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Protein

Four and a half LIM domains protein 5

Gene

Fhl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transcription coactivator activity Source: MGI

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Four and a half LIM domains protein 5
Short name:
FHL-5
Alternative name(s):
Activator of cAMP-responsive element modulator in testis
Short name:
Activator of CREM in testis
Gene namesi
Name:Fhl5
Synonyms:Act
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913192 Fhl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757431 – 284Four and a half LIM domains protein 5Add BLAST284

Proteomic databases

MaxQBiQ9WTX7
PaxDbiQ9WTX7
PRIDEiQ9WTX7

PTM databases

iPTMnetiQ9WTX7
PhosphoSitePlusiQ9WTX7

Expressioni

Tissue specificityi

Testis-specific, temporal expression is coordinated with CREM.1 Publication

Gene expression databases

BgeeiENSMUSG00000028259 Expressed in 35 organ(s), highest expression level in testis
CleanExiMM_FHL5
GenevisibleiQ9WTX7 MM

Interactioni

Subunit structurei

Interacts with CREM (via the third LIM domain) (PubMed:10086359). Interacts (via second LIM domain) with SPAG8 (PubMed:20488182).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Spag8Q3V0Q65EBI-7530396,EBI-7981981

Protein-protein interaction databases

BioGridi208318, 1 interactor
IntActiQ9WTX7, 2 interactors
MINTiQ9WTX7
STRINGi10090.ENSMUSP00000029922

Structurei

3D structure databases

ProteinModelPortaliQ9WTX7
SMRiQ9WTX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 100LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini101 – 160LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST60
Domaini161 – 220LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 32C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

LIM domain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ9WTX7
OMAiYCVSCYD
OrthoDBiEOG091G07C5
PhylomeDBiQ9WTX7
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9WTX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSQFDCQY CTSSLIGKKY VLKDDNLYCI SCYDRIFSNY CEQCKEPIES
60 70 80 90 100
DSKDLCYKNR HWHEGCFRCN KCHHSLVEKP FVAKDDRLLC TDCYSNECSS
110 120 130 140 150
KCFHCKRTIM PGSRKMEFKG NYWHETCFVC EHCRQPIGTK PLISKESGNY
160 170 180 190 200
CVPCFEKEFA HYCNFCKKVI TSGGITFRDQ IWHKECFLCS GCRKELYEEA
210 220 230 240 250
FMSKDDFPFC LDCYNHLYAK KCAACTKPIT GLRGAKFICF QDRQWHSECF
260 270 280
NCGKCSVSLV GEGFLTHNME ILCRKCGSGA DTDA
Length:284
Mass (Da):32,907
Last modified:November 1, 1999 - v1
Checksum:i0537543FC0B222E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083394 mRNA Translation: AAD23916.1
AK006414 mRNA Translation: BAB24576.1
BC048473 mRNA Translation: AAH48473.1
CCDSiCCDS18009.1
RefSeqiNP_067293.1, NM_021318.3
XP_011248382.1, XM_011250080.2
UniGeneiMm.87325

Genome annotation databases

EnsembliENSMUST00000029922; ENSMUSP00000029922; ENSMUSG00000028259
ENSMUST00000108204; ENSMUSP00000103839; ENSMUSG00000028259
GeneIDi57756
KEGGimmu:57756
UCSCiuc008sef.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083394 mRNA Translation: AAD23916.1
AK006414 mRNA Translation: BAB24576.1
BC048473 mRNA Translation: AAH48473.1
CCDSiCCDS18009.1
RefSeqiNP_067293.1, NM_021318.3
XP_011248382.1, XM_011250080.2
UniGeneiMm.87325

3D structure databases

ProteinModelPortaliQ9WTX7
SMRiQ9WTX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208318, 1 interactor
IntActiQ9WTX7, 2 interactors
MINTiQ9WTX7
STRINGi10090.ENSMUSP00000029922

PTM databases

iPTMnetiQ9WTX7
PhosphoSitePlusiQ9WTX7

Proteomic databases

MaxQBiQ9WTX7
PaxDbiQ9WTX7
PRIDEiQ9WTX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029922; ENSMUSP00000029922; ENSMUSG00000028259
ENSMUST00000108204; ENSMUSP00000103839; ENSMUSG00000028259
GeneIDi57756
KEGGimmu:57756
UCSCiuc008sef.1 mouse

Organism-specific databases

CTDi9457
MGIiMGI:1913192 Fhl5

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526
InParanoidiQ9WTX7
OMAiYCVSCYD
OrthoDBiEOG091G07C5
PhylomeDBiQ9WTX7
TreeFamiTF314113

Miscellaneous databases

ChiTaRSiFhl5 mouse
PROiPR:Q9WTX7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028259 Expressed in 35 organ(s), highest expression level in testis
CleanExiMM_FHL5
GenevisibleiQ9WTX7 MM

Family and domain databases

InterProiView protein in InterPro
IPR037987 FHL2/3/5
IPR001781 Znf_LIM
PANTHERiPTHR24205 PTHR24205, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 4 hits
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFHL5_MOUSE
AccessioniPrimary (citable) accession number: Q9WTX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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