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Entry version 137 (26 Feb. 2020)
Sequence version 1 (01 Nov. 1999)
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Protein

Teneurin-2

Gene

Tenm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity).By similarity
Induces gene transcription inhibition.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processCell adhesion, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-2
Short name:
Ten-2
Alternative name(s):
Protein Odd Oz/ten-m homolog 2
Tenascin-M2
Short name:
Ten-m2
Teneurin transmembrane protein 2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tenm2
Synonyms:Kiaa1127, Odz2, Tnm2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1345184 Tenm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 379CytoplasmicSequence analysisAdd BLAST379
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 2764ExtracellularSequence analysisAdd BLAST2364

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Postsynaptic cell membrane, Synapse, Synaptosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595021 – 2764Teneurin-2Add BLAST2764
ChainiPRO_00004210131 – ?Ten-2 intracellular domainBy similarity
ChainiPRO_0000421014529 – 2764Ten-2, soluble formBy similarityAdd BLAST2236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90PhosphoserineCombined sources1
Modified residuei124PhosphoserineBy similarity1
Modified residuei155PhosphothreonineBy similarity1
Modified residuei157PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi482N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi576 ↔ 586PROSITE-ProRule annotation
Disulfide bondi580 ↔ 591PROSITE-ProRule annotation
Disulfide bondi593 ↔ 602PROSITE-ProRule annotation
Disulfide bondi611 ↔ 622PROSITE-ProRule annotation
Disulfide bondi624 ↔ 633PROSITE-ProRule annotation
Disulfide bondi640 ↔ 651PROSITE-ProRule annotation
Disulfide bondi645 ↔ 656PROSITE-ProRule annotation
Disulfide bondi658 ↔ 667PROSITE-ProRule annotation
Disulfide bondi672 ↔ 683PROSITE-ProRule annotation
Disulfide bondi677 ↔ 688PROSITE-ProRule annotation
Disulfide bondi690 ↔ 699PROSITE-ProRule annotation
Disulfide bondi710 ↔ 723PROSITE-ProRule annotation
Disulfide bondi725 ↔ 734PROSITE-ProRule annotation
Disulfide bondi738 ↔ 748PROSITE-ProRule annotation
Disulfide bondi742 ↔ 753PROSITE-ProRule annotation
Disulfide bondi755 ↔ 764PROSITE-ProRule annotation
Disulfide bondi769 ↔ 779PROSITE-ProRule annotation
Disulfide bondi773 ↔ 784PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 819PROSITE-ProRule annotation
Disulfide bondi821 ↔ 830PROSITE-ProRule annotation
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1606N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1702N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1739N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1763N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1797N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1882N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1983N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2327N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2638N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Derives from the membrane form by proteolytic processing.By similarity
Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei528 – 529CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9WTS5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9WTS5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WTS5

PRoteomics IDEntifications database

More...
PRIDEi
Q9WTS5

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2756

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WTS5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WTS5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cortex, CA1, CA2, CA3, dentate gyrus and granular layer of the hippocampus. Expressed in the Purkinje cells and molecular layer of the cerebellum.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the midbrain and spinal cord at 12.5 dpc.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4.

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9WTS5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000052014

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9WTS5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WTS5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 375Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST375
Domaini575 – 603EGF-like 1PROSITE-ProRule annotationAdd BLAST29
Domaini598 – 634EGF-like 2PROSITE-ProRule annotationAdd BLAST37
Domaini636 – 668EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini669 – 701EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini702 – 735EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini737 – 765EGF-like 6PROSITE-ProRule annotationAdd BLAST29
Domaini768 – 796EGF-like 7PROSITE-ProRule annotationAdd BLAST29
Domaini798 – 831EGF-like 8PROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1262 – 1306NHL 1Add BLAST45
Repeati1332 – 1376NHL 2Add BLAST45
Repeati1391 – 1442NHL 3Add BLAST52
Repeati1464 – 1491NHL 4Add BLAST28
Repeati1520 – 1563NHL 5Add BLAST44
Repeati1573 – 1592YD 1Add BLAST20
Repeati1609 – 1629YD 2Add BLAST21
Repeati1672 – 1691YD 3Add BLAST20
Repeati1692 – 1714YD 4Add BLAST23
Repeati1885 – 1904YD 5Add BLAST20
Repeati1926 – 1944YD 6Add BLAST19
Repeati1945 – 1965YD 7Add BLAST21
Repeati1972 – 1989YD 8Add BLAST18
Repeati1990 – 2011YD 9Add BLAST22
Repeati2012 – 2029YD 10Add BLAST18
Repeati2032 – 2052YD 11Add BLAST21
Repeati2055 – 2075YD 12Add BLAST21
Repeati2083 – 2103YD 13Add BLAST21
Repeati2109 – 2126YD 14Add BLAST18
Repeati2127 – 2153YD 15Add BLAST27
Repeati2155 – 2168YD 16Add BLAST14
Repeati2169 – 2192YD 17Add BLAST24
Repeati2195 – 2215YD 18Add BLAST21
Repeati2216 – 2236YD 19Add BLAST21
Repeati2238 – 2258YD 20Add BLAST21
Repeati2270 – 2290YD 21Add BLAST21
Repeati2292 – 2312YD 22Add BLAST21
Repeati2338 – 2379YD 23Add BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi175 – 178Poly-Ser4
Compositional biasi331 – 334Poly-Ser4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225 Eukaryota
KOG4659 Eukaryota
ENOG410XQQD LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WTS5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9WTS5

TreeFam database of animal gene trees

More...
TreeFami
TF316833

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR008969 CarboxyPept-like_regulatory
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR022385 Rhs_assc_core
IPR027689 Ten-2/3
IPR009471 Ten_N
IPR028916 Tox-GHH_dom
IPR006530 YD

The PANTHER Classification System

More...
PANTHERi
PTHR11219:SF8 PTHR11219:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06484 Ten_N, 1 hit
PF15636 Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00181 EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464 SSF49464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03696 Rhs_assc_core, 1 hit
TIGR01643 YD_repeat_2x, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 4 hits
PS51361 TENEURIN_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WTS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVKDRRHRS LTRGRCGKEC RYTSSSLDSE DCRVPTQKSY SSSETLKAYD
60 70 80 90 100
HDSRMHYGNR VTDLVHRESD EFSRQGTNFT LAELGICEPS PHRSGYCSDM
110 120 130 140 150
GILHQGYSLS TGSDADSDTE GGMSPEHAIR LWGRGIKSRR SSGLSSRENS
160 170 180 190 200
ALTLTDSDNE NKSDDDNGRP IPPTSSSSLL PSAQLPSSHN PPPVSCQMPL
210 220 230 240 250
LDSNTSHQIM DTNPDEEFSP NSYLLRACSG PQQASSSGPP NHHSQSTLRP
260 270 280 290 300
PLPPPHNHTL SHHHSSANSL NRNSLTNRRS QIHAPAPAPN DLATTPESVQ
310 320 330 340 350
LQDSWVLNSN VPLETRHFLF KTSSGSTPLF SSSSPGYPLT SGTVYTPPPR
360 370 380 390 400
LLPRNTFSRK AFKLKKPSKY CSWKCAALSA IAAALLLAIL LAYFIAMHLL
410 420 430 440 450
GLNWQLQPAD GHTFNNGVRT GLPGNDDVAT VPSGGKVPWS LKNSSIDSGE
460 470 480 490 500
AEVGRRVTQE VPPGVFWRSQ IHISQPQFLK FNISLGKDAL FGVYIRRGLP
510 520 530 540 550
PSHAQYDFME RLDGKEKWSV VESPRERRSI QTLVQNEAVF VQYLDVGLWH
560 570 580 590 600
LAFYNDGKDK EMVSFNTVVL DSVQDCPRNC HGNGECVSGL CHCFPGFLGA
610 620 630 640 650
DCAKAACPVL CSGNGQYSKG TCQCYSGWKG AECDVPMNQC IDPSCGGHGS
660 670 680 690 700
CIDGNCVCAA GYKGEHCEEV DCLDPTCSSH GVCVNGECLC SPGWGGLNCE
710 720 730 740 750
LARVQCPDQC SGHGTYLPDS GLCSCDPNWM GPDCSVVCSV DCGTHGVCIG
760 770 780 790 800
GACRCEEGWT GAACDQRVCH PRCIEHGTCK DGKCECREGW NGEHCTIDGC
810 820 830 840 850
PDLCNGNGRC TLGQNSWQCV CQTGWRGPGC NVAMETSCAD NKDNEGDGLV
860 870 880 890 900
DCLDPDCCLQ SACQNSLLCR GSRDPLDIIQ QGQTDWPAVK SFYDRIKLLA
910 920 930 940 950
GKDSTHIIPG DNPFNSSLVS LIRGQVVTMD GTPLVGVNVS FVKYPKYGYT
960 970 980 990 1000
ITRQDGTFDL IANGGSALTL HFERAPFMSQ ERTVWLPWNS FYAMDTLVMK
1010 1020 1030 1040 1050
TEENSIPSCD LSGFVRPDPI IISSPLSTFF SASPASNPIV PETQVLHEEI
1060 1070 1080 1090 1100
ELPGTNVKLR YLSSRTAGYK SLLKITMTQS TVPLNLIRVH LMVAVEGHLF
1110 1120 1130 1140 1150
QKSFQASPNL AYTFIWDKTD AYGQRVYGLS DAVVSVGFEY ETCPSLILWE
1160 1170 1180 1190 1200
KRTALLQGFE LDPSNLGGWS LDKHHTLNVK SGILHKGTGE NQFLTQQPAI
1210 1220 1230 1240 1250
ITSIMGNGRR RSISCPSCNG LAEGNKLLAP VALAVGIDGS LFVGDFNYIR
1260 1270 1280 1290 1300
RIFPSRNVTS ILELRNKEFK HSNSPGHKYY LAVDPVTGSL YVSDTNSRRI
1310 1320 1330 1340 1350
YRVKSLSGAK DLAGNSEVVA GTGEQCLPFD EARCGDGGKA VDATLMSPRG
1360 1370 1380 1390 1400
IAVDKNGLMY FVDATMIRKV DQNGIISTLL GSNDLTAVRP LSCDSSMDVA
1410 1420 1430 1440 1450
QVRLEWPTDL AVNPMDNSLY VLENNVILRI TENHQVSIIA GRPMHCQVPG
1460 1470 1480 1490 1500
IDYSLSKLAI HSALESASAI AISHTGVLYI TETDEKKINR LRQVTTNGEI
1510 1520 1530 1540 1550
CLLAGAASDC DCKNDVNCIC YSGDDAYATD AILNSPSSLA VAPDGTIYIA
1560 1570 1580 1590 1600
DLGNIRIRAV SKNKPVLNAF NQYEAASPGE QELYVFNADG IHQYTVSLVT
1610 1620 1630 1640 1650
GEYLYNFTYS ADNDVTELID NNGNSLKIRR DSSGMPRHLL MPDNQIITLT
1660 1670 1680 1690 1700
VGTNGGLKAV STQNLELGLM TYDGNTGLLA TKSDETGWTT FYDYDHEGRL
1710 1720 1730 1740 1750
TNVTRPTGVV TSLHREMEKS ITIDIENSNR DDDVTVITNL SSVEASYTVV
1760 1770 1780 1790 1800
QDQVRNSYQL CNNGTLRVMY ANGMAVSFHS EPHVLAGTIT PTIGRCNISL
1810 1820 1830 1840 1850
PMENGLNSIE WRLRKEQIKG KVTIFGRKLR VHGRNLLSID YDRNIRTEKI
1860 1870 1880 1890 1900
YDDHRKFTLR IIYDQVGRPF LWLPSSGLAA VNVSYFFNGR LAGLQRGAMS
1910 1920 1930 1940 1950
ERTDIDKQGR IVSRMFADGK VWSYSYLDKS MVLLLQSQRQ YIFEYDSSDR
1960 1970 1980 1990 2000
LHAVTMPSVA RHSMSTHTSI GYIRNIYNPP ESNASVIFDY SDDGRILKTS
2010 2020 2030 2040 2050
FLGTGRQVFY KYGKLSKLSE IVYDSTAVTF GYDETTGVLK MVNLQSGGFS
2060 2070 2080 2090 2100
CTIRYRKVGP LVDKQIYRFS EEGMINARFD YTYHDNSFRI ASIKPVISET
2110 2120 2130 2140 2150
PLPVDLYRYD EISGKVEHFG KFGVIYYDIN QIITTAVMTL SKHFDTHGRI
2160 2170 2180 2190 2200
KEVQYEMFRS LMYWMTVQYD SMGRVIKREL KLGPYANTTK YTYDYDGDGQ
2210 2220 2230 2240 2250
LQSVAVNDRP TWRYSYDLNG NLHLLNPGNS ARLMPLRYDL RDRITRLGDV
2260 2270 2280 2290 2300
QYKIDDDGYL CQRGSDIFEY NSKGLLTRAY NKASGWSVQY RYDGVGRRAS
2310 2320 2330 2340 2350
YKTNLGHHLQ YFYSDLHNPT RITHVYNHSN SEITSLYYDL QGHLFAMESS
2360 2370 2380 2390 2400
SGEEYYVASD NTGTPLAVYS INGLMIKQLQ YTAYGEIYYD SNPDFQMVIG
2410 2420 2430 2440 2450
FHGGLYDPLT KLVHFTQRDY DVLAGRWTSP DYTMWRNVGK EPAPFNLYMF
2460 2470 2480 2490 2500
KNNNPLSNEL DLKNYVTDVK SWLVMFGFQL SNIIPGFPRA KMYFVPPPYE
2510 2520 2530 2540 2550
LSESQASENG QLITGVQQTT ERHNQAFLAL EGQVITKKLH ASIREKAGHW
2560 2570 2580 2590 2600
FATTTPIIGK GIMFAIKEGR VTTGVSSIAS EDSRKVASVL NNAYYLDKMH
2610 2620 2630 2640 2650
YSIEGKDTHY FVKIGAADGD LVTLGTTIGR KVLESGVNVT VSQPTLLVNG
2660 2670 2680 2690 2700
RTRRFTNIEF QYSTLLLSIR YGLTPDTLDE EKARVLDQAG QRALGTAWAK
2710 2720 2730 2740 2750
EQQKARDGRE GSRLWTEGEK QQLLSTGRVQ GYEGYYVLPV EQYPELADSS
2760
SNIQFLRQNE MGKR
Length:2,764
Mass (Da):306,468
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73BA3D916D0F0344
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQ92A0A0A0MQ92_MOUSE
Teneurin-2
Tenm2
2,765Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQB7A0A0A0MQB7_MOUSE
Teneurin-2
Tenm2
2,764Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti736V → VE in CAI35934 (PubMed:19468303).Curated1
Sequence conflicti736V → VE in CAI36038 (PubMed:19468303).Curated1
Sequence conflicti736V → VE in CAI35942 (PubMed:19468303).Curated1
Sequence conflicti736V → VE in CAI35945 (PubMed:19468303).Curated1
Sequence conflicti736V → VE in CAI35947 (PubMed:19468303).Curated1
Sequence conflicti736V → VE in CAI35084 (PubMed:19468303).Curated1
Sequence conflicti736V → VE in CAB57282 (PubMed:10588872).Curated1
Sequence conflicti2369Y → F in CAI35083 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35084 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35933 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35934 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35941 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35942 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35944 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35945 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35946 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI35947 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI36037 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in CAI36038 (PubMed:19468303).Curated1
Sequence conflicti2369Y → F in AAF28317 (PubMed:10625539).Curated1
Sequence conflicti2690G → R in CAI35083 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35084 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35933 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35934 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35941 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35942 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35944 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35945 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35946 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI35947 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI36037 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in CAI36038 (PubMed:19468303).Curated1
Sequence conflicti2690G → R in BAC65737 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB025411 mRNA Translation: BAA77397.1
AL713956 BX539311 Genomic DNA Translation: CAI35933.1
AL713956 BX000433 Genomic DNA Translation: CAI35934.1
BX539311 BX000433 Genomic DNA Translation: CAI36037.1
BX539311 BX000433 Genomic DNA Translation: CAI36038.1
AL713919 BX539311 Genomic DNA Translation: CAI35941.1
AL713919 BX000433 Genomic DNA Translation: CAI35942.1
AL713915 BX539311 Genomic DNA Translation: CAI35944.1
AL713915 AL645912 Genomic DNA Translation: CAI35945.1
BX000433 BX539311 Genomic DNA Translation: CAI35946.1
BX000433 BX539311 Genomic DNA Translation: CAI35947.1
AL645912 BX539311 Genomic DNA Translation: CAI35083.1
AL645912 BX539311 Genomic DNA Translation: CAI35084.1
AJ245710 mRNA Translation: CAB57282.1
AF195419 mRNA Translation: AAF28317.1
AK122455 mRNA Translation: BAC65737.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24546.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025411 mRNA Translation: BAA77397.1
AL713956 BX539311 Genomic DNA Translation: CAI35933.1
AL713956 BX000433 Genomic DNA Translation: CAI35934.1
BX539311 BX000433 Genomic DNA Translation: CAI36037.1
BX539311 BX000433 Genomic DNA Translation: CAI36038.1
AL713919 BX539311 Genomic DNA Translation: CAI35941.1
AL713919 BX000433 Genomic DNA Translation: CAI35942.1
AL713915 BX539311 Genomic DNA Translation: CAI35944.1
AL713915 AL645912 Genomic DNA Translation: CAI35945.1
BX000433 BX539311 Genomic DNA Translation: CAI35946.1
BX000433 BX539311 Genomic DNA Translation: CAI35947.1
AL645912 BX539311 Genomic DNA Translation: CAI35083.1
AL645912 BX539311 Genomic DNA Translation: CAI35084.1
AJ245710 mRNA Translation: CAB57282.1
AF195419 mRNA Translation: AAF28317.1
AK122455 mRNA Translation: BAC65737.1
CCDSiCCDS24546.1

3D structure databases

SMRiQ9WTS5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9WTS5, 1 interactor
STRINGi10090.ENSMUSP00000052014

PTM databases

GlyConnecti2756
iPTMnetiQ9WTS5
PhosphoSitePlusiQ9WTS5

Proteomic databases

EPDiQ9WTS5
MaxQBiQ9WTS5
PaxDbiQ9WTS5
PRIDEiQ9WTS5

Organism-specific databases

MGIiMGI:1345184 Tenm2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG4659 Eukaryota
ENOG410XQQD LUCA
InParanoidiQ9WTS5
PhylomeDBiQ9WTS5
TreeFamiTF316833

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tenm2 mouse

Protein Ontology

More...
PROi
PR:Q9WTS5
RNActiQ9WTS5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR008969 CarboxyPept-like_regulatory
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR022385 Rhs_assc_core
IPR027689 Ten-2/3
IPR009471 Ten_N
IPR028916 Tox-GHH_dom
IPR006530 YD
PANTHERiPTHR11219:SF8 PTHR11219:SF8, 1 hit
PfamiView protein in Pfam
PF06484 Ten_N, 1 hit
PF15636 Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SUPFAMiSSF49464 SSF49464, 1 hit
TIGRFAMsiTIGR03696 Rhs_assc_core, 1 hit
TIGR01643 YD_repeat_2x, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 4 hits
PS51361 TENEURIN_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEN2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WTS5
Secondary accession number(s): Q5NBW7
, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: February 26, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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