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Protein

Ras-related protein Rab-25

Gene

Rab25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (PubMed:22696678). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27GTPBy similarity9
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4
Nucleotide bindingi155 – 157GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • myosin V binding Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-25
Gene namesi
Name:Rab25Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1858203 Rab25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212161 – 210Ras-related protein Rab-25Add BLAST210
PropeptideiPRO_0000370822211 – 213Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi209S-geranylgeranyl cysteineBy similarity1
Modified residuei210Cysteine methyl esterSequence analysis1
Lipidationi210S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9WTL2
PaxDbiQ9WTL2
PRIDEiQ9WTL2

PTM databases

iPTMnetiQ9WTL2
PhosphoSitePlusiQ9WTL2

Expressioni

Gene expression databases

BgeeiENSMUSG00000008601 Expressed in 143 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_RAB25
ExpressionAtlasiQ9WTL2 baseline and differential
GenevisibleiQ9WTL2 MM

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9WTL2, 3 interactors
MINTiQ9WTL2
STRINGi10090.ENSMUSP00000008745

Structurei

3D structure databases

ProteinModelPortaliQ9WTL2
SMRiQ9WTL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 49Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9WTL2
KOiK07906
OMAiMGSDEAY
OrthoDBiEOG091G0JQ6
PhylomeDBiQ9WTL2
TreeFamiTF300099

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9WTL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNRTDEDYN FVFKVVLIGE SGVGKTNLLS RFTRNEFSHD SRTTIGVEFS
60 70 80 90 100
TRTVMLGTAA VKAQIWDTAG LERYRAITSA YYRGAVGALL VFDLTKHQTY
110 120 130 140 150
AVVERWLKEL YDHAEATIVV MLVGNKSDLS QAREVPTEEA CMFAENNGLL
160 170 180 190 200
FLETSALDST NVELAFQTVL KEIFAKVSKQ KQNSTRTSAI TLGNAQAGQD
210
PGPGEKRACC ISL
Length:213
Mass (Da):23,473
Last modified:April 13, 2004 - v2
Checksum:i1359F7B4EA88D070
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYB3D3YYB3_MOUSE
Ras-related protein Rab-25
Rab25
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203P → L in AAD39911 (PubMed:10708602).Curated1
Sequence conflicti203P → L in AAD39912 (PubMed:10708602).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119675 mRNA Translation: AAD39911.1
AF119676 Genomic DNA Translation: AAD39912.1
AK003260 mRNA Translation: BAB22676.1
BC006624 mRNA Translation: AAH06624.1
CCDSiCCDS17477.1
RefSeqiNP_058595.2, NM_016899.4
UniGeneiMm.26994

Genome annotation databases

EnsembliENSMUST00000008745; ENSMUSP00000008745; ENSMUSG00000008601
GeneIDi53868
KEGGimmu:53868
UCSCiuc008pvn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119675 mRNA Translation: AAD39911.1
AF119676 Genomic DNA Translation: AAD39912.1
AK003260 mRNA Translation: BAB22676.1
BC006624 mRNA Translation: AAH06624.1
CCDSiCCDS17477.1
RefSeqiNP_058595.2, NM_016899.4
UniGeneiMm.26994

3D structure databases

ProteinModelPortaliQ9WTL2
SMRiQ9WTL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9WTL2, 3 interactors
MINTiQ9WTL2
STRINGi10090.ENSMUSP00000008745

PTM databases

iPTMnetiQ9WTL2
PhosphoSitePlusiQ9WTL2

Proteomic databases

MaxQBiQ9WTL2
PaxDbiQ9WTL2
PRIDEiQ9WTL2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008745; ENSMUSP00000008745; ENSMUSG00000008601
GeneIDi53868
KEGGimmu:53868
UCSCiuc008pvn.1 mouse

Organism-specific databases

CTDi57111
MGIiMGI:1858203 Rab25

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9WTL2
KOiK07906
OMAiMGSDEAY
OrthoDBiEOG091G0JQ6
PhylomeDBiQ9WTL2
TreeFamiTF300099

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

PROiPR:Q9WTL2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008601 Expressed in 143 organ(s), highest expression level in urinary bladder urothelium
CleanExiMM_RAB25
ExpressionAtlasiQ9WTL2 baseline and differential
GenevisibleiQ9WTL2 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB25_MOUSE
AccessioniPrimary (citable) accession number: Q9WTL2
Secondary accession number(s): Q9D1P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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