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Protein

Transcription factor EC

Gene

Tfec

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor EC
Short name:
TFE-C
Short name:
mTFEC
Gene namesi
Name:Tfec
Synonyms:Tcfec
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1333760 Tfec

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003135651 – 317Transcription factor ECAdd BLAST317

Proteomic databases

MaxQBiQ9WTW4
PaxDbiQ9WTW4
PeptideAtlasiQ9WTW4
PRIDEiQ9WTW4

PTM databases

PhosphoSitePlusiQ9WTW4

Expressioni

Tissue specificityi

Expressed in osteoclast-like cells (at protein level). Expressed in cells of the mononuclear phagocyte lineage. Expressed in macrophages and in osteoclast-like cells.1 Publication

Developmental stagei

Expressed in the early developing retinal pigmented epithelium and in the peripheral retina.1 Publication

Inductioni

Up-regulated in bone marrow-derived macrophages by Th2 cytokines, IL-4, IL-13 and LPS.1 Publication

Gene expression databases

BgeeiENSMUSG00000029553 Expressed in 97 organ(s), highest expression level in ileum
CleanExiMM_TCFEC
ExpressionAtlasiQ9WTW4 baseline and differential
GenevisibleiQ9WTW4 MM

Interactioni

Subunit structurei

Homodimer. Forms heterodimers with MITF. Interacts with MITF. Forms heterodimers with TFE3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031533

Structurei

3D structure databases

ProteinModelPortaliQ9WTW4
SMRiQ9WTW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 163bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 90Necessary for transcriptional transactivationBy similarityAdd BLAST90
Regioni242 – 317Necessary for transcriptional transactivationBy similarityAdd BLAST76

Domaini

Contains an activation domain in the C-terminal region.

Sequence similaritiesi

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402
HOGENOMiHOG000231368
HOVERGENiHBG006768
InParanoidiQ9WTW4
KOiK15591
OMAiCDQAMAF
OrthoDBiEOG091G0QCO
PhylomeDBiQ9WTW4
TreeFamiTF317174

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR024101 TFEC
PANTHERiPTHR12565 PTHR12565, 2 hits
PTHR12565:SF106 PTHR12565:SF106, 2 hits
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WTW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFDCRVCDQ TLKRAQPPAA SCMPLAEHEP MSPDSDAGCA GNPFTNLLAL
60 70 80 90 100
GKKDGAEKWH LSGSILDVYS DEQGISSANA GLTDAPCPSI LPMRKEIAET
110 120 130 140 150
DGRALAKERQ KKDNHNLIER RRRYNINYRI KELGTLIPKS NDPDMRWNKG
160 170 180 190 200
TILKASVDYI KWLQKEQQRA RELEHRQKKL EHANRQLRLR IQELEIQARA
210 220 230 240 250
HGLPILASLG TADVGTHITK QQTHPERNLG GCCLQLTPTQ GTSPEFYEQA
260 270 280 290 300
VAFSDPLSHF TDLSFSAALK EEQRLDGMLL SDTICPFGTD PLLSAISPAV
310
SKASSRSSLS SEDGDEL
Length:317
Mass (Da):35,144
Last modified:November 1, 1999 - v1
Checksum:i668F186489D63AA8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YTW5A0A0J9YTW5_MOUSE
Transcription factor EC
Tfec
127Annotation score:
A0A0J9YV19A0A0J9YV19_MOUSE
Transcription factor EC
Tfec
28Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170A → V in BAE35199 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077742 mRNA Translation: AAD24426.1
AK137141 mRNA Translation: BAE23248.1
AK156327 mRNA Translation: BAE33676.1
AK159579 mRNA Translation: BAE35199.1
BC098494 mRNA Translation: AAH98494.1
CCDSiCCDS19920.1
RefSeqiNP_112475.1, NM_031198.3
UniGeneiMm.36217

Genome annotation databases

EnsembliENSMUST00000031533; ENSMUSP00000031533; ENSMUSG00000029553
GeneIDi21426
KEGGimmu:21426
UCSCiuc009aze.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077742 mRNA Translation: AAD24426.1
AK137141 mRNA Translation: BAE23248.1
AK156327 mRNA Translation: BAE33676.1
AK159579 mRNA Translation: BAE35199.1
BC098494 mRNA Translation: AAH98494.1
CCDSiCCDS19920.1
RefSeqiNP_112475.1, NM_031198.3
UniGeneiMm.36217

3D structure databases

ProteinModelPortaliQ9WTW4
SMRiQ9WTW4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031533

PTM databases

PhosphoSitePlusiQ9WTW4

Proteomic databases

MaxQBiQ9WTW4
PaxDbiQ9WTW4
PeptideAtlasiQ9WTW4
PRIDEiQ9WTW4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031533; ENSMUSP00000031533; ENSMUSG00000029553
GeneIDi21426
KEGGimmu:21426
UCSCiuc009aze.2 mouse

Organism-specific databases

CTDi22797
MGIiMGI:1333760 Tfec

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402
HOGENOMiHOG000231368
HOVERGENiHBG006768
InParanoidiQ9WTW4
KOiK15591
OMAiCDQAMAF
OrthoDBiEOG091G0QCO
PhylomeDBiQ9WTW4
TreeFamiTF317174

Miscellaneous databases

PROiPR:Q9WTW4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029553 Expressed in 97 organ(s), highest expression level in ileum
CleanExiMM_TCFEC
ExpressionAtlasiQ9WTW4 baseline and differential
GenevisibleiQ9WTW4 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR024101 TFEC
PANTHERiPTHR12565 PTHR12565, 2 hits
PTHR12565:SF106 PTHR12565:SF106, 2 hits
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTFEC_MOUSE
AccessioniPrimary (citable) accession number: Q9WTW4
Secondary accession number(s): Q3TWR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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