UniProtKB - Q9WTR5 (CAD13_MOUSE)
Cadherin-13
Cdh13
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
GO - Molecular functioni
- adiponectin binding Source: BHF-UCL
- cadherin binding Source: MGI
- calcium ion binding Source: GO_Central
- identical protein binding Source: MGI
- lipoprotein particle binding Source: MGI
- low-density lipoprotein particle binding Source: MGI
- protein homodimerization activity Source: InterPro
GO - Biological processi
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: MGI
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- endothelial cell migration Source: MGI
- homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
- keratinocyte proliferation Source: MGI
- lamellipodium assembly Source: MGI
- localization within membrane Source: MGI
- low-density lipoprotein particle mediated signaling Source: MGI
- negative regulation of cell adhesion Source: MGI
- negative regulation of cell population proliferation Source: MGI
- positive regulation of calcium-mediated signaling Source: MGI
- positive regulation of cell-matrix adhesion Source: MGI
- positive regulation of cell migration Source: MGI
- positive regulation of endothelial cell proliferation Source: MGI
- positive regulation of positive chemotaxis Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- Rac protein signal transduction Source: MGI
- regulation of endocytosis Source: MGI
- regulation of epidermal growth factor receptor signaling pathway Source: MGI
- Rho protein signal transduction Source: MGI
- sprouting angiogenesis Source: MGI
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-13Alternative name(s): Heart cadherin Short name: H-cadherin Truncated cadherin Short name: T-cad Short name: T-cadherin |
Gene namesi | Name:Cdh13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99551, Cdh13 |
VEuPathDBi | HostDB:ENSMUSG00000031841 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- catenin complex Source: GO_Central
- caveola Source: MGI
- external side of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cytoplasm Source: MGI
- GABA-ergic synapse Source: MGI
- neuron projection Source: MGI
- perinuclear region of cytoplasm Source: MGI
- synapse Source: MGI
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 152 | R → E: Strongly inhibits dimerization. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000003796 | 23 – 138 | By similarityAdd BLAST | 116 | |
ChainiPRO_0000003797 | 139 – 693 | Cadherin-13Add BLAST | 555 | |
PropeptideiPRO_0000003798 | 694 – 714 | Removed in mature formSequence analysisAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 382 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 489 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 500 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 530 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 598 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 638 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 671 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 693 | GPI-anchor amidated glycineSequence analysis | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
CPTACi | non-CPTAC-3381 |
MaxQBi | Q9WTR5 |
PaxDbi | Q9WTR5 |
PeptideAtlasi | Q9WTR5 |
PRIDEi | Q9WTR5 |
ProteomicsDBi | 265416 |
PTM databases
GlyConnecti | 2166, 21 N-Linked glycans (4 sites) |
GlyGeni | Q9WTR5, 8 sites, 20 N-linked glycans (4 sites) |
iPTMneti | Q9WTR5 |
PhosphoSitePlusi | Q9WTR5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031841, Expressed in cortical plate and 297 other tissues |
Genevisiblei | Q9WTR5, MM |
Interactioni
Subunit structurei
By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
1 PublicationGO - Molecular functioni
- adiponectin binding Source: BHF-UCL
- cadherin binding Source: MGI
- identical protein binding Source: MGI
- protein homodimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 198633, 2 interactors |
IntActi | Q9WTR5, 2 interactors |
STRINGi | 10090.ENSMUSP00000113527 |
Miscellaneous databases
RNActi | Q9WTR5, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9WTR5 |
SMRi | Q9WTR5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9WTR5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 143 – 245 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 246 – 363 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 364 – 477 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 478 – 585 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 586 – 680 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 183 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 159 – 179 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Domaini
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000155218 |
HOGENOMi | CLU_005284_5_1_1 |
InParanoidi | Q9WTR5 |
OMAi | VCTCKKS |
OrthoDBi | 215774at2759 |
PhylomeDBi | Q9WTR5 |
TreeFami | TF316817 |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR014868, Cadherin_pro_dom IPR033216, CDH13 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF80, PTHR24027:SF80, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MQPRTPLTLC VLLSQVLLVT SADDLECTPG FQRKVLHIHQ PAEFIEDQPV
60 70 80 90 100
LNLTFNDCKG NEKLHYEVSS PHFKVNSDGT LVALRNITAV GRTLFVHART
110 120 130 140 150
PHAEDMAELV IVGGKDIQGS LQDIFKFART SPVPRQKRSI VVSPILIPEN
160 170 180 190 200
QRQPFPRDVG KVVDSDRPEG SKFRLTGKGV DQDPKGTFRI NENTGSVSVT
210 220 230 240 250
RTLDRETIAT YQLYVETTDA SGKTLEGPVP LEVIVIDQND NRPIFREGPY
260 270 280 290 300
IGHVMEGSPT GTTVMRMTAF DADDPATDNA LLRYNIRQQT PDKPSPNMFY
310 320 330 340 350
IDPEKGDIVT VVSPALLDRE TLENPKYELI IEAQDMAGLD VGLTGTATAT
360 370 380 390 400
IVIDDKNDHS PKFTKKEFQA TVEEGAVGVI VNLTVEDKDD PTTGAWRAAY
410 420 430 440 450
TIINGNPGQS FEIHTNPQTN EGMLSVVKPL DYEISAFHTL LIKVENEDPL
460 470 480 490 500
VPDVSYGPSS TATVHITVLD VNEGPVFYPD PMMVTKQENI SVGSVLLTVN
510 520 530 540 550
ATDPDSLQHQ TIRYSIYKDP AGWLSINPIN GTVDTTAVLD RESPFVHNSV
560 570 580 590 600
YTALFLAIDS GNPPATGTGT LLITLEDIND NAPVIYPTVA EVCDDARNLS
610 620 630 640 650
VVILGASDKD LHPNTDPFKF EIHKQTVPDK VWKISKINNT HALVSLLQNL
660 670 680 690 700
NKANYNLPIM VTDSGKPPMT NITDLRVQVC SCKNSKVDCN GAGALHLSLS
710
LLLLFSLLSL LSGL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 282 | L → W in BAA76677 (PubMed:10737605).Curated | 1 | |
Sequence conflicti | 371 | T → R in BAA76677 (PubMed:10737605).Curated | 1 | |
Sequence conflicti | 676 | R → K in BAA76677 (PubMed:10737605).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022100 mRNA Translation: BAA76677.1 AK039438 mRNA Translation: BAC30347.1 AK048724 mRNA Translation: BAC33435.1 AK134649 mRNA Translation: BAE22225.1 CH466525 Genomic DNA Translation: EDL11590.1 |
CCDSi | CCDS52682.1 |
RefSeqi | NP_062681.2, NM_019707.5 |
Genome annotation databases
Ensembli | ENSMUST00000117160; ENSMUSP00000113527; ENSMUSG00000031841 |
GeneIDi | 12554 |
KEGGi | mmu:12554 |
UCSCi | uc009npl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022100 mRNA Translation: BAA76677.1 AK039438 mRNA Translation: BAC30347.1 AK048724 mRNA Translation: BAC33435.1 AK134649 mRNA Translation: BAE22225.1 CH466525 Genomic DNA Translation: EDL11590.1 |
CCDSi | CCDS52682.1 |
RefSeqi | NP_062681.2, NM_019707.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3K5R | X-ray | 2.00 | A/B | 140-355 | [»] | |
3K6F | X-ray | 1.81 | A/B | 140-237 | [»] | |
AlphaFoldDBi | Q9WTR5 | |||||
SMRi | Q9WTR5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198633, 2 interactors |
IntActi | Q9WTR5, 2 interactors |
STRINGi | 10090.ENSMUSP00000113527 |
PTM databases
GlyConnecti | 2166, 21 N-Linked glycans (4 sites) |
GlyGeni | Q9WTR5, 8 sites, 20 N-linked glycans (4 sites) |
iPTMneti | Q9WTR5 |
PhosphoSitePlusi | Q9WTR5 |
Proteomic databases
CPTACi | non-CPTAC-3381 |
MaxQBi | Q9WTR5 |
PaxDbi | Q9WTR5 |
PeptideAtlasi | Q9WTR5 |
PRIDEi | Q9WTR5 |
ProteomicsDBi | 265416 |
Protocols and materials databases
Antibodypediai | 667, 637 antibodies from 42 providers |
DNASUi | 12554 |
Genome annotation databases
Ensembli | ENSMUST00000117160; ENSMUSP00000113527; ENSMUSG00000031841 |
GeneIDi | 12554 |
KEGGi | mmu:12554 |
UCSCi | uc009npl.1, mouse |
Organism-specific databases
CTDi | 1012 |
MGIi | MGI:99551, Cdh13 |
VEuPathDBi | HostDB:ENSMUSG00000031841 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000155218 |
HOGENOMi | CLU_005284_5_1_1 |
InParanoidi | Q9WTR5 |
OMAi | VCTCKKS |
OrthoDBi | 215774at2759 |
PhylomeDBi | Q9WTR5 |
TreeFami | TF316817 |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Miscellaneous databases
BioGRID-ORCSi | 12554, 0 hits in 73 CRISPR screens |
ChiTaRSi | Cdh13, mouse |
EvolutionaryTracei | Q9WTR5 |
PROi | PR:Q9WTR5 |
RNActi | Q9WTR5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031841, Expressed in cortical plate and 297 other tissues |
Genevisiblei | Q9WTR5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR014868, Cadherin_pro_dom IPR033216, CDH13 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF80, PTHR24027:SF80, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CAD13_MOUSE | |
Accessioni | Q9WTR5Primary (citable) accession number: Q9WTR5 Secondary accession number(s): Q8BG11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references