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Protein

Chitinase-3-like protein 1

Gene

Chi3l1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).By similarity

Caution

Although it belongs to the glycosyl hydrolase 18 family, Leu-138 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139ChitooligosaccharideBy similarity1
Binding sitei350ChitooligosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processApoptosis, Inflammatory response
LigandLectin

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase-3-like protein 1
Alternative name(s):
Cartilage glycoprotein 39
Short name:
CGP-39
Short name:
GP-39
Gene namesi
Name:Chi3l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620874 Chi3l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001196820 – 381Chitinase-3-like protein 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 49By similarity
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi298 ↔ 362By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9WTV1
PRIDEiQ9WTV1

Expressioni

Gene expression databases

BgeeiENSRNOG00000053272
GenevisibleiQ9WTV1 RN

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065787

Structurei

3D structure databases

ProteinModelPortaliQ9WTV1
SMRiQ9WTV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 69Chitooligosaccharide bindingBy similarity2
Regioni95 – 98Chitooligosaccharide bindingBy similarity4
Regioni202 – 205Chitooligosaccharide bindingBy similarity4
Regioni322 – 336Important for AKT1 activation and IL8 productionBy similarityAdd BLAST15

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiQ9WTV1
KOiK17523
OMAiSNDHIDT
OrthoDBiEOG091G014W
PhylomeDBiQ9WTV1
TreeFamiTF315610

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR028538 CHI3L1
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11177:SF202 PTHR11177:SF202, 1 hit
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WTV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQLPGFAV LMLLQSCSAY KLVCYYTNWS QYREGNGSCF PDALDHSLCT
60 70 80 90 100
HIIYSFANIS NNKLSTSEWN DVTLYGMLNT LKTRNPRLKT LLSVGGWSFG
110 120 130 140 150
SERFSRIVSN AKSRKTFVQS VAPFLRTYGF DGLDLAWLYP GPKDKQHFTT
160 170 180 190 200
LIKELKAEFT KEVQPGTEKL LLSAAVSAGK VTLDSGYDVA QIAQHLDFIN
210 220 230 240 250
LMTYDFHGTW RHTTGHHSPL FRGQQDTGPD RFSNVDYGVG YMLRLGAPTN
260 270 280 290 300
KLVMGIPTFG KSFTLASSEN QVGAPITGSG LPGRYTKEKG TLAYYEICDF
310 320 330 340 350
LRGAEVHRIL GQQVPFATKG NQWVGYDDPE SVKNKVKYLK NKQLAGAMVW
360 370 380
AVDLDDFRGS FCGHNVHFPL TNAIKEALAV A
Length:381
Mass (Da):42,392
Last modified:November 8, 2005 - v3
Checksum:iE40BD71A658A2EBB
GO

Sequence cautioni

The sequence AAH91365 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti277T → S in AAD22610 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091365 mRNA Translation: AAH91365.1 Different initiation.
AF062038 mRNA Translation: AAD22610.1
RefSeqiNP_001296749.1, NM_001309820.1
NP_446012.2, NM_053560.2
UniGeneiRn.68940

Genome annotation databases

EnsembliENSRNOT00000078599; ENSRNOP00000074871; ENSRNOG00000053272
GeneIDi89824
KEGGirno:89824
UCSCiRGD:620874 rat

Similar proteinsi

Entry informationi

Entry nameiCH3L1_RAT
AccessioniPrimary (citable) accession number: Q9WTV1
Secondary accession number(s): Q5BJR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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