Solute carrier family 23 member 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• L-ascorbate:sodium symporter activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "A family of mammalian Na+-dependent L-ascorbic acid transporters."
    Tsukaguchi H., Tokui T., Mackenzie B., Berger U.V., Chen X.-Z., Wang Y., Brubaker R.F., Hediger M.A.
    Nature 399:70-75(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• L-ascorbic acid transmembrane transporter activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells."
    Angulo C., Castro M.A., Rivas C.I., Segretain D., Maldonado R., Yanez A.J., Slebe J.C., Vera J.C., Concha I.I.
    J Cell Physiol 217:708-716(2008) [PubMed] [Europe PMC] [Abstract]
• sodium-dependent L-ascorbate transmembrane transporter activity Source: RGDInferred from direct assayⁱ
  • Ref.1

    "A family of mammalian Na+-dependent L-ascorbic acid transporters."
    Tsukaguchi H., Tokui T., Mackenzie B., Berger U.V., Chen X.-Z., Wang Y., Brubaker R.F., Hediger M.A.
    Nature 399:70-75(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

GO - Biological processⁱ

• cellular response to ethanol Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-kappaB and miRNA125a-5p."
    Tian H., Ye X., Hou X., Yang X., Yang J., Wu C.
    Free Radic Biol Med 96:362-373(2016) [PubMed] [Europe PMC] [Abstract]
• L-ascorbic acid metabolic process Source: RGDInferred from mutant phenotypeⁱ
  • Ref.1

    "A family of mammalian Na+-dependent L-ascorbic acid transporters."
    Tsukaguchi H., Tokui T., Mackenzie B., Berger U.V., Chen X.-Z., Wang Y., Brubaker R.F., Hediger M.A.
    Nature 399:70-75(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• L-ascorbic acid transmembrane transport Source: UniProtKBInferred from direct assayⁱ
  • "Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells."
    Angulo C., Castro M.A., Rivas C.I., Segretain D., Maldonado R., Yanez A.J., Slebe J.C., Vera J.C., Concha I.I.
    J Cell Physiol 217:708-716(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron death Source: RGDInferred from mutant phenotypeⁱ
  • "SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-kappaB and miRNA125a-5p."
    Tian H., Ye X., Hou X., Yang X., Yang J., Wu C.
    Free Radic Biol Med 96:362-373(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of dendrite extension Source: RGDInferred from mutant phenotypeⁱ
  • "SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-kappaB and miRNA125a-5p."
    Tian H., Ye X., Hou X., Yang X., Yang J., Wu C.
    Free Radic Biol Med 96:362-373(2016) [PubMed] [Europe PMC] [Abstract]
• response to oxidative stress Source: RGDInferred from expression patternⁱ
  • "Effect of middle cerebral artery occlusion on mRNA expression for the sodium-coupled vitamin C transporter SVCT2 in rat brain."
    Berger U.V., Lu X.C., Liu W., Tang Z., Slusher B.S., Hediger M.A.
    J Neurochem 86:896-906(2003) [PubMed] [Europe PMC] [Abstract]
• transepithelial L-ascorbic acid transport Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MMGVGKNTSK SVEVGGSTEG KYEEEAKRPD FFTLPVVING GATSSGEQDN 
        60         70         80         90        100
EDTELMAIYT TENGIAEKSS LAETLDSTGS LDPQRSDMIY TIEDVPPWYL 
       110        120        130        140        150
CIFLGLQHYL TCFSGTIAVP FLLADAMCVG DDQWATSQLI GTIFFCVGIT 
       160        170        180        190        200
TLLQTTFGCR LPLFQASAFA FLAPARAILS LDKWKCNTTE ITVANGTAEL 
       210        220        230        240        250
LEHIWHPRIQ EIQGAIIMSS LIEVVIGLLG LPGALLRYIG PLTITPTVAL 
       260        270        280        290        300
IGLSGFQAAG ERAGKHWGIA MLTIFLVLLF SQYARNVKFP LPIYKSKKGW 
       310        320        330        340        350
TAYKLQLFKM FPIILAILVS WLLCFIFTVT DVFPSNSTDY GYYARTDARK 
       360        370        380        390        400
GVLLVAPWFK VPYPFQWGMP TVSAAGVIGM LSAVVASIIE SIGDYYACAR 
       410        420        430        440        450
LSCAPPPPIH AINRGIFVEG LSCVLDGVFG TGNGSTSSSP NIGVLGITKV 
       460        470        480        490        500
GSRRVIQYGA ALMLGLGMIG KFSALFASLP DPVLGALFCT LFGMITAVGL 
       510        520        530        540        550
SNLQFIDLNS SRNLFVLGFS IFFGLVLPSY LRQNPLVTGI TGIDQVLNVL 
       560        570        580        590        600
LTTAMFVGGC VAFILDNTIP GTPEERGIKK WKKGVSKGNK SLDGMESYNL 
       610        620        630        640 
PFGMNIIKKY RCFSYLPISP TFAGYTWKGF GKSENRRSSD KDSQATV    

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families