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UniProtKB - Q9WTM4 (NF2L3_MOUSE)
Protein
Nuclear factor erythroid 2-related factor 3
Gene
Nfe2l3
Organism
Mus musculus (Mouse)
Status
Functioni
Activates erythroid-specific, globin gene expression.
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor erythroid 2-related factor 3Short name: NF-E2-related factor 3 Short name: NFE2-related factor 3 Alternative name(s): Nuclear factor, erythroid derived 2, like 3 |
Gene namesi | Name:Nfe2l3 Synonyms:Nrf3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339958, Nfe2l3 |
VEuPathDBi | HostDB:ENSMUSG00000029832 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
- RNA polymerase II transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076453 | 1 – 660 | Nuclear factor erythroid 2-related factor 3Add BLAST | 660 |
Proteomic databases
PaxDbi | Q9WTM4 |
PRIDEi | Q9WTM4 |
Expressioni
Tissue specificityi
High level expression in brain, thymus, testis and placenta. Medium level expression in uterus, stomach and lung. Low level expression in kidney. No expression in heart, liver, spleen and ovary.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029832, Expressed in urinary bladder urothelium and 234 other tissues |
ExpressionAtlasi | Q9WTM4, baseline and differential |
Genevisiblei | Q9WTM4, MM |
Interactioni
Subunit structurei
Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000005103 |
Miscellaneous databases
RNActi | Q9WTM4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 541 – 604 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 120 – 214 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 543 – 562 | Basic motifPROSITE-ProRule annotationAdd BLAST | 20 | |
Regioni | 566 – 573 | Leucine-zipperPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 142 – 156 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 175 – 189 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | Q9WTM4 |
OMAi | LKRWWSA |
OrthoDBi | 1095280at2759 |
PhylomeDBi | Q9WTM4 |
TreeFami | TF337360 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR046347, bZIP_sf IPR029854, NF2L3 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF8, PTHR24411:SF8, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WTM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLPKPWWAG GGLLQLTILL SLVGLRVDLD LFLPPPAAAL WEELLPLCPT
60 70 80 90 100
RPASASNPFS ASEGWERTPL LPAKGRLLHE VRALGVPFIP RTRVDAWLVH
110 120 130 140 150
SVATGNADGA HGLLGTAASS AVGDGGQSAS AGGGDPRAAH SSPLAAEEEE
160 170 180 190 200
EKAAEPTAQV PDAGGCGSQE NGMLREKSEA VDHSSQQEEN EEGVSAQAKS
210 220 230 240 250
RQQSKTEEHK MACASAREAE KITEARNESH LHWSDTSFSL EDLFQLLSSQ
260 270 280 290 300
PEHSLEGISV EDIPPFLSSV CESVNSSAQN INLSQAISHD VNLHEAMLLY
310 320 330 340 350
PNNTFRRDPS ARSSQAQEPF LQLNPHTNPE QATPAMSLPP FDNQMRNLTS
360 370 380 390 400
QDLLYDLDSN IFDGINLMSL ATGFSPLEVS QLFEEPDSGL SLNSSYNSTS
410 420 430 440 450
LTNSYRIYDG TVGYNSDLQS LCHDLGAVGG CYPEPHKHCH MDHRTIAGFH
460 470 480 490 500
VSLECQQVFH DHTYHLQSGA SEPTSESFAW SEKSQKTSGC LDNPDRNLSR
510 520 530 540 550
DEQRAKALHI PFSVDEIVRM PVDSFNSMLS RYYLTDLQVS LIRDIRRRGK
560 570 580 590 600
NKVAAQNCRK RKLDIILNLE DDICNLQAKK EALKNEQTQC SKAIDIMRQK
610 620 630 640 650
LHGLHQDVFN RLRDDQGRPV NPSQYALQYS HDGTVLIVPK ELISSGHKKE
660
APKGKRERRN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PWE6 | E9PWE6_MOUSE | Nuclear factor erythroid 2-related ... | Nfe2l3 | 264 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB013852 mRNA Translation: BAA76289.1 BC005416 mRNA Translation: AAH05416.1 |
CCDSi | CCDS20134.1 |
RefSeqi | NP_035033.1, NM_010903.1 |
Genome annotation databases
Ensembli | ENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832 |
GeneIDi | 18025 |
KEGGi | mmu:18025 |
UCSCi | uc009bxl.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB013852 mRNA Translation: BAA76289.1 BC005416 mRNA Translation: AAH05416.1 |
CCDSi | CCDS20134.1 |
RefSeqi | NP_035033.1, NM_010903.1 |
3D structure databases
AlphaFoldDBi | Q9WTM4 |
SMRi | Q9WTM4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000005103 |
Proteomic databases
PaxDbi | Q9WTM4 |
PRIDEi | Q9WTM4 |
Protocols and materials databases
Antibodypediai | 12307, 183 antibodies from 27 providers |
DNASUi | 18025 |
Genome annotation databases
Ensembli | ENSMUST00000005103; ENSMUSP00000005103; ENSMUSG00000029832 |
GeneIDi | 18025 |
KEGGi | mmu:18025 |
UCSCi | uc009bxl.1, mouse |
Organism-specific databases
CTDi | 9603 |
MGIi | MGI:1339958, Nfe2l3 |
VEuPathDBi | HostDB:ENSMUSG00000029832 |
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | Q9WTM4 |
OMAi | LKRWWSA |
OrthoDBi | 1095280at2759 |
PhylomeDBi | Q9WTM4 |
TreeFami | TF337360 |
Miscellaneous databases
BioGRID-ORCSi | 18025, 5 hits in 76 CRISPR screens |
ChiTaRSi | Nfe2l3, mouse |
PROi | PR:Q9WTM4 |
RNActi | Q9WTM4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029832, Expressed in urinary bladder urothelium and 234 other tissues |
ExpressionAtlasi | Q9WTM4, baseline and differential |
Genevisiblei | Q9WTM4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR046347, bZIP_sf IPR029854, NF2L3 IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR24411:SF8, PTHR24411:SF8, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NF2L3_MOUSE | |
Accessioni | Q9WTM4Primary (citable) accession number: Q9WTM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families