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UniProtKB - Q9WTP3 (SPDEF_MOUSE)
Protein
SAM pointed domain-containing Ets transcription factor
Gene
Spdef
Organism
Mus musculus (Mouse)
Status
Functioni
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 239 – 322 | ETSPROSITE-ProRule annotationAdd BLAST | 84 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: GO_Central
- intestinal epithelial cell development Source: MGI
- lung goblet cell differentiation Source: MGI
- negative regulation of cell fate commitment Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell fate commitment Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: SAM pointed domain-containing Ets transcription factorAlternative name(s): Prostate epithelium-specific Ets transcription factor Short name: Prostate-specific Ets Prostate-derived Ets factor |
Gene namesi | Name:Spdef Synonyms:Pdef, Pse |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353422, Spdef |
VEuPathDBi | HostDB:ENSMUSG00000024215 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223959 | 1 – 325 | SAM pointed domain-containing Ets transcription factorAdd BLAST | 325 |
Proteomic databases
PaxDbi | Q9WTP3 |
PRIDEi | Q9WTP3 |
ProteomicsDBi | 261127 |
PTM databases
PhosphoSitePlusi | Q9WTP3 |
Expressioni
Tissue specificityi
Expressed in the accessory glands of sex organs including the prostate, seminal vesicle, coagulating gland in males, the oviduct in females, and in intestines. Expression is epithelial-specific.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000024215, Expressed in duodenum and 140 other tissues |
ExpressionAtlasi | Q9WTP3, baseline and differential |
Genevisiblei | Q9WTP3, MM |
Interactioni
Subunit structurei
Interacts with the DNA-binding domain of the androgen receptor.
Interacts with NKX3-1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 205953, 2 interactors |
IntActi | Q9WTP3, 1 interactor |
STRINGi | 10090.ENSMUSP00000110520 |
Miscellaneous databases
RNActi | Q9WTP3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 119 – 203 | PNTPROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 50 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 79 – 100 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3805, Eukaryota |
GeneTreei | ENSGT00940000157549 |
HOGENOMi | CLU_877059_0_0_1 |
InParanoidi | Q9WTP3 |
OMAi | DPIEWNT |
OrthoDBi | 908495at2759 |
PhylomeDBi | Q9WTP3 |
TreeFami | TF318679 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9WTP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSASPGLSN VSPGCLLLFP DVAPRTGTEK AASGAMGPEK QEWSPSPPAT
60 70 80 90 100
PEQGLSAFYL SYFNMYPDDS SWVAKVPEAR AGEDHPEEPE QCPVIDSQAS
110 120 130 140 150
GSTLDEHSLE QVQSMVVGEV LKDIETACKL LNITADPGDW SPGNVQKWLL
160 170 180 190 200
WTEHQYRLPP AGKAFQELGG KELCAMSEEQ FRQRAPLGGD VLHAHLDIWK
210 220 230 240 250
SAAWMKERTS PGTLHYCAST SEEGWTDGEV DSSCSGQPIH LWQFLKELLL
260 270 280 290 300
KPHSYGRFIR WLNKEKGIFK IEDSAQVARL WGVRKNRPAM NYDKLSRSIR
310 320
QYYKKGIIRK PDISQRLVYQ FVHPV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3F2YNL9 | A0A3F2YNL9_MOUSE | SAM pointed domain-containing Ets t... | Spdef | 309 | Annotation score: | ||
B2KF87 | B2KF87_MOUSE | SAM pointed domain-containing Ets t... | Spdef | 126 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB019436 mRNA Translation: BAA77329.1 AK078863 mRNA Translation: BAC37426.1 BC012648 mRNA Translation: AAH12648.1 |
CCDSi | CCDS28568.1 |
RefSeqi | NP_038919.1, NM_013891.4 XP_006524442.1, XM_006524379.3 XP_006524443.1, XM_006524380.3 XP_006524444.1, XM_006524381.3 XP_017172988.1, XM_017317499.1 |
Genome annotation databases
Ensembli | ENSMUST00000025054; ENSMUSP00000025054; ENSMUSG00000024215 ENSMUST00000167489; ENSMUSP00000127056; ENSMUSG00000024215 |
GeneIDi | 30051 |
KEGGi | mmu:30051 |
UCSCi | uc008bpo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB019436 mRNA Translation: BAA77329.1 AK078863 mRNA Translation: BAC37426.1 BC012648 mRNA Translation: AAH12648.1 |
CCDSi | CCDS28568.1 |
RefSeqi | NP_038919.1, NM_013891.4 XP_006524442.1, XM_006524379.3 XP_006524443.1, XM_006524380.3 XP_006524444.1, XM_006524381.3 XP_017172988.1, XM_017317499.1 |
3D structure databases
SMRi | Q9WTP3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205953, 2 interactors |
IntActi | Q9WTP3, 1 interactor |
STRINGi | 10090.ENSMUSP00000110520 |
PTM databases
PhosphoSitePlusi | Q9WTP3 |
Proteomic databases
PaxDbi | Q9WTP3 |
PRIDEi | Q9WTP3 |
ProteomicsDBi | 261127 |
Protocols and materials databases
Antibodypediai | 15077, 231 antibodies from 30 providers |
DNASUi | 30051 |
Genome annotation databases
Ensembli | ENSMUST00000025054; ENSMUSP00000025054; ENSMUSG00000024215 ENSMUST00000167489; ENSMUSP00000127056; ENSMUSG00000024215 |
GeneIDi | 30051 |
KEGGi | mmu:30051 |
UCSCi | uc008bpo.2, mouse |
Organism-specific databases
CTDi | 25803 |
MGIi | MGI:1353422, Spdef |
VEuPathDBi | HostDB:ENSMUSG00000024215 |
Phylogenomic databases
eggNOGi | KOG3805, Eukaryota |
GeneTreei | ENSGT00940000157549 |
HOGENOMi | CLU_877059_0_0_1 |
InParanoidi | Q9WTP3 |
OMAi | DPIEWNT |
OrthoDBi | 908495at2759 |
PhylomeDBi | Q9WTP3 |
TreeFami | TF318679 |
Miscellaneous databases
BioGRID-ORCSi | 30051, 2 hits in 66 CRISPR screens |
PROi | PR:Q9WTP3 |
RNActi | Q9WTP3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024215, Expressed in duodenum and 140 other tissues |
ExpressionAtlasi | Q9WTP3, baseline and differential |
Genevisiblei | Q9WTP3, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPDEF_MOUSE | |
Accessioni | Q9WTP3Primary (citable) accession number: Q9WTP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families