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Protein

Glycosylphosphatidylinositol anchor attachment 1 protein

Gene

Gpaa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.2 Publications

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

  • GPI anchor binding Source: Ensembl
  • GPI-anchor transamidase activity Source: MGI

GO - Biological processi

  • attachment of GPI anchor to protein Source: GO_Central
  • GPI anchor biosynthetic process Source: MGI

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-162791 Attachment of GPI anchor to uPAR
UniPathwayi
UPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Glycosylphosphatidylinositol anchor attachment 1 protein
Short name:
GPI anchor attachment protein 1
Alternative name(s):
GAA1 protein homolog
Short name:
mGAA1
Gene namesi
Name:Gpaa1
Synonyms:Gaa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1202392 Gpaa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 367LumenalSequence analysisAdd BLAST323
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 426CytoplasmicSequence analysisAdd BLAST38
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 457LumenalSequence analysis10
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 499CytoplasmicSequence analysisAdd BLAST21
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 542LumenalSequence analysisAdd BLAST22
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Topological domaini564 – 598CytoplasmicSequence analysisAdd BLAST35
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 621LumenalSequence analysis2

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875551 – 621Glycosylphosphatidylinositol anchor attachment 1 proteinAdd BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9WTK3
MaxQBiQ9WTK3
PaxDbiQ9WTK3
PeptideAtlasiQ9WTK3
PRIDEiQ9WTK3

PTM databases

PhosphoSitePlusiQ9WTK3

Expressioni

Tissue specificityi

Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,.1 Publication

Gene expression databases

BgeeiENSMUSG00000022561 Expressed in 228 organ(s), highest expression level in cerebellum
CleanExiMM_GPAA1
ExpressionAtlasiQ9WTK3 baseline and differential
GenevisibleiQ9WTK3 MM

Interactioni

Subunit structurei

Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023221

Structurei

3D structure databases

ProteinModelPortaliQ9WTK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3566 Eukaryota
ENOG410XT16 LUCA
GeneTreeiENSGT00390000013685
HOGENOMiHOG000045628
HOVERGENiHBG051793
InParanoidiQ9WTK3
KOiK05289
OMAiIYGNWLY
OrthoDBiEOG091G0703
PhylomeDBiQ9WTK3
TreeFamiTF313030

Family and domain databases

InterProiView protein in InterPro
IPR007246 Gaa1
PANTHERiPTHR13304 PTHR13304, 1 hit
PfamiView protein in Pfam
PF04114 Gaa1, 1 hit
PIRSFiPIRSF036762 GAA1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9WTK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLSDPVRR RALARIVLRL NTPLCVLSYV AGIAWFLALA FPPLTQRTYM
60 70 80 90 100
SENAMGSTMV EEQFVGGDRA RSFARDFAAH RKKPGALPVA WLERSMRSVG
110 120 130 140 150
LEVYTQSFSR KLPFPDETHE RYMVSGTNVY GILRAPRSAS TESLVLTVPC
160 170 180 190 200
GPDATNSQAV GLLLALAAHF RGQIYWAKDI IFLVTDHDLL GTEAWLEAYH
210 220 230 240 250
DINVTGIQSS PLQGRAGAIQ AAVALELSSD VVTSLDVTVE GLNGQLPNLD
260 270 280 290 300
LLNLFQTFCQ KGGLLCTLQG KLQPQDWTSL EGPLQGLQTL LLMVLRQASG
310 320 330 340 350
RPHGPHGLFL RYGVEALTLR GINSFRQYKY DLATVGKALE GMFRKLNHLL
360 370 380 390 400
ERLHQSFFFY LLPALSRFVS IGLYMPATGF LLLVLGLKAL ELWMQLHQAG
410 420 430 440 450
VNPEEAGKAP SPGTPLLPTQ GVGLASLTAP LLISQAMGLA LYFLPVLGQH
460 470 480 490 500
LATQHFPVAE AEAVVLTLLA IYVAGLALPH NTHRVVNSQV PDRGWMALKL
510 520 530 540 550
VALIYLALQL GCIALLNFSL GFLLAATMVP AAALAKPHGP RTLYAALLVV
560 570 580 590 600
TSPAVTLFGS LFLWRELLEV PLSLAEGWQL FLTALAQGVL EHYTYGALLF
610 620
PILALGLYPC WLLFWNVLFW K
Length:621
Mass (Da):67,949
Last modified:January 23, 2007 - v3
Checksum:i880F6E3856272C91
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW03E9PW03_MOUSE
Glycosylphosphatidylinositol anchor...
Gpaa1
561Annotation score:
E9QA52E9QA52_MOUSE
Glycosylphosphatidylinositol anchor...
Gpaa1
74Annotation score:
E9Q4I5E9Q4I5_MOUSE
Glycosylphosphatidylinositol anchor...
Gpaa1
74Annotation score:
F6T7Y8F6T7Y8_MOUSE
Glycosylphosphatidylinositol anchor...
Gpaa1
102Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002136 mRNA Translation: BAA82589.1
AB002138 Genomic DNA Translation: BAA82591.1
AB006970 mRNA Translation: BAB03274.1
AB006971 Genomic DNA Translation: BAB03275.1
AB017266 Genomic DNA Translation: BAA82586.1
AK077518 mRNA Translation: BAC36840.1
AK164219 mRNA Translation: BAE37686.1
AK164978 mRNA Translation: BAE37988.1
BC006697 mRNA Translation: AAH06697.1
CCDSiCCDS37120.1
RefSeqiNP_034461.1, NM_010331.2
UniGeneiMm.5903

Genome annotation databases

EnsembliENSMUST00000023221; ENSMUSP00000023221; ENSMUSG00000022561
GeneIDi14731
KEGGimmu:14731
UCSCiuc007wjq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002136 mRNA Translation: BAA82589.1
AB002138 Genomic DNA Translation: BAA82591.1
AB006970 mRNA Translation: BAB03274.1
AB006971 Genomic DNA Translation: BAB03275.1
AB017266 Genomic DNA Translation: BAA82586.1
AK077518 mRNA Translation: BAC36840.1
AK164219 mRNA Translation: BAE37686.1
AK164978 mRNA Translation: BAE37988.1
BC006697 mRNA Translation: AAH06697.1
CCDSiCCDS37120.1
RefSeqiNP_034461.1, NM_010331.2
UniGeneiMm.5903

3D structure databases

ProteinModelPortaliQ9WTK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023221

PTM databases

PhosphoSitePlusiQ9WTK3

Proteomic databases

EPDiQ9WTK3
MaxQBiQ9WTK3
PaxDbiQ9WTK3
PeptideAtlasiQ9WTK3
PRIDEiQ9WTK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023221; ENSMUSP00000023221; ENSMUSG00000022561
GeneIDi14731
KEGGimmu:14731
UCSCiuc007wjq.1 mouse

Organism-specific databases

CTDi8733
MGIiMGI:1202392 Gpaa1

Phylogenomic databases

eggNOGiKOG3566 Eukaryota
ENOG410XT16 LUCA
GeneTreeiENSGT00390000013685
HOGENOMiHOG000045628
HOVERGENiHBG051793
InParanoidiQ9WTK3
KOiK05289
OMAiIYGNWLY
OrthoDBiEOG091G0703
PhylomeDBiQ9WTK3
TreeFamiTF313030

Enzyme and pathway databases

UniPathwayi
UPA00196

ReactomeiR-MMU-162791 Attachment of GPI anchor to uPAR

Miscellaneous databases

PROiPR:Q9WTK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022561 Expressed in 228 organ(s), highest expression level in cerebellum
CleanExiMM_GPAA1
ExpressionAtlasiQ9WTK3 baseline and differential
GenevisibleiQ9WTK3 MM

Family and domain databases

InterProiView protein in InterPro
IPR007246 Gaa1
PANTHERiPTHR13304 PTHR13304, 1 hit
PfamiView protein in Pfam
PF04114 Gaa1, 1 hit
PIRSFiPIRSF036762 GAA1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPAA1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTK3
Secondary accession number(s): Q3TNU9, Q9R1U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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