Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear protein 1

Gene

Nupr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac) (By similarity). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3 (By similarity). NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to toxic agents, such as doxorubicin (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.By similarity1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear protein 1Curated
Alternative name(s):
Nuclear transcriptional regulator protein 1Imported
Protein p8
Gene namesi
Name:Nupr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1891834 Nupr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580081 – 80Nuclear protein 1Add BLAST80

Post-translational modificationi

Phosphorylated. Phosphorylation promotes DNA-binding activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9WTK0
PRIDEiQ9WTK0

PTM databases

PhosphoSitePlusiQ9WTK0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030717 Expressed in 249 organ(s), highest expression level in cochlea
CleanExiMM_NUPR1
ExpressionAtlasiQ9WTK0 baseline and differential
GenevisibleiQ9WTK0 MM

Interactioni

Subunit structurei

Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1.By similarity

Protein-protein interaction databases

BioGridi207894, 3 interactors
STRINGi10090.ENSMUSP00000032961

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 80Nuclear localization signalSequence analysisAdd BLAST17

Domaini

May exhibit the features of HMG-I(Y) proteins.By similarity

Sequence similaritiesi

Belongs to the NUPR family.Curated

Phylogenomic databases

eggNOGiKOG4319 Eukaryota
ENOG4112B8R LUCA
GeneTreeiENSGT00530000064242
HOGENOMiHOG000007609
HOVERGENiHBG052704
InParanoidiQ9WTK0
KOiK15626
OMAiRHSPGGH
OrthoDBiEOG091G0X6Z
PhylomeDBiQ9WTK0
TreeFamiTF324649

Family and domain databases

InterProiView protein in InterPro
IPR018792 NUPR1-like
PfamiView protein in Pfam
PF10195 Phospho_p8, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WTK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLPPTANP SQQPLNLEDE DGILDEYDQY SLAHPCVVGG GRKGRTKREA
60 70 80
AANTNRPSPG GHERKLLTKF QNSERKKAWR
Length:80
Mass (Da):8,901
Last modified:November 1, 1999 - v1
Checksum:i8AF6CEF99F66ED67
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNT8A0A087WNT8_MOUSE
Nuclear protein 1
Nupr1
29Annotation score:
A0A0U1RPB6A0A0U1RPB6_MOUSE
Nuclear protein 1
Nupr1 mCG_22384
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41G → V in BAB26369 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131195 Genomic DNA Translation: AAD41784.1
AF131196 mRNA Translation: AAD41785.1
AK009572 mRNA Translation: BAB26369.1
BC002109 mRNA Translation: AAH02109.1
CCDSiCCDS40127.1
RefSeqiNP_062712.1, NM_019738.1
UniGeneiMm.18742

Genome annotation databases

EnsembliENSMUST00000032961; ENSMUSP00000032961; ENSMUSG00000030717
GeneIDi56312
KEGGimmu:56312
UCSCiuc009jsd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131195 Genomic DNA Translation: AAD41784.1
AF131196 mRNA Translation: AAD41785.1
AK009572 mRNA Translation: BAB26369.1
BC002109 mRNA Translation: AAH02109.1
CCDSiCCDS40127.1
RefSeqiNP_062712.1, NM_019738.1
UniGeneiMm.18742

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207894, 3 interactors
STRINGi10090.ENSMUSP00000032961

PTM databases

PhosphoSitePlusiQ9WTK0

Proteomic databases

PaxDbiQ9WTK0
PRIDEiQ9WTK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032961; ENSMUSP00000032961; ENSMUSG00000030717
GeneIDi56312
KEGGimmu:56312
UCSCiuc009jsd.1 mouse

Organism-specific databases

CTDi26471
MGIiMGI:1891834 Nupr1

Phylogenomic databases

eggNOGiKOG4319 Eukaryota
ENOG4112B8R LUCA
GeneTreeiENSGT00530000064242
HOGENOMiHOG000007609
HOVERGENiHBG052704
InParanoidiQ9WTK0
KOiK15626
OMAiRHSPGGH
OrthoDBiEOG091G0X6Z
PhylomeDBiQ9WTK0
TreeFamiTF324649

Miscellaneous databases

ChiTaRSiNupr1 mouse
PROiPR:Q9WTK0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030717 Expressed in 249 organ(s), highest expression level in cochlea
CleanExiMM_NUPR1
ExpressionAtlasiQ9WTK0 baseline and differential
GenevisibleiQ9WTK0 MM

Family and domain databases

InterProiView protein in InterPro
IPR018792 NUPR1-like
PfamiView protein in Pfam
PF10195 Phospho_p8, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUPR1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTK0
Secondary accession number(s): Q9D756
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again