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Protein

Semaphorin-6C

Gene

Sema6c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity).By similarity

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-6C
Alternative name(s):
Semaphorin-Y
Short name:
Sema Y
Gene namesi
Name:Sema6c
Synonyms:Semay
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338032 Sema6c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 605ExtracellularSequence analysisAdd BLAST580
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Topological domaini627 – 931CytoplasmicSequence analysisAdd BLAST305

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003234526 – 931Semaphorin-6CAdd BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 122PROSITE-ProRule annotation
Disulfide bondi140 ↔ 149PROSITE-ProRule annotation
Disulfide bondi263 ↔ 374PROSITE-ProRule annotation
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi288 ↔ 333PROSITE-ProRule annotation
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi480 ↔ 511PROSITE-ProRule annotation
Disulfide bondi520 ↔ 538PROSITE-ProRule annotation
Disulfide bondi526 ↔ 571PROSITE-ProRule annotation
Disulfide bondi530 ↔ 546PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9WTM3
PaxDbiQ9WTM3
PRIDEiQ9WTM3

PTM databases

iPTMnetiQ9WTM3
PhosphoSitePlusiQ9WTM3

Expressioni

Gene expression databases

BgeeiENSMUSG00000038777 Expressed in 144 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ9WTM3 baseline and differential
GenevisibleiQ9WTM3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088331

Structurei

3D structure databases

ProteinModelPortaliQ9WTM3
SMRiQ9WTM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 517SemaPROSITE-ProRule annotationAdd BLAST487

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi663 – 669Poly-Pro7
Compositional biasi754 – 757Poly-Pro4

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOGENOMiHOG000232047
HOVERGENiHBG072910
InParanoidiQ9WTM3
KOiK06842
OMAiVPPEGRC
PhylomeDBiQ9WTM3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015514 Semaphorin_6C
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF11 PTHR11036:SF11, 1 hit
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9WTM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRAPHSMPL LLLLLLLSSL PQAQAAFPQD PTPLLTSDLQ GASPSSWFRG
60 70 80 90 100
LEDDAVAAEL GLDFQRFLTL NRTLLVAARD HVFSFDLQAQ EEGEGLVPNK
110 120 130 140 150
FLTWRSQDME NCAVRGKLTD ECYNYIRVLV PWNSQTLLAC GTNSFSPMCR
160 170 180 190 200
SYGITSLQQE GEELSGQARC PFDATQSTVA IFAEGSLYSA TAADFQASDA
210 220 230 240 250
VVYRSLGPQP PLRSAKYDSK WLREPHFVYA LEHGEHVYFF FREVSVEDAR
260 270 280 290 300
LGRVQFSRVA RVCKRDMGGS PRALDRHWTS FLKLRLNCSV PGDSTFYFDV
310 320 330 340 350
LQSLTGPVNL HGRSALFGVF TTQTNSIPGS AVCAFYLDDI ERGFEGKFKE
360 370 380 390 400
QRSLDGAWTP VSEDKVPSPR PGSCAGVGAA ASFSSSQDLP DDVLLFIKAH
410 420 430 440 450
PLLDPAVPPA THQPLLTLTS RALLTQVAVD GMAGPHRNTT VLFLGSNDGT
460 470 480 490 500
VLKVLPPGGQ SLGSEPIVLE EIDAYSHARC SGKRSPRAAR RIIGLELDTE
510 520 530 540 550
GHRLFVAFPG CIVYLSLSRC ARHGACQRSC LASLDPYCGW HRSRGCMSIR
560 570 580 590 600
GPGGTDVDLT GNQESTEHGD CQDGATGSQS GPGDSAYGVR RDLSPASASR
610 620 630 640 650
SIPIPLLLAC VAAAFALGAS VSGLLVSCAC RRANRRRSKD IETPGLPRPL
660 670 680 690 700
SLRSLARLHG GGPEPPPPPK DGDAAQTPQL YTTFLPPPDG GSPPELACLP
710 720 730 740 750
TPETTPELPV KHLRASGGPW EWNQNGNNAS EGPGRPPRGC SGAGGPAPRV
760 770 780 790 800
LVRPPPPGCP GQAVEVTTLE ELLRYLHGPQ PPRKGSEPLA SAPFTSRPPA
810 820 830 840 850
SEPGASLFVD SSPMPRDGVP PLRLDVPPEG KRAAPSGRPA LSAPAPRLGV
860 870 880 890 900
GGSRRLPFPT HRAPPGLLTR VPSGGPARYS GGPGRHLLYL GRPEGHRGRS
910 920 930
LKRVDVKSPL SPKPPLASPP QPAPHGGHFN F
Length:931
Mass (Da):99,538
Last modified:November 1, 1999 - v1
Checksum:iB0D99D594209F125
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q613E9Q613_MOUSE
Semaphorin-6C
Sema6c
963Annotation score:
G5E8N4G5E8N4_MOUSE
Sema domain, transmembrane domain (...
Sema6c mCG_13711
923Annotation score:
S4R1B4S4R1B4_MOUSE
Semaphorin-6C
Sema6c
80Annotation score:
E9Q4N1E9Q4N1_MOUSE
Semaphorin-6C
Sema6c
124Annotation score:
A0A0G2JDV7A0A0G2JDV7_MOUSE
Semaphorin-6C
Sema6c
29Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013729 mRNA Translation: BAA76294.1
CCDSiCCDS17604.1
RefSeqiNP_001258953.1, NM_001272024.1
NP_035481.1, NM_011351.2
XP_006501268.1, XM_006501205.1
UniGeneiMm.23662

Genome annotation databases

EnsembliENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777
ENSMUST00000202315; ENSMUSP00000144039; ENSMUSG00000038777
GeneIDi20360
KEGGimmu:20360
UCSCiuc008qij.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013729 mRNA Translation: BAA76294.1
CCDSiCCDS17604.1
RefSeqiNP_001258953.1, NM_001272024.1
NP_035481.1, NM_011351.2
XP_006501268.1, XM_006501205.1
UniGeneiMm.23662

3D structure databases

ProteinModelPortaliQ9WTM3
SMRiQ9WTM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088331

PTM databases

iPTMnetiQ9WTM3
PhosphoSitePlusiQ9WTM3

Proteomic databases

MaxQBiQ9WTM3
PaxDbiQ9WTM3
PRIDEiQ9WTM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090821; ENSMUSP00000088331; ENSMUSG00000038777
ENSMUST00000202315; ENSMUSP00000144039; ENSMUSG00000038777
GeneIDi20360
KEGGimmu:20360
UCSCiuc008qij.2 mouse

Organism-specific databases

CTDi10500
MGIiMGI:1338032 Sema6c

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOGENOMiHOG000232047
HOVERGENiHBG072910
InParanoidiQ9WTM3
KOiK06842
OMAiVPPEGRC
PhylomeDBiQ9WTM3

Miscellaneous databases

PROiPR:Q9WTM3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038777 Expressed in 144 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ9WTM3 baseline and differential
GenevisibleiQ9WTM3 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015514 Semaphorin_6C
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF11 PTHR11036:SF11, 1 hit
PfamiView protein in Pfam
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM6C_MOUSE
AccessioniPrimary (citable) accession number: Q9WTM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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