Unconventional myosin-Ic

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 15976448
• actin-dependent ATPase activity Source: MGI
• actin filament binding Source: MGI
• ATP binding Source: UniProtKBNon-traceable author statementⁱ
  • 15976448
• calmodulin binding Source: MGI
• microfilament motor activity Source: ReactomeInferred from experimentⁱ
  • 19046570
• phospholipid binding Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 15976448
• protein C-terminus binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 15976448
• Ral GTPase binding Source: MGI
• signaling receptor binding Source: MGI

GO - Biological processⁱ

• cellular response to interferon-gamma Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 19144319
• mRNA transport Source: UniProtKB-KW
• positive regulation of actin filament polymerization Source: MGI
• positive regulation of cell migration Source: MGI
• positive regulation of cell migration by vascular endothelial growth factor signaling pathway Source: MGI
• positive regulation of cellular response to insulin stimulus Source: MGIInferred from direct assayⁱ
  • 12490950
• positive regulation of protein targeting to membrane Source: MGIInferred from direct assayⁱ
  • 12490950
• positive regulation of vascular endothelial growth factor signaling pathway Source: MGI
• protein targeting Source: MGI
• protein targeting to membrane Source: MGI
• regulation of bicellular tight junction assembly Source: MGI
• vesicle transport along actin filament Source: MGIInferred from direct assayⁱ
  • 12490950

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• actin binding Source: UniProtKBNon-traceable author statementⁱ
  • 15976448
• actin filament binding Source: MGI
• calmodulin binding Source: MGI
• protein C-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • 15976448
• Ral GTPase binding Source: MGI
• signaling receptor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD 
        60         70         80         90        100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH 
       110        120        130        140        150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT 
       160        170        180        190        200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK 
       210        220        230        240        250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHVF YQLLEGGEEE 
       260        270        280        290        300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVMRKA LSVIDFTEDE 
       310        320        330        340        350
VEDLLSIVAS VLHLGNIHFA ADEDSNAQVT TENQLKYLTR LLGVEGTTLR 
       360        370        380        390        400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVRKINRS 
       410        420        430        440        450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI 
       460        470        480        490        500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR 
       510        520        530        540        550
PGEATDLTFL EKLEDTVKPH PHFLTHKLAD QKTRKSLDRG EFRLLHYAGE 
       560        570        580        590        600
VTYSVTGFLD KNNDLLFRNL KETMCSSMNP IMAQCFDKSE LSDKKRPETV 
       610        620        630        640        650
ATQFKMSLLQ LVEILRSKEP AYIRCIKPND AKQPGRFDEV LIRHQVKYLG 
       660        670        680        690        700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPMWAGRP QDGVAVLVRH 
       710        720        730        740        750
LGYKPEEYKM GRTKIFIRFP KTLFATEDSL EVRRQSLATK IQAAWRGFHW 
       760        770        780        790        800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IRGFILRHSP 
       810        820        830        840        850
RCPENAFFLD HVRASFLLNL RRQLPRNVLD TSWPTPPPAL REASELLREL 
       860        870        880        890        900
CMKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 
       910        920        930        940        950
LGTEEISPRV LQSLGSEPIQ YAVPVVKYDR KGYKPRPRQL LLTPSAVVIV 
       960        970        980        990       1000
EDAKVKQRID YANLTGISVS SLSDSLFVLH VQREDNKQKG DVVLQSDHVI 
      1010       1020       1030       1040       1050
ETLTKTALSA DRVNNININQ GSITFAGGPG RDGIIDFTSG SELLITKAKN 
      1060 
GHLAVVAPRL NSR                                         

        10         20         30         40         50
MESALTARDR VGVQDFVLLE NFTSEAAFIE NLRRRFRENL IYTYIGPVLV 
        60         70         80         90        100
SVNPYRDLQI YSRQHMERYR GVSFYEVPPH LFAVADTVYR ALRTERRDQA 
       110        120        130        140        150
VMISGESGAG KTEATKRLLQ FYAETCPAPE RGGAVRDRLL QSNPVLEAFG 
       160        170        180        190        200
NAKTLRNDNS SRFGKYMDVQ FDFKGAPVGG HILSYLLEKS RVVHQNHGER 
       210        220        230        240        250
NFHVFYQLLE GGEEETLRRL GLERNPQSYL YLVKGQCAKV SSINDKSDWK 
       260        270        280        290        300
VMRKALSVID FTEDEVEDLL SIVASVLHLG NIHFAADEDS NAQVTTENQL 
       310        320        330        340        350
KYLTRLLGVE GTTLREALTH RKIIAKGEEL LSPLNLEQAA YARDALAKAV 
       360        370        380        390        400
YSRTFTWLVR KINRSLASKD AESPSWRSTT VLGLLDIYGF EVFQHNSFEQ 
       410        420        430        440        450
FCINYCNEKL QQLFIELTLK SEQEEYEAEG IAWEPVQYFN NKIICDLVEE 
       460        470        480        490        500
KFKGIISILD EECLRPGEAT DLTFLEKLED TVKPHPHFLT HKLADQKTRK 
       510        520        530        540        550
SLDRGEFRLL HYAGEVTYSV TGFLDKNNDL LFRNLKETMC SSMNPIMAQC 
       560        570        580        590        600
FDKSELSDKK RPETVATQFK MSLLQLVEIL RSKEPAYIRC IKPNDAKQPG 
       610        620        630        640        650
RFDEVLIRHQ VKYLGLMENL RVRRAGFAYR RKYEAFLQRY KSLCPETWPM 
       660        670        680        690        700
WAGRPQDGVA VLVRHLGYKP EEYKMGRTKI FIRFPKTLFA TEDSLEVRRQ 
       710        720        730        740        750
SLATKIQAAW RGFHWRQKFL RVKRSAICIQ SWWRGTLGRR KAAKRKWAAQ 
       760        770        780        790        800
TIRRLIRGFI LRHSPRCPEN AFFLDHVRAS FLLNLRRQLP RNVLDTSWPT 
       810        820        830        840        850
PPPALREASE LLRELCMKNM VWKYCRSISP EWKQQLQQKA VASEIFKGKK 
       860        870        880        890        900
DNYPQSVPRL FISTRLGTEE ISPRVLQSLG SEPIQYAVPV VKYDRKGYKP 
       910        920        930        940        950
RPRQLLLTPS AVVIVEDAKV KQRIDYANLT GISVSSLSDS LFVLHVQRED 
       960        970        980        990       1000
NKQKGDVVLQ SDHVIETLTK TALSADRVNN ININQGSITF AGGPGRDGII 
      1010       1020 
DFTSGSELLI TKAKNGHLAV VAPRLNSR                         

        10         20         30         40         50
MRYRASALGS DGVRVTMESA LTARDRVGVQ DFVLLENFTS EAAFIENLRR 
        60         70         80         90        100
RFRENLIYTY IGPVLVSVNP YRDLQIYSRQ HMERYRGVSF YEVPPHLFAV 
       110        120        130        140        150
ADTVYRALRT ERRDQAVMIS GESGAGKTEA TKRLLQFYAE TCPAPERGGA 
       160        170        180        190        200
VRDRLLQSNP VLEAFGNAKT LRNDNSSRFG KYMDVQFDFK GAPVGGHILS 
       210        220        230        240        250
YLLEKSRVVH QNHGERNFHV FYQLLEGGEE ETLRRLGLER NPQSYLYLVK 
       260        270        280        290        300
GQCAKVSSIN DKSDWKVMRK ALSVIDFTED EVEDLLSIVA SVLHLGNIHF 
       310        320        330        340        350
AADEDSNAQV TTENQLKYLT RLLGVEGTTL REALTHRKII AKGEELLSPL 
       360        370        380        390        400
NLEQAAYARD ALAKAVYSRT FTWLVRKINR SLASKDAESP SWRSTTVLGL 
       410        420        430        440        450
LDIYGFEVFQ HNSFEQFCIN YCNEKLQQLF IELTLKSEQE EYEAEGIAWE 
       460        470        480        490        500
PVQYFNNKII CDLVEEKFKG IISILDEECL RPGEATDLTF LEKLEDTVKP 
       510        520        530        540        550
HPHFLTHKLA DQKTRKSLDR GEFRLLHYAG EVTYSVTGFL DKNNDLLFRN 
       560        570        580        590        600
LKETMCSSMN PIMAQCFDKS ELSDKKRPET VATQFKMSLL QLVEILRSKE 
       610        620        630        640        650
PAYIRCIKPN DAKQPGRFDE VLIRHQVKYL GLMENLRVRR AGFAYRRKYE 
       660        670        680        690        700
AFLQRYKSLC PETWPMWAGR PQDGVAVLVR HLGYKPEEYK MGRTKIFIRF 
       710        720        730        740        750
PKTLFATEDS LEVRRQSLAT KIQAAWRGFH WRQKFLRVKR SAICIQSWWR 
       760        770        780        790        800
GTLGRRKAAK RKWAAQTIRR LIRGFILRHS PRCPENAFFL DHVRASFLLN 
       810        820        830        840        850
LRRQLPRNVL DTSWPTPPPA LREASELLRE LCMKNMVWKY CRSISPEWKQ 
       860        870        880        890        900
QLQQKAVASE IFKGKKDNYP QSVPRLFIST RLGTEEISPR VLQSLGSEPI 
       910        920        930        940        950
QYAVPVVKYD RKGYKPRPRQ LLLTPSAVVI VEDAKVKQRI DYANLTGISV 
       960        970        980        990       1000
SSLSDSLFVL HVQREDNKQK GDVVLQSDHV IETLTKTALS ADRVNNININ 
      1010       1020       1030       1040 
QGSITFAGGP GRDGIIDFTS GSELLITKAK NGHLAVVAPR LNSR       

        10         20         30         40         50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD 
        60         70         80         90        100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH 
       110        120        130        140        150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT 
       160        170        180        190        200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK 
       210        220        230        240        250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHVF YQLLEGGEEE 
       260        270        280        290        300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVMRKA LSVIDFTEDE 
       310        320        330        340        350
VEDLLSIVAS VLHLGNIHFA ADEDSNAQVT TENQLKYLTR LLGVEGTTLR 
       360        370        380        390        400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVRKINRS 
       410        420        430        440        450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI 
       460        470        480        490        500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR 
       510        520        530        540        550
PGEATDLTFL EKLEDTVKPH PHFLTHKLAD QKTRKSLDRG EFRLLHYAGE 
       560        570        580        590        600
VTYSVTGFLD KNNDLLFRNL KETMCSSMNP IMAQCFDKSE LSDKKRPETV 
       610        620        630        640        650
ATQFKMSLLQ LVEILRSKEP AYIRCIKPND AKQPGRFDEV LIRHQVKYLG 
       660        670        680        690        700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPMWAGRP QDGVAVLVRH 
       710        720        730        740        750
LGYKPEEYKM GRTKIFIRFP KTLFATEDSL EVRRQSLATK IQAAWRGFHW 
       760        770        780        790        800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IRGFILRHSP 
       810        820        830        840        850
RCPENAFFLD HVRASFLLNL RRQLPRNVLD TSWPTPPPAL REASELLREL 
       860        870        880        890        900
CMKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 
       910        920        930        940        950
LGTEEISPRV LQSLGSEPIQ YAVPVVKYDR KVTSLAPGSC CSRPVLWSLW 
       960 
RMLKSSRELI MPT                                         

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot