280Annotation score:
A0A1L1SQ83A0A1L1SQ83_MOUSE
Programmed cell death protein 7
Pdcd7
287Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083929 mRNA Translation: AAD20240.1
BC022772 mRNA Translation: AAH22772.2
UniGeneiMm.29193

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083929 mRNA Translation: AAD20240.1
BC022772 mRNA Translation: AAH22772.2
UniGeneiMm.29193

3D structure databases

ProteinModelPortaliQ9WTY1
SMRiQ9WTY1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9WTY1
PhosphoSitePlusiQ9WTY1

Proteomic databases

EPDiQ9WTY1
MaxQBiQ9WTY1
PRIDEiQ9WTY1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1859170 Pdcd7

Phylogenomic databases

HOVERGENiHBG053537
InParanoidiQ9WTY1
PhylomeDBiQ9WTY1

Miscellaneous databases

PROiPR:Q9WTY1
SOURCEiSearch...

Gene expression databases

CleanExiMM_PDCD7

Family and domain databases

InterProiView protein in InterPro
IPR031974 PDCD7
PfamiView protein in Pfam
PF16021 PDCD7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD7_MOUSE
AccessioniPrimary (citable) accession number: Q9WTY1
Secondary accession number(s): Q8R5D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 1, 1999
Last modified: May 10, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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