UniProtKB - Q9WTW8 (S23A2_RAT)
Protein
Solute carrier family 23 member 2
Gene
Slc23a2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.
GO - Molecular functioni
- L-ascorbate:sodium symporter activity Source: RGD
- L-ascorbic acid transmembrane transporter activity Source: UniProtKB
- sodium-dependent L-ascorbate transmembrane transporter activity Source: RGD
GO - Biological processi
- cellular response to ethanol Source: RGD
- L-ascorbic acid metabolic process Source: RGD
- L-ascorbic acid transmembrane transport Source: UniProtKB
- negative regulation of neuron death Source: RGD
- positive regulation of dendrite extension Source: RGD
- response to oxidative stress Source: RGD
- transepithelial L-ascorbic acid transport Source: RGD
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-196836, Vitamin C (ascorbate) metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 23 member 2Alternative name(s): Na(+)/L-ascorbic acid transporter 2 Sodium-dependent vitamin C transporter 2 |
Gene namesi | Name:Slc23a2 Synonyms:Svct2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619876, Slc23a2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein
Plasma Membrane
- apical plasma membrane Source: RGD
- basal plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: RGD
- integral component of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 8 – 109 | CytoplasmicSequence analysisAdd BLAST | 102 | |
Transmembranei | 110 – 130 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 131 – 138 | ExtracellularSequence analysis | 8 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 160 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 215 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 263 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 264 – 281 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 282 – 285 | ExtracellularSequence analysis | 4 | |
Intramembranei | 286 – 299 | HelicalSequence analysisAdd BLAST | 14 | |
Topological domaini | 300 – 306 | ExtracellularSequence analysis | 7 | |
Transmembranei | 307 – 327 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 328 – 368 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 369 – 389 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 390 – 414 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 415 – 435 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 436 – 458 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 459 – 479 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 480 – 482 | ExtracellularSequence analysis | 3 | |
Transmembranei | 483 – 503 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 504 – 513 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 514 – 534 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 535 – 544 | ExtracellularSequence analysis | 10 | |
Transmembranei | 545 – 565 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 566 – 647 | CytoplasmicSequence analysisAdd BLAST | 82 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000165980 | 1 – 647 | Solute carrier family 23 member 2Add BLAST | 647 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 69 | PhosphoserineBy similarity | 1 | |
Modified residuei | 74 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 77 | PhosphoserineBy similarity | 1 | |
Modified residuei | 78 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 80 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 646 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9WTW8 |
PRIDEi | Q9WTW8 |
PTM databases
GlyGeni | Q9WTW8, 2 sites |
iPTMneti | Q9WTW8 |
PhosphoSitePlusi | Q9WTW8 |
SwissPalmi | Q9WTW8 |
Expressioni
Tissue specificityi
Highly expressed in neural, neuroendocrine, exocrine and endothelial tissues and in osteoblasts. Detected in neurons throughout the central nervous system, in meninges and choroid plexus, in the anterior pituitary, the intermediate lobe, in pancreas, adrenal cortex, gastric glands, and in the inner nuclear layer of the retina.
Gene expression databases
Bgeei | ENSRNOG00000021262, Expressed in stomach and 21 other tissues |
Genevisiblei | Q9WTW8, RN |
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1292, Eukaryota |
GeneTreei | ENSGT00950000182953 |
HOGENOMi | CLU_017959_5_4_1 |
InParanoidi | Q9WTW8 |
OMAi | PGMLLKY |
OrthoDBi | 387031at2759 |
PhylomeDBi | Q9WTW8 |
TreeFami | TF313272 |
Family and domain databases
InterProi | View protein in InterPro IPR029956, SlC23A2 IPR006042, Xan_ur_permease IPR006043, Xant/urac/vitC |
PANTHERi | PTHR11119:SF33, PTHR11119:SF33, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PROSITEi | View protein in PROSITE PS01116, XANTH_URACIL_PERMASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9WTW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMGVGKNTSK SVEVGGSTEG KYEEEAKRPD FFTLPVVING GATSSGEQDN
60 70 80 90 100
EDTELMAIYT TENGIAEKSS LAETLDSTGS LDPQRSDMIY TIEDVPPWYL
110 120 130 140 150
CIFLGLQHYL TCFSGTIAVP FLLADAMCVG DDQWATSQLI GTIFFCVGIT
160 170 180 190 200
TLLQTTFGCR LPLFQASAFA FLAPARAILS LDKWKCNTTE ITVANGTAEL
210 220 230 240 250
LEHIWHPRIQ EIQGAIIMSS LIEVVIGLLG LPGALLRYIG PLTITPTVAL
260 270 280 290 300
IGLSGFQAAG ERAGKHWGIA MLTIFLVLLF SQYARNVKFP LPIYKSKKGW
310 320 330 340 350
TAYKLQLFKM FPIILAILVS WLLCFIFTVT DVFPSNSTDY GYYARTDARK
360 370 380 390 400
GVLLVAPWFK VPYPFQWGMP TVSAAGVIGM LSAVVASIIE SIGDYYACAR
410 420 430 440 450
LSCAPPPPIH AINRGIFVEG LSCVLDGVFG TGNGSTSSSP NIGVLGITKV
460 470 480 490 500
GSRRVIQYGA ALMLGLGMIG KFSALFASLP DPVLGALFCT LFGMITAVGL
510 520 530 540 550
SNLQFIDLNS SRNLFVLGFS IFFGLVLPSY LRQNPLVTGI TGIDQVLNVL
560 570 580 590 600
LTTAMFVGGC VAFILDNTIP GTPEERGIKK WKKGVSKGNK SLDGMESYNL
610 620 630 640
PFGMNIIKKY RCFSYLPISP TFAGYTWKGF GKSENRRSSD KDSQATV
Sequence cautioni
The sequence AAD30368 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF080453 mRNA Translation: AAD30368.1 Different initiation. |
RefSeqi | NP_059012.2, NM_017316.2 XP_006235129.1, XM_006235067.3 XP_006235130.1, XM_006235068.3 |
Genome annotation databases
Ensembli | ENSRNOT00000028885; ENSRNOP00000028885; ENSRNOG00000021262 |
GeneIDi | 50622 |
KEGGi | rno:50622 |
UCSCi | RGD:619876, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF080453 mRNA Translation: AAD30368.1 Different initiation. |
RefSeqi | NP_059012.2, NM_017316.2 XP_006235129.1, XM_006235067.3 XP_006235130.1, XM_006235068.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000028885 |
PTM databases
GlyGeni | Q9WTW8, 2 sites |
iPTMneti | Q9WTW8 |
PhosphoSitePlusi | Q9WTW8 |
SwissPalmi | Q9WTW8 |
Proteomic databases
PaxDbi | Q9WTW8 |
PRIDEi | Q9WTW8 |
Genome annotation databases
Ensembli | ENSRNOT00000028885; ENSRNOP00000028885; ENSRNOG00000021262 |
GeneIDi | 50622 |
KEGGi | rno:50622 |
UCSCi | RGD:619876, rat |
Organism-specific databases
CTDi | 9962 |
RGDi | 619876, Slc23a2 |
Phylogenomic databases
eggNOGi | KOG1292, Eukaryota |
GeneTreei | ENSGT00950000182953 |
HOGENOMi | CLU_017959_5_4_1 |
InParanoidi | Q9WTW8 |
OMAi | PGMLLKY |
OrthoDBi | 387031at2759 |
PhylomeDBi | Q9WTW8 |
TreeFami | TF313272 |
Enzyme and pathway databases
Reactomei | R-RNO-196836, Vitamin C (ascorbate) metabolism |
Miscellaneous databases
PROi | PR:Q9WTW8 |
Gene expression databases
Bgeei | ENSRNOG00000021262, Expressed in stomach and 21 other tissues |
Genevisiblei | Q9WTW8, RN |
Family and domain databases
InterProi | View protein in InterPro IPR029956, SlC23A2 IPR006042, Xan_ur_permease IPR006043, Xant/urac/vitC |
PANTHERi | PTHR11119:SF33, PTHR11119:SF33, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PROSITEi | View protein in PROSITE PS01116, XANTH_URACIL_PERMASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S23A2_RAT | |
Accessioni | Q9WTW8Primary (citable) accession number: Q9WTW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families