Skp1

Functionⁱ

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2 (By similarity).By similarity3 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

beta-catenin binding Source: MGI
cullin family protein binding Source: MGI
protein domain specific binding Source: MGI
ubiquitin protein ligase activity Source: Ensembl
ubiquitin-protein transferase activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H2A monoubiquitination Source: MGI
maintenance of protein location in nucleus Source: MGI
protein ubiquitination Source: MGI
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12140560
ubiquitin-dependent protein catabolic process
Source: MGI
Inferred by curatorⁱ
- 12665572

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1169091 Activation of NF-kappaB in B cells R-MMU-1170546 Prolactin receptor signaling R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253 Degradation of beta-catenin by the destruction complex R-MMU-202424 Downstream TCR signaling R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-2871837 FCERI mediated NF-kB activation R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764 CLEC7A (Dectin-1) signaling R-MMU-5610780 Degradation of GLI1 by the proteasome R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome R-MMU-5676590 NIK-->noncanonical NF-kB signaling R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-68949 Orc1 removal from chromatin R-MMU-69231 Cyclin D associated events in G1 R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939902 Regulation of RUNX2 expression and activity R-MMU-8951664 Neddylation R-MMU-9020702 Interleukin-1 signaling R-MMU-917937 Iron uptake and transport R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayⁱ	UPA00143

Reactomeⁱ

R-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1170546 Prolactin receptor signaling
R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69231 Cyclin D associated events in G1
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8951664 Neddylation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-917937 Iron uptake and transport
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: S-phase kinase-associated protein 1 Alternative name(s): Cyclin-A/CDK2-associated protein p19 S-phase kinase-associated protein 1A p19A p19skp1
Gene namesⁱ	Name:Skp1 Synonyms:Skp1a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:103575 Skp1a

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000187252	1 – 163	S-phase kinase-associated protein 1Add BLAST		163

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	131	PhosphothreonineCombined sources		1
Cross-linkⁱ	142	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9WTX5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9WTX5
PaxDbⁱ	Q9WTX5
PRIDEⁱ	Q9WTX5

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q9WTX5

REPRODUCTION-2DPAGEⁱ

Q9WTX5

PTM databases

iPTMnetⁱ	Q9WTX5
PhosphoSitePlusⁱ	Q9WTX5
SwissPalmⁱ	Q9WTX5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000036309 Expressed in 299 organ(s), highest expression level in cochlea
CleanExⁱ	MM_SKP1A
ExpressionAtlasⁱ	Q9WTX5 baseline and differential
Genevisibleⁱ	Q9WTX5 MM

Interactionⁱ

Subunit structureⁱ

Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Component of the SCF(FBXW15) complex containing FBXW15 (PubMed:23319590). Interacts with CEP68 (By similarity). Interacts with FBXW15 (PubMed:23319590). Interacts with NOTCH2 (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Fbxw5	Q9QXW2	2	EBI-1202363,EBI-16031930
Ppp1ca	P62137	2	EBI-1202363,EBI-357187
Rnf2	Q9CQJ4	4	EBI-1202363,EBI-927321

GO - Molecular functionⁱ

beta-catenin binding Source: MGI
cullin family protein binding Source: MGI
protein domain specific binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203998, 73 interactors
CORUMⁱ	Q9WTX5
Database of interacting proteins More...DIPⁱ	DIP-38596N
IntActⁱ	Q9WTX5, 54 interactors
Molecular INTeraction database More...MINTⁱ	Q9WTX5
STRINGⁱ	10090.ENSMUSP00000038744

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WTX5
SMRⁱ	Q9WTX5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	104 – 163	Interaction with the F-box domain of F-box proteinsBy similarityAdd BLAST		60

Sequence similaritiesⁱ

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1724 Eukaryota COG5201 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012652
HOGENOMⁱ	HOG000172184
HOVERGENⁱ	HBG057008
InParanoidⁱ	Q9WTX5
KEGG Orthology (KO) More...KOⁱ	K03094
OMAⁱ	ENKWCEE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OU2
PhylomeDBⁱ	Q9WTX5
TreeFamⁱ	TF354233

Family and domain databases

InterProⁱ	View protein in InterPro IPR016897 SKP1 IPR001232 SKP1-like IPR036296 SKP1-like_dim_sf IPR011333 SKP1/BTB/POZ_sf IPR016072 Skp1_comp_dimer IPR016073 Skp1_comp_POZ
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01466 Skp1, 1 hit PF03931 Skp1_POZ, 1 hit
PIRSFⁱ	PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTⁱ	View protein in SMART SM00512 Skp1, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF81382 SSF81382, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9WTX5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPTIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV 
        60         70         80         90        100
NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL 
       110        120        130        140        150
FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE 
       160 
AQVRKENQWC EEK

Length:163

Mass (Da):18,672

Last modified:January 23, 2007 - v3

Checksum:ⁱAE184C00BE6556DB

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PUV4	E9PUV4_MOUSE	S-phase kinase-associated protein 1... S-phase kinase-associated protein 1A	Skp1a	96	Annotation score:
E9Q3Q7	E9Q3Q7_MOUSE	S-phase kinase-associated protein 1... S-phase kinase-associated protein 1A	Skp1a	56	Annotation score:
F6TGP8	F6TGP8_MOUSE	S-phase kinase-associated protein 1... S-phase kinase-associated protein 1A	Skp1a	50	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	41	D → N in BAC37220 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF083214 mRNA Translation: AAD16036.1 AK002983 mRNA Translation: BAB22496.1 AK010628 mRNA Translation: BAB27074.1 AK012498 mRNA Translation: BAB28281.1 AK014245 mRNA Translation: BAB29222.1 AK027909 mRNA Translation: BAC25660.1 AK078330 mRNA Translation: BAC37220.1 AK088339 mRNA Translation: BAC40292.1 BC002115 mRNA Translation: AAH02115.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24669.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035673.3, NM_011543.4 XP_006532849.1, XM_006532786.2
UniGeneⁱ	Mm.42944

Genome annotation databases

Ensemblⁱ	ENSMUST00000037324; ENSMUSP00000038744; ENSMUSG00000036309 ENSMUST00000109072; ENSMUSP00000104700; ENSMUSG00000036309
GeneIDⁱ	21402
KEGGⁱ	mmu:21402
UCSC genome browser More...UCSCⁱ	uc007ivf.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q9WTX5	S-phase kinase-associated protein 1		RAT		163	UniRef100_Q9WTX5
S-phase kinase-associated protein 1		FUNHE		208
MCG3634, isoform CRA_b		MOUSE		163
S-phase kinase-associated protein 1		NOTFU		163
S-phase kinase-associated protein 1		SALSA		163
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9WTX5	S-phase kinase-associated protein 1		RAT		163	UniRef90_Q9WTX5
S-phase kinase-associated protein 1		FUNHE		208
MCG3634, isoform CRA_b		MOUSE		163
S-phase kinase-associated protein 1		NOTFU		163
S-phase kinase-associated protein 1		SALSA		163
+34

Protein	Similar proteins		Species	Score	Length	Source
Q9WTX5	S-phase kinase-associated protein 1		RAT		163	UniRef50_Q9WTX5
S-phase kinase-associated protein 1		FUNHE		208
MCG3634, isoform CRA_b		MOUSE		163
S-phase kinase-associated protein 1		NOTFU		163
S-phase kinase-associated protein 1		SALSA		163
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF083214 mRNA Translation: AAD16036.1 AK002983 mRNA Translation: BAB22496.1 AK010628 mRNA Translation: BAB27074.1 AK012498 mRNA Translation: BAB28281.1 AK014245 mRNA Translation: BAB29222.1 AK027909 mRNA Translation: BAC25660.1 AK078330 mRNA Translation: BAC37220.1 AK088339 mRNA Translation: BAC40292.1 BC002115 mRNA Translation: AAH02115.1
CCDSⁱ	CCDS24669.1
RefSeqⁱ	NP_035673.3, NM_011543.4 XP_006532849.1, XM_006532786.2
UniGeneⁱ	Mm.42944

3D structure databases

ProteinModelPortalⁱ	Q9WTX5
SMRⁱ	Q9WTX5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203998, 73 interactors
CORUMⁱ	Q9WTX5
DIPⁱ	DIP-38596N
IntActⁱ	Q9WTX5, 54 interactors
MINTⁱ	Q9WTX5
STRINGⁱ	10090.ENSMUSP00000038744

PTM databases

iPTMnetⁱ	Q9WTX5
PhosphoSitePlusⁱ	Q9WTX5
SwissPalmⁱ	Q9WTX5

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q9WTX5

REPRODUCTION-2DPAGEⁱ

Q9WTX5

Proteomic databases

EPDⁱ	Q9WTX5
MaxQBⁱ	Q9WTX5
PaxDbⁱ	Q9WTX5
PRIDEⁱ	Q9WTX5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000037324; ENSMUSP00000038744; ENSMUSG00000036309 ENSMUST00000109072; ENSMUSP00000104700; ENSMUSG00000036309
GeneIDⁱ	21402
KEGGⁱ	mmu:21402
UCSCⁱ	uc007ivf.2 mouse

Organism-specific databases

CTDⁱ	21402
MGIⁱ	MGI:103575 Skp1a

Phylogenomic databases

eggNOGⁱ	KOG1724 Eukaryota COG5201 LUCA
GeneTreeⁱ	ENSGT00390000012652
HOGENOMⁱ	HOG000172184
HOVERGENⁱ	HBG057008
InParanoidⁱ	Q9WTX5
KOⁱ	K03094
OMAⁱ	ENKWCEE
OrthoDBⁱ	EOG091G0OU2
PhylomeDBⁱ	Q9WTX5
TreeFamⁱ	TF354233

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-MMU-1169091 Activation of NF-kappaB in B cells R-MMU-1170546 Prolactin receptor signaling R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253 Degradation of beta-catenin by the destruction complex R-MMU-202424 Downstream TCR signaling R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-2871837 FCERI mediated NF-kB activation R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764 CLEC7A (Dectin-1) signaling R-MMU-5610780 Degradation of GLI1 by the proteasome R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome R-MMU-5676590 NIK-->noncanonical NF-kB signaling R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-68949 Orc1 removal from chromatin R-MMU-69231 Cyclin D associated events in G1 R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8939902 Regulation of RUNX2 expression and activity R-MMU-8951664 Neddylation R-MMU-9020702 Interleukin-1 signaling R-MMU-917937 Iron uptake and transport R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathwayⁱ

UPA00143

Reactomeⁱ

R-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1170546 Prolactin receptor signaling
R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69231 Cyclin D associated events in G1
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8951664 Neddylation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-917937 Iron uptake and transport
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSⁱ	Skp1a mouse
Protein Ontology More...PROⁱ	PR:Q9WTX5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000036309 Expressed in 299 organ(s), highest expression level in cochlea
CleanExⁱ	MM_SKP1A
ExpressionAtlasⁱ	Q9WTX5 baseline and differential
Genevisibleⁱ	Q9WTX5 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR016897 SKP1 IPR001232 SKP1-like IPR036296 SKP1-like_dim_sf IPR011333 SKP1/BTB/POZ_sf IPR016072 Skp1_comp_dimer IPR016073 Skp1_comp_POZ
Pfamⁱ	View protein in Pfam PF01466 Skp1, 1 hit PF03931 Skp1_POZ, 1 hit
PIRSFⁱ	PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTⁱ	View protein in SMART SM00512 Skp1, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF81382 SSF81382, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SKP1_MOUSE
Accessionⁱ	Q9WTX5Primary (citable) accession number: Q9WTX5 Secondary accession number(s): Q8C5H6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - Q9WTX5 (SKP1_MOUSE)

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S-phase kinase-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ