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Protein

GTP:AMP phosphotransferase AK3, mitochondrial

Gene

Ak3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.UniRule annotation

Catalytic activityi

NTP + AMP = NDP + ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38AMPUniRule annotation1
Binding sitei43AMPUniRule annotation1
Binding sitei98AMPUniRule annotation1
Binding sitei128GTPUniRule annotation1
Binding sitei161AMPUniRule annotation1
Binding sitei172AMPUniRule annotation1
Binding sitei201GTP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22GTPUniRule annotation6
Nucleotide bindingi64 – 66AMPUniRule annotation3
Nucleotide bindingi91 – 94AMPUniRule annotation4
Nucleotide bindingi137 – 138GTPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
GTP:AMP phosphotransferase AK3, mitochondrialUniRule annotation (EC:2.7.4.10UniRule annotation)
Alternative name(s):
Adenylate kinase 3UniRule annotation
Short name:
AK 3UniRule annotation
Adenylate kinase 3 alpha-like 1UniRule annotation
Gene namesi
Name:Ak3
Synonyms:Ak3l, Ak3l1, Akl3l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1860835 Ak3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589231 – 227GTP:AMP phosphotransferase AK3, mitochondrialAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20N6-succinyllysineCombined sources1
Modified residuei29N6-acetyllysine; alternateCombined sources1
Modified residuei29N6-succinyllysine; alternateCombined sources1
Modified residuei34N6-acetyllysineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei57N6-succinyllysineCombined sources1
Modified residuei64N6-acetyllysine; alternateCombined sources1
Modified residuei64N6-succinyllysine; alternateCombined sources1
Modified residuei80N6-acetyllysine; alternateCombined sources1
Modified residuei80N6-succinyllysine; alternateCombined sources1
Modified residuei174N6-acetyllysine; alternateCombined sources1
Modified residuei174N6-succinyllysine; alternateCombined sources1
Modified residuei189N6-acetyllysine; alternateCombined sources1
Modified residuei189N6-succinyllysine; alternateCombined sources1
Modified residuei203N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9WTP7
MaxQBiQ9WTP7
PaxDbiQ9WTP7
PeptideAtlasiQ9WTP7
PRIDEiQ9WTP7

PTM databases

iPTMnetiQ9WTP7
PhosphoSitePlusiQ9WTP7
SwissPalmiQ9WTP7

Expressioni

Gene expression databases

BgeeiENSMUSG00000024782 Expressed in 317 organ(s), highest expression level in epithelium of stomach
CleanExiMM_AK3
MM_AK3L1
ExpressionAtlasiQ9WTP7 baseline and differential
GenevisibleiQ9WTP7 MM

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WTP7, 3 interactors
MINTiQ9WTP7
STRINGi10090.ENSMUSP00000025696

Structurei

3D structure databases

ProteinModelPortaliQ9WTP7
SMRiQ9WTP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 66NMPbindUniRule annotationAdd BLAST30
Regioni127 – 164LIDUniRule annotationAdd BLAST38

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family. AK3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
GeneTreeiENSGT00550000074679
HOGENOMiHOG000238772
HOVERGENiHBG000458
InParanoidiQ9WTP7
KOiK00944
OMAiVKNRWIH
OrthoDBiEOG091G06BH
PhylomeDBiQ9WTP7
TreeFamiTF312916

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
MF_03169 Adenylate_kinase_AK3, 1 hit
InterProiView protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR036193 ADK_active_lid_dom_sf
IPR028586 AK3/Ak4_mitochondrial
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191 ADK_lid, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
SSF57774 SSF57774, 1 hit
TIGRFAMsiTIGR01351 adk, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WTP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGASGRLLRA VIMGAPGSGK GTVSSRITKH FELKHLSSGD LLRQNMLQGT
60 70 80 90 100
EIGVLAKTFI DQGKLIPDDV MTRLALHELK TLTQCSWLLD GFPRTLPQAE
110 120 130 140 150
ALDKVYQIDT VINLNVPFEV IKQRLTARWI HPASGRVYNI EFNPPKTVGI
160 170 180 190 200
DDLTGEPLIQ REDDKPETVI KRLKAYEAQT EPVLQYYQKK GVLETFSGTE
210 220
TNKIWPHVYS FLQTKVPETT QKASVTP
Length:227
Mass (Da):25,426
Last modified:January 23, 2007 - v3
Checksum:i6601DF10971DE5AC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RP11F6RP11_MOUSE
GTP:AMP phosphotransferase AK3, mit...
Ak3
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171K → E in BAB23625 (PubMed:16141072).Curated1
Sequence conflicti202N → D in BAB23876 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004864 mRNA Translation: BAB23625.1
AK005194 mRNA Translation: BAB23876.1
AK008681 mRNA Translation: BAB25829.1
AK031631 mRNA Translation: BAC27488.1
AK053644 mRNA Translation: BAC35459.1
AK089027 mRNA Translation: BAC40707.1
AK147060 mRNA Translation: BAE27644.1
AK149996 mRNA Translation: BAE29224.1
BC016432 mRNA Translation: AAH16432.1
BC019174 mRNA Translation: AAH19174.1
BC024871 mRNA Translation: AAH24871.1
BC058191 mRNA Translation: AAH58191.1
AB020203 mRNA Translation: BAA77360.1
CCDSiCCDS29730.1
RefSeqiNP_067274.1, NM_021299.1
UniGeneiMm.196067

Genome annotation databases

EnsembliENSMUST00000025696; ENSMUSP00000025696; ENSMUSG00000024782
GeneIDi56248
KEGGimmu:56248
UCSCiuc008hcx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004864 mRNA Translation: BAB23625.1
AK005194 mRNA Translation: BAB23876.1
AK008681 mRNA Translation: BAB25829.1
AK031631 mRNA Translation: BAC27488.1
AK053644 mRNA Translation: BAC35459.1
AK089027 mRNA Translation: BAC40707.1
AK147060 mRNA Translation: BAE27644.1
AK149996 mRNA Translation: BAE29224.1
BC016432 mRNA Translation: AAH16432.1
BC019174 mRNA Translation: AAH19174.1
BC024871 mRNA Translation: AAH24871.1
BC058191 mRNA Translation: AAH58191.1
AB020203 mRNA Translation: BAA77360.1
CCDSiCCDS29730.1
RefSeqiNP_067274.1, NM_021299.1
UniGeneiMm.196067

3D structure databases

ProteinModelPortaliQ9WTP7
SMRiQ9WTP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WTP7, 3 interactors
MINTiQ9WTP7
STRINGi10090.ENSMUSP00000025696

PTM databases

iPTMnetiQ9WTP7
PhosphoSitePlusiQ9WTP7
SwissPalmiQ9WTP7

Proteomic databases

EPDiQ9WTP7
MaxQBiQ9WTP7
PaxDbiQ9WTP7
PeptideAtlasiQ9WTP7
PRIDEiQ9WTP7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025696; ENSMUSP00000025696; ENSMUSG00000024782
GeneIDi56248
KEGGimmu:56248
UCSCiuc008hcx.1 mouse

Organism-specific databases

CTDi50808
MGIiMGI:1860835 Ak3

Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
GeneTreeiENSGT00550000074679
HOGENOMiHOG000238772
HOVERGENiHBG000458
InParanoidiQ9WTP7
KOiK00944
OMAiVKNRWIH
OrthoDBiEOG091G06BH
PhylomeDBiQ9WTP7
TreeFamiTF312916

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

PROiPR:Q9WTP7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024782 Expressed in 317 organ(s), highest expression level in epithelium of stomach
CleanExiMM_AK3
MM_AK3L1
ExpressionAtlasiQ9WTP7 baseline and differential
GenevisibleiQ9WTP7 MM

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
MF_03169 Adenylate_kinase_AK3, 1 hit
InterProiView protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR036193 ADK_active_lid_dom_sf
IPR028586 AK3/Ak4_mitochondrial
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191 ADK_lid, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
SSF57774 SSF57774, 1 hit
TIGRFAMsiTIGR01351 adk, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAD3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTP7
Secondary accession number(s): Q3UDN7
, Q8BGX5, Q9D7Z1, Q9DB57, Q9DBM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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