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Protein

SAM pointed domain-containing Ets transcription factor

Gene

Spdef

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi239 – 322ETSPROSITE-ProRule annotationAdd BLAST84

GO - Molecular functioni

GO - Biological processi

  • intestinal epithelial cell development Source: MGI
  • lung goblet cell differentiation Source: MGI
  • negative regulation of cell fate commitment Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of cell fate commitment Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SAM pointed domain-containing Ets transcription factor
Alternative name(s):
Prostate epithelium-specific Ets transcription factor
Short name:
Prostate-specific Ets
Prostate-derived Ets factor
Gene namesi
Name:Spdef
Synonyms:Pdef, Pse
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1353422 Spdef

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239591 – 325SAM pointed domain-containing Ets transcription factorAdd BLAST325

Proteomic databases

PaxDbiQ9WTP3
PRIDEiQ9WTP3

PTM databases

PhosphoSitePlusiQ9WTP3

Expressioni

Tissue specificityi

Expressed in the accessory glands of sex organs including the prostate, seminal vesicle, coagulating gland in males, the oviduct in females, and in intestines. Expression is epithelial-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000024215
ExpressionAtlasiQ9WTP3 baseline and differential
GenevisibleiQ9WTP3 MM

Interactioni

Subunit structurei

Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205953, 2 interactors
STRINGi10090.ENSMUSP00000025054

Structurei

3D structure databases

ProteinModelPortaliQ9WTP3
SMRiQ9WTP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 203PNTPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3805 Eukaryota
ENOG410XSXU LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000237327
HOVERGENiHBG080776
InParanoidiQ9WTP3
KOiK09442
OMAiYPEDSSW
OrthoDBiEOG091G07NK
PhylomeDBiQ9WTP3
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9WTP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSASPGLSN VSPGCLLLFP DVAPRTGTEK AASGAMGPEK QEWSPSPPAT
60 70 80 90 100
PEQGLSAFYL SYFNMYPDDS SWVAKVPEAR AGEDHPEEPE QCPVIDSQAS
110 120 130 140 150
GSTLDEHSLE QVQSMVVGEV LKDIETACKL LNITADPGDW SPGNVQKWLL
160 170 180 190 200
WTEHQYRLPP AGKAFQELGG KELCAMSEEQ FRQRAPLGGD VLHAHLDIWK
210 220 230 240 250
SAAWMKERTS PGTLHYCAST SEEGWTDGEV DSSCSGQPIH LWQFLKELLL
260 270 280 290 300
KPHSYGRFIR WLNKEKGIFK IEDSAQVARL WGVRKNRPAM NYDKLSRSIR
310 320
QYYKKGIIRK PDISQRLVYQ FVHPV
Length:325
Mass (Da):36,356
Last modified:November 1, 1999 - v1
Checksum:iB55CF6CEC4501125
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019436 mRNA Translation: BAA77329.1
AK078863 mRNA Translation: BAC37426.1
BC012648 mRNA Translation: AAH12648.1
CCDSiCCDS28568.1
RefSeqiNP_038919.1, NM_013891.4
XP_006524442.1, XM_006524379.3
XP_006524443.1, XM_006524380.3
XP_006524444.1, XM_006524381.3
XP_017172988.1, XM_017317499.1
UniGeneiMm.26768

Genome annotation databases

EnsembliENSMUST00000025054; ENSMUSP00000025054; ENSMUSG00000024215
ENSMUST00000114870; ENSMUSP00000110520; ENSMUSG00000024215
ENSMUST00000167489; ENSMUSP00000127056; ENSMUSG00000024215
GeneIDi30051
KEGGimmu:30051
UCSCiuc008bpo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSPDEF_MOUSE
AccessioniPrimary (citable) accession number: Q9WTP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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