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UniProtKB - Q9WTJ5 (RAMP1_MOUSE)
Protein
Receptor activity-modifying protein 1
Gene
Ramp1
Organism
Mus musculus (Mouse)
Status
Functioni
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
2 PublicationsGO - Molecular functioni
- amylin receptor activity Source: MGI
- calcitonin gene-related peptide binding Source: MGI
- calcitonin gene-related peptide receptor activity Source: MGI
- coreceptor activity Source: MGI
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- amylin receptor signaling pathway Source: MGI
- angiogenesis Source: MGI
- calcitonin gene-related peptide receptor signaling pathway Source: MGI
- calcium ion transport Source: MGI
- cellular response to hormone stimulus Source: GO_Central
- G protein-coupled receptor signaling pathway Source: MGI
- intracellular protein transport Source: InterPro
- positive regulation of protein binding Source: MGI
- positive regulation of protein glycosylation Source: MGI
- protein localization to plasma membrane Source: MGI
- protein transport Source: MGI
- receptor internalization Source: MGI
- regulation of G protein-coupled receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | Receptor |
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events R-MMU-419812, Calcitonin-like ligand receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor activity-modifying protein 1 |
Gene namesi | Name:Ramp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1858418, Ramp1 |
VEuPathDBi | HostDB:ENSMUSG00000034353 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- amylin receptor complex 1 Source: MGI
- CGRP receptor complex Source: MGI
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 117 | ExtracellularSequence analysisAdd BLAST | 91 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 148 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000030169 | 27 – 148 | Receptor activity-modifying protein 1Add BLAST | 122 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 82 | By similarity | ||
Disulfide bondi | 40 ↔ 72 | By similarity | ||
Disulfide bondi | 57 ↔ 104 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MaxQBi | Q9WTJ5 |
PaxDbi | Q9WTJ5 |
PRIDEi | Q9WTJ5 |
ProteomicsDBi | 255091 |
PTM databases
iPTMneti | Q9WTJ5 |
PhosphoSitePlusi | Q9WTJ5 |
Expressioni
Tissue specificityi
Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon.3 Publications
Gene expression databases
Bgeei | ENSMUSG00000034353, Expressed in thymus and 261 other tissues |
Genevisiblei | Q9WTJ5, MM |
Interactioni
Subunit structurei
Heterodimer of CALCRL and RAMP1.
Protein-protein interaction databases
ComplexPortali | CPX-3149, CGRP receptor complex CPX-3235, Amylin receptor 1 complex |
STRINGi | 10090.ENSMUSP00000095253 |
Miscellaneous databases
RNActi | Q9WTJ5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the RAMP family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0TC, Eukaryota |
GeneTreei | ENSGT00940000159224 |
HOGENOMi | CLU_116349_3_0_1 |
InParanoidi | Q9WTJ5 |
OMAi | CYWPNRM |
OrthoDBi | 1432933at2759 |
PhylomeDBi | Q9WTJ5 |
TreeFami | TF333286 |
Family and domain databases
Gene3Di | 1.10.150.510, 1 hit |
InterProi | View protein in InterPro IPR006985, RAMP IPR038126, RAMP_sf |
PANTHERi | PTHR14076, PTHR14076, 1 hit |
Pfami | View protein in Pfam PF04901, RAMP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9WTJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPGLRGLPR CGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKENMET
60 70 80 90 100
IGKTLWCDWG KTIQSYGELT YCTKHVAHTI GCFWPNPEVD RFFIAVHHRY
110 120 130 140
FSKCPISGRA LRDPPNSILC PFIALPITVT LLMTALVVWR SKRTEGIV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WPC6 | A0A087WPC6_MOUSE | Receptor activity-modifying protein... | Ramp1 | 105 | Annotation score: | ||
E9Q915 | E9Q915_MOUSE | Receptor activity-modifying protein... | Ramp1 | 103 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB019046 mRNA Translation: BAA76617.1 AF146522 mRNA Translation: AAD35018.1 AJ250489 mRNA Translation: CAB59511.1 AF209904 mRNA Translation: AAF21036.1 BC012644 mRNA Translation: AAH12644.1 |
CCDSi | CCDS15158.1 |
PIRi | JC7261 |
RefSeqi | NP_058590.1, NM_016894.3 |
Genome annotation databases
Ensembli | ENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353 |
GeneIDi | 51801 |
KEGGi | mmu:51801 |
UCSCi | uc007bzx.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB019046 mRNA Translation: BAA76617.1 AF146522 mRNA Translation: AAD35018.1 AJ250489 mRNA Translation: CAB59511.1 AF209904 mRNA Translation: AAF21036.1 BC012644 mRNA Translation: AAH12644.1 |
CCDSi | CCDS15158.1 |
PIRi | JC7261 |
RefSeqi | NP_058590.1, NM_016894.3 |
3D structure databases
AlphaFoldDBi | Q9WTJ5 |
SMRi | Q9WTJ5 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-3149, CGRP receptor complex CPX-3235, Amylin receptor 1 complex |
STRINGi | 10090.ENSMUSP00000095253 |
Chemistry databases
GuidetoPHARMACOLOGYi | 51 |
PTM databases
iPTMneti | Q9WTJ5 |
PhosphoSitePlusi | Q9WTJ5 |
Proteomic databases
MaxQBi | Q9WTJ5 |
PaxDbi | Q9WTJ5 |
PRIDEi | Q9WTJ5 |
ProteomicsDBi | 255091 |
Protocols and materials databases
Antibodypediai | 34486, 239 antibodies from 39 providers |
DNASUi | 51801 |
Genome annotation databases
Ensembli | ENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353 |
GeneIDi | 51801 |
KEGGi | mmu:51801 |
UCSCi | uc007bzx.2, mouse |
Organism-specific databases
CTDi | 10267 |
MGIi | MGI:1858418, Ramp1 |
VEuPathDBi | HostDB:ENSMUSG00000034353 |
Phylogenomic databases
eggNOGi | ENOG502S0TC, Eukaryota |
GeneTreei | ENSGT00940000159224 |
HOGENOMi | CLU_116349_3_0_1 |
InParanoidi | Q9WTJ5 |
OMAi | CYWPNRM |
OrthoDBi | 1432933at2759 |
PhylomeDBi | Q9WTJ5 |
TreeFami | TF333286 |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events R-MMU-419812, Calcitonin-like ligand receptors |
Miscellaneous databases
BioGRID-ORCSi | 51801, 1 hit in 74 CRISPR screens |
ChiTaRSi | Ramp1, mouse |
PROi | PR:Q9WTJ5 |
RNActi | Q9WTJ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034353, Expressed in thymus and 261 other tissues |
Genevisiblei | Q9WTJ5, MM |
Family and domain databases
Gene3Di | 1.10.150.510, 1 hit |
InterProi | View protein in InterPro IPR006985, RAMP IPR038126, RAMP_sf |
PANTHERi | PTHR14076, PTHR14076, 1 hit |
Pfami | View protein in Pfam PF04901, RAMP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAMP1_MOUSE | |
Accessioni | Q9WTJ5Primary (citable) accession number: Q9WTJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families