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Protein

Nuclear factor erythroid 2-related factor 3

Gene

Nfe2l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates erythroid-specific, globin gene expression.

GO - Molecular functioni

  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name:
NF-E2-related factor 3
Short name:
NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene namesi
Name:Nfe2l3
Synonyms:Nrf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1339958 Nfe2l3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764531 – 660Nuclear factor erythroid 2-related factor 3Add BLAST660

Proteomic databases

PaxDbiQ9WTM4
PRIDEiQ9WTM4

Expressioni

Tissue specificityi

High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary.1 Publication

Gene expression databases

BgeeiENSMUSG00000029832 Expressed in 202 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_NFE2L3
ExpressionAtlasiQ9WTM4 baseline and differential
GenevisibleiQ9WTM4 MM

Interactioni

Subunit structurei

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005103

Structurei

3D structure databases

ProteinModelPortaliQ9WTM4
SMRiQ9WTM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini541 – 604bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni543 – 562Basic motifPROSITE-ProRule annotationAdd BLAST20
Regioni566 – 573Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

eggNOGiKOG3863 Eukaryota
ENOG410ZGMS LUCA
GeneTreeiENSGT00920000148991
HOGENOMiHOG000234410
HOVERGENiHBG052609
InParanoidiQ9WTM4
KOiK09040
OMAiPFIPRTR
OrthoDBiEOG091G02EB
PhylomeDBiQ9WTM4
TreeFamiTF337360

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029854 NF2L3
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR24411:SF8 PTHR24411:SF8, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WTM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT
60 70 80 90 100
RPASASNPFS ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH
110 120 130 140 150
SVATGNADGA HGLLGTAASS AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE
160 170 180 190 200
EKAAEPTAQV PDAGGCGSQE NGMLREKSEA VDHSSQQEEN EEGVSAQAKS
210 220 230 240 250
RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL EDLFQLLSSQ
260 270 280 290 300
PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY
310 320 330 340 350
PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS
360 370 380 390 400
QDLLYDLDSN IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS
410 420 430 440 450
LTNSYRIYDG TVGYNSDLQS LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH
460 470 480 490 500
VSLECQQVFH DHTYHLQSGA SEPTSESFAW SEKSQKTSGC LDNPDRNLSR
510 520 530 540 550
DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS LIRDIRRRGK
560 570 580 590 600
NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK
610 620 630 640 650
LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE
660
APKGKRERRN
Length:660
Mass (Da):72,707
Last modified:November 1, 1999 - v1
Checksum:iF5CBEEA77E6F4438
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWE6E9PWE6_MOUSE
Nuclear factor erythroid 2-related ...
Nfe2l3
264Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013852 mRNA Translation: BAA76289.1
BC005416 mRNA Translation: AAH05416.1
CCDSiCCDS20134.1
RefSeqiNP_035033.1, NM_010903.1
UniGeneiMm.42138

Genome annotation databases

EnsembliENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832
GeneIDi18025
KEGGimmu:18025
UCSCiuc009bxl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013852 mRNA Translation: BAA76289.1
BC005416 mRNA Translation: AAH05416.1
CCDSiCCDS20134.1
RefSeqiNP_035033.1, NM_010903.1
UniGeneiMm.42138

3D structure databases

ProteinModelPortaliQ9WTM4
SMRiQ9WTM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005103

Proteomic databases

PaxDbiQ9WTM4
PRIDEiQ9WTM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832
GeneIDi18025
KEGGimmu:18025
UCSCiuc009bxl.1 mouse

Organism-specific databases

CTDi9603
MGIiMGI:1339958 Nfe2l3

Phylogenomic databases

eggNOGiKOG3863 Eukaryota
ENOG410ZGMS LUCA
GeneTreeiENSGT00920000148991
HOGENOMiHOG000234410
HOVERGENiHBG052609
InParanoidiQ9WTM4
KOiK09040
OMAiPFIPRTR
OrthoDBiEOG091G02EB
PhylomeDBiQ9WTM4
TreeFamiTF337360

Miscellaneous databases

PROiPR:Q9WTM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029832 Expressed in 202 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_NFE2L3
ExpressionAtlasiQ9WTM4 baseline and differential
GenevisibleiQ9WTM4 MM

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029854 NF2L3
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR24411:SF8 PTHR24411:SF8, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNF2L3_MOUSE
AccessioniPrimary (citable) accession number: Q9WTM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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