Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor activity-modifying protein 1

Gene

Ramp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 1
Gene namesi
Name:Ramp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1858418 Ramp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 117ExtracellularSequence analysisAdd BLAST91
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 148CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi51

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003016927 – 148Receptor activity-modifying protein 1Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82By similarity
Disulfide bondi40 ↔ 72By similarity
Disulfide bondi57 ↔ 104By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9WTJ5
PaxDbiQ9WTJ5
PRIDEiQ9WTJ5

PTM databases

iPTMnetiQ9WTJ5
PhosphoSitePlusiQ9WTJ5

Expressioni

Tissue specificityi

Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon.3 Publications

Gene expression databases

BgeeiENSMUSG00000034353 Expressed in 231 organ(s), highest expression level in thymus
ExpressionAtlasiQ9WTJ5 baseline and differential
GenevisibleiQ9WTJ5 MM

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1.

Protein-protein interaction databases

ComplexPortaliCPX-3149 CGRP receptor complex
CPX-3235 Amylin receptor 1 complex
STRINGi10090.ENSMUSP00000095253

Structurei

3D structure databases

ProteinModelPortaliQ9WTJ5
SMRiQ9WTJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZHQ Eukaryota
ENOG4111NGJ LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000253018
HOVERGENiHBG061268
InParanoidiQ9WTJ5
KOiK08447
OMAiWRSKRPE
OrthoDBiEOG091G0KY6
PhylomeDBiQ9WTJ5
TreeFamiTF333286

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9WTJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGLRGLPR CGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKENMET
60 70 80 90 100
IGKTLWCDWG KTIQSYGELT YCTKHVAHTI GCFWPNPEVD RFFIAVHHRY
110 120 130 140
FSKCPISGRA LRDPPNSILC PFIALPITVT LLMTALVVWR SKRTEGIV
Length:148
Mass (Da):16,892
Last modified:November 1, 1999 - v1
Checksum:i5EC97385EA11DF97
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q915E9Q915_MOUSE
Receptor activity-modifying protein...
Ramp1
103Annotation score:
A0A087WPC6A0A087WPC6_MOUSE
Receptor activity-modifying protein...
Ramp1
105Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019046 mRNA Translation: BAA76617.1
AF146522 mRNA Translation: AAD35018.1
AJ250489 mRNA Translation: CAB59511.1
AF209904 mRNA Translation: AAF21036.1
BC012644 mRNA Translation: AAH12644.1
CCDSiCCDS15158.1
PIRiJC7261
RefSeqiNP_058590.1, NM_016894.3
UniGeneiMm.3272

Genome annotation databases

EnsembliENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353
GeneIDi51801
KEGGimmu:51801
UCSCiuc007bzx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019046 mRNA Translation: BAA76617.1
AF146522 mRNA Translation: AAD35018.1
AJ250489 mRNA Translation: CAB59511.1
AF209904 mRNA Translation: AAF21036.1
BC012644 mRNA Translation: AAH12644.1
CCDSiCCDS15158.1
PIRiJC7261
RefSeqiNP_058590.1, NM_016894.3
UniGeneiMm.3272

3D structure databases

ProteinModelPortaliQ9WTJ5
SMRiQ9WTJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3149 CGRP receptor complex
CPX-3235 Amylin receptor 1 complex
STRINGi10090.ENSMUSP00000095253

Chemistry databases

GuidetoPHARMACOLOGYi51

PTM databases

iPTMnetiQ9WTJ5
PhosphoSitePlusiQ9WTJ5

Proteomic databases

MaxQBiQ9WTJ5
PaxDbiQ9WTJ5
PRIDEiQ9WTJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353
GeneIDi51801
KEGGimmu:51801
UCSCiuc007bzx.2 mouse

Organism-specific databases

CTDi10267
MGIiMGI:1858418 Ramp1

Phylogenomic databases

eggNOGiENOG410IZHQ Eukaryota
ENOG4111NGJ LUCA
GeneTreeiENSGT00390000016200
HOGENOMiHOG000253018
HOVERGENiHBG061268
InParanoidiQ9WTJ5
KOiK08447
OMAiWRSKRPE
OrthoDBiEOG091G0KY6
PhylomeDBiQ9WTJ5
TreeFamiTF333286

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Miscellaneous databases

PROiPR:Q9WTJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034353 Expressed in 231 organ(s), highest expression level in thymus
ExpressionAtlasiQ9WTJ5 baseline and differential
GenevisibleiQ9WTJ5 MM

Family and domain databases

Gene3Di1.10.150.510, 1 hit
InterProiView protein in InterPro
IPR006985 RAMP
IPR038126 RAMP_sf
PANTHERiPTHR14076 PTHR14076, 1 hit
PfamiView protein in Pfam
PF04901 RAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP1_MOUSE
AccessioniPrimary (citable) accession number: Q9WTJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again