UniProtKB - Q9WTJ5 (RAMP1_MOUSE)

BLAST

>sp|Q9WTJ5|RAMP1_MOUSE Receptor activity-modifying protein 1 OS=Mus musculus OX=10090 GN=Ramp1 PE=1 SV=1
MAPGLRGLPRCGLWLLLAHHLFMVTACRDPDYGTLIQELCLSRFKENMETIGKTLWCDWG
KTIQSYGELTYCTKHVAHTIGCFWPNPEVDRFFIAVHHRYFSKCPISGRALRDPPNSILC
PFIALPITVTLLMTALVVWRSKRTEGIV

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History
Entry version 127 (07 Nov 2018)
Sequence version 1 (01 Nov 1999)
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Protein

Receptor activity-modifying protein 1

Gene

Ramp1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.2 Publications

GO - Molecular functionⁱ

amylin receptor activity Source: MGI
calcitonin gene-related peptide binding Source: MGI
calcitonin gene-related peptide receptor activity Source: MGI
coreceptor activity
Source: MGI
Inferred from direct assayⁱ
- 10854696
protein transporter activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
amylin receptor signaling pathway Source: MGI
angiogenesis Source: MGI
calcitonin gene-related peptide receptor signaling pathway Source: MGI
calcium ion transport Source: MGI
cellular response to hormone stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: MGI
Inferred from physical interactionⁱ
- 10854696
intracellular protein transport Source: InterPro
positive regulation of protein glycosylation Source: MGI
protein localization to plasma membrane Source: MGI
protein transport Source: MGI
receptor internalization Source: MGI
regulation of G protein-coupled receptor signaling pathway Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-418555 G alpha (s) signalling events R-MMU-419812 Calcitonin-like ligand receptors

Reactomeⁱ

R-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor activity-modifying protein 1
Gene namesⁱ	Name:Ramp1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1858418 Ramp1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 117	ExtracellularSequence analysisAdd BLAST	91
Transmembraneⁱ	118 – 138	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	139 – 148	CytoplasmicSequence analysis	10

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	51

GuidetoPHARMACOLOGYⁱ

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000030169	27 – 148	Receptor activity-modifying protein 1Add BLAST		122

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	27 ↔ 82	By similarity
Disulfide bondⁱ	40 ↔ 72	By similarity
Disulfide bondⁱ	57 ↔ 104	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9WTJ5
PaxDbⁱ	Q9WTJ5
PRIDEⁱ	Q9WTJ5

PTM databases

iPTMnetⁱ	Q9WTJ5
PhosphoSitePlusⁱ	Q9WTJ5

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in the thymus, skeletal muscle, embryonic and adult brain, embryonic and adult lung, and colon.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000034353 Expressed in 231 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q9WTJ5 baseline and differential
Genevisibleⁱ	Q9WTJ5 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer of CALCRL and RAMP1.

Protein-protein interaction databases

ComplexPortalⁱ	CPX-3149 CGRP receptor complex CPX-3235 Amylin receptor 1 complex
STRINGⁱ	10090.ENSMUSP00000095253

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9WTJ5
SMRⁱ	Q9WTJ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the RAMP family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IZHQ Eukaryota ENOG4111NGJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016200
HOGENOMⁱ	HOG000253018
HOVERGENⁱ	HBG061268
InParanoidⁱ	Q9WTJ5
KEGG Orthology (KO) More...KOⁱ	K08447
OMAⁱ	WRSKRPE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KY6
PhylomeDBⁱ	Q9WTJ5
TreeFamⁱ	TF333286

Family and domain databases

Gene3Dⁱ	1.10.150.510, 1 hit
InterProⁱ	View protein in InterPro IPR006985 RAMP IPR038126 RAMP_sf
PANTHERⁱ	PTHR14076 PTHR14076, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04901 RAMP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9WTJ5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPGLRGLPR CGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKENMET 
        60         70         80         90        100
IGKTLWCDWG KTIQSYGELT YCTKHVAHTI GCFWPNPEVD RFFIAVHHRY 
       110        120        130        140 
FSKCPISGRA LRDPPNSILC PFIALPITVT LLMTALVVWR SKRTEGIV

Length:148

Mass (Da):16,892

Last modified:November 1, 1999 - v1

Checksum:ⁱ5EC97385EA11DF97

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q915	E9Q915_MOUSE	Receptor activity-modifying protein... Receptor activity-modifying protein 1	Ramp1	103	Annotation score:
A0A087WPC6	A0A087WPC6_MOUSE	Receptor activity-modifying protein... Receptor activity-modifying protein 1	Ramp1	105	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB019046 mRNA Translation: BAA76617.1 AF146522 mRNA Translation: AAD35018.1 AJ250489 mRNA Translation: CAB59511.1 AF209904 mRNA Translation: AAF21036.1 BC012644 mRNA Translation: AAH12644.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15158.1
PIRⁱ	JC7261
NCBI Reference Sequences More...RefSeqⁱ	NP_058590.1, NM_016894.3
UniGeneⁱ	Mm.3272

Genome annotation databases

Ensemblⁱ	ENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353
GeneIDⁱ	51801
KEGGⁱ	mmu:51801
UCSC genome browser More...UCSCⁱ	uc007bzx.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WTJ5	Receptor (Calcitonin) activity modifying protein 1, isoform CRA_a		MOUSE		148	UniRef100_Q9WTJ5
Uncharacterized protein (Fragment)		MOUSE		43
UPI0003D76B76		MOUSE		126

Protein	Similar proteins		Species	Score	Length	Source
Q9WTJ5	Receptor activity-modifying protein 1		RAT		148	UniRef90_Q9WTJ5
Receptor (Calcitonin) activity modifying protein 1, isoform CRA_a		MOUSE		148
UPI00042ACFA6		PERMB		148
UPI000A30E90C		MUSPA		148
UPI000A31870C		MUSCR		148
+3

Protein	Similar proteins		Species	Score	Length	Source
Q9WTJ5	Receptor activity-modifying protein 1	)	HUMAN		148	UniRef50_O60894
Receptor activity-modifying protein 1		CAVPO		148
Receptor activity-modifying protein 1		PIG		148
Receptor activity-modifying protein 1		RAT		148
RAMP1 isoform 1		PONAB		148
+210

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB019046 mRNA Translation: BAA76617.1 AF146522 mRNA Translation: AAD35018.1 AJ250489 mRNA Translation: CAB59511.1 AF209904 mRNA Translation: AAF21036.1 BC012644 mRNA Translation: AAH12644.1
CCDSⁱ	CCDS15158.1
PIRⁱ	JC7261
RefSeqⁱ	NP_058590.1, NM_016894.3
UniGeneⁱ	Mm.3272

3D structure databases

ProteinModelPortalⁱ	Q9WTJ5
SMRⁱ	Q9WTJ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-3149 CGRP receptor complex CPX-3235 Amylin receptor 1 complex
STRINGⁱ	10090.ENSMUSP00000095253

Chemistry databases

GuidetoPHARMACOLOGYⁱ	51

GuidetoPHARMACOLOGYⁱ

PTM databases

iPTMnetⁱ	Q9WTJ5
PhosphoSitePlusⁱ	Q9WTJ5

Proteomic databases

MaxQBⁱ	Q9WTJ5
PaxDbⁱ	Q9WTJ5
PRIDEⁱ	Q9WTJ5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353
GeneIDⁱ	51801
KEGGⁱ	mmu:51801
UCSCⁱ	uc007bzx.2 mouse

Organism-specific databases

CTDⁱ	10267
MGIⁱ	MGI:1858418 Ramp1

Phylogenomic databases

eggNOGⁱ	ENOG410IZHQ Eukaryota ENOG4111NGJ LUCA
GeneTreeⁱ	ENSGT00390000016200
HOGENOMⁱ	HOG000253018
HOVERGENⁱ	HBG061268
InParanoidⁱ	Q9WTJ5
KOⁱ	K08447
OMAⁱ	WRSKRPE
OrthoDBⁱ	EOG091G0KY6
PhylomeDBⁱ	Q9WTJ5
TreeFamⁱ	TF333286

Enzyme and pathway databases

Reactomeⁱ	R-MMU-418555 G alpha (s) signalling events R-MMU-419812 Calcitonin-like ligand receptors

Reactomeⁱ

R-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9WTJ5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034353 Expressed in 231 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q9WTJ5 baseline and differential
Genevisibleⁱ	Q9WTJ5 MM

Family and domain databases

Gene3Dⁱ	1.10.150.510, 1 hit
InterProⁱ	View protein in InterPro IPR006985 RAMP IPR038126 RAMP_sf
PANTHERⁱ	PTHR14076 PTHR14076, 1 hit
Pfamⁱ	View protein in Pfam PF04901 RAMP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAMP1_MOUSE
Accessionⁱ	Q9WTJ5Primary (citable) accession number: Q9WTJ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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Supporting data

UniProtKB - Q9WTJ5 (RAMP1_MOUSE)

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Receptor activity-modifying protein 1

Ramp1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ