UniProtKB - Q9WTL8 (BMAL1_MOUSE)
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Arntl
Functioni
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 132 | Important for interaction with CLOCKBy similarity | 1 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- bHLH transcription factor binding Source: BHF-UCL
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor binding Source: MGI
- E-box binding Source: UniProtKB
- Hsp90 protein binding Source: MGI
- protein heterodimerization activity Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
- transcription factor binding Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- circadian regulation of gene expression Source: UniProtKB
- circadian rhythm Source: MGI
- maternal process involved in parturition Source: CACAO
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of fat cell differentiation Source: UniProtKB
- negative regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
- negative regulation of TOR signaling Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- oxidative stress-induced premature senescence Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of circadian rhythm Source: UniProtKB
- positive regulation of protein acetylation Source: UniProtKB
- positive regulation of skeletal muscle cell differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein import into nucleus Source: MGI
- regulation of cell cycle Source: UniProtKB
- regulation of cellular senescence Source: UniProtKB
- regulation of hair cycle Source: UniProtKB
- regulation of insulin secretion Source: UniProtKB
- regulation of neurogenesis Source: UniProtKB
- regulation of protein catabolic process Source: MGI
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of type B pancreatic cell development Source: UniProtKB
- response to redox state Source: UniProtKB
- spermatogenesis Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor nuclear translocator-like protein 1Alternative name(s): Arnt3 Brain and muscle ARNT-like 1 |
Gene namesi | Name:Arntl Synonyms:Bmal1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096381, Arntl |
Subcellular locationi
Nucleus
Other locations
- Cytoplasm 1 Publication
Note: Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2.3 Publications
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- PML body Source: UniProtKB-SubCell
Other locations
- chromatoid body Source: UniProtKB
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: MGI
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 – 39 | KR → AA: Loss of nuclear localization. 1 Publication | 2 | |
Mutagenesisi | 97 | S → A: Impaired nuclear accumulation, decreased interaction with CLOCK and disruption of circadian clock function. 1 Publication | 1 | |
Mutagenesisi | 102 | L → E: Reduced CLOCK binding. Abolishes transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. 1 Publication | 1 | |
Mutagenesisi | 122 | L → E: Reduced CLOCK binding. Abolishes transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. 1 Publication | 1 | |
Mutagenesisi | 154 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-157. 1 Publication | 1 | |
Mutagenesisi | 157 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-154. 1 Publication | 1 | |
Mutagenesisi | 230 | K → R: No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 236 | K → R: No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 259 | K → R: Significant decrease in; transcriptional activity, localization in PML body, ubiquitination and proteasome-mediated proteolysis. 1 Publication | 1 | |
Mutagenesisi | 266 | K → R: Abolishes sumoylation. 1 Publication | 1 | |
Mutagenesisi | 279 | K → R: No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 323 | I → D: Reduced CLOCK binding. Slightly reduced transcriptional activation by the CLOCK-ARNTL/BMAL1 heterodimer. Impairs regulation of circadian clock. Loss of ability to inhibit the expression of CD274 in macrophages. 2 Publications | 1 | |
Mutagenesisi | 370 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-374. 1 Publication | 1 | |
Mutagenesisi | 374 | L → A: Significant reduction in nucleocytoplasmic shuttling; when associated with A-370. 1 Publication | 1 | |
Mutagenesisi | 418 | S → A: Decreases without abolishing O-GlcNAcylation. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127158 | 1 – 632 | Aryl hydrocarbon receptor nuclear translocator-like protein 1Add BLAST | 632 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | Phosphoserine; by GSK3-beta1 Publication | 1 | |
Modified residuei | 21 | Phosphothreonine; by GSK3-beta1 Publication | 1 | |
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 97 | Phosphoserine; by CK21 Publication | 1 | |
Cross-linki | 259 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)1 Publication | ||
Cross-linki | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication | ||
Cross-linki | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 544 | N6-acetyllysine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9WTL8 |
PRIDEi | Q9WTL8 |
PTM databases
iPTMneti | Q9WTL8 |
PhosphoSitePlusi | Q9WTL8 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000055116, Expressed in secondary oocyte and 283 other tissues |
Genevisiblei | Q9WTL8, MM |
Interactioni
Subunit structurei
Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (PubMed:11779462).
Forms a heterodimer with CLOCK (PubMed:9616112, PubMed:16717091, PubMed:16980631, PubMed:18662546, PubMed:19946213, PubMed:19330005, PubMed:21613214, PubMed:23970558, PubMed:22653727). The CLOCK-ARNTL/BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL/BMAL1 (PubMed:11779462).
Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (PubMed:20093473).
Interacts with NPAS2 (PubMed:16628007).
Interacts with EZH2 (PubMed:16717091, PubMed:23970558).
Interacts with SUMO3 (PubMed:18644859).
Interacts with SIRT1 (PubMed:18662546, PubMed:18662547, PubMed:19299583).
Interacts with AHR (PubMed:20106950).
Interacts with ID1, ID2 and ID3 (PubMed:20861012).
Interacts with DDX4 (PubMed:22900038).
Interacts with OGT (PubMed:23337503).
Interacts with EED and SUZ12 (PubMed:23970558).
Interacts with MTA1 (PubMed:24089055).
Interacts with CIART (PubMed:24385426, PubMed:24736997).
Interacts with HSP90 (By similarity).
Interacts with KAT2B and EP300 (By similarity).
Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (PubMed:12397359).
Interacts with RELB and the interaction is enhanced in the presence of CLOCK (PubMed:22894897).
Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (PubMed:18430226, PubMed:19605937, PubMed:20840750, PubMed:21613214, PubMed:24154698). Interaction of the CLOCK-ARNTL/BMAL1 heterodimer with PER or CRY inhibits transcription activation (PubMed:21613214). Interaction of the CLOCK-ARNTL/BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (PubMed:21613214). The CLOCK-ARNTL/BMAL1 heterodimer interacts with GSK3B (PubMed:19946213, PubMed:20049328).
Interacts with KDM5A (PubMed:21960634).
Interacts with KMT2A; in a circadian manner (PubMed:21113167).
Interacts with UBE3A (By similarity).
Interacts with PRKCG (PubMed:23185022).
Interacts with MAGEL2 (PubMed:22208286).
Interacts with NCOA2 (PubMed:24529706).
Interacts with THRAP3 (PubMed:24043798). The CLOCK-ARNTL/BMAL1 heterodimer interacts with PASD1 (By similarity).
Interacts with PASD1 (By similarity).
Interacts with USP9X (PubMed:29626158).
Interacts with PIWIL2 (via PIWI domain) (PubMed:28903391).
Interacts with HDAC3 (PubMed:26776516).
Interacts with HNF4A (By similarity).
By similarity37 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 84 | Interaction with E-box DNABy similarity | 1 | |
Sitei | 87 | Interaction with E-box DNABy similarity | 1 | |
Sitei | 88 | Interaction with E-box DNABy similarity | 1 | |
Sitei | 92 | Interaction with E-box DNABy similarity | 1 |
Binary interactionsi
Hide detailsQ9WTL8
Isoform 2 [Q9WTL8-2]
With | #Exp. | IntAct |
---|---|---|
Clock [O08785] | 2 | EBI-644559,EBI-79859 |
Cry1 [P97784] | 4 | EBI-644559,EBI-1266607 |
Isoform 4 [Q9WTL8-4]
With | #Exp. | IntAct |
---|---|---|
Crebbp [P45481] | 2 | EBI-644568,EBI-296306 |
Cry1 [P97784] | 4 | EBI-644568,EBI-1266607 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- bHLH transcription factor binding Source: BHF-UCL
- DNA-binding transcription factor binding Source: MGI
- Hsp90 protein binding Source: MGI
- protein heterodimerization activity Source: BHF-UCL
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198207, 18 interactors |
ComplexPortali | CPX-3225, CLOCK-BMAL1 transcription complex |
CORUMi | Q9WTL8 |
DIPi | DIP-43977N |
IntActi | Q9WTL8, 32 interactors |
MINTi | Q9WTL8 |
STRINGi | 10090.ENSMUSP00000046235 |
Miscellaneous databases
RNActi | Q9WTL8, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | Q9WTL8 |
SMRi | Q9WTL8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 132 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 150 – 222 | PAS 1PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 333 – 403 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 408 – 451 | PACAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 514 – 594 | Interaction with CIARTAdd BLAST | 81 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 36 – 41 | Nuclear localization signal1 Publication | 6 | |
Motifi | 149 – 159 | Nuclear export signal 11 PublicationAdd BLAST | 11 | |
Motifi | 367 – 375 | Nuclear export signal 21 Publication | 9 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000157523 |
HOGENOMi | CLU_011864_2_2_1 |
InParanoidi | Q9WTL8 |
OMAi | YHHEDIP |
PhylomeDBi | Q9WTL8 |
TreeFami | TF319983 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADQRMDISS TISDFMSPGP TDLLSGSLGT SGVDCNRKRK GSATDYQLDD
60 70 80 90 100
FAFEESMDTD KDDPHGRLEY AEHQGRIKNA REAHSQIEKR RRDKMNSFID
110 120 130 140 150
ELASLVPTCN AMSRKLDKLT VLRMAVQHMK TLRGATNPYT EANYKPTFLS
160 170 180 190 200
DDELKHLILR AADGFLFVVG CDRGKILFVS ESVFKILNYS QNDLIGQSLF
210 220 230 240 250
DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT PGPSRLCSGA
260 270 280 290 300
RRSFFCRMKC NRPSVKVEDK DFASTCSKKK DRKSFCTIHS TGYLKSWPPT
310 320 330 340 350
KMGLDEDNEP DNEGCNLSCL VAIGRLHSHM VPQPANGEIR VKSMEYVSRH
360 370 380 390 400
AIDGKFVFVD QRATAILAYL PQELLGTSCY EYFHQDDIGH LAECHRQVLQ
410 420 430 440 450
TREKITTNCY KFKIKDGSFI TLRSRWFSFM NPWTKEVEYI VSTNTVVLAN
460 470 480 490 500
VLEGGDPTFP QLTAPPHSMD SMLPSGEGGP KRTHPTVPGI PGGTRAGAGK
510 520 530 540 550
IGRMIAEEIM EIHRIRGSSP SSCGSSPLNI TSTPPPDASS PGGKKILNGG
560 570 580 590 600
TPDIPSTGLL PGQAQETPGY PYSDSSSILG ENPHIGIDMI DNDQGSSSPS
610 620 630
NDEAAMAVIM SLLEADAGLG GPVDFSDLPW PL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GS77 | A0A1B0GS77_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arntl | 633 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 254 | F → L in BAA76414 (PubMed:10403839).Curated | 1 | |
Sequence conflicti | 254 | F → L in BAA81898 (PubMed:10403839).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007992 | 48 – 54 | Missing in isoform 2, isoform 4 and isoform 5. 3 Publications | 7 | |
Alternative sequenceiVSP_007993 | 49 – 68 | Missing in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_007995 | 161 – 483 | AADGF…GPKRT → DVTEGRSSLSPSLSSRSSII ARMTLLARACLTTCIQKILP KLRNSYLPRTLRPGSDSLMP RLDFRLKRI in isoform 5. 1 PublicationAdd BLAST | 323 | |
Alternative sequenceiVSP_007994 | 280 | K → KA in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_007996 | 484 – 632 | Missing in isoform 5. 1 PublicationAdd BLAST | 149 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012601 mRNA Translation: BAA76414.1 AB015203 mRNA Translation: BAA81898.1 AB012602 mRNA Translation: BAA76415.1 AB014494 mRNA Translation: BAA32208.1 BC025973 mRNA Translation: AAH25973.1 BC011080 mRNA Translation: AAH11080.1 |
CCDSi | CCDS40092.1 [Q9WTL8-4] CCDS85390.1 [Q9WTL8-3] |
PIRi | JE0270 |
RefSeqi | NP_001229977.1, NM_001243048.1 [Q9WTL8-3] NP_031515.1, NM_007489.4 [Q9WTL8-4] XP_006507314.1, XM_006507251.2 XP_017177438.1, XM_017321949.1 XP_017177439.1, XM_017321950.1 [Q9WTL8-2] |
Genome annotation databases
Ensembli | ENSMUST00000047321; ENSMUSP00000046235; ENSMUSG00000055116 [Q9WTL8-4] ENSMUST00000210074; ENSMUSP00000147764; ENSMUSG00000055116 [Q9WTL8-3] ENSMUST00000210238; ENSMUSP00000147989; ENSMUSG00000055116 [Q9WTL8-4] |
GeneIDi | 11865 |
KEGGi | mmu:11865 |
UCSCi | uc009jhf.2, mouse [Q9WTL8-3] uc009jhi.2, mouse [Q9WTL8-2] uc009jhj.2, mouse [Q9WTL8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012601 mRNA Translation: BAA76414.1 AB015203 mRNA Translation: BAA81898.1 AB012602 mRNA Translation: BAA76415.1 AB014494 mRNA Translation: BAA32208.1 BC025973 mRNA Translation: AAH25973.1 BC011080 mRNA Translation: AAH11080.1 |
CCDSi | CCDS40092.1 [Q9WTL8-4] CCDS85390.1 [Q9WTL8-3] |
PIRi | JE0270 |
RefSeqi | NP_001229977.1, NM_001243048.1 [Q9WTL8-3] NP_031515.1, NM_007489.4 [Q9WTL8-4] XP_006507314.1, XM_006507251.2 XP_017177438.1, XM_017321949.1 XP_017177439.1, XM_017321950.1 [Q9WTL8-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4F3L | X-ray | 2.27 | B | 69-453 | [»] | |
SASBDBi | Q9WTL8 | |||||
SMRi | Q9WTL8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198207, 18 interactors |
ComplexPortali | CPX-3225, CLOCK-BMAL1 transcription complex |
CORUMi | Q9WTL8 |
DIPi | DIP-43977N |
IntActi | Q9WTL8, 32 interactors |
MINTi | Q9WTL8 |
STRINGi | 10090.ENSMUSP00000046235 |
PTM databases
iPTMneti | Q9WTL8 |
PhosphoSitePlusi | Q9WTL8 |
Proteomic databases
PaxDbi | Q9WTL8 |
PRIDEi | Q9WTL8 |
Protocols and materials databases
Antibodypediai | 11861, 521 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000047321; ENSMUSP00000046235; ENSMUSG00000055116 [Q9WTL8-4] ENSMUST00000210074; ENSMUSP00000147764; ENSMUSG00000055116 [Q9WTL8-3] ENSMUST00000210238; ENSMUSP00000147989; ENSMUSG00000055116 [Q9WTL8-4] |
GeneIDi | 11865 |
KEGGi | mmu:11865 |
UCSCi | uc009jhf.2, mouse [Q9WTL8-3] uc009jhi.2, mouse [Q9WTL8-2] uc009jhj.2, mouse [Q9WTL8-1] |
Organism-specific databases
CTDi | 406 |
MGIi | MGI:1096381, Arntl |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000157523 |
HOGENOMi | CLU_011864_2_2_1 |
InParanoidi | Q9WTL8 |
OMAi | YHHEDIP |
PhylomeDBi | Q9WTL8 |
TreeFami | TF319983 |
Miscellaneous databases
BioGRID-ORCSi | 11865, 2 hits in 17 CRISPR screens |
ChiTaRSi | Arntl, mouse |
PROi | PR:Q9WTL8 |
RNActi | Q9WTL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055116, Expressed in secondary oocyte and 283 other tissues |
Genevisiblei | Q9WTL8, MM |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMAL1_MOUSE | |
Accessioni | Q9WTL8Primary (citable) accession number: Q9WTL8 Secondary accession number(s): O88295 Q9WTL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | August 15, 2003 | |
Last modified: | February 10, 2021 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references