UniProtKB - Q9WTL8 (BMAL1_MOUSE)
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Arntl
Functioni
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (By similarity).
CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (By similarity).
The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (By similarity).
Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504).
Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (PubMed:29996098).
Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (PubMed:30096135).
By similarity41 PublicationsActivity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 132 | Important for interaction with CLOCKBy similarity | 1 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- bHLH transcription factor binding Source: BHF-UCL
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor binding Source: MGI
- E-box binding Source: UniProtKB
- Hsp90 protein binding Source: MGI
- protein heterodimerization activity Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- circadian regulation of gene expression Source: UniProtKB
- circadian rhythm Source: MGI
- maternal process involved in parturition Source: CACAO
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of fat cell differentiation Source: UniProtKB
- negative regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
- negative regulation of TOR signaling Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- oxidative stress-induced premature senescence Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of circadian rhythm Source: UniProtKB
- positive regulation of protein acetylation Source: UniProtKB
- positive regulation of skeletal muscle cell differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein import into nucleus Source: MGI
- regulation of cell cycle Source: UniProtKB
- regulation of cellular senescence Source: UniProtKB
- regulation of hair cycle Source: UniProtKB
- regulation of insulin secretion Source: UniProtKB
- regulation of neurogenesis Source: UniProtKB
- regulation of protein catabolic process Source: MGI
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of type B pancreatic cell development Source: UniProtKB
- response to redox state Source: UniProtKB
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor nuclear translocator-like protein 1Alternative name(s): Arnt3 Brain and muscle ARNT-like 1 |
Gene namesi | Name:Arntl Synonyms:Bmal1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096381, Arntl |
VEuPathDBi | HostDB:ENSMUSG00000055116 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
Note: Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2.3 Publications
Cytosol
- cytosol Source: Reactome
Nucleus
- CLOCK-BMAL transcription complex Source: ComplexPortal
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- PML body Source: UniProtKB-SubCell
Other locations
- aryl hydrocarbon receptor complex Source: GO_Central
- chromatoid body Source: UniProtKB
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: MGI
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 – 39 | KR → AA: Loss of nuclear localization. 1 Publication | 2 | |
Mutagenesisi | 97 | S → A: Impaired nuclear accumulation, decreased interaction with CLOCK and disruption of circadian clock function. 1 Publication | 1 | |
Mutagenesisi | 102 | L → E: Reduced CLOCK binding. Abolishes transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. 1 Publication | 1 | |
Mutagenesisi | 122 | L → E: Reduced CLOCK binding. Abolishes transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. 1 Publication | 1 | |
Mutagenesisi | 154 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-157. 1 Publication | 1 | |
Mutagenesisi | 157 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-154. 1 Publication | 1 | |
Mutagenesisi | 230 | K → R: No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 236 | K → R: No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 259 | K → R: Significant decrease in; transcriptional activity, localization in PML body, ubiquitination and proteasome-mediated proteolysis. 1 Publication | 1 | |
Mutagenesisi | 266 | K → R: Abolishes sumoylation. 1 Publication | 1 | |
Mutagenesisi | 279 | K → R: No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 323 | I → D: Reduced CLOCK binding. Slightly reduced transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. Impairs regulation of circadian clock. Loss of ability to inhibit the expression of CD274 in macrophages. 2 Publications | 1 | |
Mutagenesisi | 370 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-374. 1 Publication | 1 | |
Mutagenesisi | 374 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-370. 1 Publication | 1 | |
Mutagenesisi | 418 | S → A: Decreases without abolishing O-GlcNAcylation. 1 Publication | 1 | |
Mutagenesisi | 544 | K → R: Decreased acetylation, leading to decreased transcription elongation during the activation phase of the circadian cycle. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127158 | 1 – 632 | Aryl hydrocarbon receptor nuclear translocator-like protein 1Add BLAST | 632 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | Phosphoserine; by GSK3-beta1 Publication | 1 | |
Modified residuei | 21 | Phosphothreonine; by GSK3-beta1 Publication | 1 | |
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 97 | Phosphoserine; by CK21 Publication | 1 | |
Cross-linki | 259 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)1 Publication | ||
Cross-linki | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication | ||
Cross-linki | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 544 | N6-acetyllysine3 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q9WTL8 |
PaxDbi | Q9WTL8 |
PRIDEi | Q9WTL8 |
ProteomicsDBi | 265307 [Q9WTL8-1] 265308 [Q9WTL8-2] 265309 [Q9WTL8-3] 265310 [Q9WTL8-4] 265311 [Q9WTL8-5] |
PTM databases
iPTMneti | Q9WTL8 |
PhosphoSitePlusi | Q9WTL8 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000055116, Expressed in secondary oocyte and 290 other tissues |
Genevisiblei | Q9WTL8, MM |
Interactioni
Subunit structurei
Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (PubMed:11779462).
Forms a heterodimer with CLOCK (PubMed:9616112, PubMed:16717091, PubMed:16980631, PubMed:18662546, PubMed:19946213, PubMed:19330005, PubMed:21613214, PubMed:23970558, PubMed:22653727). The CLOCK-ARNTL/BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL/BMAL1 (PubMed:11779462).
Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (PubMed:20093473).
Interacts with NPAS2 (PubMed:16628007).
Interacts with EZH2 (PubMed:16717091, PubMed:23970558).
Interacts with SUMO3 (PubMed:18644859).
Interacts with SIRT1 (PubMed:18662546, PubMed:18662547, PubMed:19299583).
Interacts with AHR (PubMed:20106950).
Interacts with ID1, ID2 and ID3 (PubMed:20861012).
Interacts with DDX4 (PubMed:22900038).
Interacts with OGT (PubMed:23337503).
Interacts with EED and SUZ12 (PubMed:23970558).
Interacts with MTA1 (PubMed:24089055).
Interacts with CIART (PubMed:24385426, PubMed:24736997).
Interacts with HSP90 (By similarity).
Interacts with KAT2B and EP300 (By similarity).
Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (PubMed:12397359).
Interacts with RELB and the interaction is enhanced in the presence of CLOCK (PubMed:22894897).
Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (PubMed:18430226, PubMed:19605937, PubMed:20840750, PubMed:21613214, PubMed:24154698). Interaction of the CLOCK-ARNTL/BMAL1 heterodimer with PER or CRY inhibits transcription activation (PubMed:21613214). Interaction of the CLOCK-ARNTL/BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (PubMed:21613214). The CLOCK-ARNTL/BMAL1 heterodimer interacts with GSK3B (PubMed:19946213, PubMed:20049328).
Interacts with KDM5A (PubMed:21960634).
Interacts with KMT2A; in a circadian manner (PubMed:21113167).
Interacts with UBE3A (By similarity).
Interacts with PRKCG (PubMed:23185022).
Interacts with MAGEL2 (PubMed:22208286).
Interacts with NCOA2 (PubMed:24529706).
Interacts with THRAP3 (PubMed:24043798). The CLOCK-ARNTL/BMAL1 heterodimer interacts with PASD1 (By similarity).
Interacts with PASD1 (By similarity).
Interacts with USP9X (PubMed:29626158).
Interacts with PIWIL2 (via PIWI domain) (PubMed:28903391).
Interacts with HDAC3 (PubMed:26776516).
Interacts with HNF4A (By similarity).
By similarity37 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 84 | Interaction with E-box DNABy similarity | 1 | |
Sitei | 87 | Interaction with E-box DNABy similarity | 1 | |
Sitei | 88 | Interaction with E-box DNABy similarity | 1 | |
Sitei | 92 | Interaction with E-box DNABy similarity | 1 |
Binary interactionsi
Q9WTL8
Isoform 2 [Q9WTL8-2]
With | #Exp. | IntAct |
---|---|---|
Clock [O08785] | 2 | EBI-644559,EBI-79859 |
Cry1 [P97784] | 4 | EBI-644559,EBI-1266607 |
Isoform 4 [Q9WTL8-4]
With | #Exp. | IntAct |
---|---|---|
Clock [O08785] | 10 | EBI-644568,EBI-79859 |
Crebbp [P45481] | 2 | EBI-644568,EBI-296306 |
Cry1 [P97784] | 4 | EBI-644568,EBI-1266607 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- bHLH transcription factor binding Source: BHF-UCL
- DNA-binding transcription factor binding Source: MGI
- Hsp90 protein binding Source: MGI
- protein heterodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 198207, 20 interactors |
ComplexPortali | CPX-3225, CLOCK-BMAL1 transcription complex |
CORUMi | Q9WTL8 |
DIPi | DIP-43977N |
IntActi | Q9WTL8, 32 interactors |
MINTi | Q9WTL8 |
STRINGi | 10090.ENSMUSP00000046235 |
Miscellaneous databases
RNActi | Q9WTL8, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | Q9WTL8 |
SMRi | Q9WTL8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 132 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 150 – 222 | PAS 1PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 333 – 403 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 408 – 451 | PACAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 465 – 498 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 514 – 594 | Interaction with CIARTAdd BLAST | 81 | |
Regioni | 517 – 601 | DisorderedSequence analysisAdd BLAST | 85 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 36 – 41 | Nuclear localization signal1 Publication | 6 | |
Motifi | 149 – 159 | Nuclear export signal 11 PublicationAdd BLAST | 11 | |
Motifi | 367 – 375 | Nuclear export signal 21 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 32 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 518 – 538 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 558 – 580 | Polar residuesSequence analysisAdd BLAST | 23 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000157523 |
HOGENOMi | CLU_011864_2_2_1 |
InParanoidi | Q9WTL8 |
OMAi | YHHEDIP |
PhylomeDBi | Q9WTL8 |
TreeFami | TF319983 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADQRMDISS TISDFMSPGP TDLLSGSLGT SGVDCNRKRK GSATDYQLDD
60 70 80 90 100
FAFEESMDTD KDDPHGRLEY AEHQGRIKNA REAHSQIEKR RRDKMNSFID
110 120 130 140 150
ELASLVPTCN AMSRKLDKLT VLRMAVQHMK TLRGATNPYT EANYKPTFLS
160 170 180 190 200
DDELKHLILR AADGFLFVVG CDRGKILFVS ESVFKILNYS QNDLIGQSLF
210 220 230 240 250
DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT PGPSRLCSGA
260 270 280 290 300
RRSFFCRMKC NRPSVKVEDK DFASTCSKKK DRKSFCTIHS TGYLKSWPPT
310 320 330 340 350
KMGLDEDNEP DNEGCNLSCL VAIGRLHSHM VPQPANGEIR VKSMEYVSRH
360 370 380 390 400
AIDGKFVFVD QRATAILAYL PQELLGTSCY EYFHQDDIGH LAECHRQVLQ
410 420 430 440 450
TREKITTNCY KFKIKDGSFI TLRSRWFSFM NPWTKEVEYI VSTNTVVLAN
460 470 480 490 500
VLEGGDPTFP QLTAPPHSMD SMLPSGEGGP KRTHPTVPGI PGGTRAGAGK
510 520 530 540 550
IGRMIAEEIM EIHRIRGSSP SSCGSSPLNI TSTPPPDASS PGGKKILNGG
560 570 580 590 600
TPDIPSTGLL PGQAQETPGY PYSDSSSILG ENPHIGIDMI DNDQGSSSPS
610 620 630
NDEAAMAVIM SLLEADAGLG GPVDFSDLPW PL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GS77 | A0A1B0GS77_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arntl | 633 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 254 | F → L in BAA76414 (PubMed:10403839).Curated | 1 | |
Sequence conflicti | 254 | F → L in BAA81898 (PubMed:10403839).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007992 | 48 – 54 | Missing in isoform 2, isoform 4 and isoform 5. 3 Publications | 7 | |
Alternative sequenceiVSP_007993 | 49 – 68 | Missing in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_007995 | 161 – 483 | AADGF…GPKRT → DVTEGRSSLSPSLSSRSSII ARMTLLARACLTTCIQKILP KLRNSYLPRTLRPGSDSLMP RLDFRLKRI in isoform 5. 1 PublicationAdd BLAST | 323 | |
Alternative sequenceiVSP_007994 | 280 | K → KA in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_007996 | 484 – 632 | Missing in isoform 5. 1 PublicationAdd BLAST | 149 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012601 mRNA Translation: BAA76414.1 AB015203 mRNA Translation: BAA81898.1 AB012602 mRNA Translation: BAA76415.1 AB014494 mRNA Translation: BAA32208.1 BC025973 mRNA Translation: AAH25973.1 BC011080 mRNA Translation: AAH11080.1 |
CCDSi | CCDS40092.1 [Q9WTL8-4] CCDS85390.1 [Q9WTL8-3] |
PIRi | JE0270 |
RefSeqi | NP_001229977.1, NM_001243048.1 [Q9WTL8-3] NP_031515.1, NM_007489.4 [Q9WTL8-4] XP_006507314.1, XM_006507251.2 XP_017177438.1, XM_017321949.1 XP_017177439.1, XM_017321950.1 [Q9WTL8-2] |
Genome annotation databases
Ensembli | ENSMUST00000047321; ENSMUSP00000046235; ENSMUSG00000055116 [Q9WTL8-4] ENSMUST00000210074; ENSMUSP00000147764; ENSMUSG00000055116 [Q9WTL8-3] ENSMUST00000210238; ENSMUSP00000147989; ENSMUSG00000055116 [Q9WTL8-4] |
GeneIDi | 11865 |
KEGGi | mmu:11865 |
UCSCi | uc009jhf.2, mouse [Q9WTL8-3] uc009jhi.2, mouse [Q9WTL8-2] uc009jhj.2, mouse [Q9WTL8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012601 mRNA Translation: BAA76414.1 AB015203 mRNA Translation: BAA81898.1 AB012602 mRNA Translation: BAA76415.1 AB014494 mRNA Translation: BAA32208.1 BC025973 mRNA Translation: AAH25973.1 BC011080 mRNA Translation: AAH11080.1 |
CCDSi | CCDS40092.1 [Q9WTL8-4] CCDS85390.1 [Q9WTL8-3] |
PIRi | JE0270 |
RefSeqi | NP_001229977.1, NM_001243048.1 [Q9WTL8-3] NP_031515.1, NM_007489.4 [Q9WTL8-4] XP_006507314.1, XM_006507251.2 XP_017177438.1, XM_017321949.1 XP_017177439.1, XM_017321950.1 [Q9WTL8-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4F3L | X-ray | 2.27 | B | 69-453 | [»] | |
SASBDBi | Q9WTL8 | |||||
SMRi | Q9WTL8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198207, 20 interactors |
ComplexPortali | CPX-3225, CLOCK-BMAL1 transcription complex |
CORUMi | Q9WTL8 |
DIPi | DIP-43977N |
IntActi | Q9WTL8, 32 interactors |
MINTi | Q9WTL8 |
STRINGi | 10090.ENSMUSP00000046235 |
PTM databases
iPTMneti | Q9WTL8 |
PhosphoSitePlusi | Q9WTL8 |
Proteomic databases
MaxQBi | Q9WTL8 |
PaxDbi | Q9WTL8 |
PRIDEi | Q9WTL8 |
ProteomicsDBi | 265307 [Q9WTL8-1] 265308 [Q9WTL8-2] 265309 [Q9WTL8-3] 265310 [Q9WTL8-4] 265311 [Q9WTL8-5] |
Protocols and materials databases
Antibodypediai | 11861, 541 antibodies from 44 providers |
DNASUi | 11865 |
Genome annotation databases
Ensembli | ENSMUST00000047321; ENSMUSP00000046235; ENSMUSG00000055116 [Q9WTL8-4] ENSMUST00000210074; ENSMUSP00000147764; ENSMUSG00000055116 [Q9WTL8-3] ENSMUST00000210238; ENSMUSP00000147989; ENSMUSG00000055116 [Q9WTL8-4] |
GeneIDi | 11865 |
KEGGi | mmu:11865 |
UCSCi | uc009jhf.2, mouse [Q9WTL8-3] uc009jhi.2, mouse [Q9WTL8-2] uc009jhj.2, mouse [Q9WTL8-1] |
Organism-specific databases
CTDi | 406 |
MGIi | MGI:1096381, Arntl |
VEuPathDBi | HostDB:ENSMUSG00000055116 |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000157523 |
HOGENOMi | CLU_011864_2_2_1 |
InParanoidi | Q9WTL8 |
OMAi | YHHEDIP |
PhylomeDBi | Q9WTL8 |
TreeFami | TF319983 |
Miscellaneous databases
BioGRID-ORCSi | 11865, 4 hits in 67 CRISPR screens |
ChiTaRSi | Arntl, mouse |
PROi | PR:Q9WTL8 |
RNActi | Q9WTL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055116, Expressed in secondary oocyte and 290 other tissues |
Genevisiblei | Q9WTL8, MM |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BMAL1_MOUSE | |
Accessioni | Q9WTL8Primary (citable) accession number: Q9WTL8 Secondary accession number(s): O88295 Q9WTL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | August 15, 2003 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references