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UniProtKB - Q9WTJ2 (OVOL1_MOUSE)
Protein
Putative transcription factor Ovo-like 1
Gene
Ovol1
Organism
Mus musculus (Mouse)
Status
Functioni
Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 118 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 197 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 213 – 236 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- epidermal cell differentiation Source: GO_Central
- epidermis development Source: MGI
- germline cell cycle switching, mitotic to meiotic cell cycle Source: MGI
- kidney development Source: MGI
- mesoderm development Source: MGI
- negative regulation of meiotic cell cycle phase transition Source: MGI
- negative regulation of stem cell proliferation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- skin development Source: MGI
- spermatogenesis Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Putative transcription factor Ovo-like 1Short name: mOvo1 Short name: mOvo1a |
Gene namesi | Name:Ovol1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1330290, Ovol1 |
VEuPathDBi | HostDB:ENSMUSG00000024922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047012 | 1 – 267 | Putative transcription factor Ovo-like 1Add BLAST | 267 |
Proteomic databases
PaxDbi | Q9WTJ2 |
PRIDEi | Q9WTJ2 |
ProteomicsDBi | 295491 |
PTM databases
iPTMneti | Q9WTJ2 |
PhosphoSitePlusi | Q9WTJ2 |
Expressioni
Tissue specificityi
Expressed in skin, testis, kidney and weakly in lung. Not detected in heart, brain, spleen, liver and skeletal muscle.
Developmental stagei
First expressed at 14.5 dpc in the suprabasal layers of developing epidermis, at 15.5 dpc expression begins in the inner cells of developing hair germs and restricted to inner root sheath and/or precortical cells of developing hair follicles.
Gene expression databases
Bgeei | ENSMUSG00000024922, Expressed in lip and 139 other tissues |
ExpressionAtlasi | Q9WTJ2, baseline and differential |
Genevisiblei | Q9WTJ2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000025861 |
Miscellaneous databases
RNActi | Q9WTJ2, protein |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 118 – 140 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 146 – 168 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 174 – 197 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 213 – 236 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000161363 |
HOGENOMi | CLU_087964_0_0_1 |
InParanoidi | Q9WTJ2 |
OMAi | PLCLTKH |
OrthoDBi | 1419156at2759 |
PhylomeDBi | Q9WTJ2 |
TreeFami | TF337552 |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9WTJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEAS
60 70 80 90 100
VAEPPSCPLA LDMSLRDSSY SVAPGPCVVA QLPSEDVSHL TDPQSRDQGF
110 120 130 140 150
LRTKMKVTLG DSPNGDLFTC HICQKSFTHQ RMLNRHMKCH NDVKRHLCTY
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKERHPDSP LLRKTSKKVA
260
VALQNTVTSL LQGSPHL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494BAQ0 | A0A494BAQ0_MOUSE | Putative transcription factor Ovo-l... | Ovol1 | 42 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF134804 mRNA Translation: AAD29689.1 AF134805 mRNA Translation: AAD29690.1 AK003801 mRNA Translation: BAB23003.1 AK028577 mRNA Translation: BAC26015.1 AK132478 mRNA Translation: BAE21188.1 AK132505 mRNA Translation: BAE21208.1 AK132506 mRNA Translation: BAE21209.1 BC021411 mRNA Translation: AAH21411.1 |
CCDSi | CCDS29469.1 |
RefSeqi | NP_064319.1, NM_019935.3 |
Genome annotation databases
Ensembli | ENSMUST00000025861; ENSMUSP00000025861; ENSMUSG00000024922 |
GeneIDi | 18426 |
KEGGi | mmu:18426 |
UCSCi | uc008gdu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF134804 mRNA Translation: AAD29689.1 AF134805 mRNA Translation: AAD29690.1 AK003801 mRNA Translation: BAB23003.1 AK028577 mRNA Translation: BAC26015.1 AK132478 mRNA Translation: BAE21188.1 AK132505 mRNA Translation: BAE21208.1 AK132506 mRNA Translation: BAE21209.1 BC021411 mRNA Translation: AAH21411.1 |
CCDSi | CCDS29469.1 |
RefSeqi | NP_064319.1, NM_019935.3 |
3D structure databases
SMRi | Q9WTJ2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000025861 |
PTM databases
iPTMneti | Q9WTJ2 |
PhosphoSitePlusi | Q9WTJ2 |
Proteomic databases
PaxDbi | Q9WTJ2 |
PRIDEi | Q9WTJ2 |
ProteomicsDBi | 295491 |
Protocols and materials databases
Antibodypediai | 1312, 244 antibodies from 28 providers |
DNASUi | 18426 |
Genome annotation databases
Ensembli | ENSMUST00000025861; ENSMUSP00000025861; ENSMUSG00000024922 |
GeneIDi | 18426 |
KEGGi | mmu:18426 |
UCSCi | uc008gdu.1, mouse |
Organism-specific databases
CTDi | 5017 |
MGIi | MGI:1330290, Ovol1 |
VEuPathDBi | HostDB:ENSMUSG00000024922 |
Phylogenomic databases
eggNOGi | KOG3576, Eukaryota |
GeneTreei | ENSGT00940000161363 |
HOGENOMi | CLU_087964_0_0_1 |
InParanoidi | Q9WTJ2 |
OMAi | PLCLTKH |
OrthoDBi | 1419156at2759 |
PhylomeDBi | Q9WTJ2 |
TreeFami | TF337552 |
Miscellaneous databases
BioGRID-ORCSi | 18426, 2 hits in 64 CRISPR screens |
PROi | PR:Q9WTJ2 |
RNActi | Q9WTJ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024922, Expressed in lip and 139 other tissues |
ExpressionAtlasi | Q9WTJ2, baseline and differential |
Genevisiblei | Q9WTJ2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027756, Ovo-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR10032, PTHR10032, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | OVOL1_MOUSE | |
Accessioni | Q9WTJ2Primary (citable) accession number: Q9WTJ2 Secondary accession number(s): Q545S2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot