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UniProtKB - Q9WTK8 (SPO11_MOUSE)

Entry version 163 (10 Feb 2021)
Sequence version 2 (23 Apr 2003)
Previous versions | rss
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Protein

Meiotic recombination protein SPO11

Gene

Spo11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917764). The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (PubMed:22346761).2 Publications
In contrast to isoform 1, does not mediate DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.Curated EC:5.6.2.2

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei138NucleophileBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi224MagnesiumBy similarity1
Metal bindingi277MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Hydrolase, Isomerase
Biological processMeiosis
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meiotic recombination protein SPO11 (EC:5.6.2.2Curated)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spo11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1349669, Spo11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001454751 – 396Meiotic recombination protein SPO11Add BLAST396

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9WTK8

PRoteomics IDEntifications database

More...PRIDEi		Q9WTK8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9WTK8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9WTK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels are found only in the testis where expression is restricted primarily to meiotic germ cells. Not expressed in spermatogonia. Highest levels are found in pachytene spermatocytes. Very low levels are found in thymus, brain and oocytes of embryonic ovary. Not detected in adult ovary (PubMed:10622720, PubMed:10855504). Isoform 1: Expressed early in meiosis, when most double-strand breaks (DSB) are formed (PubMed:21330546).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Not detected at day 7 postpartum (dpp). Levels are low at 12 dpp but increase by 17 dpp. High levels are maintained throughout the remainder of testis development.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000005883, Expressed in spermatocyte and 60 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9WTK8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of SPO11 and 2 TOP6BL chains (Probable).

Interacts with TOP6BL (PubMed:26917764).

Curated1 Publication

Does not interact with TOP6BL (PubMed:26917764).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		205092, 1 interactor

Database of interacting proteins

More...DIPi		DIP-62006N

Protein interaction database and analysis system

More...IntActi		Q9WTK8, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000059056

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9WTK8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9WTK8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TOP6A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2795, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_037229_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9WTK8

Identification of Orthologs from Complete Genome Data

More...OMAi		FTDGDPY

Database of Orthologous Groups

More...OrthoDBi		1272299at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9WTK8

TreeFam database of animal gene trees

More...TreeFami		TF314157

Family and domain databases

Conserved Domains Database

More...CDDi		cd00223, TOPRIM_TopoIIB_SPO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004084, Meiosis_Spo11
IPR013048, Meiotic_Spo11
IPR002815, Spo11/TopoVI_A
IPR013049, Spo11/TopoVI_A_N
IPR036078, Spo11/TopoVI_A_sf
IPR034136, TOPRIM_Topo6A/Spo11
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR10848, PTHR10848, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03533, SPO11_like, 1 hit
PF04406, TP6A_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01551, SPO11HOMOLOG
PR01550, TOP6AFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56726, SSF56726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9WTK8-1) [UniParc]FASTAAdd to basket
Also known as: Spo11beta1 Publication, Beta1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFAPMGPEA SFFDALDRHR ASLLAMVKRG AGETPAGATR VASSSEVLTA 
        60         70         80         90        100
IENIIQDIIK SLARNEVPAF TIDNRSSWEN IMFDDSVGLR MIPQCTTRKI 
       110        120        130        140        150
RSDSPKSVKK FALILKVLSM IYKLIQSDTY ATKRDIYYTD SQLFGNQAAV 
       160        170        180        190        200
DSAIDDISCM LKVPRRSLHV LSTSKGLIAG NLRYMEEDGT RVQCTCSATA 
       210        220        230        240        250
TAVPTNIQGM QHLITDAKFL LIVEKDATFQ RLLDDNFCSR MSPCIMVTGK 
       260        270        280        290        300
GVPDLNTRLL VKKLWDTFHI PVFTLVDADP YGIEIMCIYK YGSMSMSFEA 
       310        320        330        340        350
HNLTIPTIRW LGLLPSDIQR LNIPKDSLIP LTKHDQMKLD SILKRPYITY 
       360        370        380        390 
QPLWKKELEM MADSKMKAEI QALTLLSSDY LSRVYLPNKL RFGGWI
Length:396
Mass (Da):44,570
Last modified:April 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4B9723C02844A5E
GO
Isoform 2 (identifier: Q9WTK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-216: Missing.

Show »
Length:392
Mass (Da):44,127
Checksum:iADBD0F00D8A381AB
GO
Isoform 3 (identifier: Q9WTK8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-81: Missing.
     82-82: M → R
     134-134: R → RSNAHSVLTLHLHR

Show »
Length:371
Mass (Da):41,792
Checksum:iE9696495058C76DE
GO
Isoform 4 (identifier: Q9WTK8-4) [UniParc]FASTAAdd to basket
Also known as: Spo11alpha1 Publication, Alpha1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     44-81: Missing.
     82-82: M → R

Show »
Length:358
Mass (Da):40,325
Checksum:iE400467F9DB0514A
GO
Isoform 5 (identifier: Q9WTK8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-81: Missing.
     82-82: M → R
     213-216: Missing.

Show »
Length:354
Mass (Da):39,883
Checksum:iA2891414C41A86C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00719744 – 81Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_00719882M → R in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_007199134R → RSNAHSVLTLHLHR in isoform 3. 2 Publications1
Alternative sequenceiVSP_007200213 – 216Missing in isoform 2 and isoform 5. 2 Publications4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF126400 mRNA Translation: AAD49561.1
AF149309 mRNA Translation: AAD44811.1
AF169386 mRNA Translation: AAD52563.1
AF163053 mRNA Translation: AAD43588.1
AF163052, AF163049, AF163051 Genomic DNA Translation: AAD43591.1
AF163052, AF163049, AF163051 Genomic DNA Translation: AAD43592.1
AF163054 mRNA Translation: AAD43589.1
AF165313 mRNA Translation: AAF87090.1
AF167439 mRNA Translation: AAF87094.1
AF173848 mRNA Translation: AAF87096.1
AF443910 Genomic DNA Translation: AAL32063.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17137.1 [Q9WTK8-1]
CCDS50811.1 [Q9WTK8-3]
CCDS50812.1 [Q9WTK8-4]

NCBI Reference Sequences

More...RefSeqi		NP_001077428.1, NM_001083959.1 [Q9WTK8-3]
NP_001077429.1, NM_001083960.1 [Q9WTK8-4]
NP_001292363.1, NM_001305434.1 [Q9WTK8-5]
NP_036176.1, NM_012046.2 [Q9WTK8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000050442; ENSMUSP00000059056; ENSMUSG00000005883 [Q9WTK8-1]
ENSMUST00000109125; ENSMUSP00000104753; ENSMUSG00000005883 [Q9WTK8-4]
ENSMUST00000109126; ENSMUSP00000104754; ENSMUSG00000005883 [Q9WTK8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26972

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:26972

UCSC genome browser

More...UCSCi		uc008odd.1, mouse [Q9WTK8-1]
uc008ode.1, mouse [Q9WTK8-4]
uc008odf.1, mouse [Q9WTK8-3]
uc012ckq.1, mouse [Q9WTK8-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126400 mRNA Translation: AAD49561.1
AF149309 mRNA Translation: AAD44811.1
AF169386 mRNA Translation: AAD52563.1
AF163053 mRNA Translation: AAD43588.1
AF163052, AF163049, AF163051 Genomic DNA Translation: AAD43591.1
AF163052, AF163049, AF163051 Genomic DNA Translation: AAD43592.1
AF163054 mRNA Translation: AAD43589.1
AF165313 mRNA Translation: AAF87090.1
AF167439 mRNA Translation: AAF87094.1
AF173848 mRNA Translation: AAF87096.1
AF443910 Genomic DNA Translation: AAL32063.1
CCDSiCCDS17137.1 [Q9WTK8-1]
CCDS50811.1 [Q9WTK8-3]
CCDS50812.1 [Q9WTK8-4]
RefSeqiNP_001077428.1, NM_001083959.1 [Q9WTK8-3]
NP_001077429.1, NM_001083960.1 [Q9WTK8-4]
NP_001292363.1, NM_001305434.1 [Q9WTK8-5]
NP_036176.1, NM_012046.2 [Q9WTK8-1]

3D structure databases

SMRiQ9WTK8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205092, 1 interactor
DIPiDIP-62006N
IntActiQ9WTK8, 1 interactor
STRINGi10090.ENSMUSP00000059056

PTM databases

iPTMnetiQ9WTK8
PhosphoSitePlusiQ9WTK8

Proteomic databases

PaxDbiQ9WTK8
PRIDEiQ9WTK8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28951, 189 antibodies

The DNASU plasmid repository

More...DNASUi		26972

Genome annotation databases

EnsembliENSMUST00000050442; ENSMUSP00000059056; ENSMUSG00000005883 [Q9WTK8-1]
ENSMUST00000109125; ENSMUSP00000104753; ENSMUSG00000005883 [Q9WTK8-4]
ENSMUST00000109126; ENSMUSP00000104754; ENSMUSG00000005883 [Q9WTK8-3]
GeneIDi26972
KEGGimmu:26972
UCSCiuc008odd.1, mouse [Q9WTK8-1]
uc008ode.1, mouse [Q9WTK8-4]
uc008odf.1, mouse [Q9WTK8-3]
uc012ckq.1, mouse [Q9WTK8-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23626
MGIiMGI:1349669, Spo11

Phylogenomic databases

eggNOGiKOG2795, Eukaryota
GeneTreeiENSGT00390000001787
HOGENOMiCLU_037229_1_1_1
InParanoidiQ9WTK8
OMAiFTDGDPY
OrthoDBi1272299at2759
PhylomeDBiQ9WTK8
TreeFamiTF314157

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26972, 0 hits in 17 CRISPR screens

Protein Ontology

More...PROi		PR:Q9WTK8
RNActiQ9WTK8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000005883, Expressed in spermatocyte and 60 other tissues
GenevisibleiQ9WTK8, MM

Family and domain databases

CDDicd00223, TOPRIM_TopoIIB_SPO, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004084, Meiosis_Spo11
IPR013048, Meiotic_Spo11
IPR002815, Spo11/TopoVI_A
IPR013049, Spo11/TopoVI_A_N
IPR036078, Spo11/TopoVI_A_sf
IPR034136, TOPRIM_Topo6A/Spo11
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR10848, PTHR10848, 1 hit
PfamiView protein in Pfam
PF03533, SPO11_like, 1 hit
PF04406, TP6A_N, 1 hit
PRINTSiPR01551, SPO11HOMOLOG
PR01550, TOP6AFAMILY
SUPFAMiSSF56726, SSF56726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPO11_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WTK8
Secondary accession number(s): Q8VIH6
, Q9QUK2, Q9QY57, Q9QZS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 23, 2003
Last modified: February 10, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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