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Entry version 125 (16 Oct 2019)
Sequence version 1 (01 Nov 1999)
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Protein

A-kinase anchor protein 12

Gene

Akap12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 12
Short name:
AKAP-12
Alternative name(s):
Germ cell lineage protein gercelin
Src-suppressed C kinase substrate
Short name:
SSeCKS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap12
Synonyms:Gag12, Ssecks
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932576 Akap12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003049412 – 1684A-kinase anchor protein 12Add BLAST1683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineBy similarity1
Modified residuei18PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei136PhosphoserineBy similarity1
Modified residuei234PhosphoserineCombined sources1
Modified residuei244PhosphoserineBy similarity1
Modified residuei270PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei330PhosphothreonineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei353PhosphotyrosineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei505PhosphoserineBy similarity1
Modified residuei507PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei543PhosphoserineBy similarity1
Modified residuei584PhosphoserineCombined sources1
Modified residuei598PhosphoserineBy similarity1
Modified residuei613PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1
Modified residuei628PhosphothreonineBy similarity1
Modified residuei630PhosphoserineBy similarity1
Modified residuei631PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei683PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Modified residuei745PhosphoserineBy similarity1
Modified residuei767PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei871PhosphothreonineCombined sources1
Modified residuei873PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1030Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei1059PhosphoserineBy similarity1
Modified residuei1292PhosphoserineBy similarity1
Modified residuei1351PhosphoserineCombined sources1
Modified residuei1355PhosphoserineBy similarity1
Modified residuei1357PhosphoserineBy similarity1
Modified residuei1546PhosphoserineBy similarity1
Modified residuei1645PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3631

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9WTQ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9WTQ5

PeptideAtlas

More...
PeptideAtlasi
Q9WTQ5

PRoteomics IDEntifications database

More...
PRIDEi
Q9WTQ5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9WTQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9WTQ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9WTQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is predominantly found in the nervous system. Isoform 3 is testis specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038587 Expressed in 273 organ(s), highest expression level in urinary bladder

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9WTQ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9WTQ5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to dimeric RII-alpha regulatory subunit of PKC.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
219914, 11 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9WTQ5

Protein interaction database and analysis system

More...
IntActi
Q9WTQ5, 12 interactors

Molecular INTeraction database

More...
MINTi
Q9WTQ5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035829

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9WTQ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni253 – 543Involved in PKC-bindingBy similarityAdd BLAST291
Regioni1501 – 1514RII-bindingBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi593 – 613AKAP CaM-binding 1PROSITE-ProRule annotationAdd BLAST21
Motifi740 – 760AKAP CaM-binding 2PROSITE-ProRule annotationAdd BLAST21
Motifi781 – 801AKAP CaM-binding 3PROSITE-ProRule annotationAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFC9 Eukaryota
ENOG4110Y3C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111244

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293190

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9WTQ5

KEGG Orthology (KO)

More...
KOi
K16528

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDKDSEA

Database of Orthologous Groups

More...
OrthoDBi
158752at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9WTQ5

TreeFam database of animal gene trees

More...
TreeFami
TF105411

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028540 AKAP12
IPR001573 Pkinase-A_anch_WSK-motif
IPR018459 RII_binding_1

The PANTHER Classification System

More...
PANTHERi
PTHR23209 PTHR23209, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10522 RII_binding_1, 1 hit
PF03832 WSK, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51893 AKAP_CAM_BD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9WTQ5-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAGSSTEQR SPEQPAESDT PSELELSGHG PAAEASGAAG DPADADPATK
60 70 80 90 100
LPQKNGQLSA VNGVAEQEDV HVQEESQDGQ EEEVTVEDVG QRESEDVKEK
110 120 130 140 150
DRAKEMAASS TVVEDITKDE QEETPEIIEQ IPASESNVEE MAQAAESQAN
160 170 180 190 200
DVGFKKVFKF VGFKFTVKKD KNEKSDTVQL LTVKKDEGEG AEASVGAGDH
210 220 230 240 250
QEPGVETVGE SASKESELKQ STEKQEGTLK QAQSSTEIPL QAESGQGTEE
260 270 280 290 300
EAAKDGEENR EKEPTKPLES PTSPVSNETT SSFKKFFTHG WAGWRKKTSF
310 320 330 340 350
KKPKEDDLET SEKRKEQEAE KVDEEEGEKT EPAPAEEQEP AEGTDQARLS
360 370 380 390 400
ADYEKVELPL EDQVGDLEAL SEKCAPLATE VFDEKTEAHQ EVVAEVHVST
410 420 430 440 450
VEKMTKGQGG AEVEGDVVVE GSGESLPPEK LAETQEVPQE AEPVEELMKT
460 470 480 490 500
KEVCVSGGDH TQLTDLSPEE KMLPKHPEGI VSEVEMLSSQ ERIKVQGSPL
510 520 530 540 550
KKLFSSSGLK KLSGKKQKGK RGGGGGDEEP GEYQHIQTES PESADEQKGE
560 570 580 590 600
SSASSPEEPE EIACLEKGPS EAPQEAEAEE GATSDGEKKR EGITPWASFK
610 620 630 640 650
KMVTPKKRVR RPSESDKEEE LDKVKSATLS STESTASGMQ DEVRAVGEEQ
660 670 680 690 700
RSEEPKRRVD TSVSWEALIC VGSSKKRARK ASSSDDEGGP RTLGGDGHRA
710 720 730 740 750
EEASKDKEAD ALPASTQEQD QAHGSSSPEP AGSPSEGEGV STWESFKRLV
760 770 780 790 800
TPRKKSKSKL EERAEDSGAE QLASEIEPSR EESWVSIKKF IPGRRKKRAD
810 820 830 840 850
GKQEQAAVED SGPGEINEDD PDVPAVVPLS EYDAVEREKL EAQRAQENVE
860 870 880 890 900
LPQLKGAVYV SEELSKTLVH TVSVAVIDGT RAVTSAEERS PSWISASMTE
910 920 930 940 950
PLEHAEGVAT PPVGEVTEKD ITAEATPALA QTLPGGKDAH DDIVTSEVDF
960 970 980 990 1000
TSEAVTAAET TEALRAEELT EASGAEETTD MVSAVSQLSD SPDTTEEATP
1010 1020 1030 1040 1050
VQEVEGGMLD TEEQERQTQA VLQAVADKVK EDSQVPATQT LQRAGPKALE
1060 1070 1080 1090 1100
KVEEVEEDSE VLATEKEKDV VPEGPVQEAE TEHLAQGSET VQATPESLEV
1110 1120 1130 1140 1150
PEVTEDVDRA TTCQVIKHQQ LMEQAVAPES SETLTDSETN GSTPLADSDT
1160 1170 1180 1190 1200
PNGTQQDETV DSQDSNAIAA VKQSQVTEEE AAAAQTEGPS TPSSFPAQEE
1210 1220 1230 1240 1250
HREKPGRDVL EPTQALAAGA VPILAKAEVG QEGEAGQFDG EKVKDGQCVK
1260 1270 1280 1290 1300
ELEVPVHTGP NSQKTADLTR DSEVMEVARC QETESNEEQS ISPEKREMGT
1310 1320 1330 1340 1350
DVEKEETETK TEQASEEHEQ ETAAPEHEGT HPKPVLTADM PHSERGKALG
1360 1370 1380 1390 1400
SLEGSPSLPD QDKADCIEVQ VQSSDTPVTQ TTEAVKKVEE TVATSEMDES
1410 1420 1430 1440 1450
LECAGAQSLP AEKLSETGGY GTLQHGEDTV PQGPESQAES IPIIVTPAPE
1460 1470 1480 1490 1500
SILHSDLQRE VSASQKQRSD EDNKPDAGPD AAGKESAARE KILRAEPEIL
1510 1520 1530 1540 1550
ELESKSNKIV QSVIQTAVDQ FARTETAPET HASDLQNQVP VMQADSQGAQ
1560 1570 1580 1590 1600
QMLDKDESDL QVSPQDGTLS AVAQEGLAVS DSSEGMSKAS EMITTLAVES
1610 1620 1630 1640 1650
ASVKESVEKL PLQCKDEKEH AADGPQHQSL AKAEADASGN LTKESPDTNG
1660 1670 1680
PKLTEEGDAL KEEMNKAQTE EDDLQEPKGD LTES
Length:1,684
Mass (Da):180,695
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE569D55762FCB19E
GO
Isoform 2 (identifier: Q9WTQ5-2) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Show »
Length:1,579
Mass (Da):169,743
Checksum:iD448047A8E6CE8F2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC66465 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0281351 – 105Missing in isoform 2. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF326228 mRNA Translation: AAK16150.1
AF326230 mRNA Translation: AAK16152.1
AB020886 mRNA Translation: BAA76894.1
AB025278 mRNA Translation: BAC66465.1 Frameshift.
AB051563 mRNA Translation: BAB72161.1
AB070852 mRNA Translation: BAB72164.1
AB070853 mRNA Translation: BAB72165.1
AK053844 mRNA Translation: BAC35553.1
BC042461 mRNA Translation: AAH42461.1
BC043939 mRNA Translation: AAH43939.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS56673.1 [Q9WTQ5-1]

NCBI Reference Sequences

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RefSeqi
NP_112462.1, NM_031185.3 [Q9WTQ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045730; ENSMUSP00000035829; ENSMUSG00000038587 [Q9WTQ5-1]
ENSMUST00000215696; ENSMUSP00000150261; ENSMUSG00000038587 [Q9WTQ5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:83397

UCSC genome browser

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UCSCi
uc007ehh.1 mouse [Q9WTQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326228 mRNA Translation: AAK16150.1
AF326230 mRNA Translation: AAK16152.1
AB020886 mRNA Translation: BAA76894.1
AB025278 mRNA Translation: BAC66465.1 Frameshift.
AB051563 mRNA Translation: BAB72161.1
AB070852 mRNA Translation: BAB72164.1
AB070853 mRNA Translation: BAB72165.1
AK053844 mRNA Translation: BAC35553.1
BC042461 mRNA Translation: AAH42461.1
BC043939 mRNA Translation: AAH43939.1
CCDSiCCDS56673.1 [Q9WTQ5-1]
RefSeqiNP_112462.1, NM_031185.3 [Q9WTQ5-1]

3D structure databases

SMRiQ9WTQ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi219914, 11 interactors
ELMiQ9WTQ5
IntActiQ9WTQ5, 12 interactors
MINTiQ9WTQ5
STRINGi10090.ENSMUSP00000035829

PTM databases

iPTMnetiQ9WTQ5
PhosphoSitePlusiQ9WTQ5
SwissPalmiQ9WTQ5

Proteomic databases

CPTACinon-CPTAC-3631
jPOSTiQ9WTQ5
PaxDbiQ9WTQ5
PeptideAtlasiQ9WTQ5
PRIDEiQ9WTQ5

Genome annotation databases

EnsembliENSMUST00000045730; ENSMUSP00000035829; ENSMUSG00000038587 [Q9WTQ5-1]
ENSMUST00000215696; ENSMUSP00000150261; ENSMUSG00000038587 [Q9WTQ5-2]
GeneIDi83397
KEGGimmu:83397
UCSCiuc007ehh.1 mouse [Q9WTQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9590
MGIiMGI:1932576 Akap12

Phylogenomic databases

eggNOGiENOG410IFC9 Eukaryota
ENOG4110Y3C LUCA
GeneTreeiENSGT00730000111244
HOGENOMiHOG000293190
InParanoidiQ9WTQ5
KOiK16528
OMAiHDKDSEA
OrthoDBi158752at2759
PhylomeDBiQ9WTQ5
TreeFamiTF105411

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Akap12 mouse

Protein Ontology

More...
PROi
PR:Q9WTQ5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038587 Expressed in 273 organ(s), highest expression level in urinary bladder
ExpressionAtlasiQ9WTQ5 baseline and differential
GenevisibleiQ9WTQ5 MM

Family and domain databases

InterProiView protein in InterPro
IPR028540 AKAP12
IPR001573 Pkinase-A_anch_WSK-motif
IPR018459 RII_binding_1
PANTHERiPTHR23209 PTHR23209, 1 hit
PfamiView protein in Pfam
PF10522 RII_binding_1, 1 hit
PF03832 WSK, 3 hits
PROSITEiView protein in PROSITE
PS51893 AKAP_CAM_BD, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKA12_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WTQ5
Secondary accession number(s): Q80SS4
, Q810D4, Q8BPK4, Q99MP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: October 16, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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