UniProtKB - Q9WTW3 (KCNE4_MOUSE)
Protein
Potassium voltage-gated channel subfamily E member 4
Gene
Kcne4
Organism
Mus musculus (Mouse)
Status
Functioni
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNQ1/KVLTQ1 inhibits potassium current (By similarity).By similarity
GO - Molecular functioni
- ion channel binding Source: MGI
- potassium channel activity Source: MGI
- potassium channel regulator activity Source: GO_Central
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- membrane repolarization during action potential Source: GO_Central
- membrane repolarization during ventricular cardiac muscle cell action potential Source: GOC
- negative regulation of delayed rectifier potassium channel activity Source: GO_Central
- potassium ion export across plasma membrane Source: GO_Central
- regulation of heart rate by cardiac conduction Source: GO_Central
- regulation of ventricular cardiac muscle cell membrane repolarization Source: GO_Central
- ventricular cardiac muscle cell action potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-MMU-5576890, Phase 3 - rapid repolarisation R-MMU-5576893, Phase 2 - plateau phase |
Protein family/group databases
TCDBi | 8.A.10.4.1, the slow voltage-gated k+) channel accessory protein (mink) family |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily E member 4Alternative name(s): MinK-related peptide 3 Minimum potassium ion channel-related peptide 3 Potassium channel subunit beta MiRP3 |
Gene namesi | Name:Kcne4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1891125, Kcne4 |
Subcellular locationi
Other locations
Plasma Membrane
- apical plasma membrane Source: MGI
- voltage-gated potassium channel complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 170 | CytoplasmicSequence analysisAdd BLAST | 114 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144293 | 1 – 170 | Potassium voltage-gated channel subfamily E member 4Add BLAST | 170 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9WTW3 |
PRIDEi | Q9WTW3 |
ProteomicsDBi | 269197 |
PTM databases
GlyGeni | Q9WTW3, 2 sites |
iPTMneti | Q9WTW3 |
PhosphoSitePlusi | Q9WTW3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000047330, Expressed in uterus and 185 other tissues |
Genevisiblei | Q9WTW3, MM |
Interactioni
Subunit structurei
Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.
By similarityGO - Molecular functioni
- ion channel binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 208336, 1 interactor |
STRINGi | 10090.ENSMUSP00000055415 |
Miscellaneous databases
RNActi | Q9WTW3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the potassium channel KCNE family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZ36, Eukaryota |
GeneTreei | ENSGT00390000013776 |
HOGENOMi | CLU_109412_0_0_1 |
InParanoidi | Q9WTW3 |
OMAi | HFTIQEE |
OrthoDBi | 1418062at2759 |
PhylomeDBi | Q9WTW3 |
TreeFami | TF333025 |
Family and domain databases
InterProi | View protein in InterPro IPR000369, K_chnl_KCNE |
PANTHERi | PTHR15282, PTHR15282, 1 hit |
Pfami | View protein in Pfam PF02060, ISK_Channel, 1 hit |
PRINTSi | PR00168, KCNECHANNEL |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WTW3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRMEPLNST YPSAAASSSP LESHVPSNSS GNGNEYFYIL VVMSFYGVFL
60 70 80 90 100
IGIMLGYMKS KRREKKSSLL LLYKDEERLW GEAMKPLPMM SGLRSGQVPM
110 120 130 140 150
MLNMLQESVA PALSCTLCSM EGDSVSSESS SPDVHLPIQE EGADDELEET
160 170
SETPLNDSSE GSSENIHQNS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WQK6 | A0A087WQK6_MOUSE | Potassium voltage-gated channel sub... | Kcne4 | 64 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF076533 mRNA Translation: AAD28091.1 BC032920 mRNA Translation: AAH32920.1 |
CCDSi | CCDS15088.1 |
RefSeqi | NP_067317.1, NM_021342.1 |
Genome annotation databases
Ensembli | ENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330 |
GeneIDi | 57814 |
KEGGi | mmu:57814 |
UCSCi | uc007bqq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF076533 mRNA Translation: AAD28091.1 BC032920 mRNA Translation: AAH32920.1 |
CCDSi | CCDS15088.1 |
RefSeqi | NP_067317.1, NM_021342.1 |
3D structure databases
SMRi | Q9WTW3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208336, 1 interactor |
STRINGi | 10090.ENSMUSP00000055415 |
Protein family/group databases
TCDBi | 8.A.10.4.1, the slow voltage-gated k+) channel accessory protein (mink) family |
PTM databases
GlyGeni | Q9WTW3, 2 sites |
iPTMneti | Q9WTW3 |
PhosphoSitePlusi | Q9WTW3 |
Proteomic databases
PaxDbi | Q9WTW3 |
PRIDEi | Q9WTW3 |
ProteomicsDBi | 269197 |
Protocols and materials databases
Antibodypediai | 2515, 134 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000057262; ENSMUSP00000055415; ENSMUSG00000047330 |
GeneIDi | 57814 |
KEGGi | mmu:57814 |
UCSCi | uc007bqq.1, mouse |
Organism-specific databases
CTDi | 23704 |
MGIi | MGI:1891125, Kcne4 |
Phylogenomic databases
eggNOGi | ENOG502RZ36, Eukaryota |
GeneTreei | ENSGT00390000013776 |
HOGENOMi | CLU_109412_0_0_1 |
InParanoidi | Q9WTW3 |
OMAi | HFTIQEE |
OrthoDBi | 1418062at2759 |
PhylomeDBi | Q9WTW3 |
TreeFami | TF333025 |
Enzyme and pathway databases
Reactomei | R-MMU-5576890, Phase 3 - rapid repolarisation R-MMU-5576893, Phase 2 - plateau phase |
Miscellaneous databases
BioGRID-ORCSi | 57814, 0 hits in 52 CRISPR screens |
ChiTaRSi | Kcne4, mouse |
PROi | PR:Q9WTW3 |
RNActi | Q9WTW3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047330, Expressed in uterus and 185 other tissues |
Genevisiblei | Q9WTW3, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000369, K_chnl_KCNE |
PANTHERi | PTHR15282, PTHR15282, 1 hit |
Pfami | View protein in Pfam PF02060, ISK_Channel, 1 hit |
PRINTSi | PR00168, KCNECHANNEL |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNE4_MOUSE | |
Accessioni | Q9WTW3Primary (citable) accession number: Q9WTW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families