UniProtKB - Q9WTN3 (SRBP1_MOUSE)
Sterol regulatory element-binding protein 1
Srebf1
Functioni
Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:11782483, PubMed:12855691, PubMed:19244231).
Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:11782483, PubMed:12855691, PubMed:16100574, PubMed:19244231).
4 PublicationsKey transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed:19244231, PubMed:17290224, PubMed:9329978, PubMed:9784493, PubMed:21459323).
Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (By similarity).
Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity).
Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed:19244231, PubMed:17290224, PubMed:9329978, PubMed:9784493, PubMed:21459323).
By similarity5 PublicationsIsoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (PubMed:12855691, PubMed:21531336).
Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed:8833906).
Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (PubMed:9062341, PubMed:12855691).
Required for innate immune response in macrophages by regulating lipid metabolism (PubMed:21531336).
4 PublicationsPredominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (PubMed:12855691, PubMed:21531336).
Primarily controls expression of lipogenic gene (PubMed:8833906, PubMed:9062341).
Strongly activates global lipid synthesis in rapidly growing cells (PubMed:8833906, PubMed:9062341).
4 PublicationsGO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: HGNC-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- nuclear receptor activity Source: MGI
- protein-containing complex binding Source: MGI
- protein dimerization activity Source: InterPro
- protein kinase binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- sterol response element binding Source: HGNC-UCL
- transcription coregulator binding Source: MGI
GO - Biological processi
- aging Source: Ensembl
- cellular response to fatty acid Source: Ensembl
- cellular response to starvation Source: HGNC-UCL
- cholesterol metabolic process Source: MGI
- circadian rhythm Source: UniProtKB
- fat cell differentiation Source: MGI
- insulin receptor signaling pathway Source: MGI
- lipid biosynthetic process Source: UniProtKB
- lipid localization Source: Ensembl
- lung development Source: Ensembl
- mRNA transcription by RNA polymerase II Source: MGI
- negative regulation of insulin secretion Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of cholesterol biosynthetic process Source: UniProtKB
- positive regulation of fatty acid biosynthetic process Source: BHF-UCL
- positive regulation of histone deacetylation Source: MGI
- positive regulation of innate immune response Source: UniProtKB
- positive regulation of lipid biosynthetic process Source: UniProtKB
- positive regulation of miRNA transcription Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of triglyceride biosynthetic process Source: UniProtKB
- regulation of autophagy of mitochondrion Source: MGI
- regulation of fatty acid metabolic process Source: MGI
- regulation of heart rate by chemical signal Source: MGI
- regulation of insulin secretion Source: MGI
- regulation of lipid storage Source: Ensembl
- regulation of protein stability Source: MGI
- regulation of protein targeting to mitochondrion Source: MGI
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to cAMP Source: Ensembl
- response to ethanol Source: Ensembl
- response to food Source: Ensembl
- response to glucagon Source: Ensembl
- response to glucose Source: MGI
- response to progesterone Source: Ensembl
- response to retinoic acid Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- SREBP signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-1655829, Regulation of cholesterol biosynthesis by SREBP (SREBF) [Q9WTN3-1] |
Names & Taxonomyi
Protein namesi | Recommended name: Sterol regulatory element-binding protein 12 PublicationsShort name: SREBP-12 Publications Alternative name(s): Sterol regulatory element-binding transcription factor 12 Publications Cleaved into the following chain: Alternative name(s): Transcription factor SREBF1Curated |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107606, Srebf1 |
VEuPathDBi | HostDB:ENSMUSG00000020538 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- COPII-coated vesicle membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:21459323). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:21459323).1 Publication
Nucleus
- Nucleus 3 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: BHF-UCL
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 477 | CytoplasmicSequence analysisAdd BLAST | 477 | |
Transmembranei | 478 – 498 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 499 – 536 | LumenalSequence analysisAdd BLAST | 38 | |
Transmembranei | 537 – 557 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 558 – 1134 | CytoplasmicSequence analysisAdd BLAST | 577 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 331 | S → A: Weakly affects phosphorylation by SIK1. 1 Publication | 1 | |
Mutagenesisi | 332 | S → A: Weakly affects phosphorylation by SIK1. 1 Publication | 1 | |
Mutagenesisi | 354 | S → A: Does not affect AMPK-mediated phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 389 | S → A: Abolishes AMPK-mediated phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 395 | S → A: Strongly impairs affects phosphorylation by SIK1. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3616359 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127448 | 1 – 1134 | Sterol regulatory element-binding protein 1Add BLAST | 1134 | |
ChainiPRO_0000314030 | 1 – 480 | Processed sterol regulatory element-binding protein 1By similarityAdd BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 96 | PhosphoserineBy similarity | 1 | |
Modified residuei | 115 | PhosphoserineBy similarity | 1 | |
Modified residuei | 331 | Phosphoserine; by SIK11 Publication | 1 | |
Modified residuei | 332 | Phosphoserine; by SIK11 Publication | 1 | |
Modified residuei | 389 | Phosphoserine; by AMPK1 Publication | 1 | |
Modified residuei | 395 | Phosphoserine; by SIK11 Publication | 1 | |
Modified residuei | 448 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1047 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 451 – 452 | Cleavage; by caspase-3 and caspase-7By similarity | 2 | |
Sitei | 480 – 481 | Cleavage; by MBTPS2By similarity | 2 | |
Sitei | 519 – 520 | Cleavage; by MBTPS1By similarity | 2 |
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q9WTN3 |
PaxDbi | Q9WTN3 |
PRIDEi | Q9WTN3 |
ProteomicsDBi | 254555 [Q9WTN3-1] 254556 [Q9WTN3-2] 254557 [Q9WTN3-3] 254558 [Q9WTN3-4] |
PTM databases
iPTMneti | Q9WTN3 |
PhosphoSitePlusi | Q9WTN3 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000020538, Expressed in liver and 128 other tissues |
ExpressionAtlasi | Q9WTN3, baseline and differential |
Genevisiblei | Q9WTN3, MM |
Interactioni
Subunit structurei
Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane.
By similarityBinary interactionsi
Q9WTN3
With | #Exp. | IntAct |
---|---|---|
Sirt1 [Q923E4] | 2 | EBI-5273743,EBI-1802585 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- protein kinase binding Source: UniProtKB
- transcription coregulator binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203495, 8 interactors |
IntActi | Q9WTN3, 6 interactors |
MINTi | Q9WTN3 |
STRINGi | 10090.ENSMUSP00000020846 |
Miscellaneous databases
RNActi | Q9WTN3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 317 – 367 | bHLHPROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | Transcriptional activation (acidic)By similarityAdd BLAST | 60 | |
Regioni | 46 – 73 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 130 – 149 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 170 – 195 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 227 – 487 | Interaction with LMNA1 PublicationAdd BLAST | 261 | |
Regioni | 367 – 388 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 415 – 468 | DisorderedSequence analysisAdd BLAST | 54 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 27 – 35 | 9aaTADBy similarity | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 422 – 453 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2588, Eukaryota |
GeneTreei | ENSGT00940000159156 |
InParanoidi | Q9WTN3 |
OMAi | QLCQHIP |
OrthoDBi | 330300at2759 |
PhylomeDBi | Q9WTN3 |
TreeFami | TF313894 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDELAFGEAA LEQTLAEMCE LDTAVLNDIE DMLQLINNQD SDFPGLFDAP
60 70 80 90 100
YAGGETGDTG PSSPGANSPE SFSSASLASS LEAFLGGPKV TPAPLSPPPS
110 120 130 140 150
APAALKMYPS VSPFSPGPGI KEEPVPLTIL QPAAPQPSPG TLLPPSFPAP
160 170 180 190 200
PVQLSPAPVL GYSSLPSGFS GTLPGNTQQP PSSLPLAPAP GVLPTPALHT
210 220 230 240 250
QVQSLASQQP LPASAAPRTN TVTSQVQQVP VVLQPHFIKA DSLLLTAVKT
260 270 280 290 300
DAGATVKTAG ISTLAPGTAV QAGPLQTLVS GGTILATVPL VVDTDKLPIH
310 320 330 340 350
RLAAGSKALG SAQSRGEKRT AHNAIEKRYR SSINDKIVEL KDLVVGTEAK
360 370 380 390 400
LNKSAVLRKA IDYIRFLQHS NQKLKQENLT LRSAHKSKSL KDLVSACGSG
410 420 430 440 450
GGTDVSMEGM KPEVVETLTP PPSDAGSPSQ SSPLSFGSRA SSSGGSDSEP
460 470 480 490 500
DSPAFEDSQV KAQRLPSHSR GMLDRSRLAL CVLAFLCLTC NPLASLFGWG
510 520 530 540 550
ILTPSDATGT HRSSGRSMLE AESRDGSNWT QWLLPPLVWL ANGLLVLACL
560 570 580 590 600
ALLFVYGEPV TRPHSGPAVH FWRHRKQADL DLARGDFPQA AQQLWLALQA
610 620 630 640 650
LGRPLPTSNL DLACSLLWNL IRHLLQRLWV GRWLAGQAGG LLRDRGLRKD
660 670 680 690 700
ARASARDAAV VYHKLHQLHA MGKYTGGHLA ASNLALSALN LAECAGDAIS
710 720 730 740 750
MATLAEIYVA AALRVKTSLP RALHFLTRFF LSSARQACLA QSGSVPLAMQ
760 770 780 790 800
WLCHPVGHRF FVDGDWAVHG APPESLYSVA GNPVDPLAQV TRLFREHLLE
810 820 830 840 850
RALNCIAQPS PGAADGDREF SDALGYLQLL NSCSDAAGAP ACSFSVSSSM
860 870 880 890 900
AATTGPDPVA KWWASLTAVV IHWLRRDEEA AERLYPLVEH IPQVLQDTER
910 920 930 940 950
PLPRAALYSF KAARALLDHR KVESSPASLA ICEKASGYLR DSLASTPTGS
960 970 980 990 1000
SIDKAMQLLL CDLLLVARTS LWQRQQSPAS VQVAHGTSNG PQASALELRG
1010 1020 1030 1040 1050
FQHDLSSLRR LAQSFRPAMR RVFLHEATAR LMAGASPART HQLLDRSLRR
1060 1070 1080 1090 1100
RAGSSGKGGT TAELEPRPTW REHTEALLLA SCYLPPAFLS APGQRMSMLA
1110 1120 1130
EAARTVEKLG DHRLLLDCQQ MLLRLGGGTT VTSS
The sequence of this isoform differs from the canonical sequence as follows:
90-131: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MDELAFGEAALEQTLAEMCELDTAVLNDI → MDCTF
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MDELAFGEAALEQTLAEMCELDTAVLNDI → MDCTF
90-131: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6XZS9 | F6XZS9_MOUSE | Sterol regulatory element-binding p... | Srebf1 | 1,076 | Annotation score: | ||
A0A0A0MQK3 | A0A0A0MQK3_MOUSE | Sterol regulatory element-binding p... | Srebf1 | 1,022 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 272 – 276 | Missing in BAE32576 (PubMed:16141072).Curated | 5 | |
Sequence conflicti | 272 – 276 | Missing in AAK54762 (Ref. 6) Curated | 5 | |
Sequence conflicti | 795 | R → P in BAE29268 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1003 | H → N in AAH06051 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1061 | T → A in AAH06051 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002151 | 1 – 29 | MDELA…VLNDI → MDCTF in isoform SREBP-1C and isoform SREBP-1C-W42. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_002152 | 90 – 131 | Missing in isoform SREBP-1A-W42 and isoform SREBP-1C-W42. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052628 mRNA Translation: BAC35068.1 AK150052 mRNA Translation: BAE29268.1 AK154424 mRNA Translation: BAE32576.1 AK169607 mRNA Translation: BAE41256.1 AL669954 Genomic DNA No translation available. BC006051 mRNA Translation: AAH06051.1 BC056922 mRNA Translation: AAH56922.1 AB017337 mRNA Translation: BAA74795.1 AF374266 mRNA Translation: AAK54762.1 |
CCDSi | CCDS24785.1 [Q9WTN3-1] |
PIRi | PD0035 |
RefSeqi | NP_001300908.1, NM_001313979.1 NP_035610.1, NM_011480.4 [Q9WTN3-1] XP_006532778.1, XM_006532715.2 |
Genome annotation databases
Ensembli | ENSMUST00000020846; ENSMUSP00000020846; ENSMUSG00000020538 [Q9WTN3-1] |
GeneIDi | 20787 |
KEGGi | mmu:20787 |
UCSCi | uc007jfn.1, mouse [Q9WTN3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052628 mRNA Translation: BAC35068.1 AK150052 mRNA Translation: BAE29268.1 AK154424 mRNA Translation: BAE32576.1 AK169607 mRNA Translation: BAE41256.1 AL669954 Genomic DNA No translation available. BC006051 mRNA Translation: AAH06051.1 BC056922 mRNA Translation: AAH56922.1 AB017337 mRNA Translation: BAA74795.1 AF374266 mRNA Translation: AAK54762.1 |
CCDSi | CCDS24785.1 [Q9WTN3-1] |
PIRi | PD0035 |
RefSeqi | NP_001300908.1, NM_001313979.1 NP_035610.1, NM_011480.4 [Q9WTN3-1] XP_006532778.1, XM_006532715.2 |
3D structure databases
AlphaFoldDBi | Q9WTN3 |
SMRi | Q9WTN3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203495, 8 interactors |
IntActi | Q9WTN3, 6 interactors |
MINTi | Q9WTN3 |
STRINGi | 10090.ENSMUSP00000020846 |
Chemistry databases
ChEMBLi | CHEMBL3616359 |
PTM databases
iPTMneti | Q9WTN3 |
PhosphoSitePlusi | Q9WTN3 |
Proteomic databases
MaxQBi | Q9WTN3 |
PaxDbi | Q9WTN3 |
PRIDEi | Q9WTN3 |
ProteomicsDBi | 254555 [Q9WTN3-1] 254556 [Q9WTN3-2] 254557 [Q9WTN3-3] 254558 [Q9WTN3-4] |
Protocols and materials databases
Antibodypediai | 3952, 640 antibodies from 39 providers |
DNASUi | 20787 |
Genome annotation databases
Ensembli | ENSMUST00000020846; ENSMUSP00000020846; ENSMUSG00000020538 [Q9WTN3-1] |
GeneIDi | 20787 |
KEGGi | mmu:20787 |
UCSCi | uc007jfn.1, mouse [Q9WTN3-1] |
Organism-specific databases
CTDi | 6720 |
MGIi | MGI:107606, Srebf1 |
VEuPathDBi | HostDB:ENSMUSG00000020538 |
Phylogenomic databases
eggNOGi | KOG2588, Eukaryota |
GeneTreei | ENSGT00940000159156 |
InParanoidi | Q9WTN3 |
OMAi | QLCQHIP |
OrthoDBi | 330300at2759 |
PhylomeDBi | Q9WTN3 |
TreeFami | TF313894 |
Enzyme and pathway databases
Reactomei | R-MMU-1655829, Regulation of cholesterol biosynthesis by SREBP (SREBF) [Q9WTN3-1] |
Miscellaneous databases
BioGRID-ORCSi | 20787, 5 hits in 76 CRISPR screens |
ChiTaRSi | Srebf1, mouse |
PROi | PR:Q9WTN3 |
RNActi | Q9WTN3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020538, Expressed in liver and 128 other tissues |
ExpressionAtlasi | Q9WTN3, baseline and differential |
Genevisiblei | Q9WTN3, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SRBP1_MOUSE | |
Accessioni | Q9WTN3Primary (citable) accession number: Q9WTN3 Secondary accession number(s): Q3U458 Q99JK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | July 24, 2007 | |
Last modified: | May 25, 2022 | |
This is version 197 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families