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Protein

Aryl hydrocarbon receptor nuclear translocator-like protein 1

Gene

Arntl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (By similarity). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (By similarity). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504).By similarity39 Publications

Activity regulationi

The redox state of the cell can modulate the transcriptional activity of the CLOCK-ARNTL/BMAL1 and NPAS2-ARNTL/BMAL1 heterodimers; NADH and NADPH enhance the DNA-binding activity of the heterodimers.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei132Important for interaction with CLOCKBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Alternative name(s):
Arnt3
Brain and muscle ARNT-like 1
Gene namesi
Name:Arntl
Synonyms:Bmal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096381 Arntl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are characterized by reduced lifespan, and the presence of a number of pathologies characteristic of pre-mature aging and increased oxidative stress. They show impaired functional connectivity, increased oxidative damage and severe astrogliosis in the brain. They also exhibit accelerated thrombosis with elevated levels of thrombogenic factors, including VWF, SERPINE1/PAI1, and fibrinogen. Both male and female mice are infertile and male mice have low testosterone and high luteinizing hormone serum levels and a significant decrease in sperm count.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38 – 39KR → AA: Loss of nuclear localization. 1 Publication2
Mutagenesisi97S → A: Impaired nuclear accumulation, decreased interaction with CLOCK and disruption of circadian clock function. 1 Publication1
Mutagenesisi102L → E: Reduced CLOCK binding. Abolishes transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. 1 Publication1
Mutagenesisi122L → E: Reduced CLOCK binding. Abolishes transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. 1 Publication1
Mutagenesisi154L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-157. 1 Publication1
Mutagenesisi157L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-154. 1 Publication1
Mutagenesisi230K → R: No effect on sumoylation. 1 Publication1
Mutagenesisi236K → R: No effect on sumoylation. 1 Publication1
Mutagenesisi259K → R: Significant decrease in; transcriptional activity, localization in PML body, ubiquitination and proteasome-mediated proteolysis. 1 Publication1
Mutagenesisi266K → R: Abolishes sumoylation. 1 Publication1
Mutagenesisi279K → R: No effect on sumoylation. 1 Publication1
Mutagenesisi323I → D: Reduced CLOCK binding. Slightly reduced transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. Impairs regulation of circadian clock. 1 Publication1
Mutagenesisi370L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-374. 1 Publication1
Mutagenesisi374L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-370. 1 Publication1
Mutagenesisi418S → A: Decreases without abolishing O-GlcNAcylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271581 – 632Aryl hydrocarbon receptor nuclear translocator-like protein 1Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Phosphoserine; by GSK3-beta1 Publication1
Modified residuei21Phosphothreonine; by GSK3-beta1 Publication1
Modified residuei85PhosphoserineBy similarity1
Modified residuei97Phosphoserine; by CK21 Publication1
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)1 Publication
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei544N6-acetyllysine1 Publication1

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation.3 Publications
O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-ARNTL/BMAL1 heterodimer thereby increasing CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.2 Publications
Acetylated on Lys-544 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression. Deacetylated by SIRT1, which may result in decreased protein stability.2 Publications
Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-ARNTL/BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-97 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry. Dephosphorylation at Ser-85 is important for dimerization with CLOCK and transcriptional activity (By similarity).By similarity6 Publications
Sumoylated on Lys-266 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer.2 Publications

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9WTL8
PRIDEiQ9WTL8

PTM databases

iPTMnetiQ9WTL8
PhosphoSitePlusiQ9WTL8

Expressioni

Tissue specificityi

Expressed in liver and testis (at protein level).5 Publications

Inductioni

Expressed in a circadian manner in the liver.4 Publications

Gene expression databases

BgeeiENSMUSG00000055116 Expressed in 268 organ(s), highest expression level in zygote
ExpressionAtlasiQ9WTL8 baseline and differential
GenevisibleiQ9WTL8 MM

Interactioni

Subunit structurei

Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (PubMed:11779462). Forms a heterodimer with CLOCK (PubMed:9616112, PubMed:16717091, PubMed:16980631, PubMed:18662546, PubMed:19946213, PubMed:19330005, PubMed:21613214, PubMed:23970558, PubMed:22653727). The CLOCK-ARNTL/BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL/BMAL1 (PubMed:11779462). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (PubMed:20093473). Interacts with NPAS2 (PubMed:16628007). Interacts with EZH2 (PubMed:16717091, PubMed:23970558). Interacts with SUMO3 (PubMed:18644859). Interacts with SIRT1 (PubMed:18662546, PubMed:18662547, PubMed:19299583). Interacts with AHR (PubMed:20106950). Interacts with ID1, ID2 and ID3 (PubMed:20861012). Interacts with DDX4 (PubMed:22900038). Interacts with OGT (PubMed:23337503). Interacts with EED and SUZ12 (PubMed:23970558). Interacts with MTA1 (PubMed:24089055). Interacts with CIART (PubMed:24385426, PubMed:24736997). Interacts with HSP90 (By similarity). Interacts with KAT2B and EP300 (By similarity). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (PubMed:12397359). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (PubMed:22894897). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (PubMed:18430226, PubMed:19605937, PubMed:20840750, PubMed:21613214, PubMed:24154698). Interaction of the CLOCK-ARNTL/BMAL1 heterodimer with PER or CRY inhibits transcription activation (PubMed:21613214). Interaction of the CLOCK-ARNTL/BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (PubMed:21613214). The CLOCK-ARNTL/BMAL1 heterodimer interacts with GSK3B (PubMed:19946213, PubMed:20049328). Interacts with KDM5A (PubMed:21960634). Interacts with KMT2A; in a circadian manner (PubMed:21113167). Interacts with UBE3A (By similarity). Interacts with PRKCG (PubMed:23185022). Interacts with MAGEL2 (PubMed:22208286). Interacts with NCOA2 (PubMed:24529706). Interacts with THRAP3 (PubMed:24043798). The CLOCK-ARNTL/BMAL1 heterodimer interacts with PASD1 (By similarity). Interacts with PASD1 (By similarity).By similarity34 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Interaction with E-box DNABy similarity1
Sitei87Interaction with E-box DNABy similarity1
Sitei88Interaction with E-box DNABy similarity1
Sitei92Interaction with E-box DNABy similarity1

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198207, 16 interactors
ComplexPortaliCPX-3225 CLOCK-BMAL1 transcription complex
CORUMiQ9WTL8
DIPiDIP-43977N
IntActiQ9WTL8, 31 interactors
MINTiQ9WTL8
STRINGi10090.ENSMUSP00000046235

Structurei

Secondary structure

1632
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9WTL8
SMRiQ9WTL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 132bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini150 – 222PAS 1PROSITE-ProRule annotationAdd BLAST73
Domaini333 – 403PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini408 – 451PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni514 – 594Interaction with CIARTAdd BLAST81

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 41Nuclear localization signal1 Publication6
Motifi149 – 159Nuclear export signal 11 PublicationAdd BLAST11
Motifi367 – 375Nuclear export signal 21 Publication9

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3561 Eukaryota
ENOG410XRJI LUCA
GeneTreeiENSGT00760000118788
HOGENOMiHOG000234379
HOVERGENiHBG107503
InParanoidiQ9WTL8
KOiK02296
PhylomeDBiQ9WTL8
TreeFamiTF319983

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 3 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9WTL8-1) [UniParc]FASTAAdd to basket
Also known as: b'

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSGSLGT SGVDCNRKRK GSATDYQLDD
60 70 80 90 100
FAFEESMDTD KDDPHGRLEY AEHQGRIKNA REAHSQIEKR RRDKMNSFID
110 120 130 140 150
ELASLVPTCN AMSRKLDKLT VLRMAVQHMK TLRGATNPYT EANYKPTFLS
160 170 180 190 200
DDELKHLILR AADGFLFVVG CDRGKILFVS ESVFKILNYS QNDLIGQSLF
210 220 230 240 250
DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT PGPSRLCSGA
260 270 280 290 300
RRSFFCRMKC NRPSVKVEDK DFASTCSKKK DRKSFCTIHS TGYLKSWPPT
310 320 330 340 350
KMGLDEDNEP DNEGCNLSCL VAIGRLHSHM VPQPANGEIR VKSMEYVSRH
360 370 380 390 400
AIDGKFVFVD QRATAILAYL PQELLGTSCY EYFHQDDIGH LAECHRQVLQ
410 420 430 440 450
TREKITTNCY KFKIKDGSFI TLRSRWFSFM NPWTKEVEYI VSTNTVVLAN
460 470 480 490 500
VLEGGDPTFP QLTAPPHSMD SMLPSGEGGP KRTHPTVPGI PGGTRAGAGK
510 520 530 540 550
IGRMIAEEIM EIHRIRGSSP SSCGSSPLNI TSTPPPDASS PGGKKILNGG
560 570 580 590 600
TPDIPSTGLL PGQAQETPGY PYSDSSSILG ENPHIGIDMI DNDQGSSSPS
610 620 630
NDEAAMAVIM SLLEADAGLG GPVDFSDLPW PL
Length:632
Mass (Da):69,452
Last modified:August 15, 2003 - v2
Checksum:i9669C3712A95C2DE
GO
Isoform 2 (identifier: Q9WTL8-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     48-54: Missing.

Show »
Length:625
Mass (Da):68,614
Checksum:i5A99555F851260CF
GO
Isoform 3 (identifier: Q9WTL8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-68: Missing.
     280-280: K → KA

Show »
Length:613
Mass (Da):67,200
Checksum:i24B91BA2E81D1A25
GO
Isoform 4 (identifier: Q9WTL8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-54: Missing.
     280-280: K → KA

Show »
Length:626
Mass (Da):68,685
Checksum:i837330EF65406CE4
GO
Isoform 5 (identifier: Q9WTL8-5) [UniParc]FASTAAdd to basket
Also known as: g'

The sequence of this isoform differs from the canonical sequence as follows:
     48-54: Missing.
     161-483: AADGFLFVVG...PSGEGGPKRT → DVTEGRSSLS...PRLDFRLKRI
     484-632: Missing.

Show »
Length:222
Mass (Da):25,061
Checksum:i9AE175BE7F6A446C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GS77A0A1B0GS77_MOUSE
Aryl hydrocarbon receptor nuclear t...
Arntl
633Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254F → L in BAA76414 (PubMed:10403839).Curated1
Sequence conflicti254F → L in BAA81898 (PubMed:10403839).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00799248 – 54Missing in isoform 2, isoform 4 and isoform 5. 3 Publications7
Alternative sequenceiVSP_00799349 – 68Missing in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_007995161 – 483AADGF…GPKRT → DVTEGRSSLSPSLSSRSSII ARMTLLARACLTTCIQKILP KLRNSYLPRTLRPGSDSLMP RLDFRLKRI in isoform 5. 1 PublicationAdd BLAST323
Alternative sequenceiVSP_007994280K → KA in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_007996484 – 632Missing in isoform 5. 1 PublicationAdd BLAST149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012601 mRNA Translation: BAA76414.1
AB015203 mRNA Translation: BAA81898.1
AB012602 mRNA Translation: BAA76415.1
AB014494 mRNA Translation: BAA32208.1
BC025973 mRNA Translation: AAH25973.1
BC011080 mRNA Translation: AAH11080.1
CCDSiCCDS40092.1 [Q9WTL8-4]
CCDS85390.1 [Q9WTL8-3]
PIRiJE0270
RefSeqiNP_001229977.1, NM_001243048.1 [Q9WTL8-3]
NP_031515.1, NM_007489.4 [Q9WTL8-4]
XP_006507314.1, XM_006507251.2 [Q9WTL8-1]
XP_017177438.1, XM_017321949.1
XP_017177439.1, XM_017321950.1 [Q9WTL8-2]
UniGeneiMm.33970
Mm.440371

Genome annotation databases

EnsembliENSMUST00000047321; ENSMUSP00000046235; ENSMUSG00000055116 [Q9WTL8-4]
ENSMUST00000210074; ENSMUSP00000147764; ENSMUSG00000055116 [Q9WTL8-3]
ENSMUST00000210238; ENSMUSP00000147989; ENSMUSG00000055116 [Q9WTL8-4]
GeneIDi11865
KEGGimmu:11865
UCSCiuc009jhf.2 mouse [Q9WTL8-3]
uc009jhi.2 mouse [Q9WTL8-2]
uc009jhj.2 mouse [Q9WTL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012601 mRNA Translation: BAA76414.1
AB015203 mRNA Translation: BAA81898.1
AB012602 mRNA Translation: BAA76415.1
AB014494 mRNA Translation: BAA32208.1
BC025973 mRNA Translation: AAH25973.1
BC011080 mRNA Translation: AAH11080.1
CCDSiCCDS40092.1 [Q9WTL8-4]
CCDS85390.1 [Q9WTL8-3]
PIRiJE0270
RefSeqiNP_001229977.1, NM_001243048.1 [Q9WTL8-3]
NP_031515.1, NM_007489.4 [Q9WTL8-4]
XP_006507314.1, XM_006507251.2 [Q9WTL8-1]
XP_017177438.1, XM_017321949.1
XP_017177439.1, XM_017321950.1 [Q9WTL8-2]
UniGeneiMm.33970
Mm.440371

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F3LX-ray2.27B69-453[»]
ProteinModelPortaliQ9WTL8
SMRiQ9WTL8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198207, 16 interactors
ComplexPortaliCPX-3225 CLOCK-BMAL1 transcription complex
CORUMiQ9WTL8
DIPiDIP-43977N
IntActiQ9WTL8, 31 interactors
MINTiQ9WTL8
STRINGi10090.ENSMUSP00000046235

PTM databases

iPTMnetiQ9WTL8
PhosphoSitePlusiQ9WTL8

Proteomic databases

PaxDbiQ9WTL8
PRIDEiQ9WTL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047321; ENSMUSP00000046235; ENSMUSG00000055116 [Q9WTL8-4]
ENSMUST00000210074; ENSMUSP00000147764; ENSMUSG00000055116 [Q9WTL8-3]
ENSMUST00000210238; ENSMUSP00000147989; ENSMUSG00000055116 [Q9WTL8-4]
GeneIDi11865
KEGGimmu:11865
UCSCiuc009jhf.2 mouse [Q9WTL8-3]
uc009jhi.2 mouse [Q9WTL8-2]
uc009jhj.2 mouse [Q9WTL8-1]

Organism-specific databases

CTDi406
MGIiMGI:1096381 Arntl

Phylogenomic databases

eggNOGiKOG3561 Eukaryota
ENOG410XRJI LUCA
GeneTreeiENSGT00760000118788
HOGENOMiHOG000234379
HOVERGENiHBG107503
InParanoidiQ9WTL8
KOiK02296
PhylomeDBiQ9WTL8
TreeFamiTF319983

Miscellaneous databases

PROiPR:Q9WTL8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055116 Expressed in 268 organ(s), highest expression level in zygote
ExpressionAtlasiQ9WTL8 baseline and differential
GenevisibleiQ9WTL8 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 3 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBMAL1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL8
Secondary accession number(s): O88295
, Q921S4, Q9R0U2, Q9WTL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: October 10, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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