UniProtKB - Q9WPY4 (Q9WPY4_9HIV1)
Protein
Gag polyprotein
Gene
gag
Organism
Human immunodeficiency virus 1
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
- structural molecule activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- viral budding via host ESCRT complex Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-bindingUniRule annotationARBA annotation, Viral nucleoproteinUniRule annotationARBA annotation |
Biological process | Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesARBA annotation, Viral release from host cell |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Gag polyproteinUniRule annotation |
Gene namesi | Name:gagImported |
Organismi | Human immunodeficiency virus 1Imported |
Taxonomic identifieri | 11676 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Pararnavirae › Artverviricota › Revtraviricetes › Ortervirales › Retroviridae › Orthoretrovirinae › Lentivirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Subcellular locationi
- Cytoplasm ARBA annotation
- Host cytoplasm UniRule annotationARBA annotation
- Host nucleus UniRule annotationARBA annotation
- Nucleus ARBA annotation
- Virion UniRule annotation
- Virion UniRule annotation
- Host nucleus UniRule annotation
- Host cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- viral nucleocapsid Source: UniProtKB-KW
Keywords - Cellular componenti
Capsid proteinUniRule annotationARBA annotation, Host cytoplasmUniRule annotationARBA annotation, Host nucleusUniRule annotationARBA annotation, VirionPTM / Processingi
Post-translational modificationi
Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation
Keywords - PTMi
Lipoprotein, MyristateARBA annotation, PhosphoproteinARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 391 – 406 | CCHC-typeInterPro annotationAdd BLAST | 16 | |
Domaini | 413 – 428 | CCHC-typeInterPro annotationAdd BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 128 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 437 – 490 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 467 – 481 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the primate lentivirus group gag polyprotein family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationFamily and domain databases
Gene3Di | 1.10.1200.30, 1 hit 1.10.150.90, 1 hit 1.10.375.10, 1 hit |
InterProi | View protein in InterPro IPR000721, Gag_p24 IPR014817, Gag_p6 IPR000071, Lentvrl_matrix_N IPR012344, Matrix_HIV/RSV_N IPR008916, Retrov_capsid_C IPR008919, Retrov_capsid_N IPR010999, Retrovr_matrix IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00540, Gag_p17, 1 hit PF00607, Gag_p24, 1 hit PF08705, Gag_p6, 1 hit PF00098, zf-CCHC, 2 hits |
PRINTSi | PR00234, HIV1MATRIX |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 2 hits |
SUPFAMi | SSF47836, SSF47836, 1 hit SSF47943, SSF47943, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9WPY4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGARASVLSG GKLDKWEKIR LRPGGKKTYQ LKHIVWASRE LERFAVNPGL
60 70 80 90 100
LETGGGCKQI LVQLQPSLQT GSEELKSLYN AVATLYCVHQ GIEVRDTKEA
110 120 130 140 150
LDKIEEEQNK SKKKAQQAAA DTGNSSQVSQ NYPIVQNLQG QMVHQAISPR
160 170 180 190 200
TLNAWVKVIE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM
210 220 230 240 250
LKETINEEAA EWDRLHPAHA GPNAPGQMRE PRGSDIAGTT STLQEQIGWM
260 270 280 290 300
TSNPPVPVGE IYKRWIILGL NKIVRMYSPV SILDIRQGPK EPFRDYVDRF
310 320 330 340 350
YKTLRAEQAS QDVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC
360 370 380 390 400
QGVGGPSHKA RILAEAMSQV TSPANIMMQR GNFRNQRKTI KCFNCGKEGH
410 420 430 440 450
LARHCRAPRK KGCWKCGREG HQMKDCTERQ ANFLGKIWPS HKGRPGNFLQ
460 470 480 490 500
SRPEPTAPPE ESFRFGEETT TPPQKQEPLP SQKQETIDKD LYPLASLKSL
FGNDPSLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF128998 Genomic DNA Translation: AAD39400.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingARBA annotationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF128998 Genomic DNA Translation: AAD39400.1 |
3D structure databases
SMRi | Q9WPY4 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.1200.30, 1 hit 1.10.150.90, 1 hit 1.10.375.10, 1 hit |
InterProi | View protein in InterPro IPR000721, Gag_p24 IPR014817, Gag_p6 IPR000071, Lentvrl_matrix_N IPR012344, Matrix_HIV/RSV_N IPR008916, Retrov_capsid_C IPR008919, Retrov_capsid_N IPR010999, Retrovr_matrix IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00540, Gag_p17, 1 hit PF00607, Gag_p24, 1 hit PF08705, Gag_p6, 1 hit PF00098, zf-CCHC, 2 hits |
PRINTSi | PR00234, HIV1MATRIX |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 2 hits |
SUPFAMi | SSF47836, SSF47836, 1 hit SSF47943, SSF47943, 1 hit SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9WPY4_9HIV1 | |
Accessioni | Q9WPY4Primary (citable) accession number: Q9WPY4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1999 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |