UniProtKB - Q9WTT7 (BZW2_RAT)
Protein
Basic leucine zipper and W2 domain-containing protein 2
Gene
Bzw2
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in neuronal differentiation.1 Publication
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Basic leucine zipper and W2 domain-containing protein 2Alternative name(s): Brain development-related molecule 2 |
Gene namesi | Name:Bzw2 Synonyms:Bdm2, Hfb2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621507, Bzw2 |
Subcellular locationi
Other locations
- cytoplasm Source: RGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254622 | 1 – 419 | Basic leucine zipper and W2 domain-containing protein 2Add BLAST | 419 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 412 | PhosphoserineCombined sources | 1 | |
Modified residuei | 414 | PhosphoserineCombined sources | 1 | |
Modified residuei | 419 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9WTT7 |
PaxDbi | Q9WTT7 |
PRIDEi | Q9WTT7 |
PTM databases
iPTMneti | Q9WTT7 |
PhosphoSitePlusi | Q9WTT7 |
Expressioni
Tissue specificityi
Expressed at high levels in heart, and at lower levels in skeletal muscle, spleen and lung. Expressed at low levels in brain regions where nascent and immature neurons are present.1 Publication
Developmental stagei
Expressed at E8. In brain, expression increases between E14 and E16, reaches a plateau at E18, and subsequently decreases.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000005096, Expressed in heart and 21 other tissues |
Genevisiblei | Q9WTT7, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 248 – 415 | W2PROSITE-ProRule annotationAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the BZW family.Curated
Phylogenomic databases
eggNOGi | KOG2297, Eukaryota |
GeneTreei | ENSGT00390000012561 |
HOGENOMi | CLU_032849_0_1_1 |
InParanoidi | Q9WTT7 |
OMAi | EPFCNGP |
OrthoDBi | 653740at2759 |
PhylomeDBi | Q9WTT7 |
TreeFami | TF324313 |
Family and domain databases
CDDi | cd11560, W2_eIF5C_like, 1 hit |
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR016021, MIF4-like_sf IPR043510, W2_BZW1/2 IPR003307, W2_domain |
Pfami | View protein in Pfam PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9WTT7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
VMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF031483 mRNA Translation: AAD20436.1 BC063149 mRNA Translation: AAH63149.1 |
RefSeqi | NP_599229.1, NM_134402.3 |
Genome annotation databases
Ensembli | ENSRNOT00000007414; ENSRNOP00000007414; ENSRNOG00000005096 |
GeneIDi | 171439 |
KEGGi | rno:171439 |
UCSCi | RGD:621507, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF031483 mRNA Translation: AAD20436.1 BC063149 mRNA Translation: AAH63149.1 |
RefSeqi | NP_599229.1, NM_134402.3 |
3D structure databases
SMRi | Q9WTT7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000007414 |
PTM databases
iPTMneti | Q9WTT7 |
PhosphoSitePlusi | Q9WTT7 |
Proteomic databases
jPOSTi | Q9WTT7 |
PaxDbi | Q9WTT7 |
PRIDEi | Q9WTT7 |
Genome annotation databases
Ensembli | ENSRNOT00000007414; ENSRNOP00000007414; ENSRNOG00000005096 |
GeneIDi | 171439 |
KEGGi | rno:171439 |
UCSCi | RGD:621507, rat |
Organism-specific databases
CTDi | 28969 |
RGDi | 621507, Bzw2 |
Phylogenomic databases
eggNOGi | KOG2297, Eukaryota |
GeneTreei | ENSGT00390000012561 |
HOGENOMi | CLU_032849_0_1_1 |
InParanoidi | Q9WTT7 |
OMAi | EPFCNGP |
OrthoDBi | 653740at2759 |
PhylomeDBi | Q9WTT7 |
TreeFami | TF324313 |
Miscellaneous databases
PROi | PR:Q9WTT7 |
Gene expression databases
Bgeei | ENSRNOG00000005096, Expressed in heart and 21 other tissues |
Genevisiblei | Q9WTT7, RN |
Family and domain databases
CDDi | cd11560, W2_eIF5C_like, 1 hit |
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR016021, MIF4-like_sf IPR043510, W2_BZW1/2 IPR003307, W2_domain |
Pfami | View protein in Pfam PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51363, W2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BZW2_RAT | |
Accessioni | Q9WTT7Primary (citable) accession number: Q9WTT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | November 1, 1999 | |
Last modified: | August 12, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families