UniProtKB - Q9WTL0 (DEFB3_MOUSE)
Protein
Beta-defensin 3
Gene
Defb3
Organism
Mus musculus (Mouse)
Status
Functioni
Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa.1 Publication
GO - Molecular functioni
- CCR6 chemokine receptor binding Source: GO_Central
- chemoattractant activity Source: GO_Central
GO - Biological processi
- cell chemotaxis Source: GO_Central
- chemotaxis Source: GO_Central
- defense response to bacterium Source: MGI
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Defensin |
Protein family/group databases
TCDBi | 1.C.85.1.8, the pore-forming Beta-defensin (Beta-defensin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-defensin 3Short name: BD-3 Short name: mBD-3 Alternative name(s): Defensin, beta 3 |
Gene namesi | Name:Defb3 Synonyms:Bd3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1351612, Defb3 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
PropeptideiPRO_0000006928 | 21 – 22 | Sequence analysis | 2 | |
PeptideiPRO_0000006929 | 23 – 63 | Beta-defensin 3Add BLAST | 41 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 59 | By similarity | ||
Disulfide bondi | 38 ↔ 52 | By similarity | ||
Disulfide bondi | 42 ↔ 60 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
PaxDbi | Q9WTL0 |
PRIDEi | Q9WTL0 |
Expressioni
Tissue specificityi
Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue.2 Publications
Inductioni
By bacterial infection.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000039775, Expressed in uterine cervix and 24 other tissues |
Genevisiblei | Q9WTL0, MM |
Interactioni
GO - Molecular functioni
- CCR6 chemokine receptor binding Source: GO_Central
- chemoattractant activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033852 |
Miscellaneous databases
RNActi | Q9WTL0, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502T3P6, Eukaryota |
GeneTreei | ENSGT00940000160995 |
HOGENOMi | CLU_189296_4_1_1 |
InParanoidi | Q9WTL0 |
OMAi | IRSGAIC |
OrthoDBi | 1636401at2759 |
PhylomeDBi | Q9WTL0 |
Family and domain databases
InterProi | View protein in InterPro IPR001855, Defensin_beta-typ |
Pfami | View protein in Pfam PF00711, Defensin_beta, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9WTL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRIHYLLFAF LLVLLSPPAA FSKKINNPVS CLRKGGRCWN RCIGNTRQIG
60
SCGVPFLKCC KRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF093245 Genomic DNA Translation: AAD29573.1 AF092929 mRNA Translation: AAD29572.1 BC114344 mRNA Translation: AAI14345.1 BC116176 mRNA Translation: AAI16177.1 BC116177 mRNA Translation: AAI16178.1 BC134358 mRNA Translation: AAI34359.1 |
CCDSi | CCDS40258.1 |
RefSeqi | NP_038784.1, NM_013756.2 |
Genome annotation databases
Ensembli | ENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775 |
GeneIDi | 27358 |
KEGGi | mmu:27358 |
UCSCi | uc009lao.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF093245 Genomic DNA Translation: AAD29573.1 AF092929 mRNA Translation: AAD29572.1 BC114344 mRNA Translation: AAI14345.1 BC116176 mRNA Translation: AAI16177.1 BC116177 mRNA Translation: AAI16178.1 BC134358 mRNA Translation: AAI34359.1 |
CCDSi | CCDS40258.1 |
RefSeqi | NP_038784.1, NM_013756.2 |
3D structure databases
SMRi | Q9WTL0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000033852 |
Protein family/group databases
TCDBi | 1.C.85.1.8, the pore-forming Beta-defensin (Beta-defensin) family |
Proteomic databases
PaxDbi | Q9WTL0 |
PRIDEi | Q9WTL0 |
Genome annotation databases
Ensembli | ENSMUST00000033852; ENSMUSP00000033852; ENSMUSG00000039775 |
GeneIDi | 27358 |
KEGGi | mmu:27358 |
UCSCi | uc009lao.1, mouse |
Organism-specific databases
CTDi | 27358 |
MGIi | MGI:1351612, Defb3 |
Phylogenomic databases
eggNOGi | ENOG502T3P6, Eukaryota |
GeneTreei | ENSGT00940000160995 |
HOGENOMi | CLU_189296_4_1_1 |
InParanoidi | Q9WTL0 |
OMAi | IRSGAIC |
OrthoDBi | 1636401at2759 |
PhylomeDBi | Q9WTL0 |
Miscellaneous databases
BioGRID-ORCSi | 27358, 0 hits in 17 CRISPR screens |
PROi | PR:Q9WTL0 |
RNActi | Q9WTL0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039775, Expressed in uterine cervix and 24 other tissues |
Genevisiblei | Q9WTL0, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001855, Defensin_beta-typ |
Pfami | View protein in Pfam PF00711, Defensin_beta, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DEFB3_MOUSE | |
Accessioni | Q9WTL0Primary (citable) accession number: Q9WTL0 Secondary accession number(s): Q29R78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families