UniProtKB - Q9WTK3 (GPAA1_MOUSE)

BLAST

>sp|Q9WTK3|GPAA1_MOUSE Glycosylphosphatidylinositol anchor attachment 1 protein OS=Mus musculus OX=10090 GN=Gpaa1 PE=1 SV=3
MGLLSDPVRRRALARIVLRLNTPLCVLSYVAGIAWFLALAFPPLTQRTYMSENAMGSTMV
EEQFVGGDRARSFARDFAAHRKKPGALPVAWLERSMRSVGLEVYTQSFSRKLPFPDETHE
RYMVSGTNVYGILRAPRSASTESLVLTVPCGPDATNSQAVGLLLALAAHFRGQIYWAKDI
IFLVTDHDLLGTEAWLEAYHDINVTGIQSSPLQGRAGAIQAAVALELSSDVVTSLDVTVE
GLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPQDWTSLEGPLQGLQTLLLMVLRQASG
RPHGPHGLFLRYGVEALTLRGINSFRQYKYDLATVGKALEGMFRKLNHLLERLHQSFFFY
LLPALSRFVSIGLYMPATGFLLLVLGLKALELWMQLHQAGVNPEEAGKAPSPGTPLLPTQ
GVGLASLTAPLLISQAMGLALYFLPVLGQHLATQHFPVAEAEAVVLTLLAIYVAGLALPH
NTHRVVNSQVPDRGWMALKLVALIYLALQLGCIALLNFSLGFLLAATMVPAAALAKPHGP
RTLYAALLVVTSPAVTLFGSLFLWRELLEVPLSLAEGWQLFLTALAQGVLEHYTYGALLF
PILALGLYPCWLLFWNVLFWK

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History
Entry version 128 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Glycosylphosphatidylinositol anchor attachment 1 protein

Gene

Gpaa1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.2 Publications

Pathwayⁱ: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functionⁱ

GPI anchor binding Source: Ensembl
GPI-anchor transamidase activity
Source: MGI
Traceable author statementⁱ
- 10393431

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

attachment of GPI anchor to protein
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GPI anchor biosynthetic process
Source: MGI
Inferred from sequence or structural similarityⁱ
- 10393431

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	GPI-anchor biosynthesis

Biological process

GPI-anchor biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-162791 Attachment of GPI anchor to uPAR
UniPathwayⁱ	UPA00196

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glycosylphosphatidylinositol anchor attachment 1 protein Short name: GPI anchor attachment protein 1 Alternative name(s): GAA1 protein homolog Short name: mGAA1
Gene namesⁱ	Name:Gpaa1 Synonyms:Gaa1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1202392 Gpaa1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 23	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	24 – 44	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	45 – 367	LumenalSequence analysisAdd BLAST	323
Transmembraneⁱ	368 – 388	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	389 – 426	CytoplasmicSequence analysisAdd BLAST	38
Transmembraneⁱ	427 – 447	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	448 – 457	LumenalSequence analysis	10
Transmembraneⁱ	458 – 478	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	479 – 499	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	500 – 520	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	521 – 542	LumenalSequence analysisAdd BLAST	22
Transmembraneⁱ	543 – 563	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	564 – 598	CytoplasmicSequence analysisAdd BLAST	35
Transmembraneⁱ	599 – 619	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	620 – 621	LumenalSequence analysis	2

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087555	1 – 621	Glycosylphosphatidylinositol anchor attachment 1 proteinAdd BLAST		621

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	203	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q9WTK3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9WTK3
PaxDbⁱ	Q9WTK3
PeptideAtlas More...PeptideAtlasⁱ	Q9WTK3
PRIDEⁱ	Q9WTK3

PTM databases

PhosphoSitePlusⁱ	Q9WTK3

PhosphoSitePlusⁱ

Q9WTK3

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000022561 Expressed in 228 organ(s), highest expression level in cerebellum
CleanExⁱ	MM_GPAA1
ExpressionAtlasⁱ	Q9WTK3 baseline and differential
Genevisibleⁱ	Q9WTK3 MM

Interactionⁱ

Subunit structureⁱ

Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS.1 Publication

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000023221

STRINGⁱ

10090.ENSMUSP00000023221

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WTK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3566 Eukaryota ENOG410XT16 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013685
HOGENOMⁱ	HOG000045628
HOVERGENⁱ	HBG051793
InParanoidⁱ	Q9WTK3
KEGG Orthology (KO) More...KOⁱ	K05289
OMAⁱ	IYGNWLY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0703
PhylomeDBⁱ	Q9WTK3
TreeFamⁱ	TF313030

Family and domain databases

InterProⁱ	View protein in InterPro IPR007246 Gaa1
PANTHERⁱ	PTHR13304 PTHR13304, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04114 Gaa1, 1 hit
PIRSFⁱ	PIRSF036762 GAA1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9WTK3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGLLSDPVRR RALARIVLRL NTPLCVLSYV AGIAWFLALA FPPLTQRTYM 
        60         70         80         90        100
SENAMGSTMV EEQFVGGDRA RSFARDFAAH RKKPGALPVA WLERSMRSVG 
       110        120        130        140        150
LEVYTQSFSR KLPFPDETHE RYMVSGTNVY GILRAPRSAS TESLVLTVPC 
       160        170        180        190        200
GPDATNSQAV GLLLALAAHF RGQIYWAKDI IFLVTDHDLL GTEAWLEAYH 
       210        220        230        240        250
DINVTGIQSS PLQGRAGAIQ AAVALELSSD VVTSLDVTVE GLNGQLPNLD 
       260        270        280        290        300
LLNLFQTFCQ KGGLLCTLQG KLQPQDWTSL EGPLQGLQTL LLMVLRQASG 
       310        320        330        340        350
RPHGPHGLFL RYGVEALTLR GINSFRQYKY DLATVGKALE GMFRKLNHLL 
       360        370        380        390        400
ERLHQSFFFY LLPALSRFVS IGLYMPATGF LLLVLGLKAL ELWMQLHQAG 
       410        420        430        440        450
VNPEEAGKAP SPGTPLLPTQ GVGLASLTAP LLISQAMGLA LYFLPVLGQH 
       460        470        480        490        500
LATQHFPVAE AEAVVLTLLA IYVAGLALPH NTHRVVNSQV PDRGWMALKL 
       510        520        530        540        550
VALIYLALQL GCIALLNFSL GFLLAATMVP AAALAKPHGP RTLYAALLVV 
       560        570        580        590        600
TSPAVTLFGS LFLWRELLEV PLSLAEGWQL FLTALAQGVL EHYTYGALLF 
       610        620 
PILALGLYPC WLLFWNVLFW K

Length:621

Mass (Da):67,949

Last modified:January 23, 2007 - v3

Checksum:ⁱ880F6E3856272C91

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PW03	E9PW03_MOUSE	Glycosylphosphatidylinositol anchor... Glycosylphosphatidylinositol anchor attachment 1 protein	Gpaa1	561	Annotation score:
E9QA52	E9QA52_MOUSE	Glycosylphosphatidylinositol anchor... Glycosylphosphatidylinositol anchor attachment 1 protein	Gpaa1	74	Annotation score:
E9Q4I5	E9Q4I5_MOUSE	Glycosylphosphatidylinositol anchor... Glycosylphosphatidylinositol anchor attachment 1 protein	Gpaa1	74	Annotation score:
F6T7Y8	F6T7Y8_MOUSE	Glycosylphosphatidylinositol anchor... Glycosylphosphatidylinositol anchor attachment 1 protein	Gpaa1	102	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002136 mRNA Translation: BAA82589.1 AB002138 Genomic DNA Translation: BAA82591.1 AB006970 mRNA Translation: BAB03274.1 AB006971 Genomic DNA Translation: BAB03275.1 AB017266 Genomic DNA Translation: BAA82586.1 AK077518 mRNA Translation: BAC36840.1 AK164219 mRNA Translation: BAE37686.1 AK164978 mRNA Translation: BAE37988.1 BC006697 mRNA Translation: AAH06697.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37120.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034461.1, NM_010331.2
UniGeneⁱ	Mm.5903

Genome annotation databases

Ensemblⁱ	ENSMUST00000023221; ENSMUSP00000023221; ENSMUSG00000022561
GeneIDⁱ	14731
KEGGⁱ	mmu:14731
UCSC genome browser More...UCSCⁱ	uc007wjq.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WTK3	Glycosylphosphatidylinositol anchor attachment 1 protein (Fragment)		MOUSE		74	UniRef100_Q9WTK3
UPI0003D77756		MOUSE		499

Protein	Similar proteins		Species	Score	Length	Source
Q9WTK3	Isoform 2 of Glycosylphosphatidylinositol anchor attachment 1 protein		HUMAN		561	UniRef90_O43292-2
Uncharacterized protein		RHIBE		628
Glycosylphosphatidylinositol anchor attachment 1 protein (Fragment)		MOUSE		74
Uncharacterized protein		MANLE		620
Uncharacterized protein		PAPAN		561
+22

Protein	Similar proteins		Species	Score	Length	Source
Q9WTK3	Glycosylphosphatidylinositol anchor attachment 1 protein		HUMAN		621	UniRef50_O43292
Glycosylphosphatidylinositol anchor attachment protein 1 homolog		PANTR		626
Glycosylphosphatidylinositol anchor attachment 1		RABIT		623
Uncharacterized protein		LOXAF		623
glycosylphosphatidylinositol anchor attachment 1 protein isoform X1		DELLE		622
+332

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002136 mRNA Translation: BAA82589.1 AB002138 Genomic DNA Translation: BAA82591.1 AB006970 mRNA Translation: BAB03274.1 AB006971 Genomic DNA Translation: BAB03275.1 AB017266 Genomic DNA Translation: BAA82586.1 AK077518 mRNA Translation: BAC36840.1 AK164219 mRNA Translation: BAE37686.1 AK164978 mRNA Translation: BAE37988.1 BC006697 mRNA Translation: AAH06697.1
CCDSⁱ	CCDS37120.1
RefSeqⁱ	NP_034461.1, NM_010331.2
UniGeneⁱ	Mm.5903

3D structure databases

ProteinModelPortalⁱ	Q9WTK3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000023221

STRINGⁱ

10090.ENSMUSP00000023221

PTM databases

PhosphoSitePlusⁱ	Q9WTK3

PhosphoSitePlusⁱ

Q9WTK3

Proteomic databases

EPDⁱ	Q9WTK3
MaxQBⁱ	Q9WTK3
PaxDbⁱ	Q9WTK3
PeptideAtlasⁱ	Q9WTK3
PRIDEⁱ	Q9WTK3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023221; ENSMUSP00000023221; ENSMUSG00000022561
GeneIDⁱ	14731
KEGGⁱ	mmu:14731
UCSCⁱ	uc007wjq.1 mouse

Organism-specific databases

CTDⁱ	8733
MGIⁱ	MGI:1202392 Gpaa1

Phylogenomic databases

eggNOGⁱ	KOG3566 Eukaryota ENOG410XT16 LUCA
GeneTreeⁱ	ENSGT00390000013685
HOGENOMⁱ	HOG000045628
HOVERGENⁱ	HBG051793
InParanoidⁱ	Q9WTK3
KOⁱ	K05289
OMAⁱ	IYGNWLY
OrthoDBⁱ	EOG091G0703
PhylomeDBⁱ	Q9WTK3
TreeFamⁱ	TF313030

Enzyme and pathway databases

UniPathwayⁱ	UPA00196
Reactomeⁱ	R-MMU-162791 Attachment of GPI anchor to uPAR

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9WTK3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022561 Expressed in 228 organ(s), highest expression level in cerebellum
CleanExⁱ	MM_GPAA1
ExpressionAtlasⁱ	Q9WTK3 baseline and differential
Genevisibleⁱ	Q9WTK3 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR007246 Gaa1
PANTHERⁱ	PTHR13304 PTHR13304, 1 hit
Pfamⁱ	View protein in Pfam PF04114 Gaa1, 1 hit
PIRSFⁱ	PIRSF036762 GAA1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPAA1_MOUSE
Accessionⁱ	Q9WTK3Primary (citable) accession number: Q9WTK3 Secondary accession number(s): Q3TNU9, Q9R1U8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WTK3 (GPAA1_MOUSE)

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Glycosylphosphatidylinositol anchor attachment 1 protein

Gpaa1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: glycosylphosphatidylinositol-anchor biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ