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Protein

Transient receptor potential cation channel subfamily V member 2

Gene

Trpv2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.2 Publications

GO - Molecular functioni

  • calcium channel activity Source: MGI
  • cation channel activity Source: MGI
  • identical protein binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Protein family/group databases

TCDBi1.A.4.2.4 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 2
Short name:
TrpV2
Alternative name(s):
Growth factor-regulated calcium channel
Short name:
GRC
Osm-9-like TRP channel 2
Short name:
OTRPC2
Gene namesi
Name:Trpv2
Synonyms:Grc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1341836 Trpv2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 387CytoplasmicSequence analysisAdd BLAST387
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 428ExtracellularSequence analysisAdd BLAST20
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 455CytoplasmicSequence analysis6
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 490ExtracellularSequence analysisAdd BLAST14
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 532CytoplasmicSequence analysisAdd BLAST21
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Intramembranei568 – 604Pore-formingSequence analysisAdd BLAST37
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 756CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153431 – 756Transient receptor potential cation channel subfamily V member 2Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei77PhosphoserineBy similarity1
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei743PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated by PKA.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9WTR1
MaxQBiQ9WTR1
PaxDbiQ9WTR1
PeptideAtlasiQ9WTR1
PRIDEiQ9WTR1

PTM databases

iPTMnetiQ9WTR1
PhosphoSitePlusiQ9WTR1
SwissPalmiQ9WTR1

Expressioni

Tissue specificityi

Abundantly expressed in spleen, placenta, skeleton muscle, lung and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000018507 Expressed in 160 organ(s), highest expression level in placenta
GenevisibleiQ9WTR1 MM

Interactioni

Subunit structurei

Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018651

Structurei

3D structure databases

ProteinModelPortaliQ9WTR1
SMRiQ9WTR1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 110ANK 1Add BLAST43
Repeati111 – 157ANK 2Add BLAST47
Repeati158 – 203ANK 3Add BLAST46
Repeati204 – 239ANK 4Add BLAST36
Repeati240 – 288ANK 5Add BLAST49
Repeati289 – 315ANK 6Add BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 385Required for interaction with SLC50A1By similarityAdd BLAST385

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234630
HOVERGENiHBG054085
InParanoidiQ9WTR1
KOiK04971
OMAiVEEVNWA
OrthoDBiEOG091G02AF
PhylomeDBiQ9WTR1
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024865 TRPV2_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF5 PTHR10582:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WTR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSASNPPAF RLETSDGDEE GSAEVNKGKN EPPPMESPFQ GEDRNFSPQI
60 70 80 90 100
KVNLNYRKGL GPSQQDPNRF DRDRLFSVVS RGVPEELTGL LEYLRRTSKY
110 120 130 140 150
LTDSAYTEGS TGKTCLMKAV LNLQDGVNAC ILPLLQIDRD SGNPQPLVNA
160 170 180 190 200
QCTDEFYRGH SALHIAIEKR SLWCVKLLVE NGANVHIRAC GRFFQKHQGT
210 220 230 240 250
CFYFGELPLS LAACTKQWDV VTYLLENPHQ PASLEATDSL GNTVLHALVM
260 270 280 290 300
IADNSPENSA LVIHMYDSLL QMGARLCPTV QLEDICNHQG LTPLKLAAKE
310 320 330 340 350
GKIEIFRHIL QREFSGLYQP LSRKFTEWCY GPVRVSLYDL SSVDSWEKNS
360 370 380 390 400
VLEIIAFHCK SPHRHRMVVL EPLNKLLQEK WDRLIPRFFF NFACYLVYMI
410 420 430 440 450
IFTIVAYHQP SLEQPAIPSS KATFGDSMLL LGHILILLGG IYLLLGQLWY
460 470 480 490 500
FWRRRLFIWI SFMDSYFEIL FLVQALLTVL SQVLRFVETE WYLPLLVSSL
510 520 530 540 550
VLGWLNLLYY TRGFQHTGIY SVMIQKVILR DLLRFLLVYL VFLFGFAVAL
560 570 580 590 600
VSLSREARSP KAPEDSNTTV TEKPTLGQEE EPVPYGGILD ASLELFKFTI
610 620 630 640 650
GMGELAFQEQ LRFRGVVLLL LLAYVLLTYV LLLNMLIALM SETVNSVATD
660 670 680 690 700
SWSIWKLQKA ISVLEMENGY WWCRRKRHRA GRLLKVGTKG DGIPDERWCF
710 720 730 740 750
RVEEVNWAAW EKTLPTLSED PSGAGITGYK KNPTSKPGKN SASEEDHLPL

QVLQSH
Length:756
Mass (Da):85,965
Last modified:April 26, 2005 - v2
Checksum:iC0E537AB2C86E1A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti565D → N in BAA78478 (PubMed:10559903).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021665 mRNA Translation: BAA78478.1
AK089004 mRNA Translation: BAC40695.1
AL596181 Genomic DNA No translation available.
BC005415 mRNA Translation: AAH05415.1
CCDSiCCDS24827.1
RefSeqiNP_035836.2, NM_011706.2
XP_006533228.1, XM_006533165.2
XP_011247273.1, XM_011248971.1
UniGeneiMm.288064

Genome annotation databases

EnsembliENSMUST00000018651; ENSMUSP00000018651; ENSMUSG00000018507
ENSMUST00000102643; ENSMUSP00000099703; ENSMUSG00000018507
GeneIDi22368
KEGGimmu:22368
UCSCiuc007jjh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021665 mRNA Translation: BAA78478.1
AK089004 mRNA Translation: BAC40695.1
AL596181 Genomic DNA No translation available.
BC005415 mRNA Translation: AAH05415.1
CCDSiCCDS24827.1
RefSeqiNP_035836.2, NM_011706.2
XP_006533228.1, XM_006533165.2
XP_011247273.1, XM_011248971.1
UniGeneiMm.288064

3D structure databases

ProteinModelPortaliQ9WTR1
SMRiQ9WTR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018651

Chemistry databases

GuidetoPHARMACOLOGYi508

Protein family/group databases

TCDBi1.A.4.2.4 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ9WTR1
PhosphoSitePlusiQ9WTR1
SwissPalmiQ9WTR1

Proteomic databases

EPDiQ9WTR1
MaxQBiQ9WTR1
PaxDbiQ9WTR1
PeptideAtlasiQ9WTR1
PRIDEiQ9WTR1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018651; ENSMUSP00000018651; ENSMUSG00000018507
ENSMUST00000102643; ENSMUSP00000099703; ENSMUSG00000018507
GeneIDi22368
KEGGimmu:22368
UCSCiuc007jjh.1 mouse

Organism-specific databases

CTDi51393
MGIiMGI:1341836 Trpv2

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234630
HOVERGENiHBG054085
InParanoidiQ9WTR1
KOiK04971
OMAiVEEVNWA
OrthoDBiEOG091G02AF
PhylomeDBiQ9WTR1
TreeFamiTF314711

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Miscellaneous databases

PROiPR:Q9WTR1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018507 Expressed in 160 organ(s), highest expression level in placenta
GenevisibleiQ9WTR1 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008347 TRPV1-4_channel
IPR024865 TRPV2_channel
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF5 PTHR10582:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01768 TRPVRECEPTOR
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPV2_MOUSE
AccessioniPrimary (citable) accession number: Q9WTR1
Secondary accession number(s): Q99K71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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