Myo1c

Functionⁱ

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.

1 Publication

Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	88	ATPBy similarity		1
Binding siteⁱ	96	ATPBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	139 – 148	ATPBy similarity		10
Nucleotide bindingⁱ	192 – 196	ATPBy similarity		5

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding, Motor protein, Myosin
Biological process	mRNA transport, Protein transport, Translocation, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-5250924, B-WICH complex positively regulates rRNA expression

Reactomeⁱ

R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-5250924, B-WICH complex positively regulates rRNA expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Unconventional myosin-Ic Alternative name(s): Myosin I beta Short name: MMI-beta Short name: MMIb
Gene namesⁱ	Name:Myo1c
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:106612, Myo1c

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	927	K → A: Inhibits binding to PIP2 and disrupts membrane binding. 1 Publication		1
Mutagenesisⁱ	938	R → A: Inhibits binding to PIP2 and disrupts membrane binding. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000123446	1 – 1063	Unconventional myosin-IcAdd BLAST		1063

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	383	N6-methyllysineBy similarity	1
Modified residueⁱ	408	PhosphoserineBy similarity	1
Modified residueⁱ	486	N6-acetyllysineCombined sources	1
Modified residueⁱ	536	PhosphoserineBy similarity	1
Modified residueⁱ	864	PhosphoserineBy similarity	1
Modified residueⁱ	1041	PhosphoserineBy similarity	1
Isoform 2 (identifier: Q9WTI7-2)
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Isoform 3 (identifier: Q9WTI7-3)
Modified residueⁱ	10	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Isoform 2 contains a N-acetylmethionine at position 1.By similarity

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOSTⁱ	Q9WTI7
PaxDbⁱ	Q9WTI7
PeptideAtlas More...PeptideAtlasⁱ	Q9WTI7
PRIDEⁱ	Q9WTI7
ProteomicsDBⁱ	286126 [Q9WTI7-1] 286127 [Q9WTI7-2] 286128 [Q9WTI7-3] 286129 [Q9WTI7-4]

PTM databases

iPTMnetⁱ	Q9WTI7
PhosphoSitePlusⁱ	Q9WTI7
SwissPalmⁱ	Q9WTI7

Expressionⁱ

Tissue specificityⁱ

Isoform 3 is expressed in small intestine, pancreas, brain, kidney, skin, heart muscle, testis, striated muscle, spleen, liver and lung (at protein level). Expressed in brain, testis, adrenal glands, thymus, spleen, kidney, lung, heart, cochlea and vestibule. Expressed in sensory hair cells of the inner ear. Expressed in adipocytes.4 Publications

Inductionⁱ

Up-regulated by serum.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000017774, Expressed in bone marrow and 311 other tissues
ExpressionAtlasⁱ	Q9WTI7, baseline and differential
Genevisibleⁱ	Q9WTI7, MM

Interactionⁱ

Subunit structureⁱ

Interacts (via its IQ motifs) with CALM; this precludes interaction with YWHAB.

Interacts with YWHAB; this precludes interaction with CALM.

Interacts with RPS6 (By similarity).

Interacts with actin filaments.

Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent.

Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM.

Interacts with POLR1A and POLR2A.

Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.

Interacts with GLUT4.

Interacts with LLPH (PubMed:26961175).

By similarity7 Publications

Binary interactionsⁱ

Hide details

Q9WTI7

With	#Exp.	IntAct
Plekhb1 - isoform 1 [Q9QYE9-1]	4	EBI-777558,EBI-1127141
Plekhb1 - isoform 2 [Q9QYE9-2]	2	EBI-777558,EBI-1127145

Isoform 2 [Q9WTI7-2]

With	#Exp.	IntAct
CALM3 [P62158] From a different organism.	9	EBI-16129068,EBI-397435

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	201664, 147 interactors
ComplexPortalⁱ	CPX-1133, B-WICH chromatin remodelling complex [Q9WTI7-3]
CORUMⁱ	Q9WTI7
Database of interacting proteins More...DIPⁱ	DIP-35498N
IntActⁱ	Q9WTI7, 150 interactors
Molecular INTeraction database More...MINTⁱ	Q9WTI7
STRINGⁱ	10090.ENSMUSP00000104069

Miscellaneous databases

RNActⁱ	Q9WTI7, protein

RNActⁱ

Q9WTI7, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9WTI7
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	47 – 731	Myosin motorPROSITE-ProRule annotationAdd BLAST	685
Domainⁱ	734 – 757	IQ 1PROSITE-ProRule annotationAdd BLAST	24
Domainⁱ	758 – 786	IQ 2PROSITE-ProRule annotationAdd BLAST	29
Domainⁱ	885 – 1059	TH1PROSITE-ProRule annotationAdd BLAST	175

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	608 – 630	Actin-bindingPROSITE-ProRule annotationAdd BLAST		23

Domainⁱ

Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain.1 Publication

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0164, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157915
HOGENOMⁱ	CLU_000192_7_7_1
InParanoidⁱ	Q9WTI7
Database of Orthologous Groups More...OrthoDBⁱ	122881at2759
PhylomeDBⁱ	Q9WTI7
TreeFamⁱ	TF312960

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01378, MYSc_Myo1, 1 hit
Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR010926, Myosin_TH1 IPR036072, MYSc_Myo1 IPR027417, P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00612, IQ, 2 hits PF00063, Myosin_head, 1 hit PF06017, Myosin_TH1, 1 hit
PRINTSⁱ	PR00193, MYOSINHEAVY
SMARTⁱ	View protein in SMART SM00015, IQ, 2 hits SM00242, MYSc, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50096, IQ, 2 hits PS51456, MYOSIN_MOTOR, 1 hit PS51757, TH1, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9WTI7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD 
        60         70         80         90        100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH 
       110        120        130        140        150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT 
       160        170        180        190        200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK 
       210        220        230        240        250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHVF YQLLEGGEEE 
       260        270        280        290        300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVMRKA LSVIDFTEDE 
       310        320        330        340        350
VEDLLSIVAS VLHLGNIHFA ADEDSNAQVT TENQLKYLTR LLGVEGTTLR 
       360        370        380        390        400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVRKINRS 
       410        420        430        440        450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI 
       460        470        480        490        500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR 
       510        520        530        540        550
PGEATDLTFL EKLEDTVKPH PHFLTHKLAD QKTRKSLDRG EFRLLHYAGE 
       560        570        580        590        600
VTYSVTGFLD KNNDLLFRNL KETMCSSMNP IMAQCFDKSE LSDKKRPETV 
       610        620        630        640        650
ATQFKMSLLQ LVEILRSKEP AYIRCIKPND AKQPGRFDEV LIRHQVKYLG 
       660        670        680        690        700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPMWAGRP QDGVAVLVRH 
       710        720        730        740        750
LGYKPEEYKM GRTKIFIRFP KTLFATEDSL EVRRQSLATK IQAAWRGFHW 
       760        770        780        790        800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IRGFILRHSP 
       810        820        830        840        850
RCPENAFFLD HVRASFLLNL RRQLPRNVLD TSWPTPPPAL REASELLREL 
       860        870        880        890        900
CMKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 
       910        920        930        940        950
LGTEEISPRV LQSLGSEPIQ YAVPVVKYDR KGYKPRPRQL LLTPSAVVIV 
       960        970        980        990       1000
EDAKVKQRID YANLTGISVS SLSDSLFVLH VQREDNKQKG DVVLQSDHVI 
      1010       1020       1030       1040       1050
ETLTKTALSA DRVNNININQ GSITFAGGPG RDGIIDFTSG SELLITKAKN 
      1060 
GHLAVVAPRL NSR

Length:1,063

Mass (Da):121,944

Last modified:April 14, 2009 - v2

Checksum:ⁱ494A31B8634A1AF9

GO

Isoform 2 (identifier: Q9WTI7-2) [UniParc]FASTA Add to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
1-35: Missing.

« Hide

        10         20         30         40         50
MESALTARDR VGVQDFVLLE NFTSEAAFIE NLRRRFRENL IYTYIGPVLV 
        60         70         80         90        100
SVNPYRDLQI YSRQHMERYR GVSFYEVPPH LFAVADTVYR ALRTERRDQA 
       110        120        130        140        150
VMISGESGAG KTEATKRLLQ FYAETCPAPE RGGAVRDRLL QSNPVLEAFG 
       160        170        180        190        200
NAKTLRNDNS SRFGKYMDVQ FDFKGAPVGG HILSYLLEKS RVVHQNHGER 
       210        220        230        240        250
NFHVFYQLLE GGEEETLRRL GLERNPQSYL YLVKGQCAKV SSINDKSDWK 
       260        270        280        290        300
VMRKALSVID FTEDEVEDLL SIVASVLHLG NIHFAADEDS NAQVTTENQL 
       310        320        330        340        350
KYLTRLLGVE GTTLREALTH RKIIAKGEEL LSPLNLEQAA YARDALAKAV 
       360        370        380        390        400
YSRTFTWLVR KINRSLASKD AESPSWRSTT VLGLLDIYGF EVFQHNSFEQ 
       410        420        430        440        450
FCINYCNEKL QQLFIELTLK SEQEEYEAEG IAWEPVQYFN NKIICDLVEE 
       460        470        480        490        500
KFKGIISILD EECLRPGEAT DLTFLEKLED TVKPHPHFLT HKLADQKTRK 
       510        520        530        540        550
SLDRGEFRLL HYAGEVTYSV TGFLDKNNDL LFRNLKETMC SSMNPIMAQC 
       560        570        580        590        600
FDKSELSDKK RPETVATQFK MSLLQLVEIL RSKEPAYIRC IKPNDAKQPG 
       610        620        630        640        650
RFDEVLIRHQ VKYLGLMENL RVRRAGFAYR RKYEAFLQRY KSLCPETWPM 
       660        670        680        690        700
WAGRPQDGVA VLVRHLGYKP EEYKMGRTKI FIRFPKTLFA TEDSLEVRRQ 
       710        720        730        740        750
SLATKIQAAW RGFHWRQKFL RVKRSAICIQ SWWRGTLGRR KAAKRKWAAQ 
       760        770        780        790        800
TIRRLIRGFI LRHSPRCPEN AFFLDHVRAS FLLNLRRQLP RNVLDTSWPT 
       810        820        830        840        850
PPPALREASE LLRELCMKNM VWKYCRSISP EWKQQLQQKA VASEIFKGKK 
       860        870        880        890        900
DNYPQSVPRL FISTRLGTEE ISPRVLQSLG SEPIQYAVPV VKYDRKGYKP 
       910        920        930        940        950
RPRQLLLTPS AVVIVEDAKV KQRIDYANLT GISVSSLSDS LFVLHVQRED 
       960        970        980        990       1000
NKQKGDVVLQ SDHVIETLTK TALSADRVNN ININQGSITF AGGPGRDGII 
      1010       1020 
DFTSGSELLI TKAKNGHLAV VAPRLNSR

Show »

Length:1,028

Mass (Da):118,156

Checksum:ⁱ2CF5535D816884DF

GO

Isoform 3 (identifier: Q9WTI7-3) [UniParc]FASTA Add to basket

Also known as: Nuclear myosin 1, NM1

The sequence of this isoform differs from the canonical sequence as follows:
1-25: MALQVELIPTGEIIRVVHPHRPCKL → MRYRAS

« Hide

        10         20         30         40         50
MRYRASALGS DGVRVTMESA LTARDRVGVQ DFVLLENFTS EAAFIENLRR 
        60         70         80         90        100
RFRENLIYTY IGPVLVSVNP YRDLQIYSRQ HMERYRGVSF YEVPPHLFAV 
       110        120        130        140        150
ADTVYRALRT ERRDQAVMIS GESGAGKTEA TKRLLQFYAE TCPAPERGGA 
       160        170        180        190        200
VRDRLLQSNP VLEAFGNAKT LRNDNSSRFG KYMDVQFDFK GAPVGGHILS 
       210        220        230        240        250
YLLEKSRVVH QNHGERNFHV FYQLLEGGEE ETLRRLGLER NPQSYLYLVK 
       260        270        280        290        300
GQCAKVSSIN DKSDWKVMRK ALSVIDFTED EVEDLLSIVA SVLHLGNIHF 
       310        320        330        340        350
AADEDSNAQV TTENQLKYLT RLLGVEGTTL REALTHRKII AKGEELLSPL 
       360        370        380        390        400
NLEQAAYARD ALAKAVYSRT FTWLVRKINR SLASKDAESP SWRSTTVLGL 
       410        420        430        440        450
LDIYGFEVFQ HNSFEQFCIN YCNEKLQQLF IELTLKSEQE EYEAEGIAWE 
       460        470        480        490        500
PVQYFNNKII CDLVEEKFKG IISILDEECL RPGEATDLTF LEKLEDTVKP 
       510        520        530        540        550
HPHFLTHKLA DQKTRKSLDR GEFRLLHYAG EVTYSVTGFL DKNNDLLFRN 
       560        570        580        590        600
LKETMCSSMN PIMAQCFDKS ELSDKKRPET VATQFKMSLL QLVEILRSKE 
       610        620        630        640        650
PAYIRCIKPN DAKQPGRFDE VLIRHQVKYL GLMENLRVRR AGFAYRRKYE 
       660        670        680        690        700
AFLQRYKSLC PETWPMWAGR PQDGVAVLVR HLGYKPEEYK MGRTKIFIRF 
       710        720        730        740        750
PKTLFATEDS LEVRRQSLAT KIQAAWRGFH WRQKFLRVKR SAICIQSWWR 
       760        770        780        790        800
GTLGRRKAAK RKWAAQTIRR LIRGFILRHS PRCPENAFFL DHVRASFLLN 
       810        820        830        840        850
LRRQLPRNVL DTSWPTPPPA LREASELLRE LCMKNMVWKY CRSISPEWKQ 
       860        870        880        890        900
QLQQKAVASE IFKGKKDNYP QSVPRLFIST RLGTEEISPR VLQSLGSEPI 
       910        920        930        940        950
QYAVPVVKYD RKGYKPRPRQ LLLTPSAVVI VEDAKVKQRI DYANLTGISV 
       960        970        980        990       1000
SSLSDSLFVL HVQREDNKQK GDVVLQSDHV IETLTKTALS ADRVNNININ 
      1010       1020       1030       1040 
QGSITFAGGP GRDGIIDFTS GSELLITKAK NGHLAVVAPR LNSR

Show »

Length:1,044

Mass (Da):119,877

Checksum:ⁱCDAB0FF699D041C9

GO

Isoform 4 (identifier: Q9WTI7-4) [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
932-1063: GYKPRPRQLL...AVVAPRLNSR → VTSLAPGSCCSRPVLWSLWRMLKSSRELIMPT

« Hide

        10         20         30         40         50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD 
        60         70         80         90        100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH 
       110        120        130        140        150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT 
       160        170        180        190        200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK 
       210        220        230        240        250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHVF YQLLEGGEEE 
       260        270        280        290        300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVMRKA LSVIDFTEDE 
       310        320        330        340        350
VEDLLSIVAS VLHLGNIHFA ADEDSNAQVT TENQLKYLTR LLGVEGTTLR 
       360        370        380        390        400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVRKINRS 
       410        420        430        440        450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI 
       460        470        480        490        500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR 
       510        520        530        540        550
PGEATDLTFL EKLEDTVKPH PHFLTHKLAD QKTRKSLDRG EFRLLHYAGE 
       560        570        580        590        600
VTYSVTGFLD KNNDLLFRNL KETMCSSMNP IMAQCFDKSE LSDKKRPETV 
       610        620        630        640        650
ATQFKMSLLQ LVEILRSKEP AYIRCIKPND AKQPGRFDEV LIRHQVKYLG 
       660        670        680        690        700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPMWAGRP QDGVAVLVRH 
       710        720        730        740        750
LGYKPEEYKM GRTKIFIRFP KTLFATEDSL EVRRQSLATK IQAAWRGFHW 
       760        770        780        790        800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IRGFILRHSP 
       810        820        830        840        850
RCPENAFFLD HVRASFLLNL RRQLPRNVLD TSWPTPPPAL REASELLREL 
       860        870        880        890        900
CMKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 
       910        920        930        940        950
LGTEEISPRV LQSLGSEPIQ YAVPVVKYDR KVTSLAPGSC CSRPVLWSLW 
       960 
RMLKSSRELI MPT

Note: May be due to a frameshift.Curated

Show »

Length:963

Mass (Da):111,290

Checksum:ⁱC8CEFAE7FADE5B41

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5ND45	Q5ND45_MOUSE		Unconventional myosin-Ic Unconventional myosin-Ic	Myo1c	80	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	69 – 70	RR → GG in CAA67956 (PubMed:9119401).Curated	2
Sequence conflictⁱ	97 – 99	SRQ → RRK in CAA67956 (PubMed:9119401).Curated	3
Sequence conflictⁱ	102	E → G in BAE33311 (PubMed:16141072).Curated	1
Sequence conflictⁱ	107	V → I in BAE33311 (PubMed:16141072).Curated	1
Sequence conflictⁱ	251	T → A (PubMed:8449986).Curated	1
Sequence conflictⁱ	272	C → F (PubMed:8449986).Curated	1
Sequence conflictⁱ	286 – 287	VM → LL (PubMed:8449986).Curated	2
Sequence conflictⁱ	388	R → A (PubMed:8449986).Curated	1
Sequence conflictⁱ	401 – 403	LAS → VPA (PubMed:8449986).Curated	3
Sequence conflictⁱ	446	Q → R (PubMed:8449986).Curated	1
Sequence conflictⁱ	517 – 519	VKP → IKH (PubMed:8449986).Curated	3
Sequence conflictⁱ	578	M → T (PubMed:8449986).Curated	1
Sequence conflictⁱ	607	S → G (PubMed:8449986).Curated	1
Sequence conflictⁱ	735	Q → R in CAA67956 (PubMed:9119401).Curated	1
Sequence conflictⁱ	821	R → G in CAA67956 (PubMed:9119401).Curated	1
Sequence conflictⁱ	842	E → D in CAA67956 (PubMed:9119401).Curated	1
Sequence conflictⁱ	1024	T → A in BAE33311 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_036863	1 – 35	Missing in isoform 2. 4 PublicationsAdd BLAST	35
Alternative sequenceⁱVSP_036864	1 – 25	MALQV…RPCKL → MRYRAS in isoform 3. 2 PublicationsAdd BLAST	25
Alternative sequenceⁱVSP_003350	932 – 1063	GYKPR…RLNSR → VTSLAPGSCCSRPVLWSLWR MLKSSRELIMPT in isoform 4. 1 PublicationAdd BLAST	132

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U96723 mRNA Translation: AAC53264.1 U96726 Genomic DNA Translation: AAC60758.1 AY007255 mRNA Translation: AAG02570.1 AK004743 mRNA Translation: BAB23524.1 AK154294 mRNA Translation: BAE32495.1 AK155530 mRNA Translation: BAE33311.1 AK171107 mRNA Translation: BAE42253.1 AL591440 Genomic DNA No translation available. CH466596 Genomic DNA Translation: EDL12832.1 CH466596 Genomic DNA Translation: EDL12833.1 BC021481 mRNA Translation: AAH21481.1 X99638 mRNA Translation: CAA67956.1 CF615767 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25054.1 [Q9WTI7-2] CCDS36228.1 [Q9WTI7-3] CCDS88191.1 [Q9WTI7-1]
PIRⁱ	B45438 H75634
NCBI Reference Sequences More...RefSeqⁱ	NP_001074243.1, NM_001080774.1 [Q9WTI7-2] NP_001074244.1, NM_001080775.1 [Q9WTI7-3] NP_032685.1, NM_008659.3 [Q9WTI7-2] XP_006532492.1, XM_006532429.3

Genome annotation databases

Ensemblⁱ	ENSMUST00000069057; ENSMUSP00000070388; ENSMUSG00000017774 [Q9WTI7-2] ENSMUST00000102504; ENSMUSP00000099562; ENSMUSG00000017774 [Q9WTI7-2] ENSMUST00000102505; ENSMUSP00000099563; ENSMUSG00000017774 [Q9WTI7-1] ENSMUST00000108431; ENSMUSP00000104069; ENSMUSG00000017774 [Q9WTI7-3]
GeneIDⁱ	17913
KEGGⁱ	mmu:17913
UCSC genome browser More...UCSCⁱ	uc007kem.1, mouse [Q9WTI7-1] uc007keo.1, mouse [Q9WTI7-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9WTI7	Isoform 2 of Unconventional myosin-Ic		MOUSE		1028	UniRef90_Q9WTI7
Myosin IC		SURSU		1108
Myosin IC		FELCA		1074
Myosin IC		MUSPF		1065
Myosin IC (Fragment)		NEOVI		417
+134

Protein	Similar proteins		Species	Score	Length	Source
Q9WTI7	Unconventional myosin-Ic		BOVIN		1063	UniRef50_Q9WTI7
Unconventional myosin-Ic-A		XENLA		1028
Unconventional myosin-Ic		LITCT		1028
Unconventional myosin-Ic		RAT		1044
Unconventional myosin-Ih		MOUSE		958
+1525

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U96723 mRNA Translation: AAC53264.1 U96726 Genomic DNA Translation: AAC60758.1 AY007255 mRNA Translation: AAG02570.1 AK004743 mRNA Translation: BAB23524.1 AK154294 mRNA Translation: BAE32495.1 AK155530 mRNA Translation: BAE33311.1 AK171107 mRNA Translation: BAE42253.1 AL591440 Genomic DNA No translation available. CH466596 Genomic DNA Translation: EDL12832.1 CH466596 Genomic DNA Translation: EDL12833.1 BC021481 mRNA Translation: AAH21481.1 X99638 mRNA Translation: CAA67956.1 CF615767 mRNA No translation available.
CCDSⁱ	CCDS25054.1 [Q9WTI7-2] CCDS36228.1 [Q9WTI7-3] CCDS88191.1 [Q9WTI7-1]
PIRⁱ	B45438 H75634
RefSeqⁱ	NP_001074243.1, NM_001080774.1 [Q9WTI7-2] NP_001074244.1, NM_001080775.1 [Q9WTI7-3] NP_032685.1, NM_008659.3 [Q9WTI7-2] XP_006532492.1, XM_006532429.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4R8G	X-ray	3.50	E	733-1063	[»]
SMRⁱ	Q9WTI7
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	201664, 147 interactors
ComplexPortalⁱ	CPX-1133, B-WICH chromatin remodelling complex [Q9WTI7-3]
CORUMⁱ	Q9WTI7
DIPⁱ	DIP-35498N
IntActⁱ	Q9WTI7, 150 interactors
MINTⁱ	Q9WTI7
STRINGⁱ	10090.ENSMUSP00000104069

PTM databases

iPTMnetⁱ	Q9WTI7
PhosphoSitePlusⁱ	Q9WTI7
SwissPalmⁱ	Q9WTI7

Proteomic databases

jPOSTⁱ	Q9WTI7
PaxDbⁱ	Q9WTI7
PeptideAtlasⁱ	Q9WTI7
PRIDEⁱ	Q9WTI7
ProteomicsDBⁱ	286126 [Q9WTI7-1] 286127 [Q9WTI7-2] 286128 [Q9WTI7-3] 286129 [Q9WTI7-4]

Protocols and materials databases

Antibodypediaⁱ	953, 174 antibodies
The DNASU plasmid repository More...DNASUⁱ	17913

Genome annotation databases

Ensemblⁱ	ENSMUST00000069057; ENSMUSP00000070388; ENSMUSG00000017774 [Q9WTI7-2] ENSMUST00000102504; ENSMUSP00000099562; ENSMUSG00000017774 [Q9WTI7-2] ENSMUST00000102505; ENSMUSP00000099563; ENSMUSG00000017774 [Q9WTI7-1] ENSMUST00000108431; ENSMUSP00000104069; ENSMUSG00000017774 [Q9WTI7-3]
GeneIDⁱ	17913
KEGGⁱ	mmu:17913
UCSCⁱ	uc007kem.1, mouse [Q9WTI7-1] uc007keo.1, mouse [Q9WTI7-3]

Organism-specific databases

CTDⁱ	4641
MGIⁱ	MGI:106612, Myo1c

Phylogenomic databases

eggNOGⁱ	KOG0164, Eukaryota
GeneTreeⁱ	ENSGT00940000157915
HOGENOMⁱ	CLU_000192_7_7_1
InParanoidⁱ	Q9WTI7
OrthoDBⁱ	122881at2759
PhylomeDBⁱ	Q9WTI7
TreeFamⁱ	TF312960

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-5250924, B-WICH complex positively regulates rRNA expression

Reactomeⁱ

R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-5250924, B-WICH complex positively regulates rRNA expression

Miscellaneous databases

BioGRID-ORCSⁱ	17913, 2 hits in 53 CRISPR screens
ChiTaRSⁱ	Myo1c, mouse
Protein Ontology More...PROⁱ	PR:Q9WTI7
RNActⁱ	Q9WTI7, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017774, Expressed in bone marrow and 311 other tissues
ExpressionAtlasⁱ	Q9WTI7, baseline and differential
Genevisibleⁱ	Q9WTI7, MM

Family and domain databases

CDDⁱ	cd01378, MYSc_Myo1, 1 hit
Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR010926, Myosin_TH1 IPR036072, MYSc_Myo1 IPR027417, P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00612, IQ, 2 hits PF00063, Myosin_head, 1 hit PF06017, Myosin_TH1, 1 hit
PRINTSⁱ	PR00193, MYOSINHEAVY
SMARTⁱ	View protein in SMART SM00015, IQ, 2 hits SM00242, MYSc, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50096, IQ, 2 hits PS51456, MYOSIN_MOTOR, 1 hit PS51757, TH1, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYO1C_MOUSE
Accessionⁱ	Q9WTI7Primary (citable) accession number: Q9WTI7 Secondary accession number(s): O08571 Q9QW54
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	April 14, 2009
	Last modified:	June 2, 2021
	This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9WTI7 (MYO1C_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Unconventional myosin-Ic

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoplasm and Cytosol

Other locations

Nucleus

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9WTI7

Isoform 2 [Q9WTI7-2]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ